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rs2476601 |
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PedAM |
snpId=rs2476601; pubmedId=21752868; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort.; score=0.524345611; Year=2011; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=22704547; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.; score=0.524345611; Year=2012; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=24390342; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=GWASCAT; sentence=Genetics of rheumatoid arthritis contributes to biology and drug discovery.; score=0.524345611; Year=2013; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=20498205; geneId=3798; geneSymbol=KIF5A; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.; score=0.254473634; Year=2010; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=23637320; geneId=52; geneSymbol=ACP1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=To investigate the interrelationships among smoking, protein tyrosine phosphatase non-receptor 22 (PTPN22) R620W (rs2476601) genotype, and anticitrullinated peptide antibody (ACPA) status; and among smoking, PTPN22 R620W genotype, and presence of bone erosions overall and separately by ACPA status in patients with rheumatoid arthritis (RA).; score=0.007871814; Year=2014; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=25003765; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=A single nucleotide polymorphism of PTPN22, 1858C>T (rs2476601), disrupts an interaction motif in the protein, and is the most important non-HLA genetic risk factor for rheumatoid arthritis and the second most important for juvenile idiopathic arthritis.; score=0.524345611; Year=2014; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=17553139; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.; score=0.524345611; Year=2007; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=17135225; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=We conclude that C1858T is the sole PTPN22 variant predisposing to RA in our white Dutch sample set.; score=0.524345611; Year=2007; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=21506938; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Our study suggests that the PTPN22 C1858T polymorphism acts as a susceptibility gene for autoantibody-positive RA in Turkey.; score=0.524345611; Year=2011; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=20498205; geneId=958; geneSymbol=CD40; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.; score=0.277186332; Year=2010; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=16175503; geneId=52; geneSymbol=ACP1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene, PTPN22, has been associated with multiple autoimmune diseases, including rheumatoid arthritis (RA).; score=0.007871814; Year=2005; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=22937072; geneId=6775; geneSymbol=STAT4; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.; score=0.316739695; Year=2012; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=20498205; geneId=6775; geneSymbol=STAT4; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.; score=0.316739695; Year=2010; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=21492465; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=We genotyped SNPs rs3761847 and rs7021206 at the TRAF1/C5 locus and rs2476601 SNP in the PTPN22 gene in a Han Chinese cohort composed of 576 patients with RA and 689 controls.; score=0.524345611; Year=2011; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=17436241; geneId=3123; geneSymbol=HLA-DRB1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Consistent interaction, defined as departure from additivity, between HLA-DRB1 SE alleles and the A allele of PTPN22 R620W was seen in all three studies regarding anti-CCP-positive RA.; score=0.36; Year=2007; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=21543514; geneId=26191; geneSymbol=PTPN22; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The aim of this study was to assess whether the C1858T polymorphism of PTPN22 also confers increased risk for SLE and RA in the genetically homogeneous population of Crete.; score=0.524345611; Year=2011; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=21706348; geneId=52; geneSymbol=ACP1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities.; score=0.007871814; Year=2012; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=20498205; geneId=7185; geneSymbol=TRAF1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.; score=0.311201237; Year=2010; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=25040563; geneId=52; geneSymbol=ACP1; diseaseId=umls:C0003873; sourceId=BeFree; sentence=A common polymorphism (C1858T) in the gene that encodes the protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with altered T-cell responses and increased susceptibility to rheumatoid arthritis (RA) and other autoimmune diseases.; score=0.007871814; Year=2014; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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rs2476601 |
SNP |
PedAM |
snpId=rs2476601; pubmedId=20498205; geneId=3899; geneSymbol=AFF3; diseaseId=umls:C0003873; sourceId=BeFree; sentence=Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.; score=0.129001189; Year=2010; geneSymbol_dbSNP=PTPN22;AP4B1-AS1; CHROMOSOME=1; POS=113834946; REF=A; ALT=G |
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