Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7181337 | Lysozyme concentration in tears of patients with sicca syndrome. | 1982 Nov | Fifty-three patients with sicca syndrome and 34 healthy controls had their tear lysozyme concentration examined. Lysozyme level was significantly decreased (P less than .0005) in all patients with low Schirmer test values as compared with healthy controls. Even in rheumatoid arthritis patients with normal Schirmer test results a low concentration of tear lysozyme was found. Tear lysozyme can be used to detect subclinical involvement of lacrimal glands in collagen diseases. | |
| 6691857 | The psychosocial impact of systemic lupus erythematosus and rheumatoid arthritis. | 1984 Jan | Seventy-six ambulatory patients with systemic lupus erythematosus and a comparison group of 23 ambulatory patients with rheumatoid arthritis were given a structured interview and standard psychological tests, including the Minnesota Multiphasic Personality Inventory, to determine the psychosocial impact of the illness. Both groups had significantly elevated scores on 3 Minnesota Multiphasic Personality Inventory scales: Hypochondriasis, Depression, and Hysteria. Psychological difficulties are an integral part of systemic lupus erythematosus and are as common as most other manifestations. The implications for clinical practice are discussed. | |
| 6618825 | A radiographic model for simulating rheumatoid erosions. | 1983 Jul | Lesions were mechanically created in bone specimens to find a radiographic model for skeletal disease. Drilling, sawing, and filing of the bones did not satisfactorily simulate skeletal pathology. Chipping of the juxta-articular cortex resulted in cortical defects that closely resemble rheumatoid erosions. The radiographs of 25 patients with rheumatoid arthritis were reviewed using optical magnification to determine the size and distribution of actual rheumatoid erosions. Using the pattern of erosions in the patient population, lesions can be distributed in varying sizes to produce a radiographic model for rheumatoid erosions. This model can be used for observer performance studies and to evaluate imaging technology. | |
| 229777 | Fate of herpes simplex virus in lymphocytes from inflammatory joint effusions. i. Failure | 1979 Oct | The ability of lymphocytes isolated from the blood and synovial effusions of patients with rheumatoid arthritis to support the growth of herpex simplex virus (HSV) was studied. Whereas blood lymphocytes supported virus growth, effusion lymphocytes were usually non-permissive. Lymphocytes obtained from the effusions of patients with other forms of inflammatory arthritis or suspected viral arthritis commonly failed to support the growth of HSV, but the virus grew in effusion lymphocytes from patients with noninflammatory joint disease. Several nonspecific factors which might have accounted for this non-permissiveness were excluded. | |
| 4005469 | Conceptual structure in hypochondriasis, arthritis and neurosis. | 1985 May | Three distinct clinical groups were studied using personal construct methods and two personality questionnaires. Non-articulation of conceptual structure was not specific to patients with hypochondriacal symptoms, physical illness or chronic neuroses. Articulation of the conceptual structure was significantly correlated with the practical-imaginative personality factor in all three patient groups. | |
| 2416507 | Ia antigens and susceptibility to rheumatoid arthritis. | 1985 Dec | Since the first description of human leukocyte agglutination antibodies, knowledge of the MHC, particularly the Ia region, has grown immensely and it is now recognized as a major polymorphic multigene family involved in the regulation of immune response and disease susceptibility. This review examined the hypothesis that there is another level of complexity within the Ia system, beyond multiple loci and allelic series, that involves specific epitopes as the functionally important components of the Ia molecule. Certain of these epitopes are likely to be responsible for the regulation of immune responses and susceptibility to certain autoimmune diseases such as rheumatoid arthritis (RA). Evidence was presented that certain monoclonal antibodies recognize epitopes found in a significantly more positive association with susceptibility to RA than available markers such as DR4. Biochemical characterization of the Ia molecules bearing this epitope revealed that the same epitope was present on two different molecules. The possibility was considered that such epitopes are closely related but not identical to Ia determinants that are primarily involved in producing the abnormal immune state characterizing those with RA. | |
| 789838 | Pathology of the cervical spine in rheumatoid arthritis: a controlled study of 44 spines. | 1976 Oct | Cervical spines (with occiputs) of 44 patients with rheumatoid arthritis (RA) were compared with 44 control spines from patients without RA, matched for sex and age. There were six severe and seven slight atlanto-axial dislocations (both horizontal and vertical, two of which had been treated surgically) in the RA group and none in the control group. Ankylosis, synchondrosis, syndesmosis, bone erosions, and redness of synovial tissue in the atlanto-axial, atlanto-occipital and cervical intervertebral joints were more frequent in the RA group than in the control spines. The lesions permitting the best discrimination between the RA and control groups were used to calculate an overall score for the whole cervical spine. Sixteen of the 44 RA patients scored higher than the highest control value; only nine scored lower than the median control score. A higher score than the average value found for the RA spines was obtained by the male patients, the patients with seropositivity or subcutaneous nodules, the patients treated with corticosteroids, the patients who died in the Department of Rheumatology, and those whose death was related to the RA itself or to the treatment given. | |
| 1085099 | Autoantibodies in D-penicillamine treated rheumatoid arthritis. | 1976 Feb | The D-penicillamine (D-Pen.) treatment can induce some diseases accompanied by autoantibodies: lupus, pemphigus, myasthenia. The authors present the results of a systematic study of autoantibody occurrence during D-Pen.-treatment of the rheumatoid arthritis (RA): (1) Anti-nuclear antibodies are slightly positive in 34% of the untreated RA. They appear or enhance in 44% of the treated patients (22/50). They reach high titers (1/500) in two clinical-induced lupus and in three asymptomatic cases. (2) Anti-native DNA antibodies are not found in untreated patients. They become markedly enhanced in two clinical lupus as in three asymptomatic cases (3/50). (3) Anti-epidermal intercellular substance-antibodies are absent in non-treated as well as on pemphigus-free treated patients (0/40). They are slightly elevated in 5 induced pemphigus. (4) Anti-striated muscle antibodies are absent in non-treated patients, rarely and moderately elevated (3/40) in the asymptomatic D-Pen.-treated group. These findings could have a practical interest for the survey of the treatment. | |
| 6164122 | Aortic valve replacement in rheumatoid aortic incompetence. | 1981 Feb | Cardiac valvular involvement in patients with rheumatoid arthritis is rare and seldom so severe as to require surgery. The present report is concerned with a case of rheumatoid aortic incompetence successfully treated by prosthetic valve replacement. As suggested by previous similar reports, surgery is the most effective therapy for clinically significant rheumatoid endocarditis. | |
| 7127943 | Metal concentration in synovial fluids of patients with prosthetic knee arthroplasty. | 1982 Oct | Significant levels of the major components of metal prostheses in total knee arthroplasty were measured in the synovial fluids from patients with these implants. Cobalt (Co), Chromium (Cr), and Nickel (Ni) concentrations were determined by atomic absorption spectrophotometry on 26 synovial fluid samples from 18 patients with hinged (metal-on-metal) prostheses and eight patients with nonhinged (metal-on-polyethylene) prostheses. Concentrations of Co, Cr, and Ni were significantly higher in synovial fluids from hinged knees, as were Ni concentrations in fluids from nonhinged knees. Of the three metals, Ni showed some evidence of increases solubility. The metal debris did not appear to provoke a leukocyte response, insofar as surprisingly low numbers of neutrophils were present in these fluids, all of which were obtained from nonseptic knees. However, significant numbers of lymphocytes and large mononuclear cells were present in the fluids. | |
| 978664 | Rheumatoid pericarditis: comparison of immunologic characteristics of pericardial fluid, s | 1976 Sep | A comparison was made of the immunological characteristics of serum, synovial and pericardial fluids obtained from a 54 year old man with classic rheumatoid arthritis and pericarditis. The synovial and pericardial fluids had low complement levels and immune complexes were detected using both biological and physical methods. The serum had normal complement levels and no immune complexes could be demonstrated. The presence of immune complexes and complement depletion in the synovial and pericardial fluids supports the concept of local production of immune complexes, and is in keeping with a Type III mechanism of immunologic injury. | |
| 1014627 | [Social risk factors for rheumatoid arthritis (epidemiologic social-medical study)]. | 1976 Dec | An epidemiological social-medical study was carried out in the section of IX polyclinic--Sofia, aiming at the establishment of the social risk factors effect upon the origination and course of the rheumatoid arthritis (RA), in view of the particularly social importance of the disease invalidity. The model is based on statistical methods for programmed computor processing. Two hundred and forty six subjects were examined, the basic group of 44 being with diagnosed RA according to the international criteria (0.35% from the population) and 2 control groups--patients with infectional alergic arthritis and healthy subjects. The assessment of the RA severity degree was performed according to the numeric method, elaborated for that purpose, based on the following criteria: number of the joints, kind of the joint involvement, functional capacity, patients' personal assessment of the difficulties due to the disease, disease duration, ESR, rheumatoid factor, X-ray changes according to the adopted four degrees. The following social factors were studied: occupation, kind of work, working conditions, financial status, education, home conditions, mode of life, activity in the leisure time. A statistically significant (correlation C with P less than 0,05--0,001) unfavourable effect of the following complex of risk social factors was established: 1. RA risk factors--unfavourable microclimatic working (C=0,24) and home (C=0.30) conditions: 2. Risk factors for RA invalidity--occupations with heavy physical work (C=0,40), wol income (C=0,31) and unfavourable home conditions (C=0,22). The results obtained will serve as a ground for concrete directed rheumatoid arthritis prophylaxis. That outlines the perspectives of similar studies for assessment of the effect of life environmental factors upon human health state. | |
| 433944 | Pericardial disease in rheumatoid arthritis. | 1979 Mar | Six patients with rheumatoid constrictive pericarditis, five seen in a two and one half year period, are described. All patients were male, all had rheumatoid factor, and all had active arthritis. Diagnosis was suspected from careful physical examination and confirmed in five patients by cardiac catheterization. Pericardiectomy was successful in all five patients on whom it was performed. Rheumatoid constrictive pericarditis should be suspected in any patient with rheumatoid arthritis and unexplained signs of right heart failure. | |
| 7280489 | Prevalence of the tarsal tunnel syndrome in rheumatoid arthritis. | 1981 Aug | Forty-eight patients with definite of classical rheumatoid arthritis (RA) were studied for the presence of tarsal tunnel syndrome (TTS). Nerve conduction velocities and distal latencies were determined in a constant temperature room and the findings compared with a group of 35 normal, age-matched subjects. After excluding four patients with peripheral neuropathy, a definite delay in the distal motor latency of the tibial nerve was documented in 11 subjects (25%). Two of the 11 had foot symptoms suggestive of TTS. These 11 patients with prolonged distal motor latencies did not otherwise differ from RA patients without TTS in terms of disease duration or severity, treatment, or the presence of foot deformity. Thus, compressive neuropathy of the branches of the posterior tibial nerve is a relatively frequent finding in patients with definite or classical RA. | |
| 6740267 | Glucose metabolism in patients with rheumatoid arthritis. | 1984 | Several studies made during the first half of this century suggested an association between chronic arthritis and disturbed glucose metabolism. Moreover, increased prevalence of IGT in patients with idiopathic FTS of the palms has recently been reported and RA is a disease commonly accompanied by FTS. Furthermore, patients with RA are often exposed to drugs that may precipitate or uncover mild undiagnosed DM. For these reasons, glucose tolerance was studied in 101 patients with classical or definite RA. Of these, 4 (4%) had an established type II DM and 6 (6%) a previously undiagnosed IGT. The observed frequencies of disturbed glucose metabolism in RA did not differ from the prevalence rates reported for the general population in Sweden. Hence, this study does not support the previous reports claiming an association between chronic arthritis and disturbed glucose metabolism. | |
| 7083660 | Swanson implant arthroplasty of the wrist in rheumatoid arthritis. | 1982 Jun | Severe involvement of the wrist in rheumatoid arthritis poses great functional restrictions in eating, maintaining personal hygiene, and in performing general daily activities. Twenty-six Swanson radiocarpal implant arthroplasties were performed in 23 patients. Patients' average age was 57 years, with a preoperative diagnosis in all patients of rheumatoid arthritis. Follow-up averaged 33 months (range, 5-47 months). The principal indication for surgery was pain in 23 wrists and wrist deformity in three wrists. Particular attention was paid to postoperative functional status and to any changes in performance of routine activities of daily living pertinent to the wrist. Employing a pain rating scale of 1-4, preoperative scores averaged 3.71 on the operated side and postoperative scores, 1.75. Postoperative activities of daily living that benefited from the improved extension capability of the wrist showed significant improvement. No significant improvement resulted in those activities necessitating strength or fine motor control. Prosthesis fracture in one patient, and recurrence of ulnar deviation in two patients, were the major complications. Capsular reconstruction and tendon transfer to balance the wrist were integral components of the procedure. | |
| 3984528 | [Nosologic and inductive diagnosis of chronic polyarthritis: the logical criteria chain]. | 1985 Jan | The terms of acuteness and chronicity in arthritis are being defined to their originally nosologic and fundamentally different dimension in contrast to their symptomatologic daily use. "Chronic arthritis" has on principle to be defined as being progressive and destructive causing permanent damages. The so-called ARA-criteria of rheumatoid arthritis are being pushed back to their didactic value and their originally epidemiologic purpose. In everyday life of a qualified rheumatologist they are at least superfluous, sometimes useless. The analytical-constructive train of thoughts leads from the symptom by means of methodologic steps of evidence and exclusion via nosologic categories to the respective diagnostic result. The diagnostic steps of decision are being introduced as "logic chain of criteria" and thus make the complex process of findings for our reflections at the bedside transparent. | |
| 1070994 | Drug interactions in the management of rheumatoid arthritis. | 1976 | Only some of the areas of drug interactions of relevance to those treating rheumatic diseases have been mentioned and there are still enormous gaps in our knowledge. It is likely that some potential areas of danger have been over-emphasised, being based on speculation rather than real data or purely animal experiments using non-clinical doses of drugs. We are learning how certain drugs can stimulate or inhibit the metabolism of other drugs through effects on liver enzymes systems. For example, the metabolism of corticosteroids is induced by phenylbutazone (and also by phenobarbital and phenytoin). The patient with active rheumatoid arthritis with a low serum albumin would be unusually susceptible to changes induced by combinations of highly protein-bound anti-inflammatory drugs. Finally, although drug interactions are responsible for adverse effects it has been suggested that a more frequent cause of therapeutic failure is not drug interactions but the increase in the number of drug defaulters when more than one drug is prescribed. | |
| 999736 | Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis. | 1976 Nov | A patient population admitted to the hospital for either SLE or RA was surveyed for the subsequent development of neoplasms. The frequency of neoplasm in SLE patients appeared to be exaggerated, whereas the frequency of subsequent neoplasm in rheumatoid patients was unexpectedly low. A paucity of nephritis in the SLE group was noted. Further reports are encouraged so that the magnitude of the risk of malignancy developing with immunosuppressive therapy can be more precisely ascertained. | |
| 6805691 | Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome. | 1982 Jun 12 | As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sjögren's syndrome, though this had not been suspected by most of the referring physicians. In contrast, among a group of 17 patients with overt Sjögren's syndrome, most of whom also had rheumatoid arthritis, only one had antibodies to SS-B. Patients presenting with polyarthralgia found to be SS-B positive may be likely to develop Sjögren's syndrome but unlikely to develop rheumatoid arthritis. The detection of SS-B antibodies may antedate clinical evidence of Sjögren's syndrome by months or even years. These results emphasise the clinical heterogeneity of Sjögren's syndrome. |