Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7799394 | World Health Organization and International League of Associations for Rheumatology core e | 1994 Sep | The WHO/ILAR core set of endpoints for rheumatoid arthritis clinical trials signifies progress in a continuing worldwide effort. This core set includes the following measures: pain, patient global assessment, physical disability, swollen joints, tender joints, acute phase reactants, and physician global assessment; in studies of one or more years' duration, radiographs of joints should be performed. | |
| 8369891 | Transition questions to assess outcomes in rheumatoid arthritis. | 1993 Sep | The importance of patient-based assessments of outcomes of care in RA is increasingly recognized. There are a number of methods of gaining such data. One method is to request patients to assess change in health status by means of transition questions. This is considered advantageous to other methods because is directly addresses perceptions of change over time and is short and simple. One hundred patients with RA completed a range of clinical, laboratory and health status assessments on two occasions 3 months apart. On the second occasion they also completed a transition question. Results show the question to be valid and to correlate with a number of different changes obtained from assessments. Psychological mood did not appear to influence transition judgements. A small minority of patients experienced changes for specific dimensions of health status in the opposite direction of the transition item. Transition judgements may have an important role in evaluation studies and audit. | |
| 8948296 | Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatis | 1996 Nov | In a prospective follow-up study of patients with early-onset rheumatoid arthritis, the prevalence of remission according to the 1981 American Rheumatism Association (ARA) preliminary criteria was evaluated. A total of 227 patients with a median follow-up of 3.9 yr and a total of 2832 follow-up visits were studied. The ARA remission criteria were fulfilled in 9.5% of these visits. The percentage of patients with at least one visit fulfilling the ARA criteria was for years 2-6 approximately 25%. Each year, approximately 15% of the patients were in remission for at least two consecutive visits. A comparison was made between the ARA remission criteria and the Disease Activity Score (DAS). DAS < 1.6 corresponded with being in remission according to the ARA criteria. The DAS is being proposed as a tool to define remission because absence of disease activity should be measured using the same method as for higher levels of disease activity, preferably on a continuous scale. | |
| 8236569 | [Pulmonary rheumatoid nodules. A rare disease onset in rheumatoid arthritis]. | 1993 Oct 4 | Rheumatoid nodules are a benign differential diagnosis to neoplasia and infection, when round lesions are accidental findings on chest X-ray. Two cases are reported of rheumatoid lung nodules as presenting features of rheumatoid arthritis. In each case, the diagnosis was verified by open biopsy. | |
| 1583681 | The relation between stress and disease activity in rheumatoid arthritis. | 1992 Apr | This study investigated the relation between stress and current disease activity in rheumatoid arthritis (RA). During a routine clinic appointment, subjects were given ratings of global disease status by their physicians and completed self-report measures of major stress and minor stress. In addition, each subject's erythrocyte sedimentation rate was taken. After controlling for disease severity and major stress, minor stress accounted for a significant amount of the variance in inflammation level. These results suggest that minor stress is associated with current disease activity in RA. | |
| 8426935 | MR imaging of the hands in early rheumatoid arthritis: preliminary results. | 1993 Jan | Several magnetic resonance (MR) imaging pulse sequences (unenhanced T1 weighted spin echo, with and without fat suppression; unenhanced T2 weighted with fat suppression; and spoiled gradient-recalled acquisition in the steady state [GRASS], with fat suppression, before and after gadolinium enhancement) were analyzed in 30 patients with early rheumatoid arthritis to determine which sequences were best for imaging various aspects of the disease as manifested in the hands and wrists. A single hand was imaged in all patients. Inflammation and erosions were best seen on spoiled GRASS images with fat suppression and gadolinium enhancement, with the latter also being well seen on T1-weighted images. Articular cartilage was best seen on unenhanced spoiled GRASS or T1-weighted images with fat suppression. For the latter application, increased resolution is needed before the results will be meaningful. MR imaging has potential as an objective method for evaluating rheumatoid arthritis. However, change in MR imaging findings in a single hand must be carefully monitored and compared with the overall disease course for a long period in a large number of patients to establish the clinical value of MR imaging. | |
| 1525630 | Pseudosepsis in rheumatoid arthritis due to cellular and lipid abnormalities in synovial f | 1992 Sep | In acute septic arthritis, the synovial fluid is usually frankly purulent. However, the presence of pus does not always imply the presence of infection, and some synovial fluids are easily mistaken for pus. An exaggeration of the normal leucocyte response in inflammatory joint fluids may alone simulate sepsis; marked increases in certain lipid fractions of the fluid may produce similar appearances. We describe a patient who presented with two examples of such 'pseudoseptic arthritis'. | |
| 9010056 | Video image analysis of hands: development of an 'anatomic index' as a potential outcome m | 1996 Dec | In this study, we used video image analysis for the measurement of hand dimensions to reflect destructive changes in rheumatoid arthritis. Thirteen dimensions were measured from anteroposterior and lateral views of the hands, open and closed. Comparison of measurements in 19 patients and 19 control subjects showed significant differences for nine of the 13 measurements. Five were reproducible on retesting in a subset of patients and normals. Two were eliminated because they were similar to other measurements. The three remaining measurements selected for differentiation of patients and normals, and reproducibility, were combined in an arbitrary 'anatomic index'. This enhanced separation of normals and patients with rheumatoid arthritis. The results demonstrate that measurement of certain hand dimensions and their combination in an 'anatomic index' could provide a measure reflecting the progressive anatomical abnormality caused by rheumatoid arthritis. Validation of this concept could provide a further outcome measure in patients with rheumatoid arthritis. | |
| 1582079 | The immunopathogenesis of rheumatoid arthritis. | 1992 May | Rheumatoid arthritis is a chronic inflammatory disease of unknown aetiology. The immunohistology of the rheumatoid synovial membrane (which resembles classical cell-mediated immune lesions), the response to immunomodulatory therapies (thoracic duct drainage, lymphaphoresis, total lymphoid irradiation, anti-T cell monoclonal antibodies) and the strong association with HLA-DR4/DR1 all suggest that it is a disease whose pathogenesis is dependent on the T cell. This Workshop explores the relationship between the frequency of HLA-DR4/DR1 and the clinical expression of rheumatoid arthritis in Europe, where regional differences in these variables are known or suspected to exist. | |
| 8542213 | Proteinaceous lymphadenopathy in a patient with known rheumatoid arthritis--case report an | 1995 Nov | We describe a case of proteinaceous lymphadenopathy (also called lymph node hyalinosis) in a 30-yr-old woman with known rheumatoid arthritis (RA). Amyloidosis was excluded by negative staining with congo red viewed with and without polarized light. Proteinaceous lymphadenopathy should be included in the differential diagnosis of patients with lymphadenopathy and long-standing RA. The histopathologist should be familiar with the morphological appearances of this condition, which can be confused with amyloidosis. It appears that there is a good clinical response in RA-associated proteinaceous lymphadenopathy following successful treatment of arthritis. | |
| 7858816 | Surgical treatment of the rheumatoid hand. | 1994 Oct 5 | Many rheumatoid patients either present late or are denied access to surgery which would benefit them if undertaken at an early stage. Combined clinics involving physicians, surgeons and therapists allow better assessment and help patients to receive maximum benefit from treatment. An understanding of the principles of surgery of the rheumatoid hand is important in the management of these patients. | |
| 8187446 | Randomized trial of switching rheumatoid arthritis patients in remission with injectable g | 1994 Mar | This prospective unblinded 24-month-study compared the therapeutic value of oral gold with injectable gold to maintain rheumatoid arthritis (RA) patients in clinical remission and prevent the progression of erosive disease. Forty-six patients with definite RA in remission with injectable gold were randomized into two groups: a control group, continued on maintenance injectable gold (Solganal, aurothioglucose, 50-100 mg, intramuscularly, 2 to 4 weeks); and an experimental group, switched to oral gold (6-9 mg auranofin by mouth daily). Only 29% of the original 24 oral gold patients remained on assigned treatment at 24 months compared with 64% of the injectable gold group. By six months, over one-half of the oral gold patients had electively stopped their randomized therapy. Sixty-seven percent of the oral gold patients had adverse reactions, mostly gastrointestinal complaints, compared with one proteinuria in the injectable gold group. The oral gold group experienced significantly more deterioration in all the primary measures of treatment effect over the follow-up period. At the termination of the trial, 88% of the group had increases of 5 or more points in radiographic scores suggesting progression of erosive disease compared with only 29% of the control group. These data suggest that oral gold is not an effective substitute for injectable gold in maintaining remission in rheumatoid arthritis. | |
| 8201202 | Isoelastic arthroplasty of the metacarpophalangeal joints in rheumatoid arthritis: a preli | 1994 Mar | The Isoelastic prosthesis for the metacarpophalangeal joint was used in 68 rheumatoid joints. The average follow-up period was 3 years and 3 months. The subjective score for pain, appearance, and usefulness as well as the functional outcome was determined by means of a modified Green test. All subjective scores improved postoperatively, whereas function did not change significantly. Preoperative range of motion values were not available. The extension deficit after operation was 26 degrees, the average flexion 63 degrees, and the total range of motion 37 degrees. Grip strength improved only slightly. Complications included four cases of delayed wound healing and four metacarpal fractures after operation. The Isoelastic prosthesis gives satisfactory results in rheumatoid arthritis patients. The intraoperative insertion is easy and the material is well tolerated. In vivo, the implant itself is rigid enough to resist ulnar drift, although osteolysis around the plastic surface has caused recurrence of ulnar deformity. | |
| 1551285 | Double disease in rheumatology: coexistence of rheumatoid arthritis and psoriatic arthriti | 1992 Jan | Since rheumatoid arthritis (RA) and psoriatic arthritis (PA) are common diseases, there should be a group of patients in which the two entities coexist, with an estimated prevalence ranging from 0.03/10,000 to 0.15/10,000. The two entities may share clinical, analytic and radiologic features that further complicate the diagnosis. We report here a patient in whom RA and PA coexisted. The features that differentiate peripheral arthritis in RA and PA are discussed. | |
| 8561434 | [Functional study of Swanson's metacarpophalangeal arthroplasties in rheumatoid arthritis] | 1995 | To validate a functional hand evaluation and to obtain an historical control group in a project of metacarpophalangeal total joint prosthesis, we reviewed our experience over a ten year period of Swanson's metacarpophalangeal joint arthroplasty in rheumatoid arthritis. Forty-nine implants in fourteen rheumatoid arthritis patients were reviewed clinically, radiologically and evaluated by the Arthritic Hand Function Test. The mean follow up was 4.5 years. All patients were ready to repeat the experience except one. The mean metacarpophalangeal joint range of motion was 37 degrees (18 degrees to 55 degrees) with a mean of 7 degrees ulnar deviation. Although their functional performance was 50% of normal, all patients completed the test. The strength was generally greater on the operated side. The low complication rate (6% fracture rate) with the successful functional outcome of Swanson's metacarpophalangeal joint arthroplasty in rheumatoid arthritis will be the gold standard for any new implant to develop. | |
| 8472510 | [Ocular involvement in rheumatoid arthritis]. | 1993 Jan | The authors evaluated ocular involvement in 23 patients affected by rheumatoid arthritis (RA) according to ARA criteria. Slit-lamp biomicroscopic examination showed signs of keratoconjunctivitis sicca in one patient (4%), while a positive bilateral Schirmer test was found in six subjects (26%). Fluorescein angiography, carried out in 11 of the 23 RA patients, showed retinal vasculitis in 18% of the patients examined, even if no clinical and ophthalmoscopic signs of retinal vessel inflammation were present. The authors suggest that fluorescein angiography should be performed in patients affected by particularly active RA, with recent onset of the disease (< 12 months), high titres of classical IgM rheumatoid factor and raised concentrations of circulating immune complexes. The study confirmed moreover the uncommon ocular toxicity related to the drugs frequently employed in RA treatment (antimalarials, gold salts, glucocorticoids). Indeed, only one case (4%) of posterior subcapsular cataract clearly related to steroid therapy was found. | |
| 8465134 | [Nutrition and chronic polyarthritis]. | 1993 Mar 23 | Patients suffering from chronic and incurable diseases often try to influence their symptoms by dietary modification. The effect of complete fasting on pain in rheumatoid arthritis is remarkable, but not fully understood. Polyunsaturated fatty-acids, specially omega-3-fatty-acids from fish oil, are significant as precursors of mediators for inflammation. In rare instances food allergy may cause or aggravate arthritis. The actual knowledge is presented in a concentrated form and some practical advice is given. | |
| 1555041 | Hand and upper limb problems of instrumental musicians. | 1992 Apr | Instrumental musicians are prone to a variety of occupationally determined upper limb problems that produce significant disability and loss of earnings. As the majority of these affect the musculoskeletal system in one way or another they assume a particular relevance to the practice of rheumatology. Recent advances in our understanding of the aetiology of these conditions are described together their mode of presentation, differential diagnosis, investigation and the therapeutic options available for them. | |
| 8778649 | A rare case of sarcoidosis with rheumatoid arthritis. | 1995 Dec | Sarcoidosis shows many of the clinical and immunological abnormalities and is a multi-organ granulomatous disease of unknown cause which has histological features of non-caseous epithelioid granuloma formation. Sarcoidosis is rarely coexisted rheumatoid arthritis. Although such arthropathy if occur is thought to manifest rheumatoid changes, the current presence of sarcoidosis and rheumatoid arthropathy has been reported by very few histological studies. We experienced a case of combination of sarcoidosis and rheumatoid arthritis both of which were histologically confirmed. This patient initially developed small papules on the face and was diagnosed as having sarcoidosis after one year. Later, she showed symptoms and signs of polyarthritis and was confirmed to have sarcoidosis and rheumatoid arthritis in combination by histological analysis. We present this case with some reference to literatures. | |
| 7604708 | Synovectomy and radial head excision in rheumatoid arthritis. 11 patients followed for 14 | 1995 Jun | A radial head excision and partial synovectomy of the elbow through a lateral approach was performed in 24 patients suffering from rheumatoid arthritis. At follow-up examination of 11 patients (12 elbows) 14 years postoperatively, 10 patients were still satisfied with pain reduction and improved elbow motion. 2 elbows had been reoperated on. Radiographic destruction, assessed by the Larsen index, was, on average, 2.9 preoperatively and 3.8 at follow-up. |