Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6609962 | Characterization of recirculating lymphocytes in rheumatoid arthritis patients: selective | 1984 Jun | Five patients with rheumatoid arthritis (RA), who were treated by lymphocyte depletion by using thoracic duct drainage (TDD), provided an opportunity to characterize the phenotype and function of their recirculating lymphocytes. We found that: a) thoracic duct lymphocytes (TDL) were similar in their proportion of T cells (83% +/- 6 OKT3+), OKT4+ subset (65% +/- 8), and OKT8+ subset (22% +/- 6) to peripheral blood lymphocytes (PBL): b) fewer natural killer-like cells were present in TDL (5% +/- 4 Leu-7+; 2% +/- 2 Leu-11+: 8% +/- 2 OKM -1+) than in PBL (20% +/- 10 Leu-7+: 11% +/- 6 Leu-11+; 18% +/- 5 OKM -1) (p less than 0.01); c) TDL differed from synovial fluid lymphocytes ( SFL ) and synovial membrane lymphocytes ( SML ) in that TDL lacked a high percentage of activated lymphocytes (T cells bearing Ia antigen, OKT10 , and transferrin receptor): d) immature T cells (expressing either OKT6 antigen or reactive with peanut agglutinin) were not found in TDL even late in the course of TDD: and e) in vitro functional studies demonstrated that TDL were similar to PBL in their ability to synthesize immunoglobulin after mitogen stimulation and to generate cytotoxic T lymphocytes capable of lysing autologous EBV-transformed B cells. However, natural killer activity, as measured by lysis of K562 cells was significantly lower in TDL than PBL (p less than 0.05). These results demonstrate that natural killer cells defined by phenotype and function are excluded from thoracic duct lymph and thus have a circulation pattern different from most T cells. | |
| 368535 | A comparative study of indomethacin and ibuprofen. | 1979 Jan 13 | In a double blind trial with 20 patients ibuprofen 1600 mg daily and indomethacin 100 mg daily were shown to be of comparable efficacy in the short-term treatment of rheumatoid arthritis. Reported side effects were similar, but a slightly greater incidence of gastric irritation was noted with indomethacin necessitating withdrawal of one patient from the trial. The serum concentrations for indomethacin and ibuprofen were determined for four hours after the last dose. Peak concentrations of both drugs occurred within two hours. Five of the seven patients considered to have comparable serum concentrations of both drugs demonstrated a preference for indomethacin. | |
| 6670953 | Penicillamine in rheumatoid disease. | 1983 Dec | Penicillamine is a slow acting oral antirheumatic drug and a chelating agent. Although it is derived from penicillin, allergy to that is not an absolute contraindication to the use of penicillamine. | |
| 6864672 | Chemiluminescence of polymorphonuclear leukocytes from rheumatoid joints. | 1983 Apr | Chemiluminescence (CL) was used to measure the oxidative burst of polymorphonuclear leukocytes (PMNL) from peripheral blood (PB) and synovial fluid (SF) of patients with inflammatory arthritis. The basal CL of SFPMNL was greater than that of PBPMNL. Opsonized zymosan, N-formyl methionyl-leucyl-phenylalanine (FMLP), cell-free inflammatory SF and heat aggregated human IgG (HAIG) all stimulated PMNL CL but the response of SFPMNL to HAIG or to reexposure to SF was greater than that of PBPMNL. This enhanced responsiveness of SFPMNL to HAIG could be induced in PBPMNL by preincubation with chemotactic concentrations of FMLP. These studies suggest a mechanism by which PMNL migrating to sites of inflammation may become sensitized to a subsequent stimulation by soluble immune complexes at the inflammatory site. | |
| 1007639 | Amyloid deposits in the periarticular tissue. | 1976 Nov | Periarticular and peritendinous tissue was investigated in cases of rheumatoid arthritis, osteoarthritis and carpal tunnel syndrome for the appearance of amyloid deposits. In rheumatoid arthritis no amyloid was present. In 7.8% of the cases with osteoarthritis and in 8% of the cases with carpal tunnel syndrome amyloid was present. These amyloid desposits were present essentially in old patients and since no further clinical symptoms of systemic amyloidosis were reported, these deposits are regarded as an age related phenomenon without clinical relevance. | |
| 6318335 | [Methods for evaluating non-steroidal anti-inflammatory agents in rheumatoid polyarthritis | 1983 Dec 12 | The study of the effectiveness of non-steroidal antiinflammatory drugs in rheumatoid arthritis requires only short term trials using simple, sensitive and reproducible tests based upon evaluation of pain. The estimation of spontaneous pain by the visual pain scale, number of nocturnal awakenings, Ritchie joint index, morning stiffness, grip strength and Lee functional index are the most informative parameters. The results of these quantitative tests of pain are usually in close agreement with patient judgement which remains the most important criterion. | |
| 607390 | Gold compounds in rheumatoid arthritis. Report of a symposium. | 1977 | A vast accumulation of clinical experience and controlled studies justifies the use of gold compounds in selected cases of rheumatoid arthritis. The striking therapeutical efficacy observed in some patients has stimulated active research to clarify the pharmacokinetics and mechanisms of action of gold compounds. Based on this knowledge, the possibility of selecting gold-responsive patients may be enhanced, and the frequency of adverse reactions decreased. Liberal indications and inexperience in administration and control have given gold therapy mixed reputation. A symposium in Umeå, Sweden, summarized present knowledge and current concepts among Scandinavian rheumatologists on the rational use of gold compounds. | |
| 6606039 | Analysis of lymphocyte subsets in the blood of rheumatoid arthritis patients: correlation | 1983 Oct | Various erythrocyte rosette forming cells (ERFC) were quantified in 111 patients with rheumatoid arthritis (RA): total-ERFC (t-RFC), active-ERFC (act-ERFC), autologous-ERFC (auto-ERFC) and high affinity erythrocyte-antibody rosette forming cells (EA-RFC). B lymphocytes were counted using a direct immunofluorescence method. A decrease in act-ERFC and an increase in high affinity EA-RFC was found, but only the levels of the former correlated with the degree of inflammation and may be regarded as an indicator of clinical activity. Conversely, numbers of t-ERFC, auto-ERFC and B lymphocytes were found to be approximately normal. There was no correlation between the level of act-ERFC and the presence of rheumatoid factor, circulating immune complexes or antinuclear antibodies. | |
| 6423731 | A solid-phase enzyme immunoassay for C-reactive protein: clinical value and the effect of | 1984 Mar 30 | Measurement of serum C-reactive protein (CRP) concentration is useful in monitoring the progress of chronic inflammatory diseases. Rheumatoid factor, by its interaction with the Fc portion of IgG, has the potential to interfere with solid-phase immunoassays for CRP and other serum proteins. To determine the effect of RF on a solid-phase enzyme immunoassay for CRP we compared assays employing whole antisera or F(ab')2 fragments. In 92 sera with RF latex titres ranging from 1/80 to 1/81,920, no correlation was found between RF concentrations and CRP measurements. CRP concentrations measured by use of whole antisera (mean +/- standard error of the mean, 59.7 +/- 5.7 mg/l, n = 92) were lower than those measured with F(ab')2 fragments (62.5 +/- 5 mg/l), indicating that exaggeration of CRP measurements did not occur in RF containing sera under the conditions of the assay. Our results show that in the CRP-ELISA, interference from RF was precluded by the high serum dilutions employed. At lower serum dilutions RF binding was detected. Consequently, in solid-phase enzyme immunoassays at lower serum dilutions the presence of RF may lead to false positive results and exaggerated measurements. | |
| 306485 | Chinese herbal arthritis cure and agranulocytosis. | 1977 Dec 24 | Rheumatoid arthritis remains an incurable disease, and the patient who is unable to obtain relief from standard therapies will often turn to one of the many alternative treatments available. We report an episode of agranulocytosis which occurred in a patient with rheumatoid arthritis while he was taking a Chinese herbal preparation. We understand this preparation is readily obtainable by Australians. | |
| 1222227 | Hl-A antigens associated with rheumatoid arthritis and ankylosing spondylitis in an ethnic | 1975 Apr 10 | The HL-A phenotypes of 52 patients with rhematoid arthritis and 26 patients with ankylosing spondylitis from an ethnic homogeneous population have been determined. No definite association has been established with rheumatoid arthritis, while a very significant association has been found between ankylosing spondylitis and HL-A 27 antigen. This finding suggests that certain patients with ankylosing spondylitis have a genetically determined susceptibility to their disease which could be due to a cross-tolerance mechanism enabling infectious agent antigens to mimic certain histo-compatibility antigens, or to a linkage between HL-A genes and those controlling immune responsiveness. | |
| 6189306 | [Immune complexes: mediators for the formation of inflammatory granulation tissue? Immunoh | 1983 Jan | Previous reports describe the presence of immunoglobulins and complement components within rheumatoid articular cartilage, thereby suggesting an effect of immune complexes on the formation of pannus. This hypothesis is reinvestigated in this paper. As confirmed in our work, the superficial layer of rheumatoid hyaline cartilage may fulfill the immunohistological criteria for the presence of immune complexes. In osteoarthritis, however, a noninflammatory disease not mediated by immunologic mechanisms, similar results can be obtained. The presence of immune-proteins within hyaline cartilage therefore requires a cautious interpretation. Hyaline cartilage in rheumatoid arthritis is replaced by granulation tissue growing not only at its surface (pannus), but also in subchondral bone. We therefore also thoroughly investigated deep layers of hyaline cartilage in the vicinity of such subchondral tissue, but could not obtain any evidence for the presence of immune complexes therein. The growth of subchondral granulation tissue and the accumulation of PMN in the region of its junction with hyaline cartilage therefore appear to be independent of immune complexes within rheumatoid hyaline cartilage. It is suggested on the basis of these data that immune complexes possibly present in hyaline cartilage do not play an essential role in the formation of granulation tissue replacing cartilage in rheumatoid arthritis. It is, however, not entirely excluded that during advanced stages of rheumatic cartilage degradation immune complexes are formed within the matrix or carried into it from the extra-cartilaginous environment, and that they may then contribute to further cartilage destruction by enzyme release during phagocytic processes. | |
| 6710095 | Benefits of multiple joint replacement in rheumatoid arthritis. | 1984 | The benefits of multiple joint replacements were assessed in 21 patients with rheumatoid arthritis who had bilateral hip and knee replacements. The main benefit was relief of pain with 40 hips and 25 knees becoming completely pain-free. There was an improved range of movement in 38 hips but in only 11 knees and 8 knees were stiffer after surgery. Hip replacement was the preferred initial surgery but there was a mean delay of 50 months between hip and knee surgery suggesting a "domino effect" with increasing mobility as a consequence of hip replacement eventually causing knees to deteriorate. All patients who completed a postal questionnaire found their ability to walk had improved but many noted an increase in ankle and foot pain which limited their walking. After their surgery patients were better able to perform certain activities of daily life, especially housework and dressing. It is concluded that multiple joint replacement contributes to improving the quality of life in disabled arthritic patients. | |
| 6158754 | [Beta2 microglobulin, antibeta2 microglobulin activity and circulating immune complexes in | 1980 Jul | In this work, the authors found significantly raised serum Beta2m microglobulin values in a group of 120 cases of rheumatoid arthritis, without any difference between the serum positive group (55 cases) and the serum negative group (65 cases). Such a rise was found in the synovial fluids with a beta2 serum synovial fluid greater than unity in 81 % of cases of rheumatoid arthritis as against 6 % in a control group. The comparative study and the main immunological disorders permits one to note a correlation between the levels of circulating immune complexes (CIC) fixing the Clq and the serum beta2m in serum negative cases of rheumatoid arthritis (RA) (r = 0.52 p < 0.001) whereas this link does not exist in the serum positive group (r = 0.08). These conclusions led the authors to an anti-serum beta2m activity in the serum positive and negative groups of RA, which were very significantly different from the control groups. Furthermore, a study of complement activation, by titration of C3d showed a significant correlation between the levels of CIC and of C3d in RA -, but not in RA +. The authors discuss the participation of beta2m in the formatiton of CIC during RA and its role in the activation of complement. | |
| 7443611 | Chronic eosinophilic pneumonia complicating long-standing rheumatoid arthritis. | 1980 Jul | A 54-year-old patient with long-standing rheumatoid arthritis developed chronic eosinophilic pneumonia in association with a relapse of his arthritic condition. There was a rapid and complete response to oral steroid therapy. | |
| 6457670 | [Ultrastructural and microanalytic study of gold depots in the synovial membrane of man an | 1981 | In inflammatory rheumatism treated by gold therapy synoviocytes A are stuffed with gold salt deposits leading to a therapeutic thesaurismosis. These deposits are localized in lysosomes, then called aurosomes. However they may be rarely near collagen fibers or free, particularly in ankylosing spondylitis synovitis. Their structural morphological aspect is the same in several human rheumatic diseases and in rabbit experimental arthritis whatever the gold salt used. In such deposits, microprobe analysis shows gold and sulphur. This latter is probably given by the cell. Therapeutic effect of gold salts may imply the effect of the thiol moiety and the gold metal one. | |
| 646470 | Rheumatoid synovial cells in culture produce a growth inhibitor. | 1978 Apr | Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the animals with rheumatoid synovial cell cultures. | |
| 901178 | Total replacement of the elbow joint. | 1977 Sep | Total replacement of the elbow joint has been performed on 86 elbows at the Mayo Clinic, all but 15 in patients with rheumatoid arthritis. The Mayo design, which replaces both radiohumeral and humeroulnar joints, was used in 41 elbows, almost all in rheumatoid patients, with 71% good results. The Coonrad hinge with polyethylene bushings was used in 34 elbows; it was successful in 64% of rheumatoid patients, but failed in 46% of posttraumatic patients with bone loss. Previous designs have failed because of humeral loosening. Total elbow replacement is a technique still to be perfected in medical centers before general release. | |
| 485674 | [Therapeutic efficiency of penicillamine D in rheumatic arthritis]. | 1979 Jul | 1. Penicyllamin is a useful drug in the treatment of some cases of severe rheumatoid arthritis, or in unsuccessful therapeutics. 2. It can lead to remission or to antiinflamatory activity from 20 to 40%. 3. It has a high percentage of iatrogenic effects, but they are generally slight and in a minor percentage the alterations are severe (hematological mainly). 4. Its use requires: a) Correct prescription. b) Careful clinic and paraclinic observation. c) Experience and knowledge in rheumatologic speciality. 5. It may be of use in other connective tissue diseases or in immunological processes with disfavorable consequences to the organism. | |
| 6334581 | Thoracic duct drainage in rheumatoid arthritis. | 1984 Dec | Thoracic duct drainage (TDD) led to major improvement of disease in two of five patients with severe rheumatoid arthritis and lesser improvement in two others. This improvement was maintained as long as 10 months, but reassertion of disease activity was seen despite use of azathioprine in standard immunosuppressive doses. A consistent fall in the mitogen-induced proliferative responses of blood lymphocytes occurred during TDD, along with a shift in the ratio of OKT4/T8 to a higher proportion of OKT8. However, there was minimal effect on B cell function and no demonstrable influence on complement activating events in the disease, and there was an inverse relationship between responsiveness to TDD and the degree to which in vivo complement activation was occurring. We suggest that it may be important to assess the candidacy of RA patients for given apheresis procedures by sensitive measures of the degree of activation of complement proteins. |