Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7222829 | [Algometric analysis of rheumatic pain]. | 1980 Dec 15 | On altogether 221 persons, among them 120 patients with rheumatoid arthritis of all morphological stages, in the region of soft tissues and joints of both hands pressure-algometric examinations were carried out. As reference method served thermic and electric algometry in the region of the forearm. The verbalized reaction of the test persons concerning sensitization threshold, pain threshold and border of pain tolerance was registered depending on experimentally set acute pain irritations. The results of thermic and pressure algometry were reproducible and comparable values and according to the present intermediate results they are suitable for the quantitative establishment of the pressure tolerance conditioned by arthritis as well as for their relativation on the individual sensitivity. | |
| 961078 | [Elevated C3-proactivator serum levels in patients with chronic polyarthritis]. | 1976 Jul | The C3-Proactivator (C3-PA) and the C3 and C4 complements were determined by radio-immuno diffusion in the serum of 72 patients with definite or classical rheumatoid arthritis, 51 patients with osteoarthrosis and 42 healthy subjects. C3-PA and C4 levles were significantly higher in the serum of patients with rheumatoid arthritis than in the control group (C3-PA in 72%, C4 in 37% of the RA patients). There was also a significant difference between seropositive und seronegative cases. Elevation of both components was more frequently found in patients with seronegative rheumatoid arthritis than in the seropositive cases. However, the C3-PA serum level is not correlated with the ESR. Also an elevation of the C3-PA serum level is not specific for rheumatoid arthritis, it is also found in other inflammatory diseases as well as after surgery. | |
| 4064755 | Superficial ulcerating rheumatoid necrobiosis: a perforating rheumatoid nodule. | 1985 Oct | We report a case of superficial ulcerating rheumatoid necrobiosis (SURN), which is a recently described cutaneous manifestation of severe rheumatoid arthritis. As with classic rheumatoid nodule, there is evidence that this lesion may result from a vasculitis. SURN appears to represent a form of "perforating" rheumatoid nodule, and completes a triad of major necrobiotic processes (granuloma annulare, necrobiosis lipoidica, rheumatoid nodule) that have been reported to show epidermal perforation. | |
| 818965 | Ultrastructural changes produced in rheumatoid synovial membrane by chrysotherapy. | 1976 Feb | Biopsies of rheumatoid synovial membrane before and after chrysotherapy were examined with the light and electron microscopes, and subjected to electronprobe x-ray analysis. The main change noted was the occurrence of electron-dense deposits of characteristic morphology within pre-existing lysosomes. Such deposits were also seen in other varieties of lysosomal bodies. X-ray analysis showed the presence of gold, phosphorus, osmium, and calcium in these deposits. The present study shows that gold enters the pre-existing lysosomes, supporting the concept that the beneficial effects of chrysotherapy are due to its action on the lysosome. | |
| 6518135 | The mechanism of the anaemia in rheumatoid arthritis: effects of bone marrow adherent cell | 1984 Dec | Clonal assays for erythroid progenitors (BFU-e and CFU-e) were used to study 20 patients with rheumatoid arthritis, 15 of whom had anaemia of chronic disease and five of whom were haematologically normal. The numbers of bone marrow BFU-e and CFU-e in the anaemic patients did not differ significantly from those in normal controls. Macrophages were removed from the bone marrow by a combination of adherence and buoyant density centrifugation over a sucrose gradient and the resulting fractions were cultured alone or together with autologous adherent cells in BFU-e assays. Co-culture with adherent cells significantly increased colony growth in both the controls and in seven of eight anaemic patients studied. Serum from 14 anaemic patients and from five non-anaemic patients was added to cultures of bone marrow or to control peripheral blood 'null' cells. Anaemic serum uniformly either inhibited or failed to stimulate BFU-e growth under these conditions. Serum from non-anaemic patients and from 10 healthy controls stimulated BFU-e growth from 'null' cells to an equal degree. | |
| 6870506 | Bilateral one-stage total hip replacement in rheumatoid arthritis and SPA. | 1983 | Sixteen cases of bilateral total one-stage hip replacements in patients with rheumatoid arthritis or ankylosing spondylitis are reviewed. Special reference is given to peroperative problems, complications, and indications in a hospital with on intensive care unit. The indications are discussed and the results compared with larger series published earlier in literature. One-stage procedure proves to be a proper alternative in cases with severe bilateral disease. The rate of complications is comparable to that of unilateral procedures. A marked decrease in time consumption can be achieved. | |
| 7096424 | Bilateral replacement of the hip and knee in rheumatoid arthritis. | 1982 | Twenty-six patients with rheumatoid arthritis who had undergone bilateral replacement of the hip and knee were reviewed at a mean follow-up time of 51.6 months. A further operation was necessary in five patients due to complications of replacement of the knee, and seven patients still had significant pain in at least one replaced joint. There were no cases of infection due to operation. Seventeen of the patients still used walking aids, but one-third of these did so because of pain in joints that had not been replaced. Patients preferred painless total replacement of the hip to that of the knee. | |
| 7066027 | Defective monocyte cytotoxicity in rheumatoid arthritis: a correlation with disease activi | 1982 Jan | The cytotoxic activities of human blood mononuclear cells against certain established cell lines were evaluated prospectively in 17 patients with rheumatoid arthritis before and after treatment with low (150 mg per week) and moderate doses (300 mg per week) of levamisole. Spontaneous or "natural" killer activity (NK) and antibody-dependent cellular cytotoxicity (ADCC) of plastic adherent cells ("monocytes") and lymphocytes were studied. We report a selective cytotoxic defect in monocyte NK and a correlation of this defect with severely active disease. The patients with the most severe defect responded to low-dose levamisole, but others with normal values did nor respond as well to treatment. This cytotoxic defect may be an important pathogenetic factor in rheumatoid arthritis and this new assay may be helpful in selecting candidates who are most likely to respond to levamisole. | |
| 951619 | Cholesterol-rich synovial effusions. | 1976 Jun 12 | The occurrence of cholesterol-rich synovial fluids in 2 patients with rheumatoid arthritis is described. These fluids are rare, and are readily mistaken for pus. Their origins are discussed in relation to chronic inflammation. | |
| 791161 | Auranofin. New oral gold compound for treatment of rheumatoid arthritis. | 1976 Jun | Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was effective in suppressing adjuvant-induced arthritis in rats. Clinical and humoral parameters were studied during a 3-month period of drug administration followed by a 3-month period under placebo. The drug was absorbed, well tolerated, and its action was manifested by a drop in the mean IgG blood levels in the third week of treatment accompanied by clinical improvement after 5 weeks of oral gold intake. Together with IgG changes, an increase of the albumin ratio was observed, as well as a decrease of alpha2-globulin and rheumatoid factor titres. From a total number of 60 swollen joints found initially in the 8 patients only 17 were swollen at week 12 and 9 at week 15. Although the number of patients treated was too small to allow definite conclusions, a follow-up study under placebo of clinical and laboratory changes in the same patients during another 3-month period showed that IgG serum levels rapidly reverted preceding a flare up of disease activity after withdrawal of the drug. This confirmed a direct role in cause-effect relation played by the new oral gold compound. | |
| 6217341 | Nonspecific suppressor function in rheumatoid arthritis. | 1982 Oct | Patients with rheumatoid arthritis (RA) have diminished peripheral blood cellular immune responses in vivo and in vitro. To determine whether these changes reflected excessive peripheral blood suppressor function, we compared suppressor function in 52 patients with RA with 57 normal subjects. We examined suppressor cell function for (i) preincubation sensitivity, (ii) glass adherence, (iii) indomethacin sensitivity, (iv) concanavalin (con) A inducibility, (v) aggregated IgG inducibility and (vi) quantitated Tmu and Tgamma cell populations. Con A-generated suppressor cell function was further studied by evaluating unseparated-, T-cell, glass adherent-, indomethacin sensitive-, radiosensitive-, and radioresistant-suppressor cell effects upon mitogen-stimulated allogeneic and autologous unseparated, T-cell, B-cell and IM9 lymphoblastoid cell line responses, the latter representing a newly devised and simplified assay system. We found that patients with RA exhibited: (i) significantly increased incubation-sensitive suppressor function; (ii) generally normal nonspecific suppression function in other assays, although individual patients were strikingly abnormal; and (iii) significantly increased sensitivity of B-cell proliferation to aggregated-IgG-induced T-cell suppressor function. | |
| 6432419 | The effects of auranofin and parenteral gold in the treatment of rheumatoid arthritis: an | 1984 Mar | X-rays from patients in comparative studies of auranofin and parenteral gold were obtained before and during treatment, and analysed using a modification of the method of Larsen. One hundred and nineteen auranofin-treated and 113 parenteral gold-treated patients contributed data, which were analysed for changes from 0-6 months, 0-12 months and from 0-6 and 12 months. Progression of erosive processes and of joint grade occurred with both treatments, but the proportion of patients with progression in the first six months was greater with auranofin treatment. However, there was evidence that both treatments produced slowing of the erosive process during the second six months of treatment. | |
| 6644695 | Stress fractures in rheumatoid arthritis. | 1983 Oct | Four cases of rheumatoid arthritis with a total of 12 undisplaced stress fractures of the lower extremities are described. Pain, swelling and disability arising from these fractures were initially mistaken for rheumatoid synovitis. Three patients had osteoporosis, and one had osteomalacia. A high index of suspicion is necessary in the diagnosis of these fractures. Radiographs and, if necessary, bone scans are indicated in rheumatoid patients presenting with spontaneous pain in the lower extremities in association with tenderness localized over the bone rather than the joint, particularly in the absence of other signs of rheumatoid activity. | |
| 6869410 | Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials. | 1983 Jul 18 | No eye disease was detected in over 900 rheumatoid arthritis patients treated with less than 4.0 mg/kg per day of chloroquine or less than 6.5 mg/kg per day of hydroxychloroquine for a mean of about seven years. I therefore consider these dosage rates safe, since they are below the threshold of retinal toxicity. This is based on more than 6,000 patient-years of drug exposure. That dosage threshold for retinopathy appears to be 5.1 mg/kg per day for chloroquine and 7.8 mg/kg per day for hydroxychloroquine according to my studies with these compounds. The daily dosage rate, rather than total drug accumulation, seems to determine the development of eye disease. To prevent overdosage, dosing should be calculated not on the actual weight of the patient but on ideal (lean) body weight. Furthermore, the patient's renal and liver function should also be taken into account to avoid overdosage. Since exposure to light amplifies the risk of retinopathy in patients treated with antimalarials, dark sunglasses are recommended for patients spending much time in sunlight. | |
| 4089172 | [Soft tissue changes in the wrist in chronic polyarthritis. Results of weak-radiation expo | 1985 Dec | The x-ray anatomy of the soft tissues of the wrist in three views is described and the normal width of the joint capsules, tendon sheaths and tendons at 25 suitable measurement point determined. Only the saccular recess of the inferior radio-ulnar joint depends on sex and age. The normal width of the soft tissues differs considerably within a group of individuals but not between both sides of a single person. As the width of some soft tissues depends on slight deviations from the standard position an identical and exact position is a prerequisite when both sides are to be compared. The shape of the soft tissue changes in rheumatoid arthritis has been shown. Furthermore the incidence of pathologic soft tissue changes has been determined in 86 cases of early and later stages of rheumatoid arthritis. These values show the sensitivity of the 25 measurements. The analysis of soft tissues is an integral part of the assessment of arthropathies. | |
| 7286800 | An interpositional elastomeric cap for metacarpophalangeal joint perichondrioplasty in rhe | 1981 Jun | A new interpositional elastomeric cap was developed and used for perichondrioplasty in six rheumatoid metacarpophalangeal joints. Adequate cartilage formation occurred, and the joint contours were more normal than those achieved by previous methods. | |
| 6299994 | Frequency of transforming Epstein-Barr virus in oropharyngeal secretions of rheumatoid art | 1983 | To determine if rheumatoid arthritis (RA) patients have an increased frequency of Epstein-Barr virus (EBV) shedding into saliva, throat washings were collected from 59 patients with RA and 64 healthy adult controls. EBV in filtered samples was detected by transformation of human umbilical cord lymphocytes. EBV was detected in 27% (16/59) of throat washings of RA patients compared to 11% (7/64) of control samples. This difference is significant (p less than 0.05). RA patients on steroids had a frequency of positivity of 43% (10/23) compared to 17% (6/36) in patients not on steroids. No correlation was demonstrated between steroid dose received by the patient and detection of EBV in throat washings. Parotid fluid samples were collected from 18 RA patients and 11 healthy controls and were tested for EBV by the transformation bioassay. EBV was detected in 18% (2/11) of samples from normal controls, but samples from RA patients were uniformly negative. | |
| 3157353 | Correlation of disease activity and drug therapy with the autologous mixed lymphocyte reac | 1985 Apr | The response of peripheral blood lymphocytes (PBL) to autologous synovial fluid lymphocytes (SFL) from patients with rheumatoid arthritis and Reiter's syndrome was investigated in an autologous mixed lymphocyte reaction (AMLR). SFL were found to be poor responders but strong stimulators of autologous and allogeneic PBL compared with autologous PBL. The plastic-adherent (macrophage) cells from the SFL were found to be highly stimulatory to autologous PBL, particularly when the adherent cells were removed from the responding PBL. The stimulation of these PBL non-adherent cells by SFL adherent cells follows two main trends: either no stimulation, or higher stimulation than using unseparated SFL and PBL. Patients in the high stimulator group were taking non-steroidal anti-inflammatory drugs while those in the low responder group were taking, in addition, second-line drugs such as D-penicillamine or gold. Autologous serum was found to inhibit the AMLR and this is probably due to drug metabolites in patients' sera. Initial results show that the AMLR in individual patients is highly correlated, over time, with the erythrocyte sedimentation rate (ESR). | |
| 6205792 | Detection of alpha 2-macroglobulin-associated proteases in the plasma of patients with rhe | 1984 Sep | In previous work a polyclonal B cell activator has been detected in the serum of patients with rheumatoid arthritis (RA). This activator is associated with alpha 2-macroglobulin (alpha 2M) and its activity is blocked by low-Mr trypsin inhibitors, which suggests that it may be a protease-alpha 2M complex. Here we determined the possibility of developing a routine clinical chemistry test for detection of this complex in patients' blood. We measured with chromogenic substrates the total proteolytic activity of citrated plasma and of the alpha 2M immunoabsorbed from plasma. Low-Mr substrates containing Arg were degraded much better by plasma from RA patients than by plasma from patients with other arthritides. Low-Mr substrates containing Leu, Lys, or Gly or the large-Mr substrate Azocoll were not degraded by RA patients' plasma. alpha 2M from RA patients' plasma attached to a solid-phase immunoabsorbent degraded an Arg-containing tripeptide much better than did the alpha 2M from normal donors, from patients with systemic lupus erythematosus, or from those with joint inflammation of other, "non-autoimmune" origin. Although the enzyme associated with alpha 2M in the plasma from RA patients appeared to be similar to trypsin, the differences in optimal pH, cation concentration, degradation of Lys-containing substrates, and biological activity suggest otherwise. We speculate that the alpha 2M-protease complexes are generated in the immune system and contribute to the inflammatory and autoimmune phenomena in RA. | |
| 1201825 | [Non-traumatic subluxation of the scaphoid bone of the hand]. | 1975 | It is demonstrated in three clinical case reports that a subluxation of the scaphoid bone and a diastasis between the scaphoid and the lunate can occur in association not only with traumatic injury but with chronic inflammatory conditions of the wrist. In one case the etiology was purulent synovitis, in the 2nd an unspecific synovitis with serous exudate, and in the 3rd case rheumatoid arthritis. |