Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6605745 | Plesiomonas shigelloides septic arthritis complicating rheumatoid arthritis. | 1983 Jun | A patient with severe seropositive rheumatoid arthritis and hepatic cirrhosis developed septic arthritis of his knees. Plesiomonas shigelloides was isolated from joint fluid, blood, and also from the gut. The patient's joint symptoms responded to treatment with oral trimethoprim-sulphamethoxazole, but he died of uncontrolled gastrointestinal bleeding five days later. | |
| 304282 | [Physical therapy in rheumatic diseases]. | 1977 Nov 1 | For the physiotherapy of rheumatic diseases principles of order are recommended. The aims of physiotherapy (allevition of pain, improvement of mobility, inhibition of inflammation), dosages of physiotherapy (intensity of treatment, time of treatment, region of treatment), quantification of pain and reaction to treatment are in the foreground in these cases. With regard to an appropriate choice of methods these principles of order are explained at the instance of the rheumatoid arthritis and the ankylosing spondylitis. Concerning the rheumatism of the soft tissues a classification of the therapy according to localisation and course of the disease (acute, recurrent, chronic) is explained. | |
| 6824826 | A case of toxic epidermal necrolysis secondary to indomethacin. | 1983 Feb | A middle-aged female with rheumatoid arthritis was commenced on indomethacin. Four days later she developed the classical clinical and histological features of toxic epidermal necrolysis (TEN). The association with indomethacin has not previously been reported. | |
| 6972742 | HLA DR4 and rheumatoid arthritis in Japanese people. | 1981 Jun | Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese. | |
| 7254112 | Metoclopramide. Management of gastrointestinal intolerance in rheumatoid arthritis patient | 1981 May 2 | Ten patients with rheumatoid arthritis who were unable to tolerate anti-inflammatory doses of non-steroidal anti-inflammatory drugs (NSAIDs) were admitted to the study. After endoscopy three patients were taken out of the study because of frank gastric ulceration. Seven patients entered the six-week study during which anti-inflammatory doses of NSAIDs were preceded by 30 minutes by a 10-mg dose of oral metoclopramide. The insults of this pilot study suggest that pretreatment with metoclopramide enables patients with rheumatoid arthritis who have non-ulcer dyspepsia to tolerate full dosage of NSAIDs. | |
| 64411 | [Thrombocyte kinetics before and after gold therapy in rheumatoid arthritis]. | 1976 | Before and after performing a basic therapy with sanocrysin, thromboytic kinetic examinations were carried out in 12 patients suffering from rheumatoid arthritis. The thrombocyte survival time, maximal recovery and thrombocyte turnover were determined. The surface activity values were given in the form of spleen-heart quotients and liver-heart quotients as well as by surplus impulses over these organs. The findings evaluated statistically reveal that even the untreated rheumatoid arthritis will have thrombocytic kinetics deviating from the norm. By influencing RES the gold treatment will lead to an reduction of the enhanced platelet decomposition. The behaviour of single parameters before and after gold therapy are discussed. The examination of thrombocyte kinetic could not identify a damage of thrombopoiesis in the bone-marrow and in the periphery caused by sanocrysin. | |
| 4466600 | Immunological properties of isolated IgG and IgM anti-gamma-globulins (rheumatoid factors) | 1974 May | Anti-gamma-globulins of the IgG and IgM classes have been isolated from sera of normal individuals and from patients with osteoarthritis, rheumatoid arthritis and juvenile rheumatoid arthritis. All of the isolated antibodies gave precipitin curves with heat-aggregated, reduced and alkylated gamma-globulin. IgM anti-gamma-globulins gave a positive latex fixation test at 4°C and 37°C while IgG anti-gamma-globulins generally gave a positive test only at 4°C. Anti-gamma-globulins from normals did not fix complement but IgG and IgM anti-gamma-globulins from rheumatoids fixed complement to a similar degree. This in vitro complement fixation could account at least in part for the diminished complement levels seen in many rheumatoid synovial effusions. | |
| 3886308 | Controlled, double-blind, randomized trial of amitriptyline in relieving articular pain an | 1985 | Thirty-six patients with definite or classical rheumatoid arthritis participated in a double-blind, randomized, placebo-controlled trial to assess the effectiveness of adding amitriptyline to the treatment regimen for the relief of pain not adequately controlled by non-steroidal anti-inflammatory drugs. Dosage of amitriptyline was increased gradually up to 25 mg 3-times daily and patients were followed up for 12 weeks. Assessments were made of joint pain and tenderness every 4 weeks. The results showed no difference between the amitriptyline and placebo-treated patients for either parameter. | |
| 6994789 | Homoeopathic therapy in rheumatoid arthritis: evaluation by double-blind clinical therapeu | 1980 May | Twenty-three patients with rheumatoid arthritis on orthodox first-line anti-inflammatory treatment plus homeopathy were compared wtih a similar group of twenty-three patients on orthodox first-line treatment plus an inert preparation. There was a significant improvement in subjective pain, articular index, stiffness and grip strength in those patients receiving homoeopathic remedies whereas there was no significant change in the patients who received placebo. Two physicians were involved in prescribing for the patients and there were no significant differences in the results which they obtained. No side effects were observed with the homoeopathic remedies. | |
| 1092275 | Liver disease in rheumatoid arthritis and Sjøgren's syndrome. Prospective study using bio | 1975 Feb | Inter-relationships of biochemical and immunological tests of liver function have been studied in a prospective study of 216 patients with rheumatoid arthritis (RA), 32 patients with Sjogren's syndrome, and 27 patients with the sicca syndrome, and these results have been compared with those obtained 289 patients with osteoarthrosis or with a form of seronegative polyarthropathy. In general the prevalence of abnormalities in serum alkaline phosphatase, bromsulphthalein excretion, smooth muscle antibody, and mitochondrial antibody in the former three groups was higher than in patients with osteoarthrosis. Patients with Sjogren's syndrome with RA had a higher prevalence of abnormalities of bromsulphthalein excretion, salivary duct antibody than patients with the sicca syndrome. Patients with RA had a higher pervalence of rheumatoid factor than those with the sicca syndrome. Patients with a positive smooth muscle or mitochondrial antibody were found to have a higher prevalence of hepatomegaly and splenomegaly, of abnormal liver function tests, of other autoantibodies, and of histological abnromalitis of liver than those in whom these tests were negative. | |
| 4055265 | Clinical value of serum amyloid A and C-reactive protein measurements in secondary amyloid | 1985 | Serum amyloid A protein (SAA) and C-reactive protein (CRP) are acute-phase reactants synthesized by the liver. A close relationship was found between SAA and CRP concentrations in various rheumatic diseases (rs = 0.74 to 0.83). The serum concentration of these proteins reflected the activity of the rheumatic inflammation in a sensitive way. In secondary amyloidosis, persistently high SAA and CRP levels correlated closely with the progression of the renal amyloid manifestations. The findings show that measurements of SAA and CRP concentrations are valuable in assessing disease activity and the effect of therapy in rheumatic diseases, as well as in the assessment of the prognosis in secondary amyloidosis. Therapeutic measures that decrease SAA levels may reduce amyloid formation. | |
| 548994 | Treatment of renal amyloidosis with dimethylsulphoxide (DMSO). | 1979 | Amyloid fibrils can be dissolved by dimethylsulphoxide (DMSO) in vitro and in vivo. This prompted us to investigate the therapeutic value of DMSO in renal failure caused by amyloidosis. Two patients with renal failure caused by secondary amyloidosis due to rheumatoid arthritis, showed a remarkable improvement of renal function. The effect of DMSO in amyloidosis secondary to rheumatoid arthritis seems to depend on its anti-inflammatory action, resulting in a decrease in amyloid formation. No evidence was found for an increase in amyloid degradation. The effect of DMSO in primary amyloidosis was inconclusive. | |
| 6955659 | The arthritic ulcer: a retrospective study of peptic ulceration in patients with rheumatoi | 1982 Jun 9 | Four patients with duodenal ulcer (DU) and nine with gastric ulcer (GU) were admitted to a general hospital rheumatology ward over an eighteen month period. Indigestion was the predominant though not invariable presenting symptom. Most ulcers healed with cimetidine over a period of six weeks to eight months, though two patients required surgery. Non-steroidal anti-inflammatory drugs were continued in all patients without major complications. Unanswered questions raised by the study, to which a prospective trial could be directed, include the sensitivity and specificity of indigestion as a presenting feature of peptic ulceration, the effect of non-steroidal anti-inflammatory drugs (NSAID's) other than aspirin on the aetiology and natural history of gastric ulceration, and the rational choice of antirheumatic and anti-ulcer therapy in rheumatoid patient in whom peptic ulceration has occurred. | |
| 7270341 | Cyclic nucleotides in rheumatoid arthritis. | 1980 Dec | Cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5' guanosine monophosphate (cGMP) may influence important regulatory mechanisms in the rheumatoid inflammatory process. It has been claimed that fasting improves the condition of the patient with rheumatoid arthritis (RA). The present study was designed to measure cAMP in plasma and urine cGMP in urine in medically untreated RA patients. 12 female patients were investigated in a cross-over study during a control and a fasting period. They received no other drugs than analgesics during these periods. Levels of plasma and urinary cAMP found during the control period were somewhat lower than previously reported. However, the ratio cAMP/cGMP in urine was 10 to 1 which is reported to be normal. Clinical and laboratory variables of inflammatory activity were significantly improved during the 7-day fasting period. The ratio of cAMP/cGMP in urine was significantly increased on days 2-4 and coincided in time with the maximum of clinical improvement. Cyclic AMP concentrations were lowered both in plasma and urine during fasting. This is in contrast to fasting in normal and obese subjects reported in previous studies. | |
| 6591321 | [HLA-A, B, C, and DR typing in rheumatoid polyarthritis]. | 1984 Jun | HLA-A, B, C typing were performed in 72 caucasians with rheumatoid arthritis. HLA-DR typing were accomplished in 40 patients among these 72 subjects. DR4 was clearly increased with a frequency of 55 p. 100 versus 18 p. 100 in controls. We did not find an association between DR4 and the presence of rheumatoid factor. Clinical and biological signs are similar in rheumatoid arthritis with and without DR4. Two other HLA antigens, B40 and Cw3, were increased and their frequency was twice as high in patients as compared with controls. A synthesis of six studies published in the world confirms the elevation of B40 in this disease and later on suggests the elevation of Cw3 which is often linked with B40. The association of rheumatoid arthritis with B40 and Cw3 can be explained by a linkage disequilibrium between DR4 and B40 on the one hand, between DR4 and Cw3 on the other hand. | |
| 6083657 | Analysis of mast cells in rheumatoid arthritis and osteoarthritis by an avidin-peroxidase | 1984 | As demonstrated by labeling with peroxidase, avidin was found to bind selectively and distinctly to mast cell granules. Inhibition studies suggested that avidin is bound by heparin. Based on this new mast cell staining procedure, mast cell distribution in the inflamed synovium of rheumatoid arthritis (RA) and osteoarthritis (OA) has been investigated. In the subsynovial layer, a significant decrease in mast cell numbers was observed in RA-synovium when compared with OA-synovium. This decrease correlated with the presence of lining cell ulcers and granulation tissue and can be interpreted as the result of mast cell degranuation induced by complement-mediated or immune complex-triggered mechanisms. | |
| 7002065 | Clotrimazole in rheumatoid arthritis. | 1980 Oct | Forty-seven patients with active rheumatoid arthritis took part in an 8-week controlled study in which clotrimazole was compared with a standard nonsteroidal anti-inflammatory agent, ketoprofen. Although clotrimazole was shown to be effective in the treatment of the disease and superior to ketoprofen in certain measurements, if was also responsible for a high incidence of adverse effects. Improvement with clotrimazole took place more slowly but was more sustained than with ketoprofen. A significant rise in plasma cortisol and a fall in white cell count was observed in the clotrimazole treated patients. | |
| 7455624 | Synovial fluid lipids in rheumatoid arthritis. | 1980 | Synovial fluid from the inflamed knee joints of 30 patients with rheumatoid arthritis (RA) contained 2.75 +/- 0.81 mmol/l cholesterol (51% of the corresponding mean serum level) and 0.32 +/- 0.13 mmol/l triglycerides (35% of the corresponding mean serum level). The ratio of synovial fluid triglycerides to cholesterol indicates that in RA the concentration of very low density lipoproteins (VLDL) is lower in synovial fluid than in serum. In a few patients, however, the "relative triglyceride concentration" in synovial fluid (i.e. synovial fluid tg/chol:serum tg/chol) was greater than 1. This concentration did not correlate, moreover, with the clinical activity of the disease. | |
| 7036921 | Long-term azathioprine in rheumatoid arthritis: a double-blind study. | 1981 Dec | Several studies have demonstrated the beneficial effect of azathioprine in rheumatoid arthritis. But fears have been expressed about the possible mutagenic and teratogenic effects of prolonged use. If the drug could be withdrawn once remission is achieved, and this remission be then maintained with other agents, the possible complications of long-term therapy might be avoided. A double-blind controlled study was carried out over 8 months in 32 patients receiving long-term azathioprine therapy for rheumatoid arthritis. Substitution of placebo for active drug resulted in clinical deterioration. | |
| 375372 | [Use of the computer in teaching rheumatology. Trial application in the diagnosis of an ad | 1979 Jan | The immense possibilities offered by the computer can be utilized in medical education, through a free dialogue between the student and the machine thanks to a terminal. A diagnostic simulation program has been carried out in diagnosing adult polyarthritis. This program neccesitates an analysis of diagnostic behavior and, on this basis, the preparing of a diagnostic tree or graph. The reasons leading to the plan adopted in constructing the graph, are discussed. Cases of increasing difficulty are proposed to the student, who must follow the course plan in order to arrive at a diagnosis. This teaching method, applied for thing pedagogical advantages both for the teacher and the student. The operating cost seems reasonable. |