Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2985298 | Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus eryth | 1985 Feb 28 | Collagenase-like (CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjögren's syndrome. | |
| 126543 | Serum IgD and IgE in rheumatoid arthritis. | 1975 Feb | Serum immunoglobulins IgD and IgE have been determined by a single radial immunodiffusion technique and a radioimmunoassay method in serum samples from 95 rheumatoid patients, 5 subjects with Sjögren's syndrome and 50 healthy controls, and compared with levels of IgG, IgM and IgA fractions measured in the same subjects. The IgD and IgE serum content resulted similar in the rheumatoid, Sjögren's and control sera. No correlation of IgD and IgE values with changes of other immunoglobulins or with the activity and the duration of the rheumatoid disease was observed. | |
| 2933836 | [Effect of hemosorption on the dynamics of immunopathologic changes in the skin of patient | 1985 | In the majority of diseases with the immune complexes (IC) syndrome, elimination of IC from the body is markedly disturbed. The authors carried out a study with the aid of the direct immunofluorsecence technique. The use of hemosorption in the treatment of patients with grave patterns of systemic lupus erythematosus, rheumatoid arthritis, psoriasis, systemic vasculitis and similar illnesses in conjunction with conventional therapy (corticosteroids, cytostatics) leads to sequestration of the depositions of immune complexes from the skin. As early as after the first hemosorption one can observe the displacement of IC from the derma to the epidermis, advance of IC towards the stratum corneum. After the third session in hemosorption IC granules appear on the body surface, in the form of warty formulations which are removed afterwards together with skin scales. It is assumed that hemosorption recovers the secretory function of the skin, aimed at IC elimination. | |
| 6609412 | The significance of IgM antinuclear antinuclear antibody in rheumatoid arthritis and other | 1984 | An investigation of the incidence of IgG and IgM antinuclear antibodies (ANA) in patients with connective tissue diseases showed that IgM ANA predominated in rheumatoid arthritis, whilst in systemic lupus erythematosus IgG antibodies were more common. Patients with other connective tissue diseases less frequently had antinuclear antibodies and there was little difference in the incidence of IgG and IgM antibodies. Cross reacting rheumatoid factors contributed to the IgM antinuclear activity of rheumatoid sera. IgM ANA was not related to disease activity in patients with rheumatoid arthritis. Immunoglobulin class differences of ANA in rheumatoid arthritis and systemic lupus erythematosus may reflect the differing pathological processes of these two diseases and may be of value in their differential diagnosis. | |
| 7441345 | Odontoid compression of the brain stem in a patient with rheumatoid arthritis. Case report | 1980 Dec | Cervical spine involvement by rheumatoid arthritis is common; brain-stem compression secondary to vertical subluxation of the odontoid in patients with rheumatoid arthritis is rare. Vertical subluxation results from 1) destruction of the transverse atlantal, apical, and alar ligaments of the atlas and odontoid, and 2) bone resorption in the occipital condyles, lateral masses of the atlas, and basilar processes of the skull. Neurological symptoms result from direct compression of the brain stem or from ischemia secondary to compression of vertebral arteries, anterior spinal arteries, or small perforating arteries of the brain stem and spinal cord. A case is reported in which a slowly progressive neurological deficit developed in a woman with rheumatoid arthritis following a fall from a stretcher. Neruological symptoms represented direct compression of the medulla by the dens, a mechanism confirmed at operation and autopsy. Recognition of progressive neurological deficit is often difficult in patients with rheumatoid arthritis because of their inactivity and their atrophic and immobile joints, but is essential if appropriate decompressive or stabilizing procedures are to be done. In patients with vertical subluxation of the dens, the transoral approach with removal of the odontoid is recommended. Decompression should be extensive, including the fibrous capsule around the odontoid and overlying synovial tissue as well as the odontoid itself. | |
| 6699841 | Renal papillary necrosis due to naproxen. | 1984 Feb | A 31-year-old man with rheumatoid arthritis, who had previously been treated with sulindac, fenoprofen calcium, high dose salicylates and gold salts, developed renal papillary necrosis (RPN) 4 months after institution of naproxen therapy. No other factor predisposing to RPN could be discovered. Sulindac was substituted for naproxen and no further adverse renal effects occurred over the next 12 months. We review previous reports linking RPN to antiinflammatory drug use and discuss possible advantages of sulindac in patients who have experienced renal toxicity from other antiinflammatory agents. | |
| 810671 | [Psychodynamic factors in some rheumatoid factor negative arthritic diseases (author's tra | 1975 Sep | A total of 32 patients with rheumatoid factor negative diseases were investigated by depth psychology: patients with palindromic rheumatism, Reiter's disease and psoriatic arthritis. In each case a typical psychosyndrome could be found correlative with the somatic syndrome, in which the specific form of working out of aggression was at the focal point. An association of psychic factors in the etiopathogenesis of these arthritic diseases is consequently very probable. | |
| 7371258 | Evaluation of the early result of Smith total ankle replacement. | 1980 Jan | The Smith total ankle replacement was performed in 21 joints. During a 3-year period, the function was good in 50% of the patients with traumatic degenerative arthritis and 40% with rheumatoid arthritis. Improper technique, infection and component loosening were the most common causes of failure in 11 patients, with fair to poor prognosis. | |
| 3863513 | Shoulder synovectomy. | 1985 | The technique and results of synovectomy of the shoulder joint in rheumatoid arthritis with a mean follow up time of 5.3 years (1-16 years) is described. The original method included resection of acromion after loosening of the deltoid muscle and splitting of the rotator cuff. Since 1981 the simpler approach of Neer without resection of acromion has been used (for synovectomy as well as for prosthetic replacement) with an easier postoperative management and equally good results. Only in 6 of 54 shoulders a total replacement prosthesis has been inserted later, an indication of the lasting good effect of synovectomy, even in advanced cases where an additional debridement was necessary. The best results are obtained in early cases. Radiographic changes are late, indications should be based more on clinical findings. Access to good training facilities is mandatory. | |
| 781227 | Fenoprofen in rheumatoid arthritis: a controlled crossover multi-centre study. | 1976 | The pooled data of a multi-clinic, double-blind, crossover study (16 weeks' duration), comparing fenoprofen and aspirin in 116 patients with active rheumatoid arthritis are reported. Each patient received fenoprofen (400 mg Q6H) and aspirin (1,000 mg Q6H) for six-week periods, in random fashion. Usual objective and subjective parameters were used to evaluate rheumatic activity. Side effects were obtained by daily telephone interviews, and appropriate laboratory tests were performed during weekly out-patient evaluations. Both fenoprofen and aspirin were significantly more effective than placebo in controlling rheumatoid activity. At the dosage level employed, no significant differences were noted between the two anti-inflammatory agents in regard to efficacy. However, fewer side effects were observed with fenoprofen than with aspirin. The data indicate that fenoprofen is an additional valuable agent for rheumatoid arthritis. | |
| 7468642 | Dissected popliteal cyst: an unusual presentation of acute gout. | 1981 Jan | A forty-six year old man with acute gout and a dissected popliteal cyst presented with clinical features which mimicked rheumatoid arthritis and thrombophlebitis. The clinical and laboratory diagnosis of the case are presented and similar cases previously reported are briefly reviewed. | |
| 1244092 | Tryptophan metabolism in the joint diseases. | 1975 | Tryptophan metabolites through kynurenine pathway and 5-hydroxytryptophan pathway in the synovial fluid, blood and urine of patients with rheumatoid arthritis and those with osteoarthritis were investigated in order to know the specificity of the tryptophan metabolism, especially the role of serotonin in the joint diseases. A metabolic map of tryptophan in the synovial fluid was also made. It was found that tryptophan in rheumatoid arthritis was metabolized mainly to anthranilic acid through kynurenine in the kynurenine pathway, whereas in osteoarthritis the pathway of kynurenic acid and nicotinic acid was characteristic. Otherwise in 5-hydroxytryptophan pathway there were no significant differences in the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in the synovial fluid between rheumatoid arthritis and osteoarthritis but the activity of monoamine oxidase in the synovial fluid was higher in osteoarthritis than in rheumatoid arthritis. | |
| 6605120 | HLA DR alloantigens in different subsets of patients with Sjögren's syndrome and in famil | 1983 Oct | Patients with Sjögren's syndrome alone (Ss), Sjögren's syndrome with rheumatoid arthritis (Ss-RA), and Sjögren's syndrome with Raynaud's phenomenon (Ss-RP) were typed for the HLA DR and MT antigens. Ss-RA patients had higher frequencies of HLA DR4 than did Ss patients. HLA-DR4 was also increased in frequency in patients with Ss-RP. This group of patients also showed increases in frequencies of HLA DR3. MT2 frequencies were elevated in all 3 patient groups, while MT1 was only increased in Ss. Three families with multiple individuals with Sjogren's syndrome were typed for HLA antigens. The affected individuals inherited unique combinations of haplotypes, suggesting the possibility of haplotype interaction in predisposition to disease. | |
| 3876076 | Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes. | 1985 Sep | Biochemical, hormonal, and kinetic indexes of bone turnover were measured in 17 ambulant female patients with rheumatoid arthritis (RA) of recent onset (mean disease duration 14.2 months) and 19 controls. Mean serum osteocalcin concentration and 85Sr accretion rates were reduced and mean urinary hydroxyproline-creatinine ratios were increased in RA, but these differences were not significant compared with control values. Mean total body potassium (TBK), an index of skeletal muscle mass, was significantly reduced in RA, and the ratio of observed to predicted TBK correlated with indexes of bone formation. No abnormality of skeletal metabolism could be shown in early RA, but reduced rates of bone formation associated with diminished muscle mass may influence the development of osteopenia later in the disease. | |
| 1121634 | Carcinoembryonic antigen in rheumatic diseases. | 1975 Feb | In an earlier study, the mean plasma carcinoembryonic antigen (CEA) level of patients with seropositive rheumatoid arthritis (RA) was found to be significantly higher than that of normal, control subjects. Levels of CEA in patients with seronegative RA and ankylosing spondylitis, however, did not differ from normal. In this study it was shown that the mean CEA level of 16 patients with Sjögren's syndrome was also significantly higher than normal (P equals 0.001), whereas in a group of 23 children with Still's disease the mean level fell within the normal adult range. Despite the apparent association between rheumatoid factor and raised plasma CEA, no correlation was found between titre of rheumatoid factor and CEA levels. Gel filtration studies indicated that the CEA in rheumatoid arthritis was of a similar molecular weight to that found in cancer of the colon and that there was minimal contribution by the known cross-reacting antigen CCEA2. The mean CEA level in rheumatoid synovial fluids was found to be significantly higher than in osteoarthrotic fluids. A preliminary study has also shown that CEA can be extracted from rheumatoid synovial membranes but was not detected in a normal synovium, further indicating that the source of this antigen in RA may be the inflamed synovium. | |
| 6583412 | Histopathology of the subchondral bone lesion in rheumatoid arthritis. | 1983 Dec | Lesions observed in the subchondral marrow of metatarsal and metacarpal heads in advanced rheumatoid arthritis are characterized by proliferation of fibroblasts, deposition of collagen, formation of thin-walled vascular channels, infiltrates of macrophages, lymphocytes and plasma cells, and new bone formation. The overlying hyaline articular cartilage is often necrotic; pannus formation is absent. Although the tissue reaction is basically reparative in nature, aggregates of lymphocytes and plasma cells are also observed around small blood vessels in deeper regions of the bone marrow and may point to a primary bone lesion in this disease. | |
| 516210 | Late hemorrhagic cystitis following low-dose cyclophosphamide therapy. | 1979 Dec | Hemorrhagic cystitis is a recognized acute complication of cyclophosphamide (Cytoxan) therapy in the treatment of malignant disease. More recently, lower dose, long-term cyclophosphamide therapy has been used in the treatment of autoimmune diseases including rheumatoid arthritis. In 3 patients hemorrhagic cystitis developed after long-term cyclophosphamide therapy for rheumatoid arthritis. Even in low dosage, this drug may cause hemorrhagic cystitis. | |
| 7225502 | [Technic for isolation and culture of macrophages from human synovial fluid]. | 1980 Nov | Macrophages from synovial fluid were obtained by joint puncture of patients with rheumatoid arthritis or non-rheumatoid exudative arthropathies. This fluid was subsequently centrifuged and the resulting cell pellet was recovered and distributed for in vitro culture (Falcon Petri dishes: 60 x 15 or 35 x 10). Cells were washed after 4 hours in culture to eliminate non-macrophagic cells. A second cell wash was effected 24 hours later to eliminate non-adherent cells. The culture medium employed was fetal calf serum MMP 119 (Gibco). The macrophagic nature of the cultured cells was ascertained by non specific esterase determinations (Burstone method) and estimation of the phagocytic index (using zymosan). This technique permits the conservation of viable monocytes in culture thus facilitating investigation of their metabolic activity (for example: prostaglandins, prostanoids or fatty acids) and the effects of anti-inflammatory agents. | |
| 6982292 | Diagnosis and management of rheumatic diseases in older patients. | 1982 Nov | The young and the old move differently, yet there are standards of normality for each. Chronic diseases of the joints, with their concomitant stiffness and pain, cause more fear of an impending crippling disability and loss of life space and content than actual pain and stiffness. Thus, a prime goal of physicians who treat patients who have chronic musculoskeletal diseases is to allay this fear by correcting misconceptions about arthritic diseases. Drug therapy can relieve the pain and stiffness and control the inflammation that causes these symptoms. Important aspects of rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica, a closely related disorder, are emphasized to point out the difficulty of the differential diagnosis of these diseases in older patients and the need for realistic therapeutic goals. A combination-drug regimen, with a nonsteroidal anti-inflammatory drug for alleviation of pain and control of inflammation and an analgesic drug for relief of residual pain, is the drug therapy of choice within the context of a total management program. By addressing both the physiologic and the psychologic aspects of musculoskeletal disease, physicians can help patients lead more active and useful lives. | |
| 6460054 | Efficacy and toxicity of D-penicillamine for rheumatoid disease in the elderly. | 1982 Feb | The efficacy and the toxicity pattern of D-penicillamine were studied in patients with rheumatoid disease followed up between April 1975 and March 1979. The population of patients was divided into an elderly group (greater than or equal to 60 years old, mean = 65 years) and a younger group (less than 60 years old, mean = 41 years). Patients with classic or definite rheumatoid disease not responsive to nonsteroidal drugs were eligible. The mean durations of disease prior to D-penicillamine therapy were five years in the elderly and seven years in the younger group. Overall, the mean follow-up time was 11 months. The average dosages of D-penicillamine were 461 mg/day in the elderly and 520 mg/day in the younger patients. Results indicated that D-penicillamine was efficacious in 75 per cent of the elderly during all time periods after three months, and in 75 per cent of the younger patients after three months until at least two years. Prior gold-salt therapy did not influence efficacy. Toxicity was significantly greater in the elderly for overall skin rash (P less than 0.01), severe skin rash (P less than 0.01), and marked abnormalities in the ability to taste (P less than 0.05). The incidence of hematologic toxicity was not increased in the elderly compared with the younger patients. Toxicity in either group was not influenced by prior gold-salt therapy. It is concluded that D-penicillamine was equally efficacious in both elderly and younger groups, and that the toxicity patterns were similar except for increased tendencies toward rashes and taste abnormalities in the elderly. |