Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6857170 | Intestinal permeability to different-sized polyethyleneglycols in patients with rheumatoid | 1983 | The intestinal permeability to polyethyleneglycols (PEGs) of varying size in patients with rheumatoid arthritis has been investigated. Permeability was determined by measuring the 6-hour urinary recovery of different-sized PEGs after oral intake of PEG 400, PEG 1000, or PEG 3000. Patients with rheumatoid arthritis excreted significantly less PEG 400 and PEG 1000 than healthy individuals, whereas the excretion of PEG 3000 was the same or even greater than in healthy individuals. These findings point to the possibility that intestinal permeability is altered in rheumatoid arthritis. | |
| 7323787 | Increased mortality among persons with rheumatoid arthritis, but where RA does not appear | 1981 | We have performed an 11-year follow-up study on mortality in rheumatoid arthritis (RA). The population was selected by random sampling and consisted of 293 persons with RA fulfilling two sets of relevant criteria and a contrast group of 453 healthy persons. The mortality in the RA group was found elevated, when compared with both the contrast group and the general Stockholm population. The mortality was correlated with the severity of the disease, as defined by the numbers of criteria for RA fulfilled, the Steinbrocker functional grading, and serological titres. The differences in the distribution of causes of death between RA and contrast groups were not large enough to warrant special consideration. Only 9 out of 84 death certificates in the RA group mentioned rheumatic disease, and 4 of these had RA as underlying cause of death. | |
| 2580091 | Immune complex activation of neutrophils and enhancement of the activation by rheumatoid f | 1985 Feb | The activation of human neutrophils by heat aggregated human immunoglobulin and preformed immune complexes was studied using a chemiluminescent technique. Insoluble aggregates of large size and complexes with antigen/antibody ratios at equivalence produced maximal activation. All responses were enhanced by preincubation with fresh serum. Preincubation of neutrophils with zymosan activated serum also enhanced neutrophil responses. Rheumatoid factor modulated the interaction and in excess reduced all responses, while at optimum concentration caused enhancement. These activation processes result in the release of reactive oxygen metabolites which are considered important inflammatory mediators in the pathogenesis of rheumatoid arthritis. | |
| 415451 | [Gold treatment of rheumatoid arthritis]. | 1978 Jan | In basic therapy of Rheumatoid Arthritis gold is preferred. Continued as well as discontinued therapy is used. The effect of gold is of complex nature. Gold is localized in cells of the RES and mesenchyme main in the inflammatory area. The passing acceleration of mesenchyme metabolism possibly shortens the duration of the inflammatory process. Gold further shows effects on cellular and subcellular membranes, on collagen, ACTH-production and on immune reactions. Patients with high activity and slow progression of their disease are especially suitable for chrysotherapy. Low maintenance of gold levels is effective and inhibits toxic-allergical reactions may be in a sort of desensitisation. | |
| 3904433 | Long-term studies of isoxicam in the treatment of rheumatoid arthritis. | 1985 Oct 18 | Three multicenter studies evaluating the long-term efficacy of isoxicam (Maxicam) were conducted in 745 patients with active classic or definite rheumatoid arthritis. Initially, all patients in the one-year open-label phase received isoxicam, 200 to 400 mg per day. Dosage was then reduced to 200 mg a day for all patients. Objective and subjective parameters for efficacy included the number of tender joints, number of swollen joints, grip strength, duration of morning stiffness, time to walk 50 feet, overall assessment of the patient's condition, and global assessment of change in the patient's condition since the beginning of isoxicam therapy. All parameters of efficacy showed improvement. Patients who had received aspirin or placebo in the double-blind phase experienced marked and progressive improvement while receiving open-label isoxicam. Those who had received isoxicam continued to improve. The mean erythrocyte sedimentation rates showed significant decreases (p less than 0.0005) after one year of isoxicam therapy in all three studies. The results of these studies confirm that isoxicam is clinically effective in the long-term treatment of patients with rheumatoid arthritis. | |
| 7435517 | A hypereosinophilic syndrome mimicking rheumatoid arthritis. | 1980 Nov | A 58 year old white man presented with an articular syndrome that appeared clinically to be rheumatoid arthritis with nodules. Lack of response to therapy, and laboratory and pathologic data failed to confirm the diagnostic impression. The patient's course over the ensuing seven years was compatible with the hypereosinophilic syndrome. The articular involvement represented soft tissue and synovial fibrinoid degeneration with eosinophilic infiltration. This is the first reported case of articular involvement in the hypereosinophilic syndrome and adds it to the list of processes that can cause hand deformity resembling rheumatoid arthritis. | |
| 356764 | Indomethacin and naproxen suppositories in the treatment of rheumatoid arthritis. | 1978 Aug | A double-blind cross-over study of 35 out-patients with rheumatoid arthritis showed that Naproxen and Indomethacin suppositories were both effective forms of treatment in rheumatoid arthritis, both being significantly superior to placebo in terms of relief of morning stiffness. | |
| 4050148 | [Reactions of the overlapping volo-ulnar margin of the ulnar head in chronic polyarthritis | 1985 Jul | The volo-ulnar margin of the ulnar head is mostly superimposed by the base of the ulnar styloid, but often remains visible as a contour. The ulnar head is surrounded by the radio-ulnar synovial compartment. At the wrist this compartment is one of the most often affected synovial compartments in rheumatoid arthritis. Therefore reactions often occur at this margin in rheumatoid arthritis with thinning, reactive sclerosis and erosion. These reactions occur as often as the erosions at the neighbouring ulnar styloid. | |
| 1273478 | [Dorsal tenosynovectomy of the wrist in rheumatoid arthritis. Results obtained in 30 cases | 1976 Apr | With reference to a series of thirty synovectomies of the wrist in patients with rheumatoid arthritis, the authors report the results observed after an average interval of three years and six months. There was a remarkable reduction in pain in three-quarters of the cases. On the other hand, loss of mobility was noted in 15 patients. Resection of the cubital head was carried out in half of the cases. This was followed in two cases by internal translocation of the carpus, and in three cases by internal translocation combined with cubital inclination of the hand. The results of the tenddon repairs carried out in six patients have been completely satisfactory. A study of the present cases and of data from the literature confirms the local prophylactic value of tenosynovectomy which may also prevent tendon ruptures. The best result are seen in the less evolutive forms in which the risk of relapse is least, and in cases in which surgery is carried out on stable wrists with cartilage showing little alteration. In the presence of inferior radiocubital arthritis the resection must be systematic as it makes it possible to carry out a complete synovectomy of this joint. The authors compare the value of surgical synovectomy of the wrist with that of radioactive synoviorthesis. | |
| 7100036 | Prescribing non-steroidal anti-inflammatory drugs: a prospective study of patients' prefer | 1982 Mar | Thirty-six patients with rheumatoid arthritis were allocated at random to one of 3 groups prescribed 4 different non-steroidal anti-inflammatory drugs (NSAID). Each drug was given for one week over 4 consecutive weeks in a balanced order. The patients were then asked to select one NSAID for continuation therapy and were followed-up 6 months later. The success of the patient selection method was compared with that of physician selection by retrospectively surveying NSAID prescribing in 164 patients attending 2 other rheumatology units over a 5-year period. Only 72% of patients in the prospective study felt able to choose one of the NSAIDs and 31% of these had discontinued the chosen drug within 6 months. In the retrospective study, 40% changed their NSAID within 6 months. | |
| 983357 | Amyloidosis in rheumatoid arthritis. A study of 48 histologically confirmed cases. | 1976 Sep | In a group of 269 patients with rheumatoid arthritis histological examination demonstrated amyloidosis in 48 cases, viz. in 7 post mortem cases, in 28 rectal biopsies, in 12 renal biopsies and in one liver biopsy. Examination for amyloidosis was carried out in all patients who had proteinuria, otherwise in non-selected patients with definite rheumatoid arthritis. Even through rectal biopsy is a valuable screening method, it should not be overestimated, because in 12 patients with renal biopsy positive for amyloid, the foregoing rectal biopsies had been negative. According to our experience the most valuable method for diagnosis of amyloidosis in rheumatoid patients is renal biopsy, whereas synovial biopsy is the least conclusive. This paper, according to our knowledge, is the first report on observations of a regression of the inflammatory activity of rheumatoid arthritis and nephrotic syndrome as well as a complete morphological regression of amyloidosis. | |
| 485583 | Behaviour of effector cells, synovial fluids, and sera from rheumatoid arthritis patients | 1979 Jun | Antibody-dependent cell-mediated cytotoxicity (ADCC) was examined in patients with rheumatoid arthritis (RA). The cytotoxicity of peripheral blood leucocytes from patients with RA was similar to that found in normal persons, whereas ADCC was less effective in RA synovial fluid cells. It is possible that the activity in these cells is lower because of immune complexes and other factors being absorbed from the synovial fluid itself. Although patients' sera had little effect on normal peripheral blood leucocytes, synovial fluid from RA patients was markedly inhibitory in ADCC. The degree of inhibition correlated significantly with the clinical status of the patients. | |
| 700914 | Effect of antirheumatic drugs on proteinases in synovia of patients with rheumatoid arthri | 1978 Sep | Synovia and synovial fluid proteinases were determined in 21 patients with rheumatoid arthritis who were using different kinds of antirheumatic medications. Significantly lower cathepsin B1-like proteinase activity (only 10% of control) was found in the synovial fluid of patients with chloroquine treatment, and significantly lower neutral trypsin-substrate hydrolysing proteinase activity (about 30% of control) was found in the synovia of patients with phenylbutazone treatment. No significant differences were found with other medications: gold, indomethacin, cortisone, acetylsalicyclic acid. No definitive correlations between disease activity parameters and proteinase activities could be found. | |
| 6497917 | An attempt to predict the response to gold therapy in rheumatoid arthritis. | 1984 Nov | In 54 rheumatoid arthritis patients undergoing conventional chrysotherapy, we prospectively sought predictors of response, using strict clinical and laboratory criteria of improvement. Forty-five patients who completed 6-12 months of therapy were classified into 3 outcome categories: group 0, not significantly improved (18 patients); group 1, improved (18 patients); and group 2, markedly improved (9 patients). Sixty-two entry variables were tested in univariate and multivariate analysis for predictor function. No continuous variable was predictive. The discrete variables HLA-A3 positivity and HLA-DR4 negativity were the best predictors of response to gold. In a multivariate analysis using these 2 univariates (A3 and DR4) plus hemoglobin, we developed a discriminant function that correctly predicted outcome in 21 of 23 patients in groups 0 and 2. We also observed that of 15 DR blank patients (10 of whom were DR4 blank), none entered remission. | |
| 7384542 | Indomethacin, salicylates and prostaglandin binding. | 1980 Feb | Aspirin, salicylic acid and indomethacin reversibly inhibit prostaglandin binding to human serum proteins. This effect was demonstrated in the sera of normal subjects and of rheumatoid arthritis patients treated with aspirin as well as by addition of these drugs to serum in vitro. The displacement of serum prostaglandins by salicylate is likely to affect the kinetics of prostaglandin transport and may facilitate the delivery of prostaglandins from serum to tissue receptors. | |
| 6244611 | Rheumajecta in the treatment of rheumatoid arthritis. | 1980 Feb | A double-blind controlled trial of Rheumajecta in rheumatoid arthritis demonstrated lack of effect of this compound and unacceptable side-effects. It was not felt ethically justifiable to complete the trial. | |
| 347076 | Intracranial histiocytic lymphoma with rheumatoid arthritis. | 1978 Spring | A patient with classical rheumatoid arthritis presented with a primary intracranial histiocytic lymphoma. He had not received cytotoxic drugs and had no evidence for Sjögren's syndrome or immunodeficiency. Previous radiation therapy to the shoulders is regarded as a possible, though unlikely, risk factor. | |
| 6386565 | The localization and secretion of type IV collagen in synovial capillaries by immunohistoc | 1984 | The localization and the secretion of type IV collagen in synovial capillaries have been investigated by detecting the antigenic determinant of the major triple helix of human type IV collagen. Type IV collagen was indicated to be localized mainly in the lamina densa of basement membranes (BM) and to be secreted by both endothelial cells and pericytes. The pericytes secreted this collagen to both surfaces facing endothelial cells and the interstitial connective tissue. On the contrary, the direction of type IV collagen secretion by the endothelial cells was strictly confined to one side, namely towards the surface facing the BM. The absence of the antigenic determinant in rough endoplasmic reticulum and Golgi apparatus of the endothelial cells and pericytes indicated that the major triple helix of type IV collagen is mainly formed in the secretory vesicles after budding from the Golgi apparatus. | |
| 1190847 | Some new evidence on human joint lubrication. | 1975 Aug | Theoretical consideration has been given to the use of pendulum machines which are used to examine the frictional properties of human joints by incorporating them as fulcra. As a result, a new type of pendulum machine has been built which incorporates the facility to apply sudden loads to the joint on starting the swinging motion, and also the ability to measure directly the frictional torque experienced by the joint. The results obtained from natural hip joints indicate the presence of squeeze film lubrication under conditions of sudden loading of a joint. In addition, a self-generated fluid film process was observed at low loads while at higher loads boundary lubrication appeared to be important. These results have been used to describe the lubrication regimens occurring in a normal activity such as walking. A single experiment carried out on a hip from a patient suffering from severe rheumatoid arthritis has also been reported and the frictional resistance was seen to be increased fifteenfold compared to a normal hip. | |
| 455840 | Serotonin metabolism and its enzymic activities in joint diseases. | 1979 Mar | In order to clearly understand the synovial metabolic pathway of 5-HT, which is interesting as an inflammatory mediator and a pain producing substance, in patients with RA and with OA, determinations were made of 5-HIAA levels and of the activities of MAO-A and MAO-B, in the synovial fluid and the blood. With respect to 5-HIAA levels, there was no significant difference in the synovial levels between patients with RA and those with OA, although higher values were obtained in the plasma of patients with RA. A correlation was found between synovial and plasma levels in both diseases. In patients with RA, 5-HIAA levels tended to increase in both levels of the synovial fluid and the plasma in higher stages. The activities of MAO-A and MAO-B in the synovial fluid were found to be lower in patients with RA than in those with OA. The MAO-B activity in the synovial fluid increased in higher stages and correlated with ESR in patients with RA. In patients with RA the efflux of 5-HIAA from the synovial fluid was reduced. No remarkable changes occurred in the permeability of 5-HIAA. The ability to inactivate 5-HT was lower than in OA. The determination of synovial MAO-B activity is useful in diagnosing the status of the patient with respect to rheumatoid arthritis. |