Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3995214 | Corticosteroid prescribing in rheumatoid arthritis--the fiction and the fact. | 1985 May | The results of a postal questionnaire to consultant rheumatologists (80% response rate) suggest that most comply with current teaching regarding the indications for systemic corticosteroids in articular rheumatoid arthritis (RA). They are prescribed as a last resort and most frequently in the elderly. However, a review of 100 consecutive RA out-patients revealed 24 patients currently taking corticosteroids at a mean prednisolone dosage of 5.6 mg daily. Only two had been prescribed these drugs for extra-articular problems. In 11 cases the treatment was not initiated by a rheumatologist. The discrepancies between the two surveys are discussed. | |
| 6880410 | The synovial changes in rheumatoid arthritis under corticosteroid treatment. | 1983 May | Light microscopic examination of histological sections of synovial membrane from patients with rheumatoid arthritis revealed that prolonged administration of corticosteroids had an inhibiting effect on the participation of lymphocytes and histiocytes in inflammatory infiltrates, as well as on the hypertrophy of synoviocytes, the proliferation of fibroblasts, the accumulation of fibrocytes, the deposition of fibrous tissue, and the formation of villi. Short-term (i.e., 12- to 24-h) steroid administration inhibited proliferation of fibroblasts only. | |
| 534315 | Sexual difficulties and total hip replacement in rheumatoid arthritis. | 1979 | Fifty-three patients with rheumatoid arthritis were interviewed by questionnaire. All the patients had undergone total hip replacement and were married at the time of operation. They were asked if they had had sexual difficulties because of hip pain or stiffness and if the hip operation had in any way alleviated these problems. Forty-four of the 53 patients answered the questionnaire. Twenty-eight patients had had sexual problems which they attributed to hip symptoms. Following total hip replacement the hips of 27 patients were no longer considered to be the cause of sexual difficulties, but in 10 of those patients other problems still rendered sexual life difficult. | |
| 736995 | Studies on immune complexes in rheumatoid arthritis. | 1978 Jul | Sera and synovial fluids of patients with rheumatoid arthritis were studied for immune complexes by means of the anti-antibody inhibition test; approximately 40% of these specimens were shown to contain immune complexes. To study the nature of antigens participating in the formation of complexes under investigation, the anti-antibody inhibition test was repeated after addition of various soluble antigens to the complex-positive rheumatoid arthritis sera. This resulted in conversion of some sera from inhibitory to noninhibitory. It was found that of 15 positive rheumatoid arthritis sera, 7 had complexes formed by heterophile, Hanganutziu-Deicher antigen and of 12 positive sera tested, 2 had complexes formed by human IgG. | |
| 749768 | Types of serum proteins and erythrocyte enzymes in rheumatoid patients. | 1978 | Four group systems of serum proteins (Hp, Gc, Km, Gm) and five group systems of erythrocyte enzymes (AP, PGM1, GPT, AK, EsD) were determined in samples of patients with rheumatoid arthritis and in healthy controls. Statistically significant differences were found in Gm system, namely Gm(1) factor was more frequent in rheumatoid patients than in healthy subjects. | |
| 7140072 | Tuberculosis in a rheumatoid patient. A case report. | 1982 Nov | A 72-year-old white woman with seropositive rheumatoid arthritis subsequently developed polyarticular tuberculosis. Clinical and radiographic evidence of deterioration of the right knee and left elbow was erroneously attributed to progressive rheumatoid arthritis. The diagnosis of a tuberculous infection was unduly delayed. Failure to recognize this infection might have been disastrous if a total knee arthroplasty had been performed as planned. This case illustrates the importance of awareness of other possible origins of joint destruction and infection in rheumatoid patients with rapid deterioration of joint function. | |
| 6630948 | Rheumatoid hand surgery--update. | 1983 Sep | Many varied and bizarre deformities of the hand are encountered in rheumatoid arthritis. The surgical procedures commonly performed generally fall into five groups, including: synovectomy, tenosynovectomy, tendon surgery, arthroplasty, and arthrodesis. Hand surgery plays an important role in the management of patients with rheumatoid arthritis. The surgeon trained in the techniques described should be part of any team managing the patient with arthritis, not a "course of last resort" called upon when all else fails. | |
| 6691858 | Computed tomography and conventional radiographs of the craniocervical region in rheumatoi | 1984 Jan | Radiographs and computed tomography (CT) scans of 12 patients with rheumatoid arthritis of the cervical spine were reviewed to determine whether CT provides additional information to that obtained from conventional radiography and tomography. Modalities were compared with respect to determination of the extent of erosion, C1-C2 subluxation, atlantoaxial impaction, and soft tissue findings. CT showed greater extent of erosion in 9 of 12 patients. In 11 patients with C1-C2 subluxation, CT and plain radiographs were both useful because it was necessary to demonstrate both sagittal and axial relationships. In the 5 patients with atlantoaxial impaction both CT and plain radiographs demonstrated the abnormal relationships between the odontoid and the foramen magnum. CT showed attenuation of the transverse ligament and the presence or absence of spinal cord compression, whereas plain radiographs did not. Nevertheless, significant new information regarding the spinal cord was obtained by CT in only 1 of the 12 patients. Computed tomography provides additional information about the rheumatoid cervical spine that is unobtainable by conventional modalities. In particular, CT demonstrates bone changes in the axial projection and facilitates evaluation of soft tissue, ligament, and spinal cord involvement. However, CT should be reserved for those instances in which plain radiographs and tomograms do not explain clinical findings. | |
| 6241854 | Lymphapheresis in rheumatoid arthritis. The clinical and laboratory effects of a limited c | 1983 Apr | Five patients with active rheumatoid arthritis refractory to conventional therapy were treated with a limited course of lymphapheresis--6 procedures during a two week in-hospital stay. Statistically significant improvements in assessments of rheumatoid activity were apparent by 2 weeks following lymphapheresis and persisted for 10-12 weeks. An average of 2.08 X 10(10) lymphocytes were removed from the patients and lymphopenia appeared in the 4 in whom the average daily rate of removal exceeded 1 X 10(9). However, the results of laboratory testing indicate that immuno-suppression, as based on evaluations of skin test reactivity to delayed hypersensitivity antigens and on the proportion of T cells following lymphapheresis, was not required for therapy to be deemed effective. | |
| 6821381 | Immunological studies in patients with rheumatoid arthritis receiving azathioprine and myo | 1982 Sep | Thirty-one patients with classical or definite rheumatoid arthritis (RA), on treatment with azathioprine and sodium aurothiomalate in combination were studied. Absolute lymphocyte counts and IgA levels were reduced but this did not reach statistical significance. Lymphocyte transformation with phytohaemagglutinin (PHA) showed no significant difference from a control group. However, antibody dependent cell-mediated cytotoxicity was significantly impaired compared to rheumatoid controls (p less than 0.001). There was no relation to the degree of impairment of ADCC and the current dose of azathioprine nor to the total dose or duration of therapy. Inhibiting material to cell-mediated cytotoxicity was present in the sera of 23 patients but its presence showed no relation to the degree of cytotoxicity exhibited by cells in the same patient. Our studies of cellular cytotoxicity have revealed alterations in cellular function possibly attributable to azathioprine. | |
| 364409 | [Controlled trial of levamisole in rheumatoid arthritis. Clinical and immunological study | 1978 Oct 7 | The results of a controlled trial in 22 patients indicated that levamisole, administered in a dose of 150 mg per day for 2 months, was more effective than a placebo on the clinical symptoms and signs of rheumatoid arthritis. Side effects were seen in 8 of the 12 patients treated with levamisole. They necessitated the premature interruption of treatment in three, but were never serious (no cases of agranulocytosis were seen). In the group treated with levamisole, there was a slight decrease in sedimentation rate, a significant fall in levels of the C3 fraction of serum complement and of circulating immune complexes (detected by polyethylene glycol), and a significant increase in cutaneous reaction to tuberculin and to candidin. By contrast, there were no significant variations in levels of rheumatoid factor, serum immunoglobulins, C4 fraction of complement, lymphocyte transformation indices in the presence of six dilutions of phytohaemagglutinin, nor in the percentages of T and B lymphocytes. The effectiveness of levamisole in rheumatoid arthritis would appear to be demonstrated, but its mode of action remains open to discussion, in the absence of any definite correlation between therapeutic activity and the immunostimulant effects of the drug. | |
| 57818 | Polyarthritis in adults with hypogammaglobulinaemia and its rapid response to immunoglobul | 1976 May 29 | Five patients with primary hypogammaglobulinaemia developed a severe polyarthritis that had some features in common with rheumatoid arthritis. Their joint disease could be distinguished from rheumatoid arthritis, however, by the dramatic improvement after gammaglobulin treatment. The arthritis of hypogammaglobulinaemia can, therefore, be included among the few potentially curable polyarthritides. | |
| 389568 | Ultrastructural localization and in situ analysis of iron, bismuth, and gold inclusions. | 1979 Nov | The purpose of this article is to review ultrastructural and electron probe X-ray analytical studies on metallic deposits in cells. The metals that will be dealt with are iron, bismuth, and gold, mainly because they have been extensively studied in recent years. The nature and chemical composition of endogenously (e.g., from breakdown of autologous blood) and exogenously (e.g., after a transfusion or injection of iron compounds) produced hemosiderin (i.e., iron deposits) has been the subject of time-hallowed controversies. Quite a few of these have now been resolved by ultrastructural studies and the atomic composition of such deposits has been determined by electron probe X-ray analysis. The interest in bismuth centers around the fact that this is one of the two metals (the other being lead) that produces quite large intranuclear inclusions. Here again much has been learned by ultrastructural and X-ray analytical studies. The interest in gold stems from the fact that soluble salts of this metal are used for the treatment of rheumatoid arthritis and current studies with the above-mentioned techniques indicates how gold produces its beneficial and toxic effects. | |
| 7259329 | Polymorphonuclear cell function in rheumatoid arthritis and in Felty's syndrome. | 1981 Aug | Tests for polymorphonuclear cell (PMN) chemotaxis, adherence, and electrophoretic mobility (EPM) were carried out on blood PMN isolated from 27 normal subjects, 16 patients with uncomplicated rheumatoid arthritis (RA), and 9 patients with Felty's syndrome. Chemotaxis was measured by a modification of the Boyden chamber technique, adherence by retention of cells on nylon fibre columns, and EPM in a cylindrical electrophoretic assembly. There was no significant difference between the chemotactic migration of normal and rheumatoid PMN as assessed by the leading front measurement. However, PMN from patients with Felty's syndrome showed significantly reduced chemotaxis (P less than 0.001). Computerised image analysis showed this impaired migration to be due to an overall reduction in cell motility rather than loss of a subset cells. Activated serum from patients with RA and Felty's syndrome were as good chemoattractants as activated pooled AB serum. There was no significant difference in the adhesiveness of PMN from normal persons and rheumatoid patients, though PMN from patients with Felty's syndrome did show a trend to lower adhesiveness. Both RA and Felty's syndrome patients had an increase in the proportion of PMN of lower surface charge than controls. Direct correlations were observed between cells of high surface charge and nonadhesiveness. | |
| 3872129 | Patterns of antihistone antibody specificity in systemic rheumatic disease. I Systemic lup | 1985 Mar | A new fluorimetric assay was used to measure the relative amounts of antibodies to individual nuclear histones in sera from 102 patients with systemic lupus erythematosus (SLE), mixed connective tissue disease, primary sicca syndrome, and rheumatoid arthritis with vasculitis. In SLE sera, the predominant responses were to histones H-1, H-2B, and H-3, with marked elevations of binding to H-1 and H-2B in one-third of the patients, and to H-3 in one-fourth; antibodies of both the IgG and IgM classes were also detected. In a few SLE sera, the pattern of histone response differed or was restricted to 1 immunoglobulin class. In mixed connective tissue disease, only 2 of 9 sera showed elevated histone binding activity, the response being predominantly to H-3 in 1 patient and to H-1 and H-2B in the other. Binding to H-2B was also prominent in 2 of 3 patients with primary sicca syndrome. The highest antihistone reactivity and the most heterogeneous response patterns were observed in patients who had rheumatoid arthritis with vasculitis; 6 of 8 of those sera had elevated histone reactivity. In SLE, the highest histone binding results were found among patients with a history of photosensitivity. Histones are closely associated with DNA in the nucleosome, and we speculate that antihistone antibodies could arise as a result of damage to DNA, induced by drugs or irradiation. | |
| 857805 | Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. | 1977 Apr | Antigen-induced arthritis was established in the mouse by immunizaiton with methylated bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertusis vaccine. The knee joint was injected after 21 days with mBSA in saline. The arthritis was chronic, antigen-specific, and T-cell dependent in hypothmic nu/nu mice. C57BL and balb/c mice were susceptible, whereas CBA mice were relatively resistant. Susceptibility was dominant; one gene was loosely linked to the "b" allele of the H-2 complex of C57BL mice. | |
| 2992893 | Effect of retinoids on rheumatoid arthritis, a proliferative and invasive non-malignant di | 1985 | In rheumatoid arthritis synovial tissue proliferates and destroys articular cartilage, bone and tendons. Collagenase is a major mediator of the connective tissue degradation. This enzyme is produced in large quantities by rheumatoid tissue and its synthesis can be inhibited by retinoids. However, knowledge of mechanisms controlling retinoid inhibition of collagenase production and of factors possibly controlling synovial cell proliferation is limited. We found that transforming growth factor beta in combination with epidermal growth factor, epidermal growth factor alone and immune interferon increased proliferation of cultured human and rabbit synovial fibroblasts. Only transforming growth factor beta caused a piling up of cells into foci resembling those seen in primary cultures of human rheumatoid tissue. All the factors were antagonized by retinoids but not by glucocorticoids or indomethacin. Adding retinoids or glucocorticoids to collagenase-producing cells decreased hybridizable collagenase mRNA by 50% within 24 h. Oral administration of retinoids to rats with experimental arthritis decreased clinical disease without toxicity, and inhibited collagenase synthesis by synovial cells taken from treated animals. Retinoids are both antiproliferative and anti-invasive, and therefore may be potential therapeutic agents in the treatment of rheumatoid arthritis. | |
| 7303004 | Characterization of sicca symptoms in patients with Sjögren's syndrome, and reports of si | 1981 Jul | We evaluated seventeen ocular and oral symptoms in patients with Sjögren's syndrome (SjS) to characterize the subjective sicca symptoms of this syndrome. The following eleven symptoms were characteristic in patients with SjS compared with patients with rheumatoid arthritis (RA) or healthy adults.: (1) decreased lachrymation, (2) ocular foreign body sensation, (3) ocular filmy sensation, (4) increased mucous discharge from the eyes, (5) thirsty sensation, (6) decreased salivation, (7) increased dental caries, (8) abnormal sense of taste, (9) difficulty in chewing, (10) dryness of the oral cavity, and (11) increased fluid-intake with meals. Some of the symptoms were detectable in RA patients and healthy adults although the mean number of the positive symptoms was significantly higher in patients with SjS. The demonstration of three or more symptoms, therefore, will be sufficient in the consideration of the definite sicca features for this syndrome. The present studies also confirmed the chronological influence on the development of subjective sicca features in patients with SjS, and support our concept that patients lacking subjective sicca features are those in the early stages of this syndrome. Finally, six cases of SjS lacking subjective sicca features were described. | |
| 7338349 | [Histological classification of rheumatoid synovitis compared with cell-kinetics and morph | 1981 Nov | During the course of the experimental immune arthritis of the guinea pig four phases can be distinguished: I=fibrinopurulent, partly ulcerative synovitis, II=granulocytic activee granulomatous synovitis, III=lymphocytic activ granulomatous synovitis, IV=synovitic sequelae with subintimal fibrosis. On the basis of cell-kinetic studies with initial and systemic labelling with 3H-thymidine of the synovial membrane and of the bone marrow it could be demonstrated that in this model the infiltrating cells as well as the structural cells belong to the monocyte-macrophage system. The typical multilayer of the lining cells of this immune synovitis therefore seems to be mainly as a type A cell hyperplasia of bone marrow derived cells instead of a local proliferation of the lining cells. Clinical cases of various joint diseases are described including symptoms, X-ray findings and histopathological studies. Depending on the stage of the clinical course and the number, localization and activity of the macrophages within the synovial membrane the reaction pattern can be classified in a new way using the categories mentioned above in the experimental model. Thus the classical picture of rheumatoid arthritis corresponds to the synovitis of the subintimal type. The polyarthritic syndrome which mostly is pathogenetically unclear in contrast is designated as synovitis of the intimal type. The same holds true for the activated arthrosis. | |
| 6227494 | Biphasic changes of the immunological reactivity in the course of experimental lectin-indu | 1983 | A single injection of Lens culinaris lectin (LcL) into the knee joint cavity of non-sensitized rabbits produces an arthritis with an acute and chronic phase, lasting up to one year. The persistence of the lectin in the joint, related to the strong binding affinity of lectins to glycoproteins of connective tissue structures, and the presence of specific antibodies against LcL in the serum after the intra-articular injection make this model comparable to the antigen-induced arthritis. But in our system these conditions are further modified or amplified by the mitogenic activity of LcL itself. The cell-mediated immunity, studied by mitogenic stimulation of peripheral blood lymphocytes, is characterized by a biphasic change in the course of this experimental arthritis. Hyperresponsiveness to stimulation with LcL and Concanavalin A (Con A), decreased Con A-induced suppressor cell activity, and stimulatory serum factors could be detected in the early phase of inflammation. The late phase of arthritis (8 months after the induction) was characterized by hyporesponsiveness to mitogenic stimulation, normal suppressor cell activity and inhibitory serum factors. In spite of the differences of this experimental arthritis to the human rheumatoid arthritis, concerning mainly the initiation and the lack of systemic manifestation, there are surprising similarities between both, not only in the histopathological feature and the chronicity but also in the cell-mediated immune reactions. Therefore, similar pathogenetic mechanisms for the chronic phase can be suggested. |