Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 313447 | Infectious parotitis in Sjögren's syndrome: a case report and review of the literature. | 1979 Mar | Infectious parotitis as a complication of the sicca syndrome has rarely been reported. A patient with bilateral parotitis due to H. influenza in reported and the literature regarding this rare complication of the sicca syndrome is reviewed. The host defense mechanisms which ordinarily protect normal individuals or patients with Sjögren's syndrome against purulent parotitis are discussed. | |
| 4015204 | Complete heart block and bowel infarction secondary to rheumatoid disease. | 1985 Jun | A case of complete heart block secondary to rheumatoid involvement of the conduction system is presented. The same patient died after infarction of the colon as a consequence of arterial spasm superimposed upon pre-existing rheumatoid changes in the mesenteric arteries. The coexistence of rheumatoid involvement of the heart and of the bowel vasculature has not previously been reported. | |
| 817531 | Effect of antirheumatic drugs on cathepsin B1 from bovine spleen. | 1976 Mar | The inhibitory effect on cathepsin B1 of 39 antirheumatic and other agents has been studied. The enzyme was purified from bovine spleen (specific activity 2.8 units/ml/E280 unit) and the effect of the drugs measured by determining the decrease of enzyme activity towards BANA as substrate. Analgesics, antimalarials, cytostatic agents, steroids as well as d-penicillamine, colchicine, allopurinol, chlorzoxazone and chlorpromazine either had no effect on cathepsin B1 or inhibited it to a very small extent. Typical anti-inflammatory and antirheumatic agents like gold and pyrazolone derivatives (with the exception of sulfinpyrazone) suppressed the activity of the enzyme at a concentration of 10(-6) M. Two others, indomethacin and diclofenac, suppressed it at a concentration of 10(-5) M. Two sulfonated polysaccharides, arteparon and pentosan polysulfate (SP54), were also potent inhibitors. Salicylates, however, inhibited cathepsin B1 only at much higher concentrations (10(-2) M. Higher concentrations of cysteine (2 mM) decreased the inhibitory effect of some otherwise effective drugs. Inhibition of cathepsin B1 may be one way in which some of the drugs tested exercise their therapeutic effect in rheumatic diseases. | |
| 7294991 | Our operative approach to the elbow joint. | 1981 | Several surgical approaches to the elbow joint have been described. The disadvantage of all is an insufficient view of a single incision to the anterior and posterior as well as the ulnar aspect of the joint. They require therefore an additional incision or the resection of the radial head with a detachment of the radial collateral ligament. Our single incision allows for an extensive view to the anterior and posterior aspect of the elbow joint without resection of the radial head and the sacrificing of the radial collateral ligaments. It makes in most instances an additional ulnar incision unnecessary. This incision has mainly been tested for subtotal elbow synovectomy in rheumatoid arthritis, for the mobilization of posttraumatic stiff elbows and the removal of loose bodies as in chondromatosis. | |
| 837608 | Hemiarthroplasty for the rheumatoid shoulder joint. | 1977 Jan | Hemiarthroplasty was performed in 10 patients with rheumatoid arthritis of the shoulder joint. A humeral head prosthesis was inserted to replace the articular surface of the humeral head in 12 shoulders. Marked relief of pain and improved function in long term follow-up examinations were noted in the majority of the patients. The indication for shoulder hemiarthroplasty is severe pain and chronic rheumatoid disease. | |
| 6981387 | Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis. | 1982 Aug | Forty-nine Israeli Jewish patients with rheumatoid arthritis (RA) were studied for their HLA A, B, C, DR antigen frequency. A significant increase in HLA Aw31 and HLA DR1 was observed (p less than 5.10(-5) and p less than 5.10(-3) respectively). 45% of Aw31 positive patients were sero-negative for rheumatoid factor, while most HLA DR1 positive individuals were seropositive. DR5 was found to be significantly decreased (p less than 5.10(-4)). Contrary to previous reports, DRw4 was found to be within the range of antigen frequency of the controls (34.7% vs. 32%). It is suggested that in our population of patients Aw31 and DR1 and not DR4 are highly associated with adult onset of RA. | |
| 6183639 | [Rheumatoid arthritis and HLA system. A search for correlations between histocompatibility | 1982 Sep 25 | Possible correlations between the HLA antigens A, B, C and DR and the clinical and biological features of rheumatoid arthritis were investigated in 74 patients with positive serology. The DR 4 antigen was present in 46 of these patients (62%), being apparently more frequent in those whose disease had begun before the age of 35 (p less than 0.05). DR 4 was also more common in pure rheumatoid arthritis than in forms associated with Gougerot-Sjogren's syndrome (p less than 0.05). No correlation could be found between the HLA phenotype and the other parameters studied, i.e. sex, corticosteroid therapy. Steinbrocker's radiological stages, plasma levels of rheumatoid factor and gammaglobulins and presence of antinuclear antibodies. | |
| 160456 | Tomographic examinations of sacroiliac joints in adult patients with rheumatoid arthritis. | 1979 Jul | Tomography of the sacroiliac joints (SIJ) was performed in 72 patients with rheumatoid arthritis (RA) and in 50 controls. Twenty-seven rheumatoid patients (38%) showed typical sacroilitis with predominantly severe intraarticular ankylosis and subchondral erosions. Fourteen patients (19%) had a probable sacroilitis with mild erosions and intraarticular ankylosis and concomitant degenerative changes. Fifteen patients (21%) showed predominantly degenerative changes and 16 RA patients (22%) had no radiological manifestation of the SIJ. There was no relation between typical sacroilitis and age of patients, duration of disease, rheumatoid factor, Steinbrocker's stage and frequency of HLA B27. | |
| 6454603 | Myelopathy due to atlanto-axial dislocation in a patient with Down's syndrome and rheumato | 1981 Jun | A case of Down's syndrome in association with rheumatoid arthritis is described. The patient has spastic diplegia and atlanto-axial dislocation, probably the result of ligamentous laxity which is common in both Down's syndrome and rheumatoid arthritis. This laxity may have been enhanced by tonsillar or deep cervical infection. The myelopathy was thought to be due to the atlanto-axial dislocation. Spinal fusion may reverse the neurological abnormality in some cases. | |
| 6589578 | Drug stomatitis due to gold therapy. | 1984 Jul | Eighteen patients with oral eruptions that developed during chrysotherapy for rheumatoid arthritis were studied retrospectively. The most frequent mucosal changes were nonspecific ulcerations, lichenoid eruptions, atrophy of lingual filiform papillae, and diffuse erythema. Histologic examination generally confirmed the clinical impression. All the eruptions disappeared either spontaneously or after completion of treatment. | |
| 6678693 | Lymphatic varices in blocked fistulous rheumatism. | 1983 Jun | Blockage of a chronic synovial fistula over the right elbow in a man with erosive, nodular rheumatoid arthritis is described. A subsequent synoviogram demonstrated gross lymphatic hypertrophy draining the joint. The implications of this finding are discussed. | |
| 6644699 | Health status in chronic disease: a comparative study of rheumatoid arthritis. | 1983 Oct | A self-administered questionnaire has been used to measure and compare health status in rheumatoid arthritis (RA) and 5 other chronic diseases. Subjects with RA, hypertension, cancer, diabetes, cardiac disease, or pulmonary disease were assessed along 11 aspects of health status. Results showed significant differences in health status across the 6 diseases, particularly for physical function and pain. The psychological status measures were similar. A summary estimate indicated that RA and pulmonary diseases produced poorer health status than the others. This study confirms the severe negative health status associated with chronic RA. | |
| 1189506 | [Immunosuppressive treatment of progressive chronic polyarthritis]. | 1975 Aug 15 | After description of forms and possibilities of the immunsuppression the results of this therapy are discussed in 47 own patients with clinically and paraclinically ascertained rheumatoid arthritis. The patients received the sum of 4.0 mg trenimon in combination with altogether 4.0 mg cyclophosphamide by means of 20 infusions with physiological saline solution as carrier substance. Under this treatment in 93.6% of the cases the findings of the examination of joints or the clinical stage improved. As to side effects incompatibilities on the side of the gastro-intestinal tract as well as leucopenias were observed. 18 patients could be after-examined after 6 years. Whilst in every case the clinical stage deteriorated, in the majority the degree of activity remained unchanged. All the results are compared with the results reported in literature. The authors are of the opinion that, when other forms of treatment have no success and contraindication are strongly taken into consideration, the progressing of the rheumatoid arthritis can be retarded by means of immunsuppressives. The pathophysiological processes can, however, scarcely be influenced causally. | |
| 6609411 | Increased numbers of active B cells in the circulation of patients with rheumatoid arthrit | 1984 | Increased numbers of cells secreting immunoglobulins of class G, M and A have been demonstrated in the peripheral blood of patients with active rheumatoid arthritis using the reverse haemolytic plaque assay. Lower numbers of secreting cells were detected in rheumatoid patients in spontaneous remission. Culture of the peripheral blood mononuclear cells was associated with a fall in the number of immunoglobulin secreting cells. Values for rheumatoid and normal cells did no differ significantly after 3 days of culture. The presence of an activating factor in th rheumatoid patients is postulated. | |
| 3883172 | Efficacy of low-dose methotrexate in rheumatoid arthritis. | 1985 Mar 28 | Twenty-eight patients with refractory rheumatoid arthritis completed a randomized 24-week double-blind crossover trial comparing oral methotrexate (2.5 to 5 mg every 12 hours for three doses weekly) with placebo. The methotrexate group had significant reductions (P less than 0.01 as compared with the placebo group) in the number of tender or painful joints, the duration of morning stiffness, and disease activity according to physician and patient assessments at the 12-week crossover visit; reductions in the number of swollen joints (P less than 0.05) and 15-m walking time (P less than 0.03) also occurred. These variables, as well as the grip strength and erythrocyte sedimentation rate, showed significant (P less than 0.01) improvement at 24 weeks in the population crossed over to methotrexate. A significantly increased frequency (P less than 0.03) of the HLA-DR2 haplotype occurred in the eight patients with the most substantial response to methotrexate. Adverse reactions during methotrexate therapy included transaminase elevation (21 per cent), nausea (18 per cent), and diarrhea (12 per cent); one patient was withdrawn from the trial because of diarrhea. One patient died while receiving the placebo. Methotrexate did not affect measures of humoral or cellular immunity. We conclude that this trial provides evidence of the short-term efficacy of methotrexate in rheumatoid arthritis, but the mechanism of action is unknown. Longer trials will be required to determine the ultimate safety and effectiveness of this drug. | |
| 3879831 | Single and multiple oral dose pharmacokinetics of tenoxicam in the elderly. | 1985 | Tenoxicam is a new non-steroidal anti-inflammatory drug with a long half-life. Since such drugs may be particularly prone to accumulate in elderly patients, a group of the population in which anti-inflammatory agents are most commonly prescribed, we have studied the pharmacokinetics of tenoxicam in 18 patients (age range 62-87 years) with osteoarthrosis or rheumatoid arthritis. A pharmacokinetic profile was performed after a single 20 mg oral dose. Patients then took regular medication until they had reached steady-state for chronic dosing (20 mg/day) when a further pharmacokinetic profile was performed. Approximately five-fold accumulation was found at steady-state (mean peak plasma level 2.6 micrograms/ml for a single dose against 12.4 micrograms/ml at steady-state). Twenty percent of the dose was eliminated in the first dose interval. Mean pre-dose plasma level at steady-state was 9.6 micrograms/ml with a coefficient of variation of 11%. Serial haematological and biochemical estimations during the study showed no evidence of drug toxicity. | |
| 6678699 | Investigations on vitamin E and lipid peroxide status in rheumatic diseases. | 1983 Sep | Patients of both sexes suffering from two types of rheumatic diseases-- rheumatoid arthritis and osteoarthrosis--were examined. Healthy volunteers of similar age served as controls. No significant difference was found in the plasma vitamin E content of the patients. Plasma malondialdehyde content was significantly higher /P less than 0.001/ in both sexes in the RA and OA groups as compared to the controls. Plasma catalase activity in both sexes was significantly higher (P less than 0.01) in RA and OA groups while RBC glutathione-peroxidase showed significantly (P less than 0.001) higher activity only in the female RA group, as compared to the control subjects. A difference was found between RA and OA groups in malondialdehyde content and in glutathione-peroxidase activity in subjects of both sexes. | |
| 6525788 | Coexistence of temporal arteritis/polymyalgia rheumatica and rheumatoid arthritis. | 1984 Dec | A patient with biopsy proven temporal arteritis/polymyalgia rheumatica and erosive rheumatoid arthritis is presented. Only 15 such patients have previously been documented in the literature. The coexistence has been thought to be extremely infrequent, but could merely by chance appear in far more patients than previously reported. | |
| 1191348 | Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. | 1975 Sep | The junction between pannus and cartilage was examined in the rheumatoid joint. Three types of cartilage-pannus junction were observed. In one, proliferating small blood vessels, surrounded by highly cellular infiltrates, penetrated deeply into the cartilage. Degeneration of the cartilage was observed around the cellular accumulations. In the second, phagocytic and fibroblastic cells invaded the cartilage. In the third, fibrous pannus overlay the cartilage. Lysis of cartilage by infiltrating cells appeared to be a major cause of cartilage erosion in rheumatoid arthritis. | |
| 6649966 | [Results with Guepar knee endoprostheses]. | 1983 | From 1977 to 1982 40 patients suffering from severe bilateral gonarthrosis, mostly caused by rheumatoid arthritis, underwent the implantation of 42 Guepar-endoprostheses of their knee joint. It was only in 1 case that a prosthesis got loose by infection and had to be removed without replacement. In 2 other cases of aseptic loosening a reimplantation of the prosthesis could be performed successfully. The authors emphasize the encouraging results. |