Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3923616 | IgG heavy chain (Gm) allotypes in rheumatoid arthritis and in healthy individuals seroposi | 1985 | The frequencies of Gm allotypes a, x, f, b, g and n have been investigated in classical seropositive rheumatoid arthritis (RA), erosive definite seronegative RA, non-erosive definite RA and in healthy individuals with serum IgM-RF. No differences in the frequencies of these Gm allotypes were found between patients and healthy controls. It is concluded that any possible putative genes outside the HLA region involved in RA are most likely unrelated to the genes coding for the constant regions of IgG heavy (gamma) chains. | |
| 6791940 | Fibronectin in synovial fluid and tissue in rheumatoid arthritis. | 1981 Jun | Fibronectin is a glycoprotein found in body fluids, loose connective tissue matrix and in basement membranes. Fibronectin in rheumatoid arthritis synovial fluid was immunologically indistinguishable from the plasma form, as shown by double-diffusion analysis. Fibronectin isolated from rheumatoid synovial fluid by affinity chromatography on gelatin--Sepharose had a polypeptide pattern similar to that of plasma fibronectin in SDS--polyacrylamide gel electrophoresis. In fifty-one patients with rheumatoid arthritis and related diseases fibronectin concentrations is synovial fluid were 445 +/- 103 micrograms/ml (mean +/- SD) and within normal range, 335 +/- 52 micrograms/ml, in plasma. Immunofluorescence staining showed a prominent increase of fibronectin in the proliferating synovial connective tissue in rheumatoid arthritis as compared to normal synovial membrane. The results suggest an increased local production of fibronectin in rheumatoid synovial tissue. | |
| 6520491 | Electron and immunoelectron microscopic investigation of basal lamina thickening in synovi | 1984 Oct | Capillaries and post-capillary venules in the synovium obtained from 12 rheumatoid arthritis (RA) patients have been investigated by electron microscopy and immunoelectron microscopy with a monoclonal antibody against human type IV collagen, which is one of the major basal lamina (BL) components. The level of BL thickening in RA synovial vessels is roughly parallel with that of cellular exudation. The BL thickening may be due to excessive production of BL components, in which the accelerated rate of death and replenishment of endothelial cells and pericytes plays an important role. These cells may not only produce a single layer of BL in their life-time but also produce excessive amounts of BL components to make several layers in their life-time. | |
| 3881941 | Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data. | 1985 Jan 21 | The real possibility that exogenous chemicals, including pharmaceuticals, increase risk of cancer is not a surprise. Epidemiologic systems to monitor exposure, as well as risk with or without such exposure, have been very hard to develop and very expensive to implement, and often have yielded ambiguous or questionably useful findings. The pharmaceutical industry is rising to the challenge of this situation, with attention to epidemiologic responsibilities and potential contributions deriving from them. This paper reviews the overall methodologic and public policy context surrounding pharmaco-epidemiology in the 1980s and then depicts an evolving program in pharmaco-epidemiology at one company, Burroughs Wellcome, as an example of one possible contributor. It discusses the company's epidemiologic approach to the question of association between treatment with disease-modifying antirheumatic drugs, one of which is manufactured by Burroughs Wellcome Company (Imuran brand azathioprine) and a possible increased risk of neoplasms in patients receiving these drugs as treatment for their rheumatoid arthritis. The paper will highlight specific epidemiologic applications of data bases derived from the published literature as well as voluntary reporting to industry. It will describe a proactive program in the development and conduct of epidemiologic studies to address these difficult problems. | |
| 1072576 | [The socio-medical significance of chronic rheumatoid arthritis (proceedings)]. | 1976 | The last figures, portraying to the cost complex concerning rheumatism, have been released by the Austrian Health Insurance Organisation. Attention is called to the problem of unauthorized sick leave and to the cooperation of all pertinently concerned, with regards controlling cost inflation. | |
| 3970041 | Occurrence of malignant neoplasms in the Rochester, Minnesota, rheumatoid arthritis cohort | 1985 Jan 21 | The medical records of all patients with rheumatoid arthritis diagnosed in Rochester, Minnesota, from 1950 to 1975 were examined to determine how many of them had malignant neoplasms. Follow-up averaged more than 14 years with outcome diagnoses complete in 98 percent of cases. All diagnoses of malignant neoplasm in this cohort were identified through the centralized record system based at the Mayo Clinic. Approximately 40 percent of these patients with rheumatoid arthritis were at least 60 years old at diagnosis. For comparison, the expected number of malignancies has been calculated using age-specific and site-specific rates from previous Rochester studies and the number of years of observation from date of diagnosis of rheumatoid arthritis to the date of last examination. Risk ratios have been calculated by dividing the observed number by the expected number of malignancies. Exact 95 percent confidence intervals around the risk ratios were calculated assuming that the observed number of cases has a Poisson distribution and that the expected number is fixed. Those patients with rheumatoid arthritis who had a malignancy before diagnosis have been analyzed separately, because they are at a higher risk. With the exception of multiple myeloma, no association was found between rheumatoid arthritis and subsequent cancer of any site. | |
| 7100768 | Radionuclide imaging of the neck in rheumatoid arthritis. | 1982 Aug | Blind marking was used to assess radionuclide neck images obtained with technetium-99m methylene diphosphonate in 28 patients with rheumatoid arthritis and 12 with cervical degenerative joint disease (spondylosis). Eleven out of the 16 rheumatoid arthritis patients who had neck pain when imaged showed enhanced uptake in the region of the atlantoaxial and temporomandibular joints. In contrast, no patient with cervical spondylosis and only one rheumatoid arthritis patient without neck pain had high uptake in either joint. Changes in uptake in this region on repeat imaging correlated significantly (P less than 0.01) with changes in pain. Patients with rheumatoid arthritis, with or without neck pain, and with cervical spondylosis showed similar patterns of radiological abnormality in the cervical spine. No detailed correlation was detected between radionuclide and radiographic findings. Radionuclide abnormalities were seen in the middle and lower cervical spine in both rheumatoid arthritis and cervical spondylosis. An abnormal radionuclide image of the middle or lower neck is thus of little value except when no degenerative change is present on the radiograph. An abnormal radionuclide image of the upper neck may be a useful indication of inflammation. | |
| 6225180 | [Antigenic markers of immunocompetent cells in rheumatoid synovial membrane]. | 1983 Jun | Immunologic characteristics of cells present in rheumatoid synovium from 15 patients were analyzed either "in situ" on frozen sections or after elution. Monoclonal antibodies directed against T cell subpopulation antigens and anti-Ia-like were used. T cells bearing the phenotype T3+, T4+, Ia+ are numerous, and they appeared gathered in lymphoid follicles and in perivascular areas. They are in close relationship with large Ia+ cells probably macrophagic in nature. Numerous dendritic cells as well as intimal cells are also Ia+. Some ratios T8+/T4+ cells are higher than results previously reported. This discrepancy could be related to drugs received by the patients before surgery. | |
| 821135 | [A new associated spondylarthritis: rheumatoid spondylarthritis]. | 1976 Jun | The authors analyse 7 cases which presented the criteria of ankylosing spondylarthritis and HLA 27 positivity, together with those of defined or classical rheumatoid polyarthritis with positive results in the latex test and the Waaler-Rose reaction in the joint fluid and/or the serum. The sex distribution, 6 men and 1 woman, was the same as for that disease. The clinical manifestations were very variable, with a predominance of localized, peripheral oligoarthritis in the lower limbs. Repeated iritis occurred in three cases. Two presented subcutaneous nodules on the elbow. All cases showed bilateral sacroiliitis; syndesmophytosis was rare. The overall clinical picture indicated rather a combined spondylarthritis than pure spondylarthritis. It is suggested that the occurrence of spondylarthritis in a subject with the HLA 27 gene might modify the response to the etiological factors of rheumatoid arthritis. These cases may thus be considered as a new type of combined or secondary spondylarthritis. | |
| 686859 | Experience with Silastic prostheses in the rheumatoid hand. A 5-year follow-up. | 1978 Jun | Nine patients with rheumatoid arthritis, who had Silastic prostheses (Swanson's) introduced into 34 metacarpophalangeal joints, were reviewed 5 years after surgery. The most important long-term advantage conferred by the introduction of prostheses was pain relief; functional benefit was marginal. The majority of prostheses eventually fractured but this did not necessarily lead to a functional deterioration. Impairment of function was usually the result of loss of flexion at the metacarpophalangeal joints, but it was sometimes due to excessive instability after fracture of the prostheses. It is suggested that Silastic joint replacement may be a worthwhile procedure in rheumatoid patients with moderate destruction or deformity of the metacarpophalangeal joints when pain is a predominant feature. Significant functional improvement can be anticipated only when secondary to pain relief. | |
| 7015800 | A renal biopsy study with light and immunofluorescent microscopy in rheumatoid arthritis. | 1981 | REnal biopsies were performed on 14 patients with active rheumatoid arthritis an proteinuria of whom 7 patients had reduced creatinine clearance. Glomerular hypercellularity was found in six and amyloid in seven biopsies. Immunofluorescence microscopy revealed glomerula deposits of immunoglobulins and complement in 10 of 12 biopsies, indicating an active immunologic process causing the impaired renal function. | |
| 979846 | Rheumatoid arthritis treated with chlorambucil: a five-year follow-up. | 1976 Aug 7 | The results of a five-year study of chlorambucil in patients suffering from rheumatoid arthritis are presented. The effect of treatment was to allow a reduction in corticosteroid dosage and a sustained remission of disease activity in patients. Three patients of the series of 22 developed neoplastic disease, and the signficance of this is discussed. | |
| 6398156 | Balancing effectiveness and toxicity of levamisole in the treatment of rheumatoid arthriti | 1983 Apr | One hundred and forty-four courses of levamisole were given in various dosage schedules for the treatment of rheumatoid arthritis from 1976 to 1980. A placebo-controlled double-blinded study was analyzed traditionally and life table analysis used to describe events during follow-up. Lower dosage was significantly less toxic, but not significantly better than placebo. Toxicity to other slow acting anti-rheumatic drugs did not predispose to levamisole toxicity. Because effective doses are poorly tolerated, and tolerable lower doses are relatively ineffective, levamisole cannot be recommended as standard treatment of rheumatoid arthritis. | |
| 1002755 | Complications of total hip-replacement arthorplasty in patients with rheumatoid arthritis. | 1976 Dec | During the period 1969 through 1974, 716 total hip-replacement arthorplasties were performed. The results of the surgery in 275 cases of rheumatoid arthritis as regards complications were compared with those in 382 procedures in cases of osteoarthritis. In contrast to the reports of others,the incidence of deep would infection in the two groups was found to be equal. Patients undergoing total hip-replacement arthroplasty as a revision of a previous operation had a substantially increased risk of infection. Patients with rheumatoid arthritis, however, were more subject to certain other complication (intraoperative fracture, difficulties with anesthesia, and malposition of prosthetic components), in addition to the complications that were predictable because of the involvement of multiple joints and the systemic disease process. | |
| 6756493 | A review of some statistical methods for covariance analysis of categorical data. | 1982 Sep | Three general methods for covariance analysis of categorical data are reviewed and applied to an example from a clinical trial in rheumatoid arthritis. The three methods considered are randomization-model nonparametric procedures, maximum likelihood logistic regression, and weighted least squares analysis of correlated marginal functions. A fourth heuristic approach, the unweighted linear model analysis, is an approximate procedure but it is easy to implement. The assumptions and statistical issues for each method are discussed so as to emphasize philosophical differences between their rationales. Attention is given to computational differences, but it is shown that the methods lead to similar results for analogous problems. It is argued that the essential differences between the methods lie in their underlying assumptions and the generality of the conclusions which may be drawn. | |
| 7282106 | [Current status of D-penicillamine therapy in chronic polyarthritis]. | 1981 Mar | Long-term-treatment of rheumatoid arthritis (RA) with D-Penicillamine (DPA) is well established. In several controlled clinical studies, DPA-therapy has been shown to be effective, even in lower dosage (450--600 mg/day) than used in first years after introduction of this drug. As the dosage has been reduced there was a marked decrease in unwanted drug effects. Nevertheless proteinuria, agranulocytosis and LED-like syndromes remain serious side-effects. Therefore a close supervision of patients under DPA is still necessary. The limitations for DPA-treatment are age, disease activity and LED-like symptoms. RA-patients with renal insufficiency, penicillin-allergy, hematopoietic dysfunction, cancer and chronic infections should never be treated with DPA. | |
| 7424943 | Humoral suppression of erythropoiesis in systemic lupus erythematosus (SLE) and rheumatoid | 1980 Oct | Anemia due to inadequate red cell production often accompanies systemic lupus erythematosus and rheumatoid arthritis. We investigated its pathogenesis in 17 patients with these disorders, using a plasma clot culture system. In serum from normal donors and nonanemic patients CFU-E derived colony formation was not significantly altered by normal marrow cells (mean 74 +/- 12 colonies/6 x 10(4) cells), whereas colony formation was inhibited (mean 36 +/-6 colonies/6 x 10(4) cells) in serum from 10 anemic patients. In serum from anemic patients proliferation of the more primitive BFU-E was also reduced in three cases. In two patients with a humoral inhibitor, colony growth was suppressed by autologous marrow cells. In another patient without an inhibitor, colony formation was not suppressed by autologous bone marrow. The physical properties of this inhibitor are compatible with those of an immunoglobulin. Moreover, its presence is related to disease activity and it can be removed by successful therapy with either corticosteroids or plasma exchange. Circulating inhibitors of erythropoiesis may play an important role in causing severe anemia in patients with these rheumatic diseases. | |
| 6624343 | [Changes in the nervous system in amyloidosis]. | 1983 | The author investigated different areas of the nervous system in five cases of primary and in seven cases of secondary amyloidosis--rheumatoid arthritis accompanied by amyloidosis. In nine out of the 12 cases studied, amyloid was found in the vascular walls and in the stroma of the peripheral, somatic and vegetative nervous system, by using light, polarization, fluorescent and electron microscopy. In cases of rheumatoid arthritis, apart from amyloid deposits, the connective tissue and vascular walls exhibited mucoid swelling, fibrinoid alterations and sclerosis, i.e., stages of the pathological process which are characteristic of this disease in particular and of collagen diseases in general. | |
| 6573099 | 25 year follow-up of the Aland thyroid study of 1956. Thyroid status and incidence of rheu | 1983 | In 1956, a study of the iodine metabolism in endemic goitre was made on a group of inhabitants of the Aland Islands, an autonomous province of Finland. The number of Alanders studied was 130. In a follow-up study 25 years later, 101 still living subjects from the original study could be traced. 17 of them had become hyperthyroid, 7 had been operated on for non-toxic goitre, and 4 had become hypothyroid. There was no correlation between thyroid hormone excretion values in 1956 and subsequent hyperthyroidism. Rheumatoid arthritis was overrepresented in the goitre group compared with the group without goitres, as well as compared with statistical figures on the frequency of rheumatic disease among the population in general of Aland and of Finland as a whole. | |
| 6211735 | [The surgical management of the forefoot in rheumatoid arthritis. A review of 150 cases (a | 1981 | The authors have performed 150 surgical procedures in 95 patients. In most of the cases, the procedure was a resection - realignment of the metatarsal heads. The results were assessed in 80 patients and were found to be satisfactory as regards pain and functional ability. Good results persisted as regards pain which remained absent in 90% of cases but the functional results tended to worsen with time. Good results being present in only 70% after a 10 year follow up. In 34 cases a prosthetic implant (Swanson type) was used. The results were deceptive. |