Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 140691 | Immune complexes and complement catabolism in ankylosing spondylitis. | 1977 May | In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I-Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immunochemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly (greater than 2 SD), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis. | |
| 7440604 | Total elbow replacement. | 1980 Dec | Thirty-one patients who underwent thirty-six total elbow replacements between 1974 and 1977 were followed for a minimum of two years with an average of 3.7 years. A scoring system was used to quantitate results. Patients with rheumatoid arthritis and functional disability primarily related to pain benefited most from the operation. Patients with post-traumatic arthritis and disability secondary to loss of motion benefited least. The over-all complication rate was 53 per cent and the reoperation rate was 22 percent. However, only one-fourth of the complications adversely affected the final outcome. Total elbow replacement can give good results in carefully selected patients. | |
| 788748 | How double blind is double blind? And does it matter? | 1976 Apr | In an apparently double blind crossover study, two experienced measurement technicians were able to identify many of the treatment periods. They most often correctly identified aspirin, a drug with prominent effects and side effects. It is argued that in many circumstances it is better to use a blind observer who is not concerned with the giving of treatment or the collection of side effects. | |
| 6974624 | Human post-thymic precursor cells in health and disease. IX. Immunoregulatory T cell circu | 1981 Mar | We studied T cell subpopulations and their immunoregulatory circuits in the peripheral blood of 16 patients with rheumatoid arthritis (RA) who were receiving no medications that might interfere with the results. We found normal T cells with receptors for the Fc portion of IgG or IgM as well as autologous rosette-forming T cells (Tar cells), a subpopulation of T cells we have found to have the properties of human post-thymic precursors. We also found that peripheral blood cells of RA patients have normal concanavalin A-induced or spontaneously-expanded suppressor cell functions. Also normal were the characteristic functions of the Tar cells; feedback inhibition and the generation of suppression. The normal state of these T cell subpopulations and immunoregulatory circuits in the peripheral blood of patients with RA contrasts with their various abnormalities in other connective tissue diseases. This may either mean that the immunoregulatory aberration in RA involves primarily B cells, or, if it involves T cells, that it does so primarily in the synovial membrane. | |
| 7459013 | Neo-antigenic expression in rheumatoid synovia? | 1980 Mar 31 | CEA-like activity was found in eight synovial samples of ten rheumatoid patients and in two samples of patients with recurrent arthrosynovitis. No CEA-like activity was found instead in seven synovial samples of patients with gonarthrosis. The plasmatic values result always within normal range in the non-rheumatoid patients and high only in two cases of rheumatoid ones. Since enzymatic proteolysis induces a synovial CEA-like activity fall, the A.A. think that the antigenic determinants belong to a "protein" locally synthesized. | |
| 4071429 | [Problems of rheumatoid heart defects]. | 1985 | Of 160 patients with RA treated at the clinic recently, heart disease was diagnosed in 4. In 2 patients, mitral disease was recognized as rheumatic, in one patient, aortal disease was treated with a great probability as rheumatoid. In 4 patients, rheumatoid etiology of the disease was advanced and then was confirmed at autopsy. It is assumed that rheumatoid heart disease occurs more frequently than diagnosed. | |
| 6979553 | Cellular localization of rheumatoid factor idiotypes. | 1982 Jun | the stimulation of lymphocytes from rheumatoid arthritis patients with pokeweed mitogen produces a large number of plasma cells that express the dominant cross-reactive idiotype previously found on monoclonal IgM anti-gamma-globulins from patients with mixed cryoglobulinemia. Similar experiments with the cells of normal individuals show a much lower percentage of these cells with a lower intensity of staining with the fluorescent reagents utilized. Efforts to demonstrate rheumatoid factor in the same cells by fluorescent staining with aggregated gammaglobulin were entirely unsuccessful. This also proved to be the case for pokeweed mitogen-stimulated cells from the mixed cryoglobulinemic patients with large amounts of rheumatoid factor in the serum, despite high percentages of cells expressing the cross-reactive idiotype and also the individual idiotype. On the other hand, native plasma cells from synovial tissue of rheumatoid arthritis patients showed some cells with both the cross-reactive idiotype and aggregate staining. The exact reason for the failure to demonstrate rheumatoid factor by aggregate staining in pokeweed mitogen-stimulated cultures remains to be determined despite considerable effort to resolve the problem. The most likely possibility is that these plasma cells are relatively immature and have not accumulated polymeric IgM in their cytoplasm to the degree seen in synovial tissue plasma cells. The monomeric forms are readily recognized by the antiidiotypic antibodies and these reagents appear to be of particular value for cellular studies of this type. | |
| 465102 | Glycosaminoglycan synthesis and glucose uptake by rheumatoid and nonrheumatoid fibroblasti | 1979 Aug | Glycosaminoglycan (GAG) synthesis and glucose uptake by rheumatoid (R) and nonrheumatoid (NR) synovial cells were studied at the second subculture during four different sets of nutritional conditions and at sequential, defined intervals of the growth cycle. Synovial fibroblastic cells in monolayer cultures secrete both hyaluronic acid and sulfated GAGs in a ratio of about 8 : 1. With increasing cell density the ability to sulfate GAGs appears to decrease. No significant differences in GAG synthesis between rheumatoid and nonrheumatoid lines on a per cell basis could be detected during any interval in the growth cycle. Similarly, no significant differences of glucose uptake per cell could be demonstrated between rheumatoid and nonrheumatoid lines under the various protocols applied throughout the growth cycle. The most important factor determining glucose uptake per cell is the availability of glucose in the medium which is in turn closely correlated with cell number. | |
| 7042356 | Long-term, double-blind, between patients comparison of indoprofen and indomethacin in rhe | 1981 | Forty-one patients suffering from classical or definite rheumatoid arthritis were randomly allocated to either indoprofen (800 mg/day) or indomethacin (100 mg/day) treatment in a double-blind, comparative long-term study (6 months). Both drugs reduced the symptoms of rheumatoid arthritis. A marked improvement was generally achieved within the first month and was maintained thereafter. Indoprofen was somewhat better tolerated than indomethacin. | |
| 340006 | Indoprofen and naproxen in the treatment of rheumatoid arthritis: a clinical trial. | 1978 Feb 4 | Thirty-six patients suffering from rheumatoid arthritis took part in a double-blind crossover trial, in which they received either indoprofen 800 mg/day, naproxen 500 mg/day, or a matching placebo. Indoprofen was shown to be significantly superior as an analgesic and in improving grip strength and the patients preferred it. Adverse effects were comparable, although indigestion was seen slightly more often during indoprofen treatment. Indoprofen is therefore at least as effective as existing anti-inflammatory drugs in rheumatoid arthritis and seems to be better tolerated. | |
| 778443 | An investigation of leukocyte function and phagocytosis of immune complexes in patients wi | 1975 Feb | By means of the nitroblue tetra-zolium (NBT)-dye test, patients with chronic rheumatoid arthritis (RA) were studied. It was found that patients with rheumatoid factor (RF) in their sera displayed higher levels of NBT-dye reduction than those without RF did. In RF(+) serum, the authors observed a remarkable activation of NBT-dye reduction in phagocytosis of immune complexes and 1gG-coated latex particles. A fluorescent antibody technique and immuno-electron microscopy showed an increased phagocytosis of gamma-globulin in peripheral polymorphonuclear leukocytes (PMN) from patients with activated levels of NBT-dye reduction. From these results, it is likely that PMNs from patients, particularly from those possessing high values of NBT-dye reduction, displayed the activated levels of phagocytosing autologous globulin. | |
| 7033386 | IgG rheumatoid factor. Detection by enzyme immunoassay in rheumatoid arthritis and normal | 1981 | IgG rheumatoid factors were demonstrated by enzyme immunoassay using, as antigen, goat antibodies to human serum albumin in the form of immune complexes. Elevated levels of IgG rheumatoid factor were noted in the majority of patients with seropositive rheumatoid arthritis but also relatively often in normal blood donors. Reactivity of IgG rheumatoid factor was in most instances inhibitable by IgG from various species, including man. Exceptionally, restricted specificity towards IgG from bovidae, was recognized. | |
| 653292 | [The failures of D penicillamine]. | 1978 Mar | On the basis or a study of 50 cases of rheumatoid polyarthritis treated with D penicillamine comments are made on the failure of this form of treatment by comparison of the apparent and real efficacy. Taking account of withdrawals the percentage of true success is no more than a quarter of the patients treated with D penicillamine. Failure are due to overall inefficacy, dropouts from treatment and intolerance. The practical data on the indications and contra-indications of treatment, its conduct and supervision are defined. | |
| 6996687 | Absence of immunoglobulins in rheumatoid cartilage-pannus junctions. | 1980 Jul | Immune complexes (IC) present in the superficial region of rheumatoid articular cartilage may be an important factor in the invasion of the cartilage by pannus. The presence of such IC at the cartilage-pannus junction in rheumatoid articular cartilage invaded by pannus was investigated by using immunoelectron microscopy with horseradish peroxidase anti-human immunoglobulin (Ig). It was observed that, although the pannus-free surface of the cartilage contained easily detectable deposits of Ig, the areas covered by pannus failed to show any Ig in the 5 5 patients studied. This was true even in areas immediately adjacent to the advancing edge of the pannus which presumably had only recently been invaded by the granulation tissue. These results were confirmed by fluorescent antibody ultraviolet microscopy. It was concluded that rheumatoid pannus invasion of the free cartilage surface containing trapped IC results in the disappearance of such complexes. | |
| 879863 | Functional assay of cytotoxic lymphocytes involved in antibody-mediated cytotoxicity in no | 1977 Jun | Antibody-mediated lymphocyte-induced cytotoxicity (K cell activity) was measured in a system consisting of Chang human liver cells, rabbit anti-Chang antiserum, and Triosil-Ficoll purified human lymphocytes. It was concluded that one K cell probably inactivates or kills one target cell, and that the number of active K cells is similar in the peripheral blood of normal and rheumatoid subjects and is about 0-5%. | |
| 7326067 | Permeability of rheumatoid and normal human synovium to specific plasma proteins. | 1981 Dec | A method is described for the determination of the permeability of the blood-joint barrier to specific plasma proteins, using the ratio of protein concentration in synovial fluid to that in plasma. The inadequacy of the ratio per se as a direct index of permeability is discussed. Permeabilities are evaluated for the normal and rheumatoid human knee. Permeability increases in the rhematoid knee by approximately 6 times for the rheumatoid knee by approximately 6 times for albumin and over 40 times for macroglobulins. The effect of protein molecular dimensions upon permeability is analyzed. Permeability shows less dependence upon solute dimensions in the rheumatoid knee than in the normal knee, i.e., molecular selectivity is reduced. From these data and synovial morphology, a two-membrane model of the blood-joint barrier is developed. The relative contribution of the component intimal and endothelial layers to the total barrier is found to depend upon solute dimensions. | |
| 2931852 | [Activity of short-lived suppressor lymphocytes in rheumatoid arthritis]. | 1985 | Activity of short-lived suppressor lymphocytes was studied in 26 patients with rheumatoid arthritis. Of these, 14 patients had diverse systemic manifestations: rheumatoid nodules, polyneuropathy. Sjögren's syndrome, and Felty's syndrome. It was established that attenuation of the suppressor activity in rheumatoid arthritis is characteristic of patients with systemic manifestations, who show a high level of circulating immune complexes of rheumatoid factors. The most informative data were obtained as a result of the use of the suboptimal dose of Con A having suppressor activity. | |
| 1180753 | Glaucoma in episcleritis. | 1975 Oct | Two patients had episcleritis and a secondary open angle glaucoma. Anterior uveitis was absent in three of the four eyes. The low facility of outflow suggests that increased episcleral venous pressure was not the mechanism of the glaucoma. The response of the intraocular pressure and, in one case, the outflow facility to steroid therapy suggests that inflammation of angle structures was the pathogenesis of the raised intraocular pressure. | |
| 6432405 | Plasma levels and response to prednisolone therapy in rheumatoid arthritis. | 1983 Sep | Plasma prednisolone levels were measured in parallel with clinical and laboratory assessments in seven patients with rheumatoid arthritis on single daily doses of prednisolone which were reduced at weekly intervals from 10 mg. to 7, 6 and 5 mg. A significant negative rank correlation was observed between prednisolone dose and the duration of morning stiffness (p less than 0.05). No significant correlation was observed between plasma prednisolone levels, other clinical assessment criteria or laboratory indices. | |
| 7134745 | Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drug | 1982 Nov | Ninety patients with active rheumatoid arthritis took part in a cross-over trial comparing diclofenac sodium, diflunisal and naproxen. The efficacy of the three drugs was similar though there were trends in favour of diclofenac sodium in some measurements. The incidence of side-effects was similar with the three drugs and each was chosen by a significant group of patients as continuation therapy at the end of the study. |