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hsa_circ_0060144 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0060144; Synonyms=hsa_circRNA_103047; Chromosome=20; Position=34389412-34459751; Strand=+; Genome_Version=hg19; Gene_symbol=PHF20; Circ_Sequence=GAGAATAAAGGCAGCCCCGTTGATGACTGAAAATGACAAAGCATCCACCTAACAGACGAGGAATCAGCTTTGAAGTGGGAGCCCAGTTGGAAGCCCGGGACCGTTTAAAAAACTGGTATCCAGCTCACATAGAAGACATTGACTACGAGGAAGGAAAAGTACTCATCCATTTCAAGCGTTGGAACCATCGTTATGATGAGTGGTTCTGCTGGGACAGTCCTTATTTACGCCCTTTAGAGAAAATACAGCTGAGGAAAGAGGGCTTGCATGAAGAGGATGGATCTTCTGAATTTCAAATAAATGAGCAGGTCCTTGCTTGCTGGTCTGATTGTCGTTTTTACCCGGCCAAAGTCACTGCTGTTAACAAGGATGGTACTTACACTGTGAAATTTTATGATGGAGTAGTTCAGACTGTCAAACATATTCATGTCAAAGCTTTTTCCAAAGATCAGAATATTGTGGGTAATGCTAGGCCTAAAGAAACAGATCACAAAAGTCTTTCATCATCTCCTGATAAACGAGAGAAGTTTAAAGAACAGAGAAAAGCAACAGTGAATGTGAAGAAAGACAAAGAAGATAAACCCTTAAAGACAGAAAAGCGACCCAAGCAGCCTGATAAAGAAGGAAAGTTAATCTGTTCTGAAAAGGGGAAAGTGTCAGAGAAAAGTCTTCCCAAGAACGAGAAGGAAGACAAGGAAAACATTTCCGAAAATGACAGAGAGTATTCTGGAGATGCCCAAGTGGATAAGAAACCTGAAAATGACATTGTGAAGAGTCCACAAGAAAACTTGAGGGAACCCAAAAGAAAACGAGGCAGACCCCCTTCCATAGCTCCTACTGCTGTGGATTCAAACTCTCAAACTTTGCAACCAATAACATTGGAACTGAGAAGAAGGAAAATATCAAAAGGATGTGAAGTCCCATTAAAACGTCCTCGGCTTGACAAAAATTCATCCCAGGAAAAGTCAAAAAACTACTCGGAAAACACTGACAAAGACTTATCGAGGAGACGTTCCTCCAGGCTGTCCACTAATGGGACCCATGAGATCCTAGATCCTGACTTGGTTGTATCAGATTTGGTTGATACGGATCCTTTGCAAGACACGTTGTCTAGTACCAAGGAATCTGAAGAAGGTCAGTTGAAGTCTGCTTTGGAAGCTGGCCAGGTCTCATCTGCACTGACTTGCCACTCCTTTGGGGATGGATCCGGGGCTGCAGGCTTGGAGTTGAACTGCCCATCAATGGGAGAAAACACGATGAAAACAGAACCGACTTCTCCCCTTGTGGAATTACAAGAGATTTCGACTGTGGAAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
details
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hsa_circ_0004712 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0004712; Synonyms=hsa_circRNA_104194; Chromosome=6; Position=136468488-136476896; Strand=+; Genome_Version=hg19; Gene_symbol=PDE7B; Circ_Sequence=GTACAACATACTCAGGGGAGATTGGCACCAAGAAAAAGGTGAAAAGACTATTAAGCTTTCAAAGATACTTCCATGCATCAAGGCTGCTTCGTGGAATTATACCACAAGCCCCTCTGCACCTGCTGGATGAAGACTACCTTGGACAAGCAAGGCATATGCTCTCCAAAGTGGGAATGTGGGATTTTGACATTTTCTTGTTTGATCGCTTGACAAATGGAAACAGCCTGGTAACACTGTTGTGCCACCTCTTCAATACCCATGGACTCATTCACCATTTCAAGTTAGATATGGTGACCTTACACCGATTTTTAGTCATGGTTCAAGAAGATTACCACAGCCAAAACCCGTATCACAATGCTGTTCACGCAGCCGACGTCACCCAGGCCATGCACTGCTACCTGAAAGAGCCAAAGCTTGCCAGCTTCCTCACGCCTCTGGACATCATGCTTGGACTGCTGGCTGCAGCAGCACACGATGTGGACCACCCAGGGGTGAACCAGCCATTTTTGATAAAAACTAACCACCATCTTGCAAACCTATATCAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=Microarray; qRT-PCR; Sample=PBMC from twenty RA patients and healthy people; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA.; PubMed_ID=28983619; Pub_Year=2017.9.27; Journal=Mol Med Rep.; Title=Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
details
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hsa_circ_0083964 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0083964; Synonyms=hsa_circRNA_104593; Chromosome=8; Position=37985808-37986469; Strand=+; Genome_Version=hg19; Gene_symbol=ASH2L; Circ_Sequence=CTCCCCAGTTAAAGATCTCAGATGACCGGCTGACTGTGGTTGGAGAGAAGGGCTACTCTATGGTGAGGGCCTCTCATGGAGTACGGAAAGGTGCCTGGTATTTTGAAATCACTGTGGATGAGATGCCACCAGATACCGCTGCCAGACTGGGTTGGTCCCAGCCCCTAGGAAACCTTCAAGCTCCTTTAGGTTATGATAAATTTAGCTATTCTTGGCGGAGCAAAAAGGGAACCAAGTTCCACCAGTCCATTGGCAAACACTACTCTTCTGGCTATGGACAGGGAGACGTCCTGGGATTTTATATTAATCTTCCTGAAGACACAGAGACAGCCAAGTCATTGCCAGACACATACAAAGATAAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=Microarray; qRT-PCR; Sample=PBMC from twenty RA patients and healthy people; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA.; PubMed_ID=28983619; Pub_Year=2017.9.27; Journal=Mol Med Rep.; Title=Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
details
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hsa_circ_0064996 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0064996; Synonyms=hsa_circRNA_103334; Chromosome=3; Position=43341245-43373802; Strand=+; Genome_Version=hg19; Gene_symbol=SNRK; Circ_Sequence=GAAAAAGAAGCAACTAACAAAACACTGTGATAATAAGGATTATTCAGTATGCAGTTTGCAGGATATCCATGACGACATTGAAAATGAATTTTTTGTATTCACCAGATATTCTTATATGAGAAGATCTATTTTAAACAGTCTAAATATTTTTTCTTCTGTTGGACCAGCATGGCAGGATTTAAGCGAGGGTATGATGGAAAGATTGCTGGATTATATGATCTGGATAAAACCTTGGGTCGAGGCCATTTTGCCGTGGTTAAACTTGCCAGGCATGTCTTTACGGGTGAAAAGGTGGCAGTAAAAGTTATTGACAAGACAAAACTGGACACTCTAGCTACTGGTCATCTTTTCCAGGAAGTGAGATGCATGAAACTAGTGCAGCATCCTAACATCGTCCGCCTTTATGAAGTTATTGACACCCAGACCAAACTATATCTTATTCTAGAACTTGGGGATGGAGGAGATATGTTTGATTATATAATGAAACATGAGGAGGGTCTTAATGAAGACTTGGCCAAGAAGTATTTTGCTCAGATAGTTCATGCTATATCTTATTGCCATAAACTCCATGTGGTTCACAGAGACTTAAAACCAGAGAATGTAGTCTTCTTTGAAAAACAAGGTCTTGTAAAGTTGACAGACTTTGGGTTCAGCAACAAATTTCAACCAGGGAAGAAGCTCACTACAAGCTGTGGATCTCTTGCATATTCCGCTCCAGAAATTCTGCTTGGTGATGAGTATGATGCACCTGCAGTAGATATTTGGAGTCTGGGAGTGATCCTTTTCATGTTGGTGTGTGGGCAGCCGCCCTTTCAAGAAGCCAATGACAGTGAAACACTGACAATGATCATGGATTGCAAATATACAGTACCATCCCATGTGTCTAAAGAGTGTAAAGA; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=Microarray; qRT-PCR; Sample=PBMC from twenty RA patients and healthy people; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA.; PubMed_ID=28983619; Pub_Year=2017.9.27; Journal=Mol Med Rep.; Title=Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
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hsa_circ_0032683 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0032683; Synonyms=hsa_circRNA_101407; Chromosome=14; Position=75590748-75590926; Strand=-; Genome_Version=hg19; Gene_symbol=NEK9; Circ_Sequence=GATGACTCACTGGTTGTGTGGAAGGAAGTCGATTTGACCCGGCTGTCTGAGAAGGAACGTCGTGATGCCTTGAATGAGATTGTTATTCTGGCACTGCTGCAGCACGACAACATTATTGCCTACTACAATCACTTCATGGACAATACCACGCTGCTGATTGAGCTGGAATATTGTAATG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=Microarray; qRT-PCR; Sample=PBMC from twenty RA patients and healthy people; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA.; PubMed_ID=28983619; Pub_Year=2017.9.27; Journal=Mol Med Rep.; Title=Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
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hsa_circ_0052012 |
circRNA |
Circ2Disease |
circRNA_name=hsa_circ_0052012; Synonyms=hsa_circRNA_102594; Chromosome=19; Position=50902107-50902741; Strand=+; Genome_Version=hg19; Gene_symbol=POLD1; Circ_Sequence=GATGGATGGCAAGCGGCGGCCAGGCCCAGGGCCCGGGGTGCCCCCAAAGCGGGCCCGTGGGGGCCTCTGGGATGATGATGATGCACCTCGGCCATCCCAATTCGAGGAGGACCTGGCACTGATGGAGGAGATGGAGGCAGAACACAGGCTGCAGGAGCAGGAGGAGGAGGAGCTGCAGTCAGTCCTGGAGGGGGTTGCAGACGGGCAGGTCCCACCATCAGCCATAGATCCTCGCTGGCTTCGGCCCACACCACCAGCGCTGGACCCCCAGACAGAGCCCCTCATCTTCCAACAGTTGGAGATTGACCATTATGTGG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=Microarray; qRT-PCR; Sample=PBMC from twenty RA patients and healthy people; Location=N/A; Expression_pattern=down-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=A total of 584 circRNAs were differentially expressed in RA patients vs. healthy controls, by circRNA microarray, including 255 circRNAs which were significantly upregulated and 329 downregulated among the RA samples. RT qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA.; PubMed_ID=28983619; Pub_Year=2017.9.27; Journal=Mol Med Rep.; Title=Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; details=circRNA_name=hsa_circ_0088036; Synonyms=hsa_circRNA_104871; Chromosome=9; Position=114840817-114842445; Strand=-; Genome_Version=hg19; Gene_symbol=SUSD1; Circ_Sequence=TAAAACAGACCATCAGTAACATTTCAGGATTTAATGAAACCTGCTTGAGATGGAGAAGCATCAAGACAGCTGATATGGAGGAGATGTATTTATTCCACATTTGGGGCCAGAGATGGTATCAGAAGGAATTTGCCCAGGAAATGACCTTTAATATCAGTAGCAGCAGCCGAGATCCCGAGGTGTGCTTGGACCTACGTCCGGGTACCAACTACAATGTCAGTCTCCGGGCTCTGTCTTCGGAACTTCCTGTGGTCATCTCCCTGACAACCCAGATAACAG; Circ_Type=exonic; Disease_name=rheumatoid arthritis; Methods=microarray; qRT-PCR; Sample=PBMCs from 35 patients with RA and 30 healthy controls; Location=N/A; Expression_pattern=up-regulated; miRNA=N/A; miRNA_Target=N/A; RBP=N/A; RBP_Target=N/A; Functional_description=We identified and verified five circRNAs (092516, 003524, 103047, 104871, 101873) that were significantly elevated in PBMCs from RA patients. Among these RA patients, we detected no significant correlation between the five circRNAs and the disease severity, including disease activity score (DAS28), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and health assessment questionnaire (HAQ). Yet, ROC curve analysis suggested that circRNA_104871 has significant value of RA diagnosis (AUC=0.833, P<0.001), followed by circRNA_003524 (AUC = 0.683, P = 0.020), circRNA_101873 (AUC = 0.676, P = 0.026), and circRNA_103047 (AUC = 0.671, P = 0.030). This study suggests that increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis.; PubMed_ID=28618429; Pub_Year=2017; Journal=Cell Physiol Biochem; Title=Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients; Notes=N/A; UpGene=NA; DownGene=NA; Regulation_Description=NA; NA |
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hsa-miR-1181 |
microRNA |
MiRNASNP-v3 |
Mature miRNA=hsa-miR-1181; Variation ID=rs550418881; Position=chr19:10403524; Ref/Alt=G/C; Disease=Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)(PMID:30573655); Source=GWAS; Gain=662; Loss=238 |
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hsa-miR-1181 |
microRNA |
MiRNASNP-v3 |
Mature miRNA=hsa-miR-1181; Variation ID=rs550418881; Position=chr19:10403524; Ref/Alt=G/T; Disease=Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)(PMID:30573655); Source=GWAS; Gain=757; Loss=255 |
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hsa-miR-1181 |
microRNA |
MiRNASNP-v3 |
Mature miRNA=hsa-miR-1181; Variation ID=rs550418881; Position=chr19:10403524; Ref/Alt=G/A; Disease=Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)(PMID:30573655); Source=GWAS; Gain=1145; Loss=219 |
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hsa-mir-4719 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-4719; Mutation ID=rs7499278; Position=chr16:76868953; Ref/Alt=G/A; Region=pre-miRNA; Mature miRNA=-; Exp.=mild; Source=GWAS |
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hsa-mir-4308 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-4308; Mutation ID=rs28477407; Position=chr14:54878183; Ref/Alt=C/T; Region=pre-miRNA; Mature miRNA=-; Exp.=down; Source=GWAS |
details
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hsa-mir-4305 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-4305; Mutation ID=rs67976778; Position=chr13:39664038; Ref/Alt=C/T; Region=pre-miRNA; Mature miRNA=-; Exp.=down; Source=GWAS |
details
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hsa-mir-4277 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-4277; Mutation ID=rs12523324; Position=chr5:1708868; Ref/Alt=G/A; Region=pre-miRNA; Mature miRNA=-; Exp.=mild; Source=GWAS |
details
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hsa-mir-3972 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-3972; Mutation ID=rs72646786; Position=chr1:17277942; Ref/Alt=C/T; Region=pre-miRNA; Mature miRNA=-; Exp.=mild; Source=GWAS |
details
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hsa-mir-3135b |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-3135b; Mutation ID=rs4285314; Position=chr6:32749925; Ref/Alt=G/A; Region=pre-miRNA; Mature miRNA=-; Exp.=down; Source=GWAS |
details
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hsa-mir-3135b |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-3135b; Mutation ID=rs4351242; Position=chr6:32749945; Ref/Alt=C/T; Region=pre-miRNA; Mature miRNA=-; Exp.=mild; Source=GWAS |
details
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hsa-mir-12121 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-12121; Mutation ID=rs548529289; Position=chr14:104865391; Ref/Alt=CCGGG/CCGGGCGGGCGGG; Region=pre-miRNA; Mature miRNA=-; Exp.=NA; Source=GWAS |
details
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hsa-mir-12121 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-12121; Mutation ID=rs548529289; Position=chr14:104865391; Ref/Alt=CCGGG/CCGGGCGGG; Region=pre-miRNA; Mature miRNA=-; Exp.=NA; Source=GWAS |
details
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hsa-mir-12121 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-12121; Mutation ID=rs548529289; Position=chr14:104865391; Ref/Alt=CCGGG/C; Region=pre-miRNA; Mature miRNA=-; Exp.=NA; Source=GWAS |
details
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hsa-mir-1181 |
Pre-miRNA |
MiRNASNP-v3 |
Pre-miRNA=hsa-mir-1181; Mutation ID=rs567281443; Position=chr19:10403514; Ref/Alt=T/A; Region=Mature; Mature miRNA=hsa-miR-1181; Exp.=mild; Source=GWAS |
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