Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7161400 | Medication problems of rheumatic patients assessed by domicillary visits by pharmacists. | 1982 Dec | A pilot scheme of domicillary visits to thirty-three rheumatic patients attending either a specialized clinic or general practitioners was undertaken. Patients' understanding of their therapy and compliance with prescribed regimens was assessed, and a comparison made between specialized medical records and actual medications found in the home. A number of cases are discussed in detail to highlight some of the problems uncovered. It is suggested that the visits by pharmacists were sufficiently useful to extend the scheme. | |
| 7377854 | A comparison of follow-up regimes in rheumatoid arthritis. | 1980 Feb | One hundred and thirty-two patients discharged from a rheumatology unit were randomly allocated to general practitioner care, attendance at hospital outpatient clinics, or follow-up by a senior occupational therapist attached to the hospital treatment team. At the end of 1 and 2 years a number of clinical and functional tests were applied, and information was gathered about the provision and use of aids and the provision of domestic support. In addition the standard of overall care was judged by an independent assessor. Although no significant intergroup differences in disease activity or function emerged, it is clear that patients prefer continuing contact with the hospital team, and this may lead to differences appearing in the future. The financial advantages of therapist follow-up are discussed. | |
| 6882037 | Computer aided analysis of total knee replacement in rheumatoid arthritis. | 1983 Aug | A computer-aided analysis has been carried out on 176 knee replacements performed on 129 patients during the last 12 years. Owing to the variety of knee replacements used, the number of complications seen, and the large quantity of survey data a computer was very helpful in storing this amount of data with facilities for rapid recall of information. The results of the early Shiers knee hinged arthroplasties have been less than 50% good results, and these were followed by many complications. A smaller number of other knee replacements have been analysed, namely, Freeman-Swanson, Gunston, Sheehan, and Attenborough. The best results were obtained using 60 Attenborough knee prostheses, with a low infection rate of 3.3%, a loosening rate of 5%, and good prospects of salvage by fusion of the knee if required. | |
| 6380896 | Nitrogen mustard in severe rheumatoid arthritis. | 1983 Mar | The value of intravenous bolus therapy was investigated in patients with severe active rheumatoid arthritis. Nitrogen mustard was given in 3 intravenous bolus injections (0.1 mg/kg body weight) over 3-5 weeks. In a controlled study of 11 patients the actively treated ones (7 cases) showed greater improvement in all the clinical and laboratory variables measured than did the controls (4 cases). A prospective evaluation of this treatment in 22 patients over 6-18 months showed it had a persistent effect and was associated with clinically significant improvements in the assessments of disease activity. We consider bolus therapy with intravenous nitrogen mustard to be of value, but its use should be restricted to patients with severe rheumatoid arthritis during hospital admission, and it should be combined with other therapy. | |
| 3881939 | Neoplasms of the immune system in rheumatoid arthritis. | 1985 Jan 21 | Two studies are reported of patients with rheumatoid arthritis. The first was a retrospective-prospective-prospective study and comprised a cohort of 489 patients with rheumatoid arthritis followed for a mean of 12.2 years. Lymphoproliferative malignancies developed in 10 patients (2.2 percent) after a mean interval of 11.8 years. The second was a study of 30 patients, from various centers in England, with rheumatoid arthritis and lymphoproliferative malignancies. The effects of chronicity of rheumatoid arthritis, drug therapy, and possible predisposing factors in the etiology of the lymphoproliferative malignancies were examined. Cytotoxic drugs could not be implicated in the pathogenesis of the lymphoproliferative malignancies, but phenylbutazone and D-penicillamine may have played a role in some cases. Current evidence supports the hypothesis that chronic synovitis in rheumatoid arthritis is associated with persistent activation of lymphocytes in lymph nodes and eventual malignant transformation in some cases. | |
| 161178 | General mechanisms of inflammation in rheumatoid arthritis. | 1979 Sep | Rheumatoid synovitis is characterized by the simultaneous occurrence of two major types of immunologically-induced inflammation. These usually occur concurrently in the same joint. A cellular immune response is present in the sublining layer of the synovial membrane and an immune complex-induced acute inflammatory reaction is present in the synovial effusion phase of the disease. The two reactions are closely related and mutually interdependent. The cellular immune response is reduced in rheumatoid arthritis, but the chronic inflammatory cells of the synovium are active in the synthesis of IgG and probably considerable amounts of IgG rheumatoid factor. Rheumatoid factor complexes, particularly IgG-RF complexes, appear to be responsible for the exudative, immune complex-induced inflammatory phase of the disease. | |
| 7224685 | Deforming arthritis in systemic lupus erythematosus. | 1981 Apr | Of 45 patients in the McGill Lupus Registry 6 were found to have Jaccoud's deformities. One of these 6 and 4 others had fixed flexion contractures of the elbows. Those with Jaccoud's deformities were similar to the other patients with systemic lupus erythematosus in all respects except that those with Jaccoud's syndrome had had their disease and their arthritis significantly longer. It is concluded that Jaccoud's deformities are the result of longstanding arthritis and that elbow contractures occur via a different mechanism. | |
| 6965027 | HLA-DR typing in 58 cases of rheumatoid arthritis. | 1982 Jun | The results of a previous study led us to believe that the association of HLA-DR4 and rheumatoid arthritis could be of particular interest in our region. In this work we typed 58 caucasoid patients in the Marseilles area by microlymphocytotoxicity assay in B-cells. HLA-DR4 was found to be at the same level as that observed by the authors in the 8th Workshop of histocompatibility (1980) (X2:32.36, P less than 0.001) and very high in the seropositive patients (61.5 per cent). No correlation with sex was observed. We again found a low frequency of HLA-DR4 (15.8 per cent) in our controls. | |
| 2932612 | Immunologic effects of nonsteroidal anti-inflammatory agents. | 1985 Jul | The author discusses the evidence that PGE is an immunomodulator and addresses the thesis that nonsteroidal anti-inflammatory agents, by blocking endogenous PGE production, act to partially correct the immunologic aberrations involved in the pathogenesis of rheumatoid arthritis. | |
| 231307 | [Polyarthritis in leprosy (author's transl)]. | 1979 Dec 8 | Inflammatory rhumatisms simulating rheumatoid arthritis belong to the manifestations of the reactions of leprosy. Pathology of these arthritis variate with the type of reaction. In the present observations, it must probably be the transition from a tuberculoid leprosy to a lepromatosis form in which the immunological state looks like the lupus one. | |
| 96841 | Chrysotherapy in psoriatic arthritis. Efficacy and toxicity compared to rheumatoid arthrit | 1978 Jun | Chrysotherapy was given to 14 patients with refractory psoriatic polyarthritis and to a comparable group of 42 patients with rheumatoid arthritis. The psoriatic patients had a higher rate of remission on gold and less severe toxicity than the rheumatoid arthritis patients. Psoriatic skin lesions were not affected by chrysotherapy. | |
| 6395430 | [Effectiveness of non-steroidal anti-inflammatory and psychotropic drugs in patients with | 1984 | The authors provide the data on comparative efficacy of different non-steroidal anti-inflammatory agents (220 studies), psychotropic drugs (32 cases) and combined therapy (58 cases). All the studies were made by the double blind method with the use of placebo (38 cases). As for the psychotropic drugs, use was made of the tranquilizer relanium, mild activating neuroleptic sonapax, and tricyclic antidepressant amitriptyline. Combined therapy with nonsteroidal anti-inflammatory and psychotropic drugs appeared the most efficacious. It is suggested that this is connected both with potentiation of the analgesic effect of the antirheumatic drugs and with the action on the psychological distress playing a definite role in the disease development. | |
| 3923951 | Reduction of peripheral blood lymphocytes in patients receiving gold therapy for rheumatoi | 1985 May | Peripheral blood lymphocytes were monitored prospectively in 10 patients with rheumatoid arthritis (RA) receiving up to 1 g of sodium aurothiomalate. There was a significant fall in the absolute lymphocyte count from a mean +/- SEM of 1956 +/- 190/mm3 (1.956 +/- 0.19 X 10(9)/l) to 1232 +/- 210/mm3 (1.232 +/- 0.21 X 10(9)/l) (p less than 0.01). The number of of circulating lymphocytes fell in all patients by an amount which ranged between 108/mm3 (0.108 X 10(9)/l) and 1394/mm3 (1.394 X 10(9)/l), with a mean fall of 727/mm3 (0.727 X 10(9)/l). No significant change was noted in the total white cell count or total polymorphonuclear cell count over the same period. In contrast there was no change in the total lymphocyte count in an age and sex matched group of RA patients treated with penicillamine. This previously unreported observation may give new insight into the mechanism of action of gold salts in RA. | |
| 1167114 | [Morphological changes in the joint tissues and synovial fluid in rheumatoid arthritis and | 1975 | A simultaneous morphological investigation of bioptic material of the synovial sheath, articular cartilage, and synovial fluid from patients with various forms of rheumatoid arthritis (100 patients with a typical articular form, 10 with benign evolution, and 20 with lesions of visceral organs) was carried out. It was noted that in the usual articular form of rheumatoid arthritis the most common morphological component in the synovial sheath was lympho-plasmo-cellular infiltration. In the "benign" form of rheumatoid arthritis immunomorphological shifts were manifested but slightly, in the articular-visceral form in the immunocompetent cells there were observed karyopycnosis and plasmorrhexis. Cells and the main matter of the cartilage apparently underwent an enzymatic lysis, the intensity of which correlated with the degree of phagocytosis of the synovial fluid. In the deforming osteo-arthrosis (150 observations) in the synovial sheath there were usually noted drastic sclerosis and atrophy of organ-specific structures, impairmement of the production of the synovial fluid, and dystrophic falling into fibers of the articular cartilage with intensive proliferation of the cartilage cells. It is probable that distructiion of the cartilage in arthrosis depends upon an impairment of the function of the synovial sheath to produce synovial fluid. | |
| 7161774 | Hyperviscosity syndrome in rheumatoid arthritis. | 1982 Nov | The course of a patient with rheumatoid hyperviscosity syndrome is described. Manifestations of hyperviscosity included somnolence, circulatory overload, bleeding diathesis and dilated retinal veins. Serum hyperviscosity was associated with marked hypergammaglobulinemia, elevated IgM and IgG serum concentrations, and high titers of rheumatoid factor. High molecular weight IgG-IgM immune complexes shown in the serum were considered responsible for the increased viscosity. An unusual feature of the hyperviscosity, was spurious hyponatremia and a negative anion gap. Plasmapheresis rapidly controlled acute features of hyperviscosity, lowered gamma globulin concentrations and led to normal serum sodium and anion gap. Clinical improvement was maintained with moderate prednisone doses. | |
| 954317 | Pathological human synovial fluids. Viscosity and boundary lubricating properties. | 1976 Sep | On human synovial fluids obtained during operations from the knee joints of 80 patients with different joing disease, relative viscosity was measured at 3 different shear rates and the boundary lubrication was tested by the coefficient of friction in an artificial rubber/glass system. The results were evaluated in relation to the operative findings. The viscosity showed statistically significant differences between the synovial fluids from the knee joints with rheumatoid arthritis, osteoarthritis, and torn menisci, being lowest in rheumatoid synovial fluid and highest in synovial fluids from knee joints with torn menisci. Correlations were found in the variations in the viscosity and the degree of synovitis. The boundary lubrication also showed different values inrelation to the different diseases. Synovial fluid from knee joints with torn menisci seemed to act as the best lubricant and significantly better than rheumatoid synovial fluid. Variations in the boundary lubrications reflect successive degrees of cartilage degeneration. | |
| 7149794 | Late-onset peripheral joint disease in ankylosing spondylitis. | 1982 Dec | We reviewed the records of 150 patients with definite ankylosing spondylitis who had significant peripheral arthritis and were seronegative and found 7 patients who had the onset of peripheral arthritis after their spinal disease became inactive. This late-onset peripheral arthritis may lead to significant joint deformity, and aggressive therapy may be warranted. | |
| 629612 | Cholestatic jaundice caused by D-penicillamine. | 1978 Feb | D-penicillamine is not generally considered to cause hepatic damage. Cholestatic jaundice developed in a patient with rheumatoid arthritis 4 weeks after penicillamine was added to his regimen, and he died in acute renal failure. The probability that penicillamine caused the cholestasis is discussed. | |
| 6715839 | Dorsal carpal dislocation and flexor tendon rupture in rheumatoid arthritis: a case report | 1984 Mar | A unique case of dorsal carpal dislocation of a rheumatoid wrist with an unusual pattern of flexor tendon rupture and median nerve compression is reported. The carpus was relocated and fused to the radius. The distal ulna was resected. Grafting and adjacent suturing of the tendons restored function, but late follow-up showed development of secondary deformities. | |
| 6382566 | [Cytofluorometric study of the cell cycle and various lymphocyte differentiation membrane | 1984 Jun | Synovial fluid lymphocytes were studied by cytofluorometry in 11 patients with classical or definite rheumatoid arthritis. This method allowed the study of the cellular cycle after acridine orange staining and of membrane antigens, expressed by normal and/or activated lymphocytes, which were demonstrated by using various monoclonal antibodies (OKT3, OKT4, OKT8, OKIa1, OKT10). The OKT4/OKT8 ratio was decreased in 4 out of 5 cases and the percentage of HLA DR + cells was clearly increased. In 6 out of the 11 patients, the percentage of dividing cells varied from 2.2 to 7.2 and was less than 1 in the others as in normal blood lymphocytes. Increase in cellular RNA content characterized the non dividing cells. The most elevated values of the cellular RNA content were observed in patients who had the smallest percentage of dividing cells, suggesting that the cellular cycle was stopped between the G1 and S phases. Study of the cellular cycle may reveal a lymphocyte activation parameter which could be unrelated to the expression of differentiation membrane antigens. |