Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 681721 | Flexor tenosynovectomy in the rheumatoid finger. | 1978 Jul | The usual operation fo stenosing flexor tenosynovitis is resection of the proximal pulley. In the rheumatoid hand this operation may not be proper because motion still may be limited by the thickened synovium more distally, and also because there is a greater chance for the production of ulnar drift later on if the proximal pulley system is obliterated. The operation we recommend for the finger with rheumatoid tenosynovitis is a tenosynovectomy, but with maintainence of the pulley system and resection of one slip of the superficialis in order to decompress the digital theca. We have performed this operation on 54 fingers with satisfactory results. | |
| 3909972 | Synovial fluid cells in Reiter's syndrome. | 1985 Dec | Synovial fluid cells in Reiter's syndrome were studied by cell subset specific monoclonal antibodies and avidin-biotin-peroxidase complex staining. Mean leucocyte count was 9842/mm3 (9.842 X 10(9)/l), and 71% of all cells were polymorphonuclear leucocytes. 26 +/- 11 (SEM)% and 47 +/- 5% of all mononuclear cells in synovial fluid were M1+ monocytes and Ia+ cells, respectively. T11+ T lymphocyte was the predominant synovial fluid mononuclear cell (61 +/- 8%) but, in contrast to the inflammatory joint effusions in rheumatoid arthritis, T4+ cells clearly outnumbered T8+ cells in Reiter's syndrome. Thus the synovial fluid in Reiter's syndrome contains the immunocompetent and accessory cells required for immune response, which in fact is activated as suggested by lymphocyte Ia expression. Furthermore, in contrast with rheumatoid arthritis inducer/helper cells with T4 phenotype seem to be involved preferentially in the local pathogenetic mechanisms in Reiter's syndrome. | |
| 791586 | Comparison of azapropazone and naproxen in rheumatoid arthritis. | 1976 | A double-blind crossover trial was carried out in 15 patients with definite rheumatoid arthritis to compare the effectiveness of 1200 mg azapropazone daily and 750 mg naproxen daily, each drug being given for 2 weeks. Patients also received placebo therapy before and between the two treatment periods. The results of subjective and objective assessments showed that both drugs were significantly superior to placebo, but no significant difference could be demonstrated between the two drugs. | |
| 781230 | Longterm fenoprofen therapy in patients with rheumatoid arthritis. | 1976 | Fenoprofen, a new antirheumatic agent, was evaluated in 45 patients with rheumatoid arthritis in an open study design to simulate the conditions under which the drug will be used. No control agents were used. The effectiveness of fenoprofen was demonstrated by the per cent of patients who improved during fenoprofen therapy. Duration of therapy varied from one to 629 days. Pain was the first parameter to respond, followed by an anti-inflammatory effect, which was observed after four to six weeks of therapy. Side effects consisted mainly of minor gastro-intestinal symptoms. | |
| 1083553 | [The salivary glands during rheumatoid arthritis]. | 1976 Mar | Salivary gland lesions were studied in 65 non-selected, confirmed rheumatoid polyarthritis patients. The investigations included a careful clinical study, the Schirmer test, sialography, sequential scintigraphy with Technetium 99, and a histological study of the sublingual glands. Tests were also made for salivary gland anti-epithelium antibodies. The frequency of sialography and scintigraphy anomalies is emphasized. In different degrees, two of of three patients presented anatomical or functional anomalies of the salivary glands. These disturbances were not related to the duration, the functional severity, or the treatment of the disease or to the presence of anti-salivary gland antibodies. On the other hand, there was a clear relation with both the presence of anti-nuclear antibodies and an increase in the serum gammaglobulin levels. The limits of the Gougerot syndrome are discussed and it is proposed that there is a need for a second nosological class grouping the minor scintigraphic and sialographic anomalies related to rheumatoid arthritis that has been suggested by several authors. | |
| 1138357 | [Indications and types of synovectomy]. | 1975 Mar 22 | Synovectomy is the routine surgical treatment for cases of therapy-resistant exudative synovitis or teno-synovitis, which are frequently seen in cases of rheumatoid arthritis and less frequently in synovial osteochondromatosis, pigmented villo-nodular synovitis and degenerative joint diseases. The best results are obtained following a so-called "early synovectomy", which means a synovectomy performed prior to the onset of destructive changes of bone and cartilage and before the occurrence of irreversible mechanical distension of ligaments and capsules. When carried out under the above mentioned conditions, complete local relief of pain can be achieved in nearly all cases. In rheumatoid arthritis the pain relief may be temporary or permanent depending on the disease progression in each individual case. Statistically, the danger of relapse increases in proportion to the length of time following synovectomy. Analogous results can be obtained by the use of chemical (osmic acid 2%) or radioactive (Er-165, Re-186, P-32, Y-90) synovectomy. Further experience with these agents will be necessary to determine to what degree they can replace surgical therapy. | |
| 1135612 | Effect of short-term physical training on patients with rheumatoid arthritis I. | 1975 | Thirty-four patients with rheumatoid arthritis, aged 38 to 63 years (mean age 56 years), were studied before and after a 6-week stay in hospital. Twenty-three of these patients underwent special physical training twice a day during this period. Physical performance, cardio-respiratory fitness and muscle strength improved significantly in the training group. In the control group there were no major changes in these measurements during this period except for an increase in muscle strength. Perceived exertion during submaximal exercise was much lower in the training group following the conditioning. Joint status was virtually unchanged over the experimental period in both groups. It is postulated that the low physical performance seen in these types of RA patients may, to a large extent, be attributed to lack of physical activity. | |
| 690850 | Rapid determination of gold in whole blood of arthritis patients using flameless atomic ab | 1978 Sep | An assay for gold in whole blood of arthritis patients was developed using the graphite furnace atomic absorption spectrophotometer. This method involves no pretreatment of the whole blood except for simple dilution, thereby eliminating some variables and saving laboratory time and expense. | |
| 6279671 | Stimulation of collagenase secretion from rheumatoid synovial tissue by human collagen pep | 1982 Apr | Dayer et al. demonstrated that mononuclear cells from human peripheral blood produce a mononuclear-cell factor that stimulates collagenase secretion from adherent rheumatoid synovial cells. The production of this mononuclear-cell factor can be stimulated by phytohemagglutinin, a T-cell mitogen. We have examined immune mechanisms by which collagenase secretion may be stimulated from explants of rheumatoid synovial tissue and from primary monolayer cultures of rheumatoid synovial cells. Conditioned media from cultures of normal peripheral-blood mononuclear cells that had been activated by phytohemagglutinin stimulated collagenase secretion from most explants and from all monolayer cultures that were examined. The direct addition of phytohemagglutinin stimulated collagenase secretion in explants from eight of fourteen patients and in monolayer cultures from three of six patients. These observations indicate the presence of responsive T lymphocytes in rheumatoid synovial tissue and implicate them in the stimulation of collagenase secretion from synovial cells. The direct addition of type-II collagen peptides to rheumatoid explants also stimulated collagenase secretion in explants from six to fifteen patients. Four of five of these patients displayed moderate or severe disease activity. Other patients showed a marginal stimulation of collagenase secretion on addition of type-II collagen peptides (four of fifteen patients) and type-I collagen peptides (three of twelve patients). None of the patients with mild or inactive disease responded to type-II collagen. With one exception, the addition of collagen peptides to monolayer cultures did not stimulate collagenase secretion. An increased production of factors that enhance or inhibit the migration of polymorphonuclear leukocytes was also observed in explant cultures in response to the addition of phytohemagglutinin (in seven of twelve patients), of type-I collagen peptides (in five of ten patients), and of type-II collagen peptides (in five of eleven patients). There was no correlation between production of these factors and stimulation of collagenase secretion in rheumatoid synovial tissue. | |
| 6615563 | Type II collagen-induced arthritis. Studies with purified anticollagen immunoglobulin. | 1983 Sep | Immunization of rats with native bovine type II collagen results in a polyarthritis by day 21 in approximately 40% of the rats. Sera of these rats contained anticollagen IgG, principally IgG2a. Small amounts of IgG2b were also detected, but IgG1 and IgG2c were absent. By enzyme-linked immunosorbent assay, the paw tissue of these polyarthritic rats was shown to contain anticollagen IgG, the principal subclass being IgG2a, with minor amounts of IgG2b. Immunofluorescence examination of the paws from polyarthritic rats demonstrated deposition of both IgG and C3 on the articular surface. Passive transfer of disease was accomplished by injection of affinity-purified anticollagen immunoglobulin into naive recipients; paw swelling and histopathologic changes were detected 24 hours after transfer, and by immunofluorescence techniques IgG and C3 deposits were demonstrable on the articular cartilage. On passive transfer, neutrophils invaded the joint space and became juxtaposed to the surface of the articular cartilage. Passive transfer of the disease with anticollagen immunoglobulin was unsuccessful after rats were decomplemented with cobra venom factor; immunofluorescence demonstrated IgG but not C3 on the articular cartilage of these decomplemented rats. In rats decomplemented with cobra venom factor, neutrophils did not accumulate in the joint and erosion of articular cartilage was not detected. | |
| 7207503 | Penicillamine-induced myositis in rheumatoid arthritis. | 1981 Mar | A patient with rheumatoid arthritis who developed multiple mononeuropathies multiplex was shown to have vasculitis in nerve biopsy, but no evidence of inflammatory muscle disease in muscle biopsy. Treatment with penicillamine caused the rare complication of polymyositis, documented clinically, electrophysiologically, and by light and electron microscopy in a second muscle biopsy. The evidence presented supports the concept that penicillamine may induce polymyositis or aggravate a pre-existing low-grade myositis. | |
| 686870 | Neutropenia during treatment of rheumatoid arthritis with levamisole. | 1978 Aug | Of 60 patients with rheumatoid arthritis treated with levamisole 35% showed a persistent decrease in neutrophil counts from pre-treatment levels and 6 (10%) develped severe neutropenia of less than 1.0 X 10(9)/1. One of these neutropenic patients recoverd without stopping therapy and the other 5 patients recovered rapidly when the drug was withdrawn. In some patients neutropenia recurred on reinstitution of levamisole. | |
| 908227 | Pericardial tamponade secondary to sudden steroid withdrawal in chronic rheumatoid arthrit | 1977 Oct | A patient with chronic rheumatoid arthritis was admitted to the hospital with cervical fracture. Two weeks after acute steroid withdrawal, she was noted to have pleural effusion, and signs and symptoms of acute pericardial tamponade. An open partial pericardiectomy and drainage relieved the symptoms. The sequence of events suggests that rapid steroid withdrawal might have precipitated rapid accumulation of pleural and pericardial fluid. | |
| 686864 | Prostaglandin production in arthritis. | 1978 Aug | Inflammatory cell populations from synovial effusions or synovial villi in rheumatoid arthritis have been cultured in vitro. Prostaglandin productive capacity, measured by radioimmunoassay, showed the polymorphonuclear leucocyte rich populations from synovial effusions to be poor sources of PGE production whereas the synovial fragments produced substantial amounts of PGE activity. It is suggested that the macrophage is the major source of local prostaglandin formation both in gout and rheumatoid arthritis. | |
| 6815384 | Chrysiasis resulting from gold therapy in rheumatoid arthritis: identification of gold by | 1982 Dec | A patient with blue-gray discoloration of the skin of her face, neck, and hands is described. She was a patient with rheumatoid arthritis who had received a large total cumulative dose of gold. Light microscopy of skin biopsy tissue from the forehead revealed deposits of heavy metal in macrophages. On electron microscopy, the particles were found in the lysosomes of the cell. X-ray microanalysis confirmed the presence of gold. This condition, which is called chrysiasis, may be incorrectly diagnosed as cyanosis. | |
| 866904 | Night medication in rheumatoid arthritis: II. Combined therapy with indomethacin and diaze | 1977 May | Seventeen of eighteen patients hospitalized for active rheumatoid arthritis completed a three-day randomized, double-blind comparison of 100 mg indomethacin, 100 mg indomethacin with 10 mg diazepam and matching placebo as night medication. The results showed a consistent pattern in the four functions measured--pain, morning stiffness, sleep score and patient preference. In each, indomethacin proved superior to placebo and the combined therapy better than indomethacin alone. From this it has been concluded that the combination of indomethacin and diazepam should now be considered the treatment of choice for maximum control of night pain and morning stiffness in rheumatoid arthritis. | |
| 908223 | Interstitial pneumonitis complicating rheumatoid arthritis. Sustained remission with azath | 1977 Oct | A patient with classic rheumatoid arthritis developed biopsy-proven diffuse interstitial pulmonary fibrosis and ventilatory insufficiency which appeared to be irreversible. The administration of azathioprine coincided with significant immediate improvement in pulmonary function and clinical status. During five years of continuous azathioprine therapy, progressive improvement in lung function has been accompanied by marked deterioration of the rheumatoid joint disease, suggesting that the pulmonary and joint lesions of rheumatoid disease may not be mediated by the same pathways. | |
| 7123128 | [Results more than five years after osmic acid synoviorthesis of the rheumatoid knee]. | 1982 Jun | Osmic acid synoviorthesis is an adjuvant form of local treatment for rheumatoid arthritis, the value of which has been demonstrated by a large number of studies over some 30 years. However, it is widely considered that the stability of the results of this type of synoviorthesis is less satisfactory than that obtained with isotope synoviorthesis and that osmic acid may damage the articular cartilage. The authors analyzed the results of a retrospective study of 90 rheumatoid knees treated by this method with a follow-up of more than 5 years (mean period 9 years). With such a follow-up, a satisfactory clinical result was seen in 44.5 p. cent of cases and radiological evaluation of the knees treated showed no worsening in initial signs in an identical percentage of cases. Best results were obtained in joints where there was little radiological damage and in cases of inflammatory or only moderately progressive arthritis, good results may also be hoped for in more severe or advanced cases. The good overall quality of the results obtained with a mean follow-up of 9 years would be in favour of the value of osmic acid synoviorthesis in the local treatment of rheumatoid arthritis. | |
| 1083582 | [Complications in the use of proteinase inhibitors]. | 1975 Apr | It is well known that the use of proteolysis inhibitors of animal origin can result in complications of an allergic character up to anaphylactic shock. More frequently such complications according to the authors' data occurred in intraarticular or paraarticular injection of drugs in patients suffering non-specific infectious arthritis. Some useful recommendations are given. | |
| 7009859 | A double-blind comparison of aspirin and pirprofen in the treatment of rheumatoid arthriti | 1980 Nov | Pirprofen (600 mg, 800 mg) and aspirin (3,600 mg) were compared in 30 outpatients (33-67 yr old) with definite or classical rheumatoid arthritis. After 10 wk of treatment with either pirprofen dose, the number of painful joints, grip strength, and the duration of morning stiffness improved significantly. Only the number of painful joints improved significantly with aspirin. The erythrocyte sedimentation rate decreased with aspirin and 600 mg pirprofen but increased (significantly) with 800 mg pirprofen. The differences in improvement between the 3 treatment groups were not statistically significant. Gastrointestinal disturbances were the most frequently reported side-effects in each treatment group. Central nervous system effects and tinnitus were reported by more patients in the aspirin group than in either of the pirprofen groups. |