Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8416101 | [Polyarthritis patients with and without detected rheumatoid factor: a comparison of the p | 1993 Sep | The study examined again the question whether the presence of rheumatoid factor in rheumatoid arthritis (rh.A.) patients has a bearing on their personality scores. For this purpose 20 seropositive rh.A. patients were compared by means of the FPI-R (Freiburg Personality Inventory) with 20 rh.A. patients in whom the rheumatoid factor was absent. Groups were matched for sex and age; severity and duration of disease were taken into account as covariates. The covariates showed significant correlations with some personality variables. Diagnostic subgroups, however, did not differ in any of the FPI scales. | |
| 8316905 | [A case of malignant rheumatoid arthritis with long-term improvement by regular use of cry | 1993 Apr | A Japanese man, 25 years old, suffered from stiffness, swelling, and pain of his joints in May 1983. He was diagnosed as rheumatoid arthritis and was given steroid unsuccessfully. Then, he was admitted to our hospital in February 1984. Because of the presence of high fever and rash on admission, differential diagnosis of RA from adult Stills disease was difficult. However, skin biopsy disclosed apparent vasculitis, leading to the definite diagnosis of malignant RA (MRA). We could not induce any remission by large dose of steroid including pulse therapy, various immuno-suppressants, and anti-rheumatic agents, because of lack of effectiveness and side effects of the drugs. Double filtration plasmapheresis (PA) was performed, but its beneficial effect soon disappeared. On the other hand, cryofiltration PA caused more beneficial and prolonged effect, resulting in improvement. Thereafter, he was successfully followed on regular use of PA for about 6 years. His condition depended on the interval between PA and next PA and on the volume of filtrated plasma. He died of septicemia on March, 1991. We report here the case of MRA with long time improvement by regular use of cryofiltration PA. | |
| 8146788 | [Drug-induced remission in the severe progressive variant of rheumatoid arthritis]. | 1994 | Analysis of the remission incidence and duration has been made in 71 patients with severe progressive rheumatoid arthritis (RA) during the 10-20-year follow-up period, with special attention paid to the role of the disease-modifying drugs (DMARDs). Remission occurred only in those patients who received permanent long-term systematic treatment with DMARDs. Such a therapeutic approach resulted in remission lasting from 5 to 11 years for 32% of the patients. Otherwise the patients who received episodic non-regular DMARDs therapy or symptomatic treatment with nonsteroidal anti-inflammatory drugs or steroids had no remission at all. A detailed analysis of the cases of remission is presented. The authors are of the opinion that after the disappearance of the clinical signs of RA the maintenance basic therapy may be continued. | |
| 7846568 | Rheumatoid involvement of the cervical spine. An overview. | 1994 Oct 15 | OBJECTIVE: This symposium is an update of current knowledge regarding rheumatoid involvement of the cervical spine. SUMMARY OF BACKGROUND DATA: The pathophysiology of rheumatoid involvement in the neck is the same as it is in the peripheral joints. Information regarding the natural history of this condition is incomplete, and more data are needed regarding the natural history in the untreated patient as well as the outcomes of operative management. CONCLUSIONS: Long-term studies of the natural history in the untreated patient as well as the results of operative management will be needed before definitive statements can be made regarding treatment recommendations. However, the latest information available is being presented to guide treatment at this time. | |
| 8578894 | [Atypical course in (eosinophilic) fasciitis]. | 1995 Nov | A 22-year old male patient developed--following a short phase of monarthritis--the symptoms of a symmetric, polysynoviatic, discrete erosive rheumatoid arthritis, thus fulfilling five of seven ACR criteria. Initially as well as persisting during the course of the disease the palpable swelling of synovitis showed a coarse character. The radiological progression at the hands during an interval of eight years being only minimal the loss of functions, up to contraction of joints (left hip) augmented considerably during that time. Neither rheumatoid factor or antinuclear antibodies nor evident eosinophilia or hypergammaglobulinaemia could be proved or verified. In 1994 muscle biopsy led to the diagnosis "fasciitis with low-graded eosinophilia". Anamnestic, clinical and radiological signs and data as well as the course of the disease and assessing of differential diagnoses are presented and discussed. | |
| 8262694 | 2-Buten-4-olide (2-B4O) inhibits type II collagen-induced arthritis in Lewis rats. | 1993 Oct | 2-Buten-4-olide (2-B4O) is an endogenous substance which suppresses appetite and/or food intake. We studied its effect on type II collagen-induced arthritis (CIA) in Lewis rats, an animal model for human rheumatoid arthritis. Bovine type II collagen with incomplete Freund's adjuvant was injected intradermally into Lewis rats to induce CIA. 2-B4O (50 or 100 mg/kg) significantly inhibited the expression of the clinical symptoms when administered i.p. daily from day 1 to 21 after immunization. Furthermore, administration of 2-B4O daily from day 15 to 21 significantly reduced the severity of symptoms in established CIA. In addition, the progression of soft tissue swelling and articular bone erosions were suppressed by daily administration of 2-B4O. 2-B4O also significantly suppressed the delayed-type hypersensitivity (DTH) response to type II collagen at doses of 50 and 100 mg/kg. Finally 2-B4O significantly inhibited the formation of anti-type II collagen antibody at a dose of 100 mg/kg, but not at 50 mg/kg. These results suggest that 2-B4O has the strong inhibitory effects and therapeutic usefulness effects on CIA through the suppression of immune responses to type II collagen. | |
| 7819644 | Posterior decompression and fusion in rheumatoid disease of the cervical spine: redressing | 1994 Oct | Forty-seven patients with rheumatoid disease of the cervical spine were followed over an 8-year period. Twenty-one patients with isolated atlantoaxial subluxation and four with combined atlantoaxial and subaxial disease had their atlantoaxial instability treated by posterior decompression and fusion. The incidence of surgical mortality was 8%, and clinical improvement was noted in 75%. There was no neurological deterioration in those patients who survived long term. We have found posterior decompression and fusion to be a satisfactory procedure for the treatment of atlantooccipital subluxation. In our experience, anterior decompression has not been found necessary for successful treatment of atlantoaxial subluxation in patients with rheumatoid cervical spine disease. | |
| 8496222 | Rheumatoid nodules at the cement-bone interface in revision arthroplasty of rheumatoid pat | 1993 May | We studied the histology of the cement-bone interface and the regenerated synovium in ten aseptically loosened arthroplasties in rheumatoid patients. In two patients we found rheumatoid nodules at the cement-bone interface and marked lymphoplasmacytic infiltration in another three. Failed joints in osteoarthritic patients did not show these changes, and it seems likely that the presence of abundant immunocompetent cells was due to the background disease. We speculate that rheumatoid inflammation contributed to the process of loosening. | |
| 7825267 | [A panorama of rheumatic diseases]. | 1994 Dec 1 | The developments in our health care system mean that the significance of chronic, cost-intensive diseases is continually increasing in terms of diagnosis, treatment and prevention. Under this aspect, rheumatic diseases may be regarded as prime examples in that they generate expenditure in many areas of both social insurance and private insurance. Although many of the disorders classified as rheumatic diseases manifest themselves clinically in the form of complaints in the region of the skeletal system, it should not be forgotten that they are actually systemic disorders, i.e. they have immunological or metabolic causes. This aspect plays a significant role with regard to the possibility of long-term prognosis and hence with regard to life expectancy as well. It also exerts a major influence on the selection of therapeutic concepts which are hoped to slow down the progress of a disease or stop it altogether. Precise inquiries, careful diagnosis, patient-specific therapy, and not least growing health consciousness should be capable of exerting a positive influence on the course of even relatively severe rheumatic conditions. The consequences will be felt to a corresponding degree by the private insurers too. | |
| 7593111 | Short-term complications of the lateral approach for non-constrained elbow replacement. Fo | 1995 Nov | We reviewed 50 capitellocondylar elbow replacements performed by the lateral approach in 42 rheumatoid patients, at a median follow-up of three years. There were two major and 17 minor complications; 18 were early and one was late. Eight elbows required reoperation: soft-tissue surgery was performed in seven and prosthesis removal in one because of a deep infection. There were few problems of instability, but one patient sustained a traumatic dislocation which was stabilised after ligament reconstruction. Wound healing was delayed in two of five elbows which had been immobilised postoperatively for only five days, but healing was rapid in 45 elbows immobilised for 12 days. There was transient ulnar-nerve palsy postoperatively in 11 patients, with permanent palsy in three. All elbows were painfree or only slightly painful at follow-up; 49 were stable and 43 had a range of motion sufficient for activities of daily living. Radiological loosening of the humeral component was suspected in one asymptomatic elbow. The lateral approach is recommended for use with the capitellocondylar type of prosthesis in rheumatoid elbows with reasonably well-preserved bone stock. | |
| 8519589 | [Rupture of the flexor tendons after partial arthrodesis of carpus in the rheumatoid wrist | 1995 | The author report two ruptures of flexor digitorum tendons in a series of thirteen partial wrist arthrodeses in rheumatoid arthritis. These ruptures occurred as a result of attrition at the radial epiphysis after reduction of anterior subluxation of the carpus. | |
| 7799380 | DC-ART: improvement and sustained improvement in function. | 1994 Sep | Implementation of the DC-ART category requires a quantitative definition of its descriptive components, the first of which is that such therapy "improve and sustain function." While function is generally taken to include physical, social, and emotional elements, a case is made for restricting function, in this context, to physical function. It is acknowledged that at present there are scanty data on which to determine the minimal size of improvement in function needed to satisfy DC-ART criteria and, in so doing, predict longer term benefit. Until more information is available on predictive data on patients with rheumatoid arthritis and natural course effects in healthy individuals, it is reasonable to use the arbitrary 25-50% improvements traditionally considered by clinicians to represent clinically important change. | |
| 8779796 | [Murata-Chiba (MC) support ring for acetabular defect in rheumatoid hip]. | 1996 Jun | Acetabular protrusion presents a particular challenge in rheumatoid arthritis. Our surgical plan is (1) to use autologous bone grafts for reconstruction of the acetabulum (2) to locate the correct anatomic position of the acetabulum, (3) to use a uncemented porous socket with rigid screw fixation. From 1991 we began to use MC (Murata-Chiba) support ring which was assembled with Harris-Galante porous socket for highly deformed hip such as acetabular protrusion. We evaluated the clinical and radiographic results of 10 cases. All cases had excellent or good results at follow-up with improved overall function in terms of standing, transfer activities and relief of pain. No apparent complications related to the device was noted. MC support ring is an useful device in rheumatoid hip with severe acetabular protrusion. | |
| 7848514 | When is an autoimmune disease not an autoimmune disease? | 1994 Dec | What are the environmental triggers and genetic susceptibilities underlying the development of autoimmune diseases? These and other questions were addressed at a recent meeting in Finland. | |
| 8169807 | Monarthric ankle pain. A diagnostic challenge. | 1994 Feb | A patient presented with monarthric ankle pain, which took 2 years to diagnose by numerous physicians and imaging and laboratory tests. A review of the differential diagnosis for monarthritic joint pain with guidelines for the work-up of the patient are presented. | |
| 9064112 | Pseudo-felty's syndrome. Report of a case with no symptoms for at least 15 years. | 1996 Jan | The prognosis of large granular lymphocyte proliferation with rheumatoid arthritis (pseudo-Felty's syndrome) remains uncertain. We report a case with a 15-year follow-up. To date, the patient has not developed lymphadenopathy, splenomegaly, abnormalities in erythrocyte or platelet counts, neutropenia or severe or unexplained infections. This favorable course is not ascribable to an unusual lymphocyte phenotype (CD3+, CD8+, CD57+). A beneficial effect of methotrexate therapy is possible. | |
| 8339140 | A self-report articular index: relationship to variations in mood and disease activity mea | 1993 Jul | Self-report can provide an inexpensive method for monitoring disease activity or treatment response in RA, but may be affected by confounding variables such as the patient's mood. The relationship of a self-report articular index (AI) to other relevant parameters was assessed from data gathered at approximately monthly intervals from 16 women with RA. Statistical analysis showed that the AI covaried most strongly with other measures of disease activity and functional disability, while mood variables and ESR covaried separately. These results indicated that responses on the self-report AI paralleled disease activity, and were not merely an artifact of variations in the patient's mood. | |
| 8755127 | HLA class-I and class-II antigen association in rheumatoid arthritis at Varanasi, India. | 1996 Jan | Clinical presentation of rheumatoid arthritis (RA) and its severity differs in different races. Genetic factors play a significant role in its predeliction. The present study was undertaken to find out association of HLA class I and class II antigens with rheumatoid arthritis prevalent in Asian Indians residing at Varanasi. Ninety rheumatoid arthritis patients strictly fulfilling American Rheumatism Association criteria were screened for prevalent HLA class I and class II antigen by Terasaki Microlympho-cytotoxicity test. Results were compared with 100 healthy controls and 35 Seronegative Spondyloarthritides cases (SSA). Rheumatoid arthritis patients showed increased frequency of HLA-A2 and B40 antigens compared to healthy controls (p < .001). SSA patients showed significantly increased Phenotype frequency (PF) of HLA-B27 (p < .0001) and B40 (p < .001). Significant detection of HLA-A2 exclusively in RA patients suggests a more positive association of A2 in rheumatoid arthritis at Varanasi. HLA-B40 could not be attributed absolute significance of association with SSA or RA as it showed increased frequency in both diseases. | |
| 8648306 | Long-term results of total knee arthroplasty in class 3 and 4 rheumatoid arthritis. | 1996 Feb | One hundred four total knee arthroplasties in 67 patients with class 3 and 4 rheumatoid arthritis were reviewed clinically and radiographically at an average of 12.7 years. The Hospital for Special Surgery knee scores were good to excellent in 84 knees (81%). Seventeen knees (16%) were rated as fair, and three knees (3%) as poor. The average range of motion at follow-up examination was 95 degrees. Six knees failed due to delayed sepsis (4.1%), and two failed due to aseptic loosening. At a follow-up period of 15 years, the survivorship analysis suggests a 91% probability of the arthroplasty remaining functional in situ. Cemented total condylar knee arthroplasties in severe rheumatoid arthritis provide durable pain relief and restoration of function. | |
| 8235289 | Differences in anti-Fab antibodies in adult and late onset rheumatoid arthritis. | 1993 | In the present study the ratio of antigen-bound anti-IgG-Fab antibodies (hidden aFab) to free aFab was found to be significantly increased in patients with adult onset rheumatoid arthritis (AORA) as compared to late onset rheumatoid arthritis (LORA). The overall amount of aFab was similar in both groups. The difference was only seen in seropositive patients. Within the seropositive AORA group, the aFab ratio was correlated with the duration and the stage of disease but not with the patients' age at investigation. This might reflect a higher affinity of anti-Fab antibodies and/or a greater diversity of the idiotypic repertoire in adult onset disease resulting in the formation of immune complexes, the stability of which might be enhanced further by the presence of rheumatoid factors. Although a pathophysiological involvement of aFab cannot be concluded from our observations, it is conceivable that different immunoregulatory mechanisms could be operative in RA with onset at different ages. |