Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6398183 | Splinting the rheumatoid hand. | 1984 Dec | Splinting of the rheumatoid hand is a complex topic. Understanding is assisted by the use of precise terminology and so is accurate prescription. Dynamic and static orthoses can be prescribed for any part of the upper limb to assist function or provide resistance exercise. Orthoses can be valuable in planning surgery and assisting return of function postoperatively. The importance of training in prescription, manufacture, fitting and wearing of orthoses is stressed and careful discussion with the patient is vital. Thermoplastic materials have provided a new spectrum of designs. Spring wire attachments developed at Chessington (Wynn Parry et al, 1970), Odstock (Glanville, 1962) and The London Hospital (Ellis, 1981) have introduced further possibilities. Designs should be functional and must be acceptable to the patient. | |
| 7406622 | Rheumatoid pleurisy. observations on the development of low pleural fluid pH and glucose l | 1980 Sep | A patient with rheumatoid pleurisy provided the opportunity to observe the time course of development of the low glucose level and low pH characteristic of these pleural effusions. During six days, the effusion evolved from one with a normal glucose value and pH to one with a glucose value of 20 mg/dL and a pH of 6.78. The mechanisms responsible for these phenomena probably are (1) a selective block to glucose transport from blood to pleural fluid, (2) enhanced glucose use by rheumatoid pleura, and (3) an efflux block to the end products of pleural space glucose metabolism. Once the low glucose value-low pH rheumatoid effusion develops, it seems not to revert to an effusion with a normal glucose level and pH. | |
| 7317115 | The influence of fibronectin on cryoprecipitate formation in rheumatoid arthritis and syst | 1981 Nov | Fibronectin, a human fibroblast surface and plasma protein, is present in cryoprecipitates of synovial fluids and/or sera from patients with rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and mixed essential cryoglobulinemia. Fibronectin was shown to be capable of influencing cryoprecipitate formation. No antibodies to fibronectin could be detected, thus ruling out the possibility that it was directly involved in the formation of cold-insoluble antigen--antibody complexes. Fibrinogen or fibrinogen degradation products were frequently present in synovial fluid cryoprecipitates but rarely in serum cryoprecipitates. Since complexes of fibronectin--fibrin--fibrinogen are known to be cold-insoluble, such interactions could occur in synovial fluids and contribute to the formation of cryoprecipitates. In serum, however, this is not likely to occur, and the mechanism by which fibronectin influences cryoprecipitate formation remains to be elucidated. | |
| 56827 | [LE cells in the synovial fluid]. | 1976 Jan | The occurence of LE cells in the synovial fluids of two patients is reported. The demonostration of LE cells in synovial exudate is clinically valuable. Examination of joint fluid should therefore pay attention to the search for LE cells and their precursors. Reoccurrence of E-cells in the synovial fluid indicates their origin in the joint cavit. They could still be found even after multiple intraarticular injections of triamcinolone acetonide. | |
| 7354474 | Streptococcus MG-intermedius (Streptococcus milleri) septic arthritis in a patient with rh | 1980 Jan | Streptococcus MG-Intermedius (S. milleri) septic arthritis in a patient with rheumatoid arthritis is presented. The unusual nature of this infection and the difficulties with the identification of S. milleri are discussed. | |
| 6224467 | Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rhe | 1983 Aug | In an attempt to define the immunoregulatory mechanisms operating in rheumatoid arthritis we have enumerated T cell subsets in the peripheral blood and synovial fluid of patients with this disease. The peripheral blood analysis revealed an elevation of the ratio of inducer T cells (OKT4 positive) to suppressor/cytotoxic T cells (OKT5 positive) in patients with clinically active rheumatoid arthritis when compared with normal persons. This was due to a reduction in the percentage of suppressor/cytotoxic T lymphocytes in these patients. The synovial fluid in rheumatoid arthritis differed from the peripheral blood in 2 respects. Firstly, synovial fluid was characterised by a lower helper: suppressor ratio due to an increased number of suppressor/cytotoxic cells, and, secondly, it contained an increased number of activated T cells bearing HLA DR antigens. The majority of these activated T cells belonged to the helper/inducer T cell subset. | |
| 6582269 | Low prevalence of rheumatoid arthritis in Chinese. Prevalence survey in a rural community. | 1983 Nov | A prevalence survey for arthritis among the general adult population of a rural island off the coast of China revealed a prevalence of rheumatoid arthritis (RA) of no more than 0.3% compared with 1.0% among Americans in the National Health Examination Survey (NHES). The frequency of clinical ankylosing spondylitis (AS) (0.2%) appears to be higher than expected, although limited data are available for comparison. No clinically unusual features of these diseases were recognized. | |
| 6224984 | Peripheral arthritis in ankylosing spondylitis. A review of 209 patients followed up for m | 1983 Sep | Charts of 209 patients with ankylosing spondylitis were reviewed with regard to the occurrence of seronegative peripheral arthritis. Peripheral arthritis, excluding hip and shoulder involvement, occurred in 67 of the 209 patients (32%). No relationship was found between the age at onset of spondylitis and the onset of the peripheral arthritis. Among the 67 patients with peripheral arthritis, 19 (28%) had recurrent flares. X-ray findings similar to those of rheumatoid arthritis were seen in 22 patients (33%) with peripheral arthritis. Confusion about the cause of the peripheral arthritis frequently arose in patients who had the onset of the disease when the spondylitis was in remission. | |
| 6398158 | A clinical and biochemical evaluation of Clozic, a novel disease modifying drug in rheumat | 1983 Apr | We have compared two dose levels of Clozic, a novel agent with potential anti-rheumatoid activity, to D-penicillamine and aspirin in an observer blind randomised parallel group study of 56 patients with active rheumatoid arthritis. Eight clinical assessments and 26 laboratory assessments were performed on each patient at each visit over a six month period. Results were analysed by conventional methods and also by correlation matrices constructed between clinical and laboratory variables. Patients treated with D-penicillamine (500 mg/day) responded adequately and the control group on aspirin (up to 3.6 g of enteric coated formulation/day) performed well, though the withdrawal rate from this latter group was high, predominantly because of continued disease activity. Patients receiving Clozic (100 mg/day or 300 mg/day) improved more than patients receiving penicillamine, particularly at the higher dose. Comparison of methods of analysis validates the use of correlation matrices both for detecting anti-rheumatoid activity and for determining the optimum dose of a novel compound. This trial illustrates the problems of a study of this nature, with the powerful effect on patients of being enrolled in such a closely monitored investigation. It emphasises the greater value of biochemical changes in following disease changes. | |
| 10260456 | Chronic illness as biographical disruption. | 1982 Jul | The paper is based on semi-structured interviews with a series of rheumatoid arthritis patients. Chronic illness is conceptualised as a particular type of disruptive event. This disruption highlights the resources (cognitive and material) available to individuals, modes of explanation for pain and suffering, continuities and discontinuities between professional and lay thought, and sources of variation in experience. | |
| 6402992 | Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovia | 1983 Feb | Specimens of human rheumatoid and nonrheumatoid synovial lining were maintained in nonproliferative organ culture for 20 hours. The culture fluids were then assayed for prostaglandin E(2) (PGE(2)), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) by specific radioimmunoassay. The presence of each of these substances was confirmed by gas chromatography and mass spectrometry. Rheumatoid tissue produced significantly more of each cyclo-oxygenase product than nonrheumatoid tissue. | |
| 724226 | Combined wrist arthrodesis and metacarpophalangeal joint arthroplasty in rheumatoid arthri | 1978 Jan | This paper describes a surgical procedure which combines wrist arthrodesis and metacarpophalangeal joint arthroplasty into one operation. Its basic indication is the severely crippled rheumatoid patient who is faced with multiple reconstructive surgical procedures. In addition to the combined wrist fusion and metacarpophalangeal joint arthroplasty, other surgical procedures can sometimes be performed into same hand, thereby completing the entire reconstruction in one operation. Of the 19 patients who have undergone the combined procedure, only one failed to obtain a solid clinical arthrodesis. There were no infections, skin sluffs or other complications. Combining the two procedures did not jeopardize either wrist fusion or metacarpophalangeal joint arthroplasty. Specific contraindications for the procedure are fixed wrist flexion contracture or a complete dislocation requiring extensive exposure in order to align or reduce the radiocarpal joint. | |
| 6610913 | Psoriasis and arthritis. II. A cross-sectional comparative study of patients with "psoriat | 1984 | Arthritis of the terminal joints of the hands and feet occurred more frequently (P less than 0.015) in patients with seronegative poly-arthritis combined with psoriasis (S- P+; n = 92) than in patients with seronegative polyarthritis alone (S- P-; n = 72). However, the prevalence of affection of these joints was too low to consider this feature a sensitive marker for psoriatic arthritis. Furthermore, neither asymmetrical joint involvement nor the absence of ulnar deviation of the fingers appeared to be characteristic of this disease. A positive correlation was found between the presence of nail psoriasis and limitation of function of the distal interphalangeal (DIP) joints. The DIP finger joints and the interphalangeal joints of the toes were affected more often in the S- P+ group than in patients with seropositive polyarthritis without psoriasis (S+ P-; n = 46), but arthritis of the other joints was observed more frequently in the latter group. | |
| 488793 | The pathogenesis of the rheumatoid swan neck deformity. | 1979 Jun | Disappointment with the late results of intrinsic release for the rheumatoid "intrinsic-plus" hand has led to a re-appraisal of the role of intrinsic muscle contracture in the pathogenesis of the rheumatoid swan neck deformity. In cadaveric fingers, a properly placed suture typing the lateral band to the middle slip insertion causes a swan neck deformity. It is suggested that the usual "intrinsic-plus" hand and the fixed swan neck deformity of rheumatoid arthritis is caused by adhesions between the extensor tendons on the dorsum of the proximal interphalangeal joint, rather than by intrinsic muscle contracture and/or metacarpo-phalangeal dislocation. | |
| 6405140 | Gold colitis. | 1983 Feb 19 | A case of severe colitis, which developed in a patient with rheumatoid arthritis after administration of sodium aurothiomalate, is reported. Early recognition of this rare, but potentially fatal, complication is essential. Rectal biopsy should be performed as part of the early assessment. | |
| 412921 | Gold encephalopathy. | 1977 Oct | Encephalopathy is described developing in a 42 year old man who was receiving gold treatment for rheumatoid arthritis. | |
| 6983192 | [Cytotoxic complement-dependent anti-thrombocyte antibodies in rheumatoid arthritis patien | 1982 Sep 1 | Sera of 38 patients and 10 blood donors were examined for cytotoxicity against human thymocytes. As method for testing the complement-dependent cytotoxicity the lymphocytotoxicity test was adapted for thymocytes. The sera of blood donors and of patients with non-rheumatic diseases showed no or only a very small rate of cytolysis (3.6%). The rate of cytolysis of sera of patients with arthroses (8.5%) and of collagenoses (14.5%) were below 20%, i.e. still within the limits of normal. The sera of seronegative arthritides (30%) and of patients with rheumatoid arthritis (40%) showed an unequivocally pathological cytotoxicity. The complement-dependent thymocytotoxicity might be coordinated to the clinical arthritis. | |
| 6221703 | Increased bone metabolism in rheumatoid arthritis as measured by the whole-body retention | 1983 Apr | Bone metabolism in 21 patients with rheumatoid disease was investigated by measurement of the 24-hour whole body retention (WBR) of 99Tcm methylene diphosphonate (MDP) in parallel with clinical, radiological, and biochemical measurements (urinary excretion of hydroxyproline) of disease activity. Corticosteroid-treated patients of those with other forms of metabolic bone disease were excluded from the study. WBR was increased in the rheumatoid patients as compared with 21 age- and sex-matched controls (p less than 0.05), and there was a significant correlation in the rheumatoid group between WBR and urinary excretion of hydroxyproline (p less than 0.01) and between urinary excretion of hydroxyproline and an articular index (p less than 0.05) and global index (p less than 0.01) of disease activity. The increased WBR of the rheumatoid patients was not explicable by factors such as immobilisation, and the results are interpreted as reflecting an overall increase in bone metabolism which may occur in rheumatoid arthritis as part of the disease process. | |
| 6971627 | IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinica | 1981 Apr | A radioimmunoassay has been developed for measuring IgG antiglobulins using baboon IgG as antigen. Raised levels were virtually confined to the sera of patients with rheumatoid arthritis (RA) and not found in other seronegative arthritides. High levels were found in both seropositive and seronegative (as judged by latex slide and sheep cell differential agglutination for IgM antiglobulins) patients with RA and were associated with systemic disease but not synovitis. Very high levels (more than twice the upper limit of normal) showed a strong association with vasculitis. | |
| 6373974 | [Study of lysosomal enzymes in human synovial membrane and fluid from rheumatoid and non-r | 1983 Dec | In rheumatoid arthritis, it is well known that lysosomal enzymes such as lysozyme and acid phosphatase have a function of destroying bone and synovial tissue of joints. In order to analyze the localization and the difference of distribution of lysozyme and acid phosphatase on the synovial tissue of rheumatoid arthritis (RA) and non-RA joints, immunohistochemical and histochemical methods were employed. Lysozyme was detected with formalin-fixed, paraffin-embedded materials in 82 cases of synovial tissue (RA 50 cases, non-RA 32 cases) using the unlabelled peroxidase anti-peroxidase (PAP) method following Taylor, et al. Acid phosphatase was detected with the naphthol AS method using frozen sections. In addition, in some cases of RA, alpha 1-antitrypsin and alpha 1-antichymotrypsin were also examined in synovium by the PAP method. For quantitative analysis of lysozyme in synovial fluid, lyso-plate were used on 98 cases (RA 58 cases, non-RA 40 cases). Further, acid phosphatase was quantitated with phenyl phosphoric acid. The results show, histologically, that lysozyme was more predominantly and more specifically located in the synovial cells, especially in the synovial lining cells of RA joints than non-RA joints. Lysozyme was distributed in the cytoplasm of synovial cells in a fine granular or small globoid pattern. On the other hand, no lysozyme was detected on the infiltrated lymphocytes and plasma cells. Infiltration of leukocytes was relatively slight. Acid phosphatase was intensively located in the same portion of RA synovium as that of lysozyme. Electron microscopically, synovial surface cells showed an increase in number, and they contained dominant, well-developed, rough endoplasmic reticulum and electron dense bodies. Fibrillar matrix were present in the cytoplasm and in the extracellular space in an amorphous pattern. Enzyme activity of lysozyme in 58 RA synovial fluid was 113 +/- 101 (mean +/- standard deviation) micrograms/ml and that in 40 non-RA (11 osteoarthritis, 20 autopsy cases, and others) was 35 +/- 31 micrograms/ml. Acid phosphatase activity of 47 RA was 11.97 +/- 10.45 I.U. (International Unit) and that of 38 non-RA was 5.16 +/- 3.77 I.U. A significant difference of lysosomal enzyme activity was thus found in the synovial fluid between RA and non-RA. Clinical laboratory data, namely, ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) as an activity of rheumatic disease were evaluated. Correlation rate between ESR and lysozyme in RA synovial fluid was 0.279 (the value of P less than 0.05) and between ESR and acid phosphatase was 0.259 (P less than 0.05). Thus no significant correlation was found among them.(ABSTRACT TRUNCATED AT 400 WORDS) |