Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6982334 | Clinical characteristics and course in patients with high titer anti-RNP antibodies. | 1982 Jul | Forty-four patients with high titers of anti-RNP antibodies, without anti-Sm or anti-nDNA antibodies, were studied retrospectively for clinical symptomatology, morbidity and mortality. Seven had died. Eleven had renal disease. Of patients with disease course greater than 7 years, only half had features of overlapping connective tissue diseases. The finding of high titer anti-RNP antibodies without anti-Sm or anti-nDNA did not appear to imply a distinct or unique clinical diagnosis or prognosis. | |
| 6382973 | Remittive therapy in rheumatoid arthritis: clinical uses and mechanisms of action. | 1984 | Evidence has been reviewed supporting the conclusion that gold compounds, anti-malarials and D-penicillamine have the capacity to function as immunosuppressive drugs. Moreover, the results indicate that each has a unique site of action, specifically inhibiting the function of only one of the populations of cells likely to be involved in chronic immunologically-mediated inflammation. Gold compounds and anti-malarials appear to be active by virtue of their capacity to depress the function of mononuclear phagocytes, while D-penicillamine acts by inhibiting a number of the activities of T lymphocytes. These results imply that the means by which these drugs suppress rheumatoid inflammation are fundamentally different. Thus, while each of these compounds acts as a selective immunosuppressive agent, the target cell inhibited appears to be different. The conclusion that the remission-inducing drugs have different modes of action in RA is supported by the clinical observation that the success rate of therapy with one is comparable regardless of antecedent therapy with another (125, 126). | |
| 7328569 | A double-blind comparison of high and low doses of levamisole in rheumatoid arthritis. | 1981 Nov | A randomized, double-blind study was performed to compare the efficacy of 2 different regimens for levamisole in the treatment of rheumatoid arthritis over a period of six months. A dose of 150 mg once weekly was shown to be less efficacious than 150 mg on 3 consecutive days. Although the low dose produced fewer adverse effects, only subjective improvement was demonstrated. Only 14% of patients responded to the low dose, according to defined criteria, compared with 45% response to the high dose. | |
| 7149797 | Trochanteric bursitis--a frequent cause of 'hip' pain in rheumatoid arthritis. | 1982 Dec | One hundred consecutive patients with rheumatoid arthritis (RA) were examined for the presence of trochanteric bursitis. This condition was found in 15. Ten patients responded to a single local injection of corticosteroid and the remaining 5 to a second injection. Trochanteric bursitis is an underdiagnosed, easily remediable cause of pain in RA. Specific examination for in presence should be a routine in all patients with RA, especially those with hip pain. | |
| 711796 | Charnley low-friction arthroplasties of the hip in rheumatoid arthritis. A study of the co | 1978 Nov | During the years 1971 to 1975, 378 Charnley low-friction arthroplasties of the hip were performed on 278 patients with rheumatoid arthritis. The average age at operation was thirty-nine years. The follow-up time ranged from one to six years (mean two and a half years). Forty per cent of patients were receiving steroids at the time of operation. The most common complications were loosening of the prosthesis (3.4%), perforation of the femoral cortex and fracture. Deep infection occurred in 0.7%, dislocation in 0.7%, and thromboembolic episodes in 1.3%. Ninety-five per cent of patients were free of pain at follow-up compared to 84% who were severely handicapped by pain before operation. In addition, the increased mobility in 98.5% of patients and their improved independence makes hip replacement a recommendable procedure in these patients. | |
| 6723126 | Penicillamine and other remittive agents in rheumatoid arthritis: comparisons and interact | 1984 | Penicillamine treatment of rheumatoid arthritis was compared with gold and other remittive agents by reviewing the literature and studying the patients in our penicillamine clinic with respect to their previous responses to chrysotherapy. Penicillamine compares well with other remittive agents with respect to efficacy and toxicity. Prior chrysotherapy does not determine or predict the subsequent efficacy of penicillamine . Patients who reacted adversely to gold tended to react adversely to penicillamine; proteinuria and rash tended to recur. | |
| 4716102 | Lymphocyte sensitivity to skeletal muscle in patients with polymyositis and other disorder | 1973 May | The transformation response of peripheral blood lymphocytes in vitro to human muscle antigen has been studied in patients with polymyositis, polymyalgia rheumatica and rheumatoid arthritis. Lymphocytes from patients with polymyositis and polymyalgia rheumatica, but not rheumatoid arthritis, showed transformation responses significantly higher than those in control groups, and the highest responses were found in patients with evidence of the most active clinical disease at the time of testing. The significance of finding hypersensitivity to crude muscle antigen in both these conditions is discussed. | |
| 7466295 | Measurement of bone mineral content (BMC) of the lumbar spine, II. correlation between for | 1980 | A comparison between forearm bone mineral content (BMC) and lumbar BMC was made in post-menopausal women. Women without symptoms, women with clinical spinal osteoporosis, and women with prednisone-treated rheumatoid arthritis were studied. A conventional two-dimensional single-photon osteodensitometer was used for measurement of forearm BMC. A new two-dimensional dual-photon osteodensitometer was used for measurement of lumbar BMC. Its radioactive source was 153Gadolinium. The mean lumbar BMC was significantly reduced in women with clinical spinal osteoporosis (P < 0.001). The mean forearm of BMC of those patients was normal. Thus, forearm BMC was a poor indicator of spinal osteopenia. If forearm BMC was used to predict lumbar BMC erroneously high results were obtained in women with clinical spinal osteoporosis, and erroneously low values were obtained in prednisone-treated women with rheumatoid arthritis. | |
| 2982258 | Immune system in rheumatoid arthritis: possible implications in neoplasms. | 1985 Jan 21 | Although the immune system in rheumatoid arthritis is generally in a state of hyperactivity, deficient function can be demonstrated in certain specific parts of the system. This has been most clearly demonstrated in studies of the response of blood lymphocytes from demonstrated in studies of the response of blood lymphocytes from patients with rheumatoid arthritis to in vitro infection by the Epstein-Barr virus. The virus normally infects B cells promoting proliferation. This results in the establishment of permanent lines of infected B cells more commonly than normal in rheumatoid arthritis. This condition is associated with decreased production of lymphokines, interleukin-2, and gamma interferon. Similar in vitro problems in immune responses to other antigens have also been described. Although natural killer cells are scarce among synovial cells, they are present in normal numbers in the blood. Whether these select immunodeficiencies make patients with rheumatoid arthritis more prone to neoplasms, particularly lymphomas, is a question that has not been investigated until now. Nor has it been determined whether the immune abnormalities in rheumatoid arthritis make patients more prone to neoplasms from the therapeutic agents used in their treatment. | |
| 1224808 | [Diagnostic-therapeutic problems on heart involvement in chronic polyarthritis]. | 1975 Jan | 200 in-patients with rheumatoid arthritis (RA) were examined with regard to the diagnostic criteria for early recognition of rheumatoid heart involvement. 75 patients showed some evidence (37.5%). The criteria are: subjectively, reduced general state, feeling of oppression, disproportional tachycardia and dyspnea: objectively, changes in the electrocardiogram (tachycardia, T-inversions sometimes resembling to infarct pictures, disturbances of repolarization, extrasystoles and AV blocks). The severity of the change may alter rapidly. Severe myocarditides may manifest as heart failure and dilatation of rapid onset. For prognostic and therapeutic reasons the recognition of a heart involvement, despite these often minimal appearances, is important. It is remarkable that there was no correlation between the activity of rheumatoid process, the titre of rheumatoid factor, and the degree of heart involvement. Age and age of onset, duration of disease and sex also showed no correlation with rheumatoid heart involvement. | |
| 6380897 | Comparison of diclofenac and indomethacin suppositories in rheumatoid arthritis. | 1984 Mar | The efficacy and tolerability of 100 mg suppositories of diclofenac sodium (Voltaren) and indomethacin were investigated in relieving symptoms of rheumatoid arthritis. Thirty patients were included in a double-blind, cross-over study for two weeks - six days with diclofenac suppositories, following two days with placebo and six days with indomethacin. Diclofenac sodium and indomethacin were given in random order. Both treatments improved the status of the disease as compared with the situation before the treatment (p less than 0.01). No statistically significant difference was found between the efficacy of indomethacin and diclofenac sodium, as regards both the doctor's and the patient's global assessments. The two treatments were equally well tolerated. | |
| 6339997 | [Basic therapy of rheumatoid arthritis with thiopronine. Preliminary results]. | 1983 Mar 31 | A long term open study of the use of thiopronine in the treatment of 38 patients with ARA classified "classic" or "definite" rheumatoid arthritis is reported. Doses of the drug were increased from an initial 250 mg per diem by the addition of 250 mg every 15 days to 1 g per diem. After 6 months testing, results were satisfactory (good and fair) in 65% of the cases in both biological and clinical terms. In 15% of the cases, treatment was interrupted mainly due to mucous and cutaneous side effects. These preliminary results confirm reports in the literature and encourage further experiment. | |
| 4045843 | Measurement of exercise tolerance in patients with rheumatoid arthritis and osteoarthritis | 1985 Jun | We evaluated the effect of strenuous aerobic exercise on joint symptoms and compared the functional capacity and muscle strength among patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and very sedentary matched controls. Strenuous ergometer exercise did not exacerbate joint symptoms in these patients. Isotonic leg extension and flexion as well as grip strength were diminished in the RA and OA subjects compared to controls (p less than 0.05). All subjects displayed low maximum oxygen consumption indicating reduced functional capacity. Acute bouts of strenuous exercise performed on bicycle ergometer do not appear harmful to the nonacute arthritis patient. | |
| 4091059 | Cervical neurological complications of rheumatoid arthritis. Surgical treatment techniques | 1985 | A critical study of 11 cases with neurological complications resulting from damage to the cervical spine during rheumatoid arthritis prompts the authors to reconsider their therapeutic strategy. After recalling the various neurological complications and their mechanisms, they propose an extension of the range of indications for surgical treatment. The limits of this extension are defined according to neurological and radiological criteria and the risks inherent in each method. | |
| 238275 | Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthriti | 1975 May | Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen. It could be a most useful drug when gastric problems limit the dose of aspirin or of other analgesics. | |
| 38216 | Cutaneous rheumatoid vasculitis. | 1979 Jun | Rheumatoid arthritis is a multisystem disease, with many clinical forms bearing close resemblance to systemic lupus erythematosus, dermatomyositis or polyarteritis nodosa. Although the involvement of the integument is not as disabiling as the joint disease, the extent of disability may be of sufficient magnitude to necessitate therapeutic intervention. Two patients are presented whose skin involvement was suggestive of cutaneous angiitis and who responded dramatically to treatment using sulfasalazine. | |
| 7299760 | Levamisole in rheumatoid arthritis: a comparison with D-penicillamine. | 1981 Jul | Levamisole (150 mg 3 days/week) was compared with D-penicillamine (250 mg increments at 2--3 monthly intervals) in a single, blind independent observer trial of 1 years' duration in 32 patients with rheumatoid arthritis. The clinical responses, evident after 3 months, were comparable and significant. Six patients on levamisole and 4 on penicillamine withdrew due to side effects. In the subsequent open study 3 of 8 patients continued on levamisole for up to 4 years, while 6 of 9 remained on penicillamine. The findings are compared with those of other trials. | |
| 64412 | [Fibrinolysis before and after gold therapy in rheumatoid arthritis]. | 1976 | In 12 patients with chronic rheumatoid arthritis the immunoglobulins IgG, IgA and IgM were determined according to Mancini and the fibrinolytic split products according to Nilehn before and after a gold treatment of 3 to 6 months. The IgG values were always increased and even after the treatment there was only little regression. The fibrinolytic split products found in 5 cases speak in favour of an enhanced intravasal coagulation, which increased still further after the gold therapy. In spite of clinical improvement the immunological processes and latent actions of coagulation seem to pass almost undiminished. | |
| 6978279 | [Immunological diagnosis of connective tissue diseases (author's transl)]. | 1981 Nov | Collagenoses are diseases which belong to rheumatological disorders however are not easily defined. Especially at the beginning they may show various symptoms typical for one or the other well defined entity as rheumatoid arthritis, systemic sclerosis or lupus erythematodes. Etiology and pathogenesis are nearly unknown. The attempt is made by the author with differentiated descriptions of the multiple laboratory parameters to facilitate the diagnostic classification. | |
| 7455638 | Rheumatoid backward dislocation of the atlas with compression of the spinal cord. | 1980 | A 61-year-old man suffered a rheumatoid destruction of the dens of the C-2 vertebra with subsequent backward dislocation of the atlas resulting in tetraparesis. The clinical picture was consistent with a central spinal cord syndrome with motor impairment more of the upper than of the lower extremities. Reduction of the dislocation with skull traction followed by a posterior fixation from the occiput to C-3 resulted in a marked neurological restitution. |