Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 8070156 | The Chronic Arthritis Systemic Index (CASI). | 1994 May | Ninety-four rheumatoid patients were studied through laboratory, clinical, algometric, functional and psychological parameters (29 variables in all). Using factorial analysis, four factors emerged which explained 74% of the common variance. The four factors were: the disability factor (explaining 39% of the variance); the biology factor (explaining 21%); the algology factor (explaining 8%); and the clinical factor represented by the Ritchie Articular Index (RAI) (explaining 6%). The four items were used to construct a Chronic Arthritis Systemic Index (CASI) which correlated significantly with other indices, such as the Mallya-Mace, the Thompson and the limited Lansbury indices. CASI provided to be very useful in monitoring the disease course in a short term study of 22 patients undergoing DMARD treatment. Taking into account the parameters proposed as outcome measures by several workshops, CASI can monitor both the activity and severity of chronic arthritides through simple measures. | |
| 7940334 | [The interrelation of vascular, neurological and functional disorders in the hand of rheum | 1994 | The hands of 45 RA patients were studied for vascular, neurological and functional characteristics. The patients underwent functional tests, dopplerography (to study regional arterial flow) and electroneuromyography (to study the peripheral nerves). Induration and defective elasticity of the vascular wall in the radial and ulnar arteries were disclosed in 74% of the cases. Digital arteries suffered occlusive lesion of degree III-IV in 46% of the examinees. One-third of the patients showed signs of polyneuropathy. Among functional defects, the upper grasp incompetence appeared the first. It is stated that parallel affections of the vascular, neurological and functional origin contribute to deficient functional performance of the hand in RA patients. | |
| 1588734 | [Clinical evaluation and application of new ARA criteria for rheumatoid arthritis]. | 1992 Mar | At the 51st American Rheumatism Association meeting, a new ARA criteria for rheumatoid arthritis (RA) was proposed. According to this criteria, both the sensitivity and the specificity have improved to 93% and 90%, respectively. We investigated the adequacy of this criteria by applying this to Japanese patients with RA and control subjects with rheumatic diseases, other than RA. By using new criteria the sensitivity was decreased from 89.6% to 85.3% and the specificity was increased from 82.7% to 92.8%. The factors for the decreased sensitivity of the new criteria were 1) morning stiffness which became more than 1 hour, 2) the number of swelling joints increased from one to three and 3) radiologic changes, which were restricted to the hand only. On the other hand, the factors for increased specificity were (1) morning stiffness, (2) deletion of criterion of joint pain and (3) joint swelling. According to the classification tree method, the sensitivity and the specificity were 96.3% and 90.0% respectively in this study. Continued nationwide study on this new criteria, whether this is applicable and useful to classify Japanese patients with RA is necessary. | |
| 1411206 | [Rheumatoid metatarsals, original development of the first metatarsals]. | 1992 Jun | Weight-bearing roentgenograms of 308 feet of rheumatoid arthritis patients were analyzed. Several angles were determined, including the metatarsus primus adductus angle (between the first and second metatarsals, > or = 10 degrees) and the forefoot spread angle (between the first and fifth metatarsals, > or = 30 degrees). Pes planus was diagnosed when the internal arch angle was equal to or greater than 130 degrees. Tarsal arthritis was defined as the presence of joint space narrowing. Varus of the first metatarsal was correlated with tarsal arthritis and pes planus but not with duration of the disease. Forefoot spread was correlated with duration of the disease and erosive metatarsal disease but not with involvement of the midfoot. These data demonstrate that orthopedic treatment should be initiated as soon as involvement of the first metatarsal is detected and should be directed at the hindfoot, midfoot, and first metatarsal whose deformations occur concomitantly. | |
| 7638779 | [Does the basic therapy affect the development of secondary amyloidosis in rheumatoid arth | 1995 | Anti-rheumatic drug treatments were studied in 260 patients from Finland and Russia suffering from rheumatoid arthritis (RA) with or without biopsy-proven secondary amyloidosis (RSA). Chloroquine was used for longer period in RSA group in Russia (p = 0.003) and in Finland (p = 0.06). In Finland chloroquine was used more often in the RSA group (p = 0.02), and sulphasalazine (p = 0.02), D-penicillamine (p = 0.03) and cytotoxics (p = 0.04) in the control group. The role of therapy in the prevention of RSA in chronic inflammation is discussed. | |
| 1440354 | [The prediction of the late effect of charcoal hemoperfusion in rheumatoid arthritis patie | 1992 | Hemocarboperfusion is effectively used for the treatment of serious cases of rheumatoid arthritis (RA). The effectiveness of the treatment may be decreased by possible development of the rebound syndrome (RS) after the treatment. The useful retrospective frequency analysis does not often allow predicting the development of RS. The authors devised the system of forecasting the development of RS depending on the body state by means of an analysis of the results in the group of 38 patients with classical RA treated by hemocarboperfusion. They also designed a statistical model with the help of linear regression and correlation methods. It allows counting the degree of the predisposition to RS development for each patient both numerically and individually. The precision of the conclusion based on the method is about 90%. The results of the forecasting give the general characteristics of RA development and can be used as an additional argument for prescription of hemocarboperfusion. | |
| 1413679 | [The use of thermographic and immunological indices in choosing adequate treatment for pat | 1992 Mar | A study is presented of the thermal semeiotics and the state of cellular and humoral immunity in 29 patients with osteoarthrosis deformans, 35 patients with rheumatoid arthritis of different activity. It is recommended to use data of the thermographic picture and immunological status for objectivation of the character of the pathological process, differential diagnosis and dynamic express-evaluation of treatment adequacy. | |
| 8441146 | Apparent cure of rheumatoid arthritis by bone marrow transplantation. | 1993 Jan | We describe the induction of sustained remissions and possible cure of severe erosive rheumatoid arthritis (RA) by bone marrow transplantation (BMT) in 2 patients. BMT was used to treat severe aplastic anemia which was caused by gold in one case and D-penicillamine in the other. In the 8 and 6 years since the transplants (representing 8 and 4 years since cessation of all immunosuppressive therapy, respectively), the RA in each case has been completely quiescent. Although short term remission of severe RA following BMT has been reported, these are the first cases for which prolonged followup has been available. This experience raises the question of the role of BMT itself as a therapeutic option for patients with uncontrolled destructive synovitis. | |
| 1404158 | Character of precolumbian North American spondyloarthropathy. | 1992 Aug | Shared characteristics and concurrent occurrence of rheumatoid arthritis (RA) and spondyloarthropathy in contemporary populations have compromised development of clear diagnostic criteria for distinguishing them. Although modern populations contain individuals with both RA and spondyloarthropathy, ancient populations often manifest only one. The presence of spondyloarthropathy as the sole erosive disease in selected ancient populations allows further clarification of its nature. The tendency towards pauciarticular, asymmetrical involvement, axial involvement and peripheral joint fusion in these populations clarifies diagnosis and distinguishes this phenomenon from RA. The significance of peripheral joint fusion appears to be unequivocally established on the basis of these findings. | |
| 8779793 | [A case report of systemic calcinosis associated with rheumatoid arthritis]. | 1996 Jun | A 69-year-old female with a fourty-year history of rheumatoid arthritis visited Kobe University hospital with complaints of subcutaneous soft tumor on both hands and arthritic pain of both knees. She has been given 10 mg of predonisolone for several years and had a history of hydronephrosis. Her radiographs revealed periarticular calcification in the hands, shoulder joints and posterior thoracic wall. She had high titer of rheumatoid factor and both erythrocyte sedimentation rate (79 mm/hr) and C-reactive protein (12.79 mg/ml) were elevated. The examination of her serum showed the following values: Ca 7.9 mg/dl, P 5.0 mg/dl, 25 (OH) D3 < 3.6 pg/ml, 1 alpha-. 25 (OH)2 Vit D3 < 6.1 pg/ml, osmolality 974 mOsm/kg, BUN 61 mg/dl, creatinine 1.9 mg/ml, creatinine clearance less than 20 ml/min, indicating chronic renal failure. Intact PTH level was normal, although plasma parathyroid hormone-C (PTH-C) level increased. Together with these findings, it is suggested that metabolic disorders associated with chronic renal failure and tissue damages due to the severe rheumatoid arthritis led to the formation of diffuse soft tissue calcification. | |
| 7688233 | [Rehabilitation of the rheumatoid dorsal wrist by the Sauve-Kapandji operation combined wi | 1993 | The authors present a series of 25 cases of rheumatoid wrists, operated by tendon and intra-carpal synovectomy, accompanied by an arthrodesis of the lower ulnar articulation following a metaphyseal resection of the lower extremity of the ulnar according to Sauve and Kapandji. This series is "young", as the mean follow-up is 2 years. It involves 25 patients, including 4 operated on both wrists. This series has the advantage of being coherent as all the operations were performed by the same surgeon. The results concerning pain are good; 87% of the wrists were painless or only periodically painful, and 88% of the patients say they are well or very much better. This operation offers the satisfying aspect of prevention; an absence of pain in the wrist when inflamed and the absence of complications such as ruptured tendons. The study of the range of motion shows a global loss of 9% in the sagittal plane and a significant reduction in the score for motion in palmar flexion. The radiological signs of deterioration of carpitis are not stopped despite the operation but it does seem to be slowed down after intra-carpal synovectomy. Ulnar sliding has been carefully studied. We observe that a further sliding is more obvious in the Larsen 2 phase than in the Larsen 3 phase. This sliding is very slight. The comparison between the different series shows that operation protects the wrist from ulnar sliding more than ulnar head resections. | |
| 8118981 | Intramedullary deposits of hydroxyapatite crystals in a patient with rheumatoid arthritis. | 1994 Jan | A 63-year-old women with a 12-year history of rheumatoid arthritis (RA) had calcific deposits in the periarticular soft tissues with subsequent involvement of the medullary canals of adjacent bones. Except for the RA, there was no evidence of other abnormalities of the bones or mineral homeostasis. Chemical analyses of the deposits identified the crystalline material as apatite. Although the deposition of apatite in the soft tissues of RA is known to occur rarely, this is the first known case of intraosseous apatite deposition. | |
| 7788319 | Polyarthritis in HTLV-1-infected patients. A review of 17 cases. | 1995 Jan | A retrospective study was conducted in Martinique to identify patients with polyarthritis and positive serologic tests for the human T-cell lymphotropic virus Type I (HTLV-1). Patients with metabolic or bacterial causes of polyarthritis were excluded. We found 17 cases of HTLV-1-positive polyarthritis (6.7% of the total of polyarthritis patients followed in our department); there were 14 females and three males, and all the patients were West-Indian blacks. Mean age at diagnosis was 50 years. Five patients also had tropical spastic paraparesis. The polyarthritis was the inaugural manifestation of T-cell leukemia in one patient. Four patients had received blood transfusions. Fever, myalgia, and/or skin lesions were present at onset of the polyarthritis in seven cases. All 17 patients had peripheral, bilateral, symmetric polyarthritis; the most commonly involved sites were the hands (17/17) and knees (14/17). Three patients had rheumatoid factor and five had antinuclear antibody. Ten patients met at least four American Rheumatism Association criteria for rheumatoid arthritis; they accounted for 6.7% (10/150) of all polyarthritis patients managed in the same hospital department during the same period. We compared these ten patients with 20 HTLV-1-negative rheumatoid arthritis patients matched on gender, ethnic origin, and disease duration. There were no significant differences between the two groups for any of the parameters studied. | |
| 8478877 | Interpretation and power of a pooled index. | 1993 Mar | OBJECTIVE: To describe, illustrate, provide statistical rationale and give clinical examples of the concept of a pooled index. METHODS: No explicit design. Randomized control trials of patients diagnosed with rheumatoid arthritis from Rheumatic disease clinics, tertiary care hospitals and communities are used as examples to illustrate the pooled index technique. Interventions in rheumatic disease unit inpatient and outpatient care, occupational therapy and physiotherapy provided by Arthritis Society Therapists in the community were compared. Variables included active joint count, morning stiffness in min, mean of right and left grip strength in mm Hg, erythrocyte sedimentation rate in mm/h, a functional change score, and a pooled index. RESULTS: The pooled index in each study detected a clinically important effect while individual measures were generally not able to declare the effect statistically significant. CONCLUSIONS: The pooled index is a more powerful clinical outcome than any individual measure provided it is computed from at least 2 relevant clinical outcome measures that have low correlation with each other. | |
| 1547293 | [The end stage of a rheumatoid arthritis presenting as a tumorous space-occupying lesion o | 1992 Jan | In this paper we report on a 67-year old woman suffering from long-term rheumatoid arthritis. She was admitted to hospital because of a hard tumour with the size of a fist in her left axilla. The supposed tumour was proved by conventional radiological and CT examination as an excessive manifestation of the basic disease in the left shoulder joint. | |
| 1287774 | [Inflammatory rheumatism flare-up after surgical treatment of Cushing's disease: two cases | 1992 Jul | The anti-inflammatory effect of natural glucocorticoids is often overlooked, as shown by these two cases of inflammatory rheumatism flare-up which occurred after surgical treatment of Cushing's syndrome. The disorder in the first case was exacerbation of a probable rheumatoid arthritis; in the second case an unlabelled inflammatory rheumatism appeared in a context of postoperative corticotropic deficiency. In both cases a purely substitutive hydrocortisone therapy resulted in dramatic regression of the articular symptoms. It is well known that rheumatismal manifestations may occur in patients with slow adrenal failure. The determinant factor seems to be a glucocorticoid deficiency, either isolated or associated with others, since cortisol exerts and anti-inflammatory activity. In patients with corticotropic deficiency following surgical treatment of Cushing's disease, the endogenous corticosteroid therapy of hypercortisolism is interrupted, allowing the aggravation or emergence of inflammatory rheumatism. | |
| 1384888 | [Surgical treatment of rheumatoid lesions of the joints]. | 1992 | Thirty-four years of experience gained with the treatment of patients suffering from rheumatoid arthritis made it possible to develop a complex of orthopedic treatment methods (conservative and surgical) based on the clinical, x-ray and morphological classification. These methods allow arresting inflammation in the joint, preventing destruction of the joint and formation of concordant and disconcordant deformities, correcting deformities, recovering function, the patients activity, returning ability to active life, to social useful work, and minimizing the patients' disability. | |
| 7605421 | Patients' rights and ethical dilemmas in home care: incorporation of psychological concept | 1994 Sep | As home care acuity increases, so will the ethical challenges faced by home care providers. This article discusses how one healthcare provider faced these challenges, as she worked with a patient enduring rheumatoid arthritis. A commentary on the ethical issues, by a nurse ethicist, follows the case study. | |
| 8924886 | [A case of pleurisy with effusion in the course of rheumatoid arthritis]. | 1996 | The case of pleurisy with effusion in the rheumatoid arthritis (RA), observed in the Chest Diseases and Tuberculosis Clinic in Szczecin is described. Diagnosis was based on the presence of rheumatoid factor and low glucose level in the pleural effusion, (the glucose level in serum was normal) and the aggravation symptoms of RA. Pleural biopsy did not confirmed the presence of rheumatoid nodules. | |
| 8091867 | [Management of rheumatoid patients by rheumatologists in a large metropolitan area]. | 1994 May | Five outpatients clinics and four private practices in Berlin have participated in a uniform outpatient register in 1992. This documentation has been used since 1993 in all of the 21 rheumacenters funded by the Federal Minister of Health. It gives information on diagnoses, ways of admission, therapies, complaints as well as functional and socioeconomic status of the patients. Data of about 3000 patients pertaining to earliness of admission, therapies, work disability, and correlations of education and prognosis of R.A. are reported. |