RABC

Browse

Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
4081661	HLA antigens in rheumatoid arthritis patients with and without a family history of polyart	1985	The HLA antigens, A, B and DR, were studied in 141 patients with erosive, seropositive rheumatoid arthritis (RA). The frequency of the B27 antigen was significantly increased among patients with a family history of symmetrical polyarthritis compared with blood donor controls (p less than 0.001) and with patients without a family history of polyarthritis (p less than 0.005). The frequency of DR4 was significantly (p less than 0.001) increased among the RA patients, but there was no significant association between DR4 and a family history of polyarthritis.
6678198	Echocardiographic evaluation of patients with rheumatoid arthritis.	1983 Dec	Mode M echocardiograms in 34 consecutive adult RA patients revealed no significant differences with the findings obtained in 18 normal controls of similar age and sex. One patient had an 11 mm separation between the anterior chest wall and the right ventricle suggestive of a 350 ml pericardial effusion but had no corresponding findings between the posterior left ventricular wall and the pericardium. In this patient the electrocardiogram showed low voltage and the chest roentgenogram an enlarged cardiac silhouette. The differences between these series and other series reported in the literature may reflect ethnic and therapeutic differences between the respective RA populations.
7063809	Influence of fasting on intestinal permeability and disease activity in patients with rheu	1982	We have investigated the influence of fasting and lactovegetarian diet on intestinal and non-intestinal permeability in 5 patients with rheumatoid arthritis. We used low-molecular weight polyethyleneglycols (PEG 400) as probe molecules and a deterministic mathematical model to assess the permeability characteristics. Both intestinal and non-intestinal permeability decreased after fasting, but increased again during a subsequent lactovegetarian diet regime. Concomitantly it appeared that disease activity, as shown by a clinical six-joint score, first decreased and then increased again. The results indicate that, unlike lactovegetarian diet, fasting may ameliorate the disease activity and reduce both the intestinal and the non-intestinal permeability in rheumatoid arthritis.
1166980	Absence of echocardiographic abnormalities of the anterior mitral valve leaflet in rheumat	1975 Oct	Thirty-five consecutives patients with classic or definite rheumatoid arthritis underwent echocardiography to evaluate the motion of the anterior mitral valve leaflet. Adequate echocardiograms were obtained in 31 patients. All 31 patients showed normal valve motion and a normal EF slope. If meticulous technique was not observed, a falsely low value for the EF slope was obtained and a normal slope was found when the method was improved. This study shows that echocardiographic abnormalities of the anterior mitral valve leaflet rarely, if ever, occur in patients with rheumatoid arthritis, provided that careful attention to recording method is observed.
2864664	[Synthetic antimalarials in the therapy of rheumatoid arthritis: adverse effects and advan	1985 Oct 6	The drugs used in the treatment of rheumatoid arthritis are divided into two classes: a "first aid" and a "back up" group. The synthetic antimalarial drugs examined belong to the second group. Table 1 assesses the pros and cons of such treatment and clearly indicates the prevalence of its advantages.
307933	Immunogenetic determinants of familial acute lymphocytic leukemia.	1978 Aug	Acute lymphocytic leukemia developed almost simultaneously in two adolescent brothers, and another brother and both parents had rheumatoid arthritis. Laboratory studies uncovered no evidence for an underlying immunodeficiency state in the family. Immunogenetic evaluation showed the leukemic siblings to be HLA- and mixed-leukocyte-culture identical and homozygous for a recessively inherited locus dictating the presence of antigens on the surface of B-cells. This Ia antigen, as detected by sera from mothers of leukemic children, appeared to be mapped within the major histocompatibility region and may be a human analogue to murine immune-response antigens associated with susceptibility to leukemia.
6371884	[Biometric evaluation of the use of a battery of tests for studying the rheumatoid factor]	1983 Mar	The research has been executed on a sample embracing 253 patients affected with rheumatid arthritis (ARA criteria), 177 patients affected with osteoarthritis and 104 healthy subjects forming the standard sample. On the serum of every subject we have used a series of five different tests in order to find the rheumatoid factor. The results we obtained have been weighed with biometrical criteria of various kinds in order to single out any possible common behaviour-pattern and to determine the tests diagnostic value as regards the considered disease. We have noticed a different result of single tests as regards the same diagnosis so we can exclude an absolute equivalence of the five tests, though for some of them there is a high mutual relation.
7306228	Monocyte receptor function in patients with rheumatoid arthritis.	1981 Oct	Monocytes from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and normal volunteers were studied for abnormalities of Fc and C3 receptor function. Monocytes from the majority of 22 patients with active RA showed enhanced E-rosette formation and Ea phagocytosis compared to monocytes from 20 normal volunteers and 10 OA patients, However, no significant differences in binding of EAC or uptake of iodinated aggregated gamma globulin were found among the 3 groups. Corticosteroid-treated RA patients exhibited significant depression of EA-rosette formation and phagocytosis. These results suggest that there is modulation of EA receptor function in monocytes from RA patients.
7183585	Rheumatoid arthritis: vocational rehabilitation.	1982	The consequences of inflation and accelerating introduction of automation and microprocessors into industry are a shift from unskilled to skilled work, the lessening of opportunities for the unskilled worker, and growing unemployment. If disabled people are competing for employment they must take every opportunity to extend education and acquire skills. Juvenile chronic arthritis presents one set of problems in vocational rehabilitation at the beginning of a working career and adult rheumatoid arthritis another, commonly in those over 45 years old and previously established in work. The prevalence of severe disability in juvenile chronic arthritis is about 1 in 20 000 of the population, females are affected twice as often as males and 1 in 10 has defective vision or blindness due to chronic iridocyclitis. At school, besides education, there must be emphasis on encouraging independence, self-confidence, mobility and determination. A School Leavers' Conference early in the last year at school gives the adolescent the best chance of choosing a career. Rheumatoid arthritis is three times more common in women and increasingly, over the last 40 years, women are working besides home-making. Morning stiffness, fatigue, immobility and pain are the common symptoms of widespread involvement of joints and systemic disturbance. The principal determinant in the success of vocational rehabilitation is personality, and the social and environmental factors are more significant than the degree of disability. The Disablement Resettlement Officer can assure continuity of rehabilitation between the health and employment services: a favourable outcome is work, self-derived income independence and freedom of movement using whatever technical aids are required to achieve this.
850779	Chemical synovectomy with Varicocid in rheumatoid arthritis--further results.	1977	Varicoid was administered to 170 patients with rheumatoid arthritis, to 11 patients with a diagnostically uncertain monarthritis, to 12 patients with exudative gonarthrosis and also to 4 patients with lupus erythematodes visceralis. A total of 262 joints were treated. The short-term results, which were evaluated 4 weeks after the administration of Varicocid, revealed improvement is 95% of the patients. After 12 months, 46% of the patients were found to be free from symptoms within the area of the treated joint, and 33% of the patients showed a considerable improvement. An objectively evident improvement was found in 35 out of 40 patients with rheumatoid arthritis followed up over a period of 3 years. Comparable results after treatment with Varicocid were also obtained in patients suffering from any one of the above-mentioned rheumatic diseases. A new inflammation activity/function index for the evaluation of the local joint therapy has been used. The first investigations both of function and of morphology of the synovial membrane treated with Varicocid are reported. In our opinion, chemical synovectomy with Varicocid fills a gap in the therapy of the rheumatoid arthritis. The essential value of this type of therapy is the absence of toxicity, a temporary increase in local reactions only, and also a continuous improvement, especially in early cases.
7416816	Lymphatic obstruction in rheumatoid arthritis: a cause for upper limb oedema.	1980 Jun	Peripheral lymphatic obstruction has been demonstrated by lymphangiography as a cause of upper limb oedema in 2 patients with seronegative rheumatoid disease.
7409618	Arthrodesis of the wrist joint in rheumatoid arthritis.	1980 Jun	Fifty six fusions of the wrist joint were performed using a slight modification of the method described by Mannerfelt and Malmsten (1971). All but one of the patients had rheumatoid arthritis. The patients were reviewed one to eight years after the operation. Ankylosis in useful position was achievedin nearly 100 percent of the cases. The operation is simple and does not require any special instruments, but x-ray facilities in the operating room are necessary. Normally there is no need for any kind of external immobilisation.
6358281	Histamine-triggered localized vasculitis in patients with seropositive rheumatoid arthriti	1983 Dec	To gain some insight into the pathogenesis of vasculitis in rheumatoid arthritis, and to investigate its relation to circulating immunoreactants, we injected 50 microliters of histamine intradermally in four seropositive and four seronegative patients with rheumatoid arthritis. Skin biopsies obtained before histamine and at 4 hours after histamine were studied by immunofluorescence microscopy, and skin biopsies 24 hours after histamine were studied by light microscopy. At 4 hours after histamine, all seropositive patients demonstrated deposits of IgM and complement components in dermal vessels; by 24 hours, various degrees of leukocytoclastic vasculitis were noted. Circulating material reactive with Raji cells, C1q, or both, was present in 3/3 seropositive patients. In contrast, none of the seronegative patients exhibited vascular deposits of immunoreactants or vasculitis. The results indicate that patients with rheumatoid arthritis who are seropositive may have circulating complexes with appropriate characteristics to induce vasculitis and that vasoactive substances may be used to trigger their local deposition in vessels.
921342	Ulceration of the cornea in rheumatoid arthritis.	1977 Oct	Five patients with melting of the cornea in association with rheumatoid arthritis are described. The arthritis was often inactive and without systemic manifestations, in contrast to that seen in association with scleritis. In 3 there was evidence of reduced tear formation, but in none was tear production absent. In 3 patients the lesions healed during treatment with azathioprine or penicillamine.
848241	Synthesis rates of fibrinogen and albumin in patients with rheumatoid arthritis.	1977 Feb	In four patients with rheumatoid arthritis synthesis rates of fibrinogen and albumin were studied with and 14C carbonate method described by Mc Farlane and Reeve. One of the patients was studied twice with and without steroid treatment. The following results were obtained: 1. There was no correlation between plasma fibrinogen levels and fibrinogen synthesis rates. Contrary to the results from turnover studies of labelled fibrinogen reported in the literature normal fibrinogen synthesis rates were found in the presence of elevated plasma fibrinogen levels in three of the five studies performed, corresponding to low fractional synthesis rates. Two patients showed elevated fibrinogen synthesis rates. In these patients the fractional synthesis rate was also well above normal. 2. Albumin synthesis rates were elvated in one patients treated with steroids and in one patient with very active arthritis. In the rest of the studies albumin synthesis was low. There was no correlation with fibrinogen synthesis rates.
968340	The effect of rheumatoid arthritis on the social situation of housewives.	1976 Aug	Thirty-seven housewives treated in hospital for rheumatoid arthritis were investigated with particular reference to their husbands' reactions. Although most patients had 'accepted' the disease, many were distressed by both the physical aspects of it (tiredness, pain and limitation of activities) and by the psychological aspects (guilt, fear of being a burden, and not understanding the disease). In 70% it was felt that their husbands understood the disease, but half the patients had difficulties in coping with the anxiety of their husbands. Those whose arthritis had developed before marriage fared better in terms of fear of losing their independence, understanding the disease, guilt feelings, adjustment to the disease, their husbands' understanding and friction in the home. Patients with milder disease were more anxious, but experienced the greater understanding of their husbands. Help was required in enabling the patients to cope with their fears, to manage practically, and to deal with the anxiety of their husbands. Help in coping with the fears and in allaying the anxiety of their husbands was most required in those with mild disease and those in whom it had progressed to become socially disabling, but without confining the patients to their homes.
7458433	An inhibitor of leucocyte movement in the plasma of patients with rheumatoid arthritis.	1980 Dec	Plasma from patients with rheumatoid arthritis shows inhibitory activity towards the random and stimulated movement of human polymorphonuclear leucocytes and peripheral phagocytic monocytes in vitro. The inhibitory activity is heat-labile, not present in plasma from patients with noninflammatory diseases, and appears to exert its inhibitory effects by occupying sites on the cell cell membrane from where it may be removed by washing. It is suggested that this factor(s) is responsible for the diminished accumulation of polymorphonuclear leucocytes into skin chambers with occurs in patients with rheumatoid arthritis.
6230447	Cells with immunoregulatory function: the human macrophages and the effects of remittive d	1983 Dec	Different inhibitory effects on the mixed leukocyte reaction were noted with sodium aurothiomalate (GSTM) and D-penicillamine (D-Pen) depending on the lymphocyte/macrophage ratio of responder cell populations. GSTM and auranofin strongly inhibited oxy radical generation whereas D-Pen had a selective effect.
7373630	Some effects on house officers of an elective rheumatology rotation.	1980 Mar	To ascertain whether a rheumatology elective (RE) increases the skills of house officers (HOs) managing patients with rheumatic disease, and whether these skills persist after the RE, medical records of 164 gouty patients, seen by 16 HOs who had had an RE and 73 who had not, were audited. The RE led to more complete documentation of history and physical examination and possibly to more frequent use of diagnostic arthrocentesis. Over the 30-month period of the study, no increase in scores of HOs not having a RE was apparent, while some deterioration, related to the interval between the RE and audit, was seen in scores of those who had an RE.
983355	[Significance of coagulation disorders and inflammatory immune reaction in an infectious m	1976 Sep	A combined study employing plethysmographical, scintillation counting and coagulation methods indicates that a coagulation crisis in combination with fibrin overproduction may be an indicator of a beginning arthritis of rheumatoid character. Rats which received a single subcutaneous infection with erysipelas bacteria exhibit a shock resembling crisis two days post inoculation as substantiated by the consumption of coagulation factors II, V, VIII, XII and decrease of platelets. This consumption of coagulation factors is characterized by a rapid compensatory increase of platelets, antihaemophilic factor VIII and fibrin, 5 times more in the pig and 3 1/2 times more in the rat than in control animals. In adult rats the overproduction of fibrin is combined with an intense concealed consumption of fibrin in all organs of manifestation. Only in young rats an absolute consumption of fibrin is observed. The incorporation of fibrin into connective tissue is accompanied by fibrin consumption as demonstrated by immunofluorescence, by oedema of the paw, and by mesenchymal proliferation as substantiated by scintillation counting of incorporated 35SO4 and 3H-Proline, as markers for the beginning synthesis of ground substances and collagen. This model supports the importance of an initial vascular phase for the subsequent phase of manifestation in chronic rheumatoid diseases. It is discussed whether the organ specific permeability of the affected organs (joints, heart, arteries and eyes) may be a localizing factor of organ manifestation, parallel to the hormonal mesenchymal reaction.