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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
3841160	Immunogenetic studies in families with rheumatoid arthritis and autoimmune thyroid disease	1985 Dec	HLA and Gm typing were carried out in 16 families. Seven families included 10 sib pairs with rheumatoid arthritis (RA) and autoimmune thyroid disease (ATD) respectively, and nine families included 16 sib pairs with RA and circulating thyroid autoantibodies respectively. Eight, 11, and seven sib pairs with either RA or clinical or immunological evidence of ATD shared none, one, and two HLA haplotypes respectively, and two, seven, and two informative sib pairs shared none, one, and two Gm haplotypes respectively. This random haplotype sharing of HLA and Gm haplotypes suggests that non-HLA, non-Gm linked genes are likely to be involved in any genetic predisposition common to RA and ATD.
1173037	Anti-inflammatory action of an s-triazine derivative in rats.	1975 Feb	Anti-inflammatory action of an s-triazine derivate (M 1704, 2-amino-4-(p-fluoroanilino)-6-n-propyl-1,3,5-triazine) was studied in rats. M 1704 inhibited carrageenan edema, cotton-pellet granuloma and adjuvant arthritis in intact rats. M 1704 was not effective on carrageenan edema in adrenalectomized rats, but effective when administered with cortisol. The drug appeared to potentiate the anti-inflammatory effects of cortisol on cotton-pellet granuloma. The results obtained in this and a previous study suggest that M 1704 exerts the anti-inflammatory action mainly by potentiating the peripheral anti-inflammatory action of endogenous steroid and partly by stimulating the secretion of corticosteroids.
87780	Liposomes in arthritis: a new approach.	1979 Jun 23	Intra-articular liposomal cortisol palmitate in a dose equivalent to 2 mg of cortisol produced a worthwhile therapeutic response in patients with rheumatoid arthritis. This may represent a valuable new approach to treatment.
7051254	Degradation in vivo of articular cartilage in rheumatoid arthritis by leucocyte elastase f	1981	Using a specific substrate, no leucocyte elastase activity could be detected in 55 synovial fluids, including 29 from patients with rheumatoid arthritis (RA). However, a high percentage of samples contained phagocytic inclusions of elastase, alpha 1-proteinase inhibitor (alpha 1-PI) and alpha 2-macroglobulin (alpha 2-MG) in both the polymorphonuclear (PMN) and mononuclear phagocytes. Immunofluorescence and indirect peroxidase-antiperoxidase staining of articular cartilage (ACA) from 52% of 21 patients with RA and one with juvenile RA (JRA) showed presence of elastase in the superficial layer of microscopically intact but proteoglycan depleted pannus-free ACA. In histologically altered pannus-free RA-ACA superficial elastase deposits were found in 24% of the cases. Adjacent ACA sections contained IgG, C3, alpha 1-PI and rarely alpha 2-MG. RA-ACA below or surrounded by pannus showed close contact with intact and decaying PMN in 62% and 48% of the cases, respectively. ACA specimens from patients with degenerative disease and systemic lupus were negative. These findings strongly suggest that PMN leucocyte elastase is operative in the degradation of RA-ACA and JRA-ACA, and that this activity is largely dependent upon the presence of entrapped immune complexes in such cartilage.
451490	Interobserver variation in the evaluation of radiologic changes of rheumatoid arthritis.	1979	The variation between four radiologists in the evaluation of hand, wrist, and foot radiographs of rheumatoid arthritis was examined. The recognition of individual radiologic changes varied considerably as judged by the findings of the different observers. Erosion and joint space narrowing were interpreted more uniformly than soft tissue swelling and osteoporosis. When the radiographs were graded from 0 to 5 using standard reference radiographs, more than 90% of them were graded uniformly or with a difference of only one grade. The investigation has shown that when applying grading of rheumatoid arthritis according to standard reference radiographs, the interobserver variation is considerably less than when pure individual radiological changes of rheumatoid arhtritis are considered.
3980538	Bilateral hip and knee replacement for rheumatoid arthritis.	1985 Mar	A series of 19 patients with severe rheumatoid arthritis had replacement of both hips and both knees. They are reviewed after a mean follow-up of 27 months. The preferred programme is to replace hips before knees. Pain was relieved in all the patients and function was improved in all but two. Severe rheumatoid disease and prolonged immobilisation before the operations were not contra-indications to a successful outcome, but the presence or the development of cervical myelopathy combined with gross upper limb deformity militated against a good result.
729712	The synovial fluid hyaluronic acid in rheumatoid arthritis.	1978 Dec 15	The intrinsic viscosity of hyaluronic acid in synovial fluid decreases significatively in mild and severe arthritis (24% and 37% respectively). Variation in hyaluronic acid concentration parallels the above results. Chondroitin-6-sulfate can be detected in about 30% of the arthritic fluids.
3919401	Gold concentrations and toxicity during oral gold treatment with auranofin.	1985	The concentrations of gold in whole blood, serum, urine and blood cells of patients with rheumatoid arthritis were measured during 6 months of oral treatment either with Auranofin or placebo. Any adverse effects attributable to the treatments were also recorded. Although the time course of gold during Auranofin therapy was similar to that of injected gold, the blood and serum gold concentrations were significantly lower than those measured in patients receiving injected gold. Between 45 and 58% of Auranofin gold in the blood was associated with blood cells. In comparison, following injections of gold thiomalate, only about 4% of the gold was present in the blood cells. During the 6-month period, 2 patients receiving Auranofin withdrew because of diarrhoea and another because of rash. 1 placebo patient withdrew because of headaches. No laboratory evidence of haematological, renal or hepatic abnormality was encountered. It is suggested that the markedly lower concentrations of gold in the body sustained during treatment with Auranofin may be the critical factor towards a greater tolerance of the drug in the treatment of rheumatoid arthritis.
278177	Influence of proquazone (Biarison) on the levels of complement components (C3 and C4) in s	1978	Four patients with erosive rheumatoid arthritis and one with psoriasis arthropathy were treated with 600-900 mg/day proquazone for 4-7 weeks. All patients had acute knee effusions. The complement components C3 and C4, as well as IgG, IgA, IgM and total protein, were measured in both the synovial fluid and serum before and after treatment. In the 4 patients with rheumatoid arthritis, a marked increase in C3 and/or C4 levels in the synovial fluid was found, correlating in 3 cases with a good clinical response. However, no corresponding changes in complement levels were recorded in the serum. The patient with psoriasis arthropathy did not show any reaction. These preliminary results suggest that proquazone may influence the immunological processes in rheumatoid arthritis.
3869440	Measuring physicians' judgment--the use of clinical data by Australian rheumatologists.	1985 Dec	Most therapeutic decisions depend upon the clinical judgment of physicians assessing their patients. However the inherent and wide variation in such judgments is usually ignored. Rheumatoid arthritis typifies those diseases in which much information is available on which to base decisions, but little is known about how physicians combine the data to evaluate their patients' response to treatment. Thirty-four Australian rheumatologists recorded their assessments of the progress of 50 rheumatoid patients treated with 'second line' agents, based on data presented on previously validated written forms. Clinical judgment analysis, a form of multiple regression analysis, was then used to model the way physicians' judgments related to the available data. There were major differences of judgment in the assessments of response to therapy. This was so even when only 'clinically important' changes were identified. The variance in judgments which could be modelled by clinical judgment analysis ranged from 45% to 94%. Both individual inconsistency and differences in the underlying use of data contributed to disagreements between clinicians' assessments of identical cases. Identifying underlying differences in the way clinical data relate to clinicians' judgments is a step towards improving clinical consistency.
1080876	[HL-A and psoriatic rheumatism].	1975 Jul	The HL-A groups, including the characteristics of 25 antigens, were measured in 61 patients suffering from psoriatic rheumatism, among them 9 with central forms (pelvispondylitis) and 52 with peripheral forms (polyarthritis with or without sacroileitis). Analysis of the results and comparison of them with those of other workers led to the following conclusions: 1) Central psoriatic rheumatism is associated mainly with W27 and Da31, less closely with HL-A13, and slightly or not at all with W17. 2) Peripheral psoriatic rheumatism has the same relationship with the HL-A system as has psoriasis without anthropathy. It is associated mainly with W17, less closely with Da31 and HL-A13, and slightly or not at all with W27. 3) By their relationship to the HL-A system, the two varieties of psoriatic rheumatism may be clearly distinguished from one another and from other inflammatory rheumatisms. The HL-A groupings are of considerable value in the differential diagnosis between central psoriatic rheumatism, peripheral psoriatic rheumatism, ankylosing spondylarthritis, the Fiessinger-Leroy-Reiter syndrome and rheumatoid arthritis.
1129585	[Several synovial enzymes in rheumatoid arthritis].	1975 Feb	The authors show that although the enzyme variations are nil or unimportant in the mechanical joint fluids, they are of some importance in the inflammation fluids, particularly in cases of rheumatoid arthritis. Of those studied so far, the variations are most notable in the dehydrogenases and the phosphatases, the variations being highly significant and related to one another and to the sedimentation rate.
6626353	The chiromorphoergometry and the chirophotogrammetry.	1983 Aug 30	The authors suggest a suitable method for "measuring" morpho-functional involvement of hands (and wrists). This method analyzes four tests: three postural tests and a photogrammetric test. The three positions are: - "Praying hands" (fig. 1) - "Dorsum of the hands opposed" (fig. 2) - "Phalanges opposed (by their dorsum)" (fig. 3) These positions (1-2-3) define three angles alpha 1, alpha 2, alpha 3. The corresponding indices I1, I2, I3 are synthetized by the following mathematical formula: Ii = 1 - alpha i/90 Patients, in the photogrammetric (or surface) test, lean their hands on a Chigot's plantiscope. The illuminated area provides the fourth index expressed by this formula: I4 = 2,5 Sc/St - 0,25 It is possible to calculate a general index It with the following formula: (formula; see text) Angles and surfaces are documented photographically. The method may be very helpful in evaluating the clinical course and therapy of rheumatoid arthritis.
26226	[DNA--"rejoining" in lymphycytes of patients with a minifestation of rheumatoid arthritis	1977 Dec	Relations between the time of manifestation of the disease and the course of the rheumatoid arthritis were found from the clinic frequently. Patients with later first manifestation of rheumatoid arthritis show clear differences against patients with earlier manifestation of the disease at which the late first manifestation a high activity of the process of the disease exhibit. In males first manifestation of rheumatoid arthritis in middle age of 54,5 years was observed, while in a first manifestation of rheumatoid arthritis in middle age of 47 years a normal course of the disease was found. The difference between the both courses was proved as significantly. In former investigations we could prove that in patients with rheumatoid arthritis the 3H-Thymidin-build in the course of not programmed DNA-synthesis in the DNA of lymphocytes after damage with ionizing was retarded. The rate of not programmed DNA synthesis seems to be in old persons equal. The ligase reaction is possibly diminished because the number of DNA-strand breakes with the age is strong increasing.
6415637	Gold-induced lung disease.	1983 Jun	A 70-year-old female with seronegative rheumatoid arthritis developed interstitial pneumonitis while on chrysotherapy. The reversibility of lung disease and favourable response to steroid treatment support the diagnosis of gold-induced lung disease and distinguish this entity from other forms of interstitial lung disease associated with rheumatoid arthritis. The relevant literature related to gold-induced lung disease is briefly reviewed.
579202	Brain-stem compression in rheumatoid arthritis.	1977 Dec 12	A woman had cervical C-1 to C-2 subluxation with dysphagia. Initial improvement with halo cast and posterior fusion was followed by recurrence of symptoms, but transpharyngeal resection of the odontoid process had continued to alleviate symptoms at 18-month follow-up examination. The importance of vertical C-1 to C-2 subluxation in rheumatoid cervical arthritis is emphasized.
3880183	S-100 protein in normal, osteoarthrotic, and arthritic cartilage.	1985	The occurrence of the S-100 protein was studied in normal and pathological cartilage from patients with osteoarthrosis and rheumatoid arthritis. In normal cartilage all cells of the different zones exhibit immunoreactivity for this protein. An identical distribution is observed in cases of osteoarthrosis and rheumatoid arthritis. Cellular pannus tissue usually is devoid of the S-100 protein. However, if chondroid metaplasia occurs in this tissue the cells become positive for the S-100 protein. From these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes.
1199712	Synovectomy of the elbow in rheumatoid arthritis.	1975 Nov	The results of 105 synovectomies + resection of the radial head in 84 patients with rheumatoid arthritis are shown. Pain was the main indication for surgery, and 1 1/4-6 2/4 years later about 80 per cent had pain relief at work, 90 per cent pain relief at rest. About 60 per cent of the elbows gained in rotation movement; about 40 per cent gained in hinge movement. Thirteen elbows had to be reoperated. In all cases there was only radial approach to the joint, which the authors find gives adequate exposure, few complications, and easy postoperative treatment.
3856400	Fibromyalgia and major affective disorder: a controlled phenomenology and family history s	1985 Apr	Fibromyalgia is a form of nonarticular rheumatism characterized by diffuse musculoskeletal pain. To investigate the relationship between fibromyalgia and major affective disorder, the authors evaluated 31 patients with fibromyalgia and 14 patients with rheumatoid arthritis for rates of current or past major affective disorder and family history of major affective disorder. Both the rate of major affective disorder and the familial prevalence of major affective disorder were significantly higher in the fibromyalgia patients than the rheumatoid arthritis patients. The results suggest that fibromyalgia may be related to major affective disorder.
6366987	A simple pressure dolorimeter for the quantification of joint tenderness in inflammatory a	1983	A simple pressure dolorimeter for the detection and quantification of joint tenderness is described and evaluated. The pressure dolorimeter was more sensitive than a modified Ritchie Index in measuring degree of joint tenderness and as sensitive in detecting tender joints. The interobserver error of the pressure dolorimeter was low, and in a drug withdrawal study, the pressure dolorimeter was able to detect change in joint tenderness whereas the conventional Ritchie Index was not. These results suggest that the pressure dolorimeter is a simple, reliable and sensitive instrument for measuring joint tenderness in patients with inflammatory joint disease. It is also inexpensive and readily available.