Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1055974 | The oral component of Sjögren's syndrome. | 1975 Jun | This study reports the results of an interdisciplinary approach to the diagnosis of Sjögren's syndrome in 100 patients. Ocular and systemic diagnoses and oral features from the history and physical examination are correlated with measurements of stimulated parotid flow rate and labial salivary gland histopathology. A new diagnostic criterion is introduced whereby labial salivary gland focus scores are used to establish the presence of the oral component of Sjögren's syndrome in place of the subjective evaluation of xerostomia. The differential diagnosis of the oral clinical features of Sjögren's syndrome and the clinical management of the oral component of this disease are discussed. | |
| 6748994 | Do we get too much iron? | 1984 Jun | Iron in hemoglobin of 14 gm/100 ml, which is considered normal, may predispose to malignancies and to rheumatoid, heart, bacterial and other infective diseases. Conversely, a mild state of iron-deficiency anemia as presented by hemoglobin of 10 gm/100 ml may be an affordable price for protection from these disease states. The harm due to too much iron is discussed. | |
| 1139963 | Relationship between haemoglobin and the other clinical and laboratory parameters in rheum | 1975 | A retrospective study is reported of 160 patients with definite or classical rheumatoid arthritis, in which changes in haemoglobin concentration were analysed against changes in various routine clinical and laboratory indices of disease activity over a period of time. Although statistically significant correlations were found between haemoglobin concentrations and the articular index of joint tenderness, serum albumin concentration, and erythrocyte sedimentation rate at one point in time, significant relationships in changes in haemoglobin concentration were only found with changes in the latter two laboratory indices. The significant correlations were weak and less important than the cumulative effect of unknown variables in determining haemoglobin level. The study shows that the routine clinical and laboratory parameters of disease activity in rheumatoid arthritis are of no value in predicting the haemoglobin concentration. | |
| 1087638 | Laboratory diagnosis of rheumatoid arthritis: a solid phase radioassay for IgG and IgM ant | 1976 Dec | A technique suitable for the routine estimation of IgM and IgG antiglobulins has been devised. The assay involves the binding of antiglobulins to plastic tubes coated with rabbit immunoglobulin: the amount of antiglobulin bound is then determined by adding radiolabelled antihuman IgG or IgM. The conditions for the assay have been examined and optimal incubation times and amounts of reagents established. Verification of the antibody nature of antiglobulin activity has been obtained. Both IgG and IgM antiglobulins were raised in virtually all seropositive rheumatoid arthritics, and most seronegative patients gave elevated values for either IgM or IgG rheumatoid factors. The use of an anti-light chain reagent as a screening test for total antiglobulins was investigated. These tests should prove valuable in diagnosis and permit quantitative evaluation of research studies. | |
| 7353265 | Pattern of urinary proteins and peptides in patients with rheumatoid arthritis investigate | 1980 Feb | Characteristic differences in the pattern of urinary proteins and peptides have been found in patients with rheumatoid arthritis, compared with patterns from healthy controls. These differences have been demonstrated with a two-dimensional gel electrophoretic technique (Iso-Dalt) involving isoelectric focusing in the first dimension, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the second dimension. Using simple photographic techniques, one can obtain a composite pattern of the individual protein-stained gels for each group. Comparison of the composite patterns from the rheumatoid arthritis group and the control group revealed several proteins in the urine of the rheumatoid arthritis patients not found in the control group. Two groupings of these proteins were identified: acidic, high-Mr proteins and more basic, low-Mr proteins. | |
| 6300996 | A comparison of 99mTc-MDP and 99mTc-pertechnetate by computerized quantitative joint scint | 1983 | Computerized, quantitative joint scintigraphies were performed using both 99mTc-MDP and 99mTc-pertechnetate. 17 joint pairs with asymmetric active arthritis were selected for the study. The joint activity ratio was calculated by dividing the curve peak value of the inflamed joint by the curve maximum of the contralateral symptomless joint. A very high joint activity ratio with 99mTc-MDP was observed in the case of septic arthritis with osteolytic lesions. In all the rheumatoid joints the activity ratios were higher with 99mTc-MDP than with 99mTc-pertechnetate. In reactive arthritis the mean joint activity ratio was equal with both tracers. It appears that 99mTc-MDP is more sensitive in detecting active rheumatoid arthritis than 99mTc-pertechnetate and that high 99mTc-MDP values might be prognostic of destructive changes. | |
| 3904270 | [Blood pressure in arm and finger arteries in rheumatoid arthritis]. | 1985 May | The pressure load is critical for vascular wall alteration. Systolic blood pressure was measured by Doppler sonography in the finger and arm arteries of 24 patients with rheumatoid arthritis and compared to a control group (n = 22) of nearly the same age. The transmitter frequency of the ultrasound probe was 9.6 MHz. In contrast to upper arm arteries the blood pressure values of the radial and ulnar arteries in the forearm and the finger arteries were significantly higher (two-sided test a = 2% or 0.1%) in rheumatoid arthritis. | |
| 6699048 | Total ankle replacement in rheumatoid arthritis. | 1984 Mar | The indications for total ankle-replacement arthroplasty are controversial. Some preliminary experience with its use in patients with rheumatoid arthritis has been disappointing. However, in our fifteen single-axis arthroplasties, fourteen of the Mayo and one of the Buchholz type, after an average follow-up of thirty-nine months seven ankles were rated excellent and eight, good. The relief of pain was gratifying in all of the patients, only four patients having residual slight pain with starting activity. The average gain in the range of motion was 9 degrees. No patient had loosening that required reoperation, although radiolucent lines were seen in eleven ankles. Thirteen of the fifteen ankles had moderate to severe arthritic changes in the talonavicular, subtalar, or other intertarsal joints. | |
| 6849768 | Characterization of chloroquine plasma protein binding in man. | 1983 Mar | Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/- 9% in plasma from healthy subjects (range 46-74%) and 64 +/- 7% in plasma from rheumatoid arthritis patients (range 55-79%). Albumin and alpha 1-acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response. | |
| 6857175 | Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. | 1983 | The effect of pregnancy on the activity of rheumatoid arthritis (RA) was evaluated in 31 patients who had given birth to 49 infants after the onset of their disease. Pregnancy-associated remission of RA was experienced by 75% of the patients. On the other hand, disease exacerbation after delivery occurred in 62% of them. RA had no harmful effect on pregnancy or on the fetus. Hormonal changes during the menstrual cycle or during the use of hormonal contraceptives did not seem to influence the symptoms of RA. Factors possibly involved in remission of RA during pregnancy are discussed. | |
| 6815137 | Association between HLA and Japanese patients with rheumatoid arthritis. | 1982 Oct | Japanese patients with rheumatoid arthritis (RA) were observed to have a statistical association with HLA-DR4, MT3. Strong association between the clinical severity of RA and HLA was also observed. Male patients had a stronger association with HLA than female patients. Males are more resistant to RA than females. This suggested that the threshold of liability for RA is higher in males than in females. Japanese patients with RA with systemic vasculitis were negative for HLA-Bw44 and had antilymphocytotoxic autoantibody, indicating that RA with systemic vasculitis is different in etiology from RA without systemic vasculitis. | |
| 7089504 | Increased mortality in rheumatoid arthritis. | 1982 | A mortality study was performed on all patients treated in hospitals in Stockholm County who were diagnosed during 1971 as having rheumatoid arthritis. The group consisted of 1165 patients. They were followed up through 1978. The mortality was about 2.5 times higher than for the general Stockholm population, and the females had the highest excess mortality. The excess mortality was particularly high in cases of infection, and of gastrointestinal, urogenital and rheumatic disease. The mortality in cancer was no different from that of the general population, and there was also no excess mortality regarding any particular site or type of cancer. 20% of the deceased had RA as the underlying cause of death and 18% as contributory cause of death. | |
| 3885371 | Differences between plasma and synovial fluid fibronectin. | 1985 | Fibronectin is a high molecular weight glycoprotein of plasma and tissue fluids, and one of its functions is to opsonise particulate material. Chromatographic and electrophoretic analyses showed that the main components of fibronectin are biochemically similar in rheumatoid patients' plasma and synovial fluid. But synovial fluid fibronectin also contains a slow-moving component seen on two-dimensional immunoelectrophoresis, suggesting the presence of fibronectin complexes. Affinity chromatography provided evidence that these involved IgG, and in vitro studies showed that fibronectin influenced the reaction between IgG and anti-IgG. Synovial fluid fibronectin is functionally active in binding to gelatin in an haemagglutination assay, and it gave a relatively higher degree of haemagglutination than did plasma fibronectin, supporting the concept of multivalent fibronectin complexes in synovial fluid. These results suggest synovial fluid fibronectin may be involved in the opsonic removal of IgG-containing complexes from synovial fluid. | |
| 7404145 | Total replacement of the rheumatoid knee: a review of currently available prostheses and a | 1980 Feb 23 | Total replacement of the knee has become an essential part of the overall management of rheumatoid arthritis. This paper reviews briefly the various forms of arthroplasty currently available, touching on some design features and associated problems. A study has been made of 50 knees in which one prosthetic design (the ICLH) has been used. The follow-up period varied between 2 and 7 years. Analysis of pain, walking ability and anatomical integrity before and after operation revealed an incidence of 82% good or fair results. Four patients (8%) developed septic complications, a higher incidence than that associated with total hip replacement. The factors associated with this increased incidence include steroid medication, previous surgery, general debility, and the thin soft-tissue cover of the knee. | |
| 6857416 | The antirheumatic effect of benoxaprofen. | 1983 Jun 11 | This study was undertaken to investigate the antirheumatic activity of the non-steroidal anti-inflammatory drug benoxaprofen. Ten patients with definite or classic rheumatoid arthritis were assessed before beginning drug therapy, using standard clinical criteria and serological tests of disease activity. These tests were repeated monthly during treatment with benoxaprofen for a period of 6 months. The results showed that benoxaprofen improved clinical parameters of disease activity, including morning stiffness, walking time, tenderness and swelling of joints and pain rating, in 7 of the 10 patients studied. One patient's condition remained unchanged and 2 deteriorated during the trial period. In the group of 7 patients who showed clinical improvement there were significant reductions in serum levels of rheumatoid factor, C-reactive protein, alpha 1-antitrypsin, IgA, IgM and IgE, as well as in erythrocyte sedimentation rates. Five of the 10 patients, all of whom were initially seropositive for rheumatoid factor, became seronegative at the end of the trial and 5 of 6 with raised C-reactive protein levels registered undetectable levels. Although this trial was uncontrolled, these findings indicate that benoxaprofen has antirheumatic properties. | |
| 1272072 | Free serum histidine levels in patients with rheumatoid arthritis and control subjects fol | 1976 Jun | A dose of 3.7 g of free-L-histidine was administered by mouth to 26 patients with active rheumatoid arthritis and to 29 control subjects. The patients with rheumatoid arthritis had a statistically significant (p=10(-12)) lower pretreatment concentration of free histidine in serum (1.20 mg/100 ml, SE=0.04) than the control subjects (1.90 mg/100 ml, SE=0.06). However, there were no statistically significant differences between rheumatoid and control subjects with respect to the serum histidine concentrations 1 hr, 3 hr, and 4 hr after the ingestion of L-histidine. The changes in the serum histidine concentrations at 1 hr, 3 hr, and 4 hr (compared to the pretest values) were also not significantly different in the patients with rheumatoid arthritis relative to the control subjects. This study suggests that the subnormal free serum histidine concentration of rheumatoid arthritis is not associated with abnormal serum levels of free histidine following an oral load of free histidine. | |
| 477067 | Bilateral total knee replacement under one anesthetic. | 1979 May | The postoperative results and complications among 41 patients undergoing bilateral total knee arthroplasty were compared with 40 patients who underwent unilateral total knee replacement. Among the bilateral group, the most common diagnosis was rheumatoid arthritis (68%), while degenerative arthritis prevailed in the unilateral group (50%). Preoperatively, patients in the bilateral group exhibited generally a greater degree of physical disability and limitation of activity due to multiple joint involvement. Postoperatively, no change in the arc of motion was noted in either group, although flexion contractures were significantly diminished in both. The degree of postoperative pain relief was identical in both groups as was the decreased need for walking devices. The most commonly observed complication among the unilateral group was prosthetic loosening (12.%). This was felt explainable on the basis of the increased postoperative activity level of patients with degenerative arthritis and single joint disease. Patients in the bilateral group showed a higher incidence of wound problems, presumably secondary to the long-term use of steroids. The infection rate was identical in each group, but the bilateral group displayed a higher incidence of pulmonary emboli (9.7 vs. 2.5%). The postoperative need for rehabilitation services and the duration of time before dependent walking was achieved was not prolonged in the bilateral group. Hospitalization of the bilateral group was increased only 20%. No deaths were reported in either group. When the need for total knee replacement exists bilaterally, bilateral replacement with a single anesthetic would appear reasonable, provided careful patient selection and technical guidelines are followed. | |
| 1172989 | Osteoarthritis beginning with inflammation. Definitions and correlations. | 1975 Apr 14 | A syndrome of acute onset of inflammation over interphalangeal joints heralding deforming osteoarthritis may be intermediate between degenerative and rheumatoid joint diseases. The syndrome appears predominantly in women of menopausal age and is remarkably symmetrical. In a prospective study of 170 propositi, later changes more characteristic of rheumatoid arthritis than of generalized or erosive osteoarthritis developed in 15.3%. | |
| 6939412 | Lymphocytotoxins in rheumatoid arthritis: prevalence, lymphocyte specificity, and HLA-DR a | 1981 Apr | 37% (57/155) of sera from patients with rheumatoid arthritis contain cold-reacting lymphocytotoxic antibodies. Lymphocytotoxins were predominantly of the weakly reactive type and were more likely to be present in patients who were HLA-DR4 positive. By contrast, patients who were HLA-DR3 positive were more likely to have strongly reactive lymphocytotoxins. The lymphocyte subclass reactivity of the lymphocytotoxins was: 67% versus B lymphocytes, 27% against both T and B cells, and 7% for T cells. | |
| 811742 | The influence of chrysotherapy on serum protein and immunoglobulin levels, rheumatoid fact | 1975 Dec | Serum protein and immunoglobulin concentrations, rheumatoid factor (RF) titers, and erythrocyte sedimentation rates (ESR) from 18 patients with active rheumatoid arthritis (RA) who were being treated with gold sodium thiomalate (Myochrysine) and monitored clinically were measured serially. Serum antiepithelial antibody (AEA) titers from 10 patients with pemphigus who were similarly treated were measured at frequent intervals. Statistically significant reductions of alpha2, gamma, and total globulins, IgG, IgA, and IgM, ESR, and RF, and AEA titers were found after 3 to 6 months of gold treatment. Serum albumin levels rose significantly, but alpha1, beta-globulin, and total protein did not change. A temporal relationship between the alteration of these serological tests and the clinical response to treatment was noted, but the magnitude of protein change did not correlate with the degree of clinical improvement within a given patient. These findings indicate that gold treatment influences serum protein and antibody concentrations in two diseases having diverse target organs and different etiologies. The question of whether gold compounds exert an immunosuppressive action, or whether the serologic changes are a secondary phenomenon reflecting amelioration of disease activity, is unresolved. |