Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7830475 | Histological studies on the rheumatoid synovial membrane irradiated with a low energy lase | 1994 | The beneficial effects of low energy laser irradiation on rheumatoid arthritis (RA) joints have been reported, but the mechanisms of action of low energy lasers in RA are unclear. The synovial membrane in cases of RA was studied histologically to observe the effects of low energy laser irradiation. Fourteen knee joints of RA cases, which had been scheduled for arthroplasty, were irradiated with a gallium-aluminium-arsenide (Ga-Al-As) laser (790 nm in wavelength and 10 mW of output power) prior to the surgical operation, at six points of the external aspect of the knee joint for 80 seconds at each points once a day for 6 days. On the day following the last irradiation, pieces of synovial membrane from the lateral irradiated area and from the median nonirradiated area as a control were resected during the arthroplasty. The histological findings of the irradiated synovial membrane showed flattening of epithelial cells, decreased villous proliferation, narrowed vascular lumen, and less infiltration of inflammatory cells compared with those of nonirradiated synovia. The evaluation of slides was done in a blinded manner, and significant differences was seen by Wilcoxon's t-test (P < 0.01). Histological findings suggested that the low energy laser irradiation induced suppression of inflammation in the synovial membrane of RA. | |
| 1613739 | Immunopathogenesis and treatment of rheumatoid arthritis. | 1992 Jan | Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology. Recent advances have suggested that T cells play a critical role in the immunopathogenesis of RA. A variety of clinical trials using a number of monoclonal antibodies have confirmed the hypothesis that CD4+ T cells play a central role in propagating the disease. Moreover, these trials have suggested rational approaches for the treatment of RA in the future. Despite a comprehensive view of the immunopathogenic processes causing the manifestations of the disease, the underlying cause of RA remains unknown. Critical aspects of RA that might be important in the early diagnosis and prognosis of the disease remain to be delineated. These include the precise role of the association with gene products of the major histocompatibility complex and possibly the role of other genetic elements. In addition, there is no information concerning potential etiologic agents. Delineation of these issues should provide additional insight into RA and potential approaches to treatment and prevention. | |
| 8431208 | Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease a | 1993 Feb | OBJECTIVE: To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA). METHODS: Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated. RESULTS: Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain. CONCLUSION: These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity. | |
| 9082591 | [The negative effects of low-intensity laser therapy in rheumatoid arthritis]. | 1996 | Intravascular laser therapy of 129 patients with rheumatoid arthritis (RA) had a negative effect on articular syndrome, clinical and laboratory activity of inflammation. One female showed new systemic manifestations of RA. In control subjects on placebo the above unfavorable effects were absent. It is concluded that RA patients do not always benefit from laser therapy which should be assigned only after consideration of listed contraindications. | |
| 8153798 | Nystagmus and joint position sensation: their importance in posterior occipitocervical fus | 1994 Jan 1 | It is widely believed that brain stem dysfunction and cranial nerve palsies in patients with rheumatoid arthritis (RA) are common and related to the vertical translocation of the odontoid process. In our database of 235 patients with seropositive RA and craniocervical junction involvement, we have found a very low incidence of such problems. Long tract signs were common, but loss of proprioception (joint position sensation) as the sole neurologic deficit was rare. Nystagmus was found to be associated with the tonsillar herniation of a Chiari 1 malformation and loss of joint position sensation with severe compression of the posterior aspect of the spinal cord at the craniocervical junction. The implications for posterior occipitocervical fusion, particularly by sublaminar wiring, are discussed. | |
| 7976291 | Silastic arthroplasty in rheumatoid MCP-joints. 60 joints followed for 7 years. | 1994 Aug | 16 patients with rheumatoid arthritis underwent Swanson silastic arthroplasty in 60 MCP-joints. After 7 (5-10) years only 8 patients had pain relief, 7 were satisfied, and 13 implants had fractured. We conclude that the effects of Swanson silastic arthroplasty deteriorate with time. | |
| 8108660 | Long-term outcome of rheumatoid arthritis has improved. | 1994 | X-rays of 20 finger joints, 10 foot joints and 2 wrists of 50 female patients with seropositive rheumatoid arthritis of 10-15 years' duration from 1962, 1972, 1982 and 1992 were evaluated blindly for erosions. A highly significant decline was observed in erosions in finger joints. Erosions had also declined in wrists and in foot joints, though less than in fingers. This may indicate improvement in the long-term outcome of rheumatoid arthritis. | |
| 8515603 | [A case of rheumatoid arthritis accompanied by repeated pleural effusion associated with r | 1993 Feb | A 65-year-old woman was referred to our department because of general fatigue and anorexia for one month. The patient has received anti-rheumatoid therapy with aurothiomalate and bucillamine for the last two years for rheumatoid arthritis diagnosed 11 years earlier. Based on her systemic arthralgia, positive RA factor, and characteristic pleural effusion, the diagnosis of rheumatoid pleural effusion was made and prednisolone was administered. Two weeks later, the pleural effusion had improved. Rapid tapering of the drug over one month resulted in reappearance of pleural effusion. Slow tapering of prednisolone resulted in disappearance of the pleural effusion. One year after discharge, the patient was again referred to our department because of increased arthralgia. Pleural effusion reappeared after similar rapid tapering of the drug. These results suggest that induction of pleural effusion may occur in rheumatoid arthritis patients as a result of rapid tapering of steroids. Tapering of steroids in rheumatoid patients should be performed with care. | |
| 1512758 | Rheumatology function tests: grip strength, walking time, button test and questionnaires d | 1992 Jul | Four quantitative measures of functional status, grip strength, walking time, the button test, and a questionnaire regarding activities of daily living, were assessed nine years apart in 75 patients with rheumatoid arthritis (RA). After 9 years, 20 patients had died; none were lost to followup. Functional status had declined in more than 80% of patients according to each of the 4 measures, and patients with poor values at baseline were most likely to die over the next 5 years, as reported. We report that baseline values of these measures of functional status were predictive of values 9 years later. These measures may be regarded as "rheumatology function tests" to document and predict morbidity and mortality in RA over long periods. | |
| 7924052 | Unconstrained shoulder arthroplasty in rheumatoid arthritis. | 1994 Oct | The shoulder complex is commonly involved in patients who have rheumatoid arthritis. Highly satisfactory results have been reported after shoulder arthroplasty in patients with rheumatoid arthritis. There is considerable variability in the pathology within the rheumatic glenohumeral joint. Four radiologic patterns have been identified that correlate well with the pathologic findings. The wet pattern is frequently associated with early rupture of the rotator cuff. Certain technical considerations that apply to the performance of shoulder arthroplasty in these patients are addressed herein. Despite early concerns about fixation of the glenoid component, a long-term study performed at the author's institution suggested that this was no greater a problem than loosening of the humeral component, signs of which are increasingly seen with lengthening followup. There is currently a trend toward use of humeral head replacements alone, which may be an acceptable form of management of the rheumatic glenohumeral joint. | |
| 1486740 | Serum N terminal procollagen III fragment: a predictive marker of joint destruction in rhe | 1992 Dec | The level of the N terminal fragment of procollagen III (P3NP) levels of 100 consecutive patients affected by rheumatoid arthritis (RA) were evaluated in comparison with disease activity markers (erythrocytes sedimentation rate, C reactive protein), immunological status (rheumatoid factors, immune complexes) and joint destruction (assessed according to the Steinbrocker index). P3NP levels showed no significant relationship either to disease activity or to immunological status; however, a strong association was fond between X-ray grade and P3NP values. A two-year retrospective study of 32 patients belonging to the original 100 patient population allowed us to assign a predictive value for joint destruction to the P3NP level in the early stage of the disease. | |
| 7709609 | [The use of low-temperature peloids in treating patients with rheumatoid arthritis (I)]. | 1994 Sep | The effect of peloids having low temperatures of +23-25 degrees C was studied in 65 patients with rheumatoid arthritis. Pelotherapy was found to produce antiinflammatory, anesthetic, desensitizing effects, to improve metabolic trophic processes, locomotor activity, and to exert immunomediator action. The therapy is indicated for patients with rheumatoid arthritis, activity degree II and III, its seropositive type in the presence of exudative proliferative manifestations in the articulations. | |
| 7931051 | Familial occurrence of two patients with malignant rheumatoid arthritis. | 1994 Oct | In Japan, patients with rheumatoid arthritis associated with severe extra-articular manifestations due to vasculitis are diagnosed as having malignant rheumatoid arthritis. We report the occurrence of two cases of malignant rheumatoid arthritis in a Japanese family. Both patients, a father and son, expressed HLA-DR4 (Dw15), and were infected with Epstein-Barr virus. Moreover, the father developed malignant rheumatoid arthritis during reactivation of the Epstein-Barr virus. An unaffected male family member with the same HLA haplotypes was not infected by the virus. The possible role of the virus infection in the pathogenesis of malignant rheumatoid arthritis in a genetically susceptible family is discussed. | |
| 8761195 | Treatment of rheumatoid arthritis--does it affect society's cost for the disease? | 1996 Aug | To assess whether the treatment of rheumatoid arthritis reduces the cost to society of the disease, 62 patients were studied retrospectively over an 18 month period. The first 6 months (period 1) was the time before treatment with remission-inducing drugs (RID). The following 6 month period (period 2) was the time when RID treatment was started and suitable doses were evaluated. The last 6 month period (period 3) was the follow-up period when the results of the treatment were evaluated. The cost for drugs, surgical treatment, out-patient visits, blood tests and hospitalization days during periods 2 and 3 was calculated as 1.6 million SEK. During the same period, the cost for loss of productivity to society was reduced by 1.5 million SEK, assuming that the cost to society would have been unchanged, compared to period 1, if therapy had not been given. In a small group of patients who entered remission, the net saving for society exceeded the cost of treatment. The study indicates that the treatment of rheumatoid arthritis can lead to a reduced cost to society. | |
| 8233583 | MP implants for rheumatoid arthritis of the hand. | 1993 Sep | Rheumatoid arthritis is a devastating disease, which can incapacitate a person in activities of daily living. Only after all other methods have been exhausted, should patients undergo surgery for pain relief, mobility, and cosmetic reasons. A lengthy rehabilitative period following the placement of the metacarpophalangeal implants assures maximum mobility in the new joints. Nurses must be aware of their educational responsibilities to the patient before, during, and after the surgery for patient compliance. | |
| 8145504 | [Therapeutic nutrition and sparing diet therapy in the combined treatment of rheumatoid ar | 1993 | 93 patients with rheumatoid arthritis (RA) were given diet therapy and unloading diets (ULD). Adjuvant diets appeared beneficial for RA patients, allowed reduction in antirheumatic drug dosages. ULD are recommended as an alternative treatment of RA dependent on the process activity and pattern. | |
| 7835006 | Sjogren's syndrome in Israel: primary versus secondary disease. | 1994 Sep | Sixty Israeli patients, 30 with primary Sjögren's syndrome (SS) and 30 with rheumatoid arthritis (RA) and secondary SS, were evaluated. The Schirmer-1 test and a positive labial salivary gland biopsy were found to be the most helpful tools in assessing the diagnosis of SS. Extraglandular features such as Raynaud's phenomenon, lymphadenopathy and CNS involvement as well as parotid gland enlargement (p < 0.05) were more common in primary SS. Antinuclear antibodies, especially anti-Ro (SSA) and anti-La (SSB) were also more common in primary SS (p < 0.05). Our results are in accord with those of many European centers, despite the different genetic background. | |
| 8546726 | Healing phenomena of erosive changes in rheumatoid arthritis patients undergoing disease-m | 1996 Jan | OBJECTIVE: To describe radiographic healing phenomena and reparative changes of joint destruction in rheumatoid arthritis (RA). METHODS: Serial radiographs of 6 patients with erosive RA undergoing long-term treatment with disease-modifying antirheumatic drugs (DMARDs) were studied. Radiographs showing healing phenomena were reproduced, and examples of single joints are shown. RESULTS: The examples show recortication of erosions, filling in of erosions with new bone, and secondary osteoarthrosis with bone sclerosis and osteophyte formation. Commonly use radiographic scoring methods do not have the capacity to account for these reparative changes. CONCLUSION: Healing phenomena can be observed in RA patients undergoing long-term DMARD treatment. These phenomena can be regarded as clinical end points, and their assessment should be incorporated into existing standardized methods for radiologic evaluation and scoring of RA. | |
| 8467613 | Capillaritis: a manifestation of rheumatoid disease. | 1993 Mar | We present seven cases of capillaritis arising in patients with rheumatoid arthritis and suggest that it is primarily related to disease activity and not drugs. In the majority, the rash resolved spontaneously with the use of a topical steroid to treat the symptom of itch. | |
| 1535376 | Trends in the incidence and severity of rheumatoid arthritis. | 1992 Jan | Data are relatively sparse on the trends of incidence and severity of rheumatoid arthritis (RA). Most of the available data indicate a recent decline in the incidence of RA that is particularly marked in women who are more at risk for RA. The data also suggest that there is a decline in disease severity. There are a number of artefactual explanations in the way the data were collected for these studies, but they could represent real changes and provide clues for future studies into both causation and the effectiveness of treatment of RA. |