Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6456498 | [The role of the retinaculum extensorum in the stability of the wrist (author's transl)]. | 1981 | The carpus is attached to the radius mainly by two radiocarpal ligaments, anterior and posterior. These ligaments are not symmetrical and cannot oppose on the ulnar side the action of the longitudinal force of the extrinsic muscles of the fingers. This force is directed by the volar and ulnar inclination of the radial articular surface. This force initiates a movement of supination of the carpus and of anterior subluxation. The main fibrous structure which may oppose this force is the posterior annular ligament (retinaculum extensorum). | |
| 7280487 | Gold lung. | 1981 Aug | A rare syndrome of acute pulmonary damage due to gold therapy is described. It appears to be an entity separate from the usually reported side-effects of gold. It has a good prognosis, responding to the cessation of gold and to corticosteroid therapy. Apart from this syndrome of acute pulmonary damage, there is, as yet, no convincing evidence to incriminate gold as a cause of other pulmonary manifestations which have been attributed to rheumatoid arthritis. | |
| 6320710 | In vitro production of monoclonal human rheumatoid factors. | 1984 Jan | Lymphocytes from rheumatoid arthritis patients have been fused with drug-marked human myeloma cell lines and hybrids selected which secrete rheumatoid factors. Limiting dilution and soft agarose plates have been used to clone these hybrids, but so far stable clones have not been obtained. Epstein-Barr virus has been used to transform lymphocytes, and clones which secrete rheumatoid factors have been obtained. | |
| 4001889 | Hydroxychloroquine treatment and the eye. | 1985 | The eyes of 63 patients, age range 28 to 79 years, affected by rheumatoid arthritis and undergoing long-term hydroxychloroquine treatment were followed from 3 to 95 months. The daily dose of hydroxychloroquine was 300 mg, and after 5 months there was a pause of one month in the treatment. The total amount of hydroxychloroquine received ranged between 27 and 630 g. In the eye examination only one patient had corneal changes, and another patient had suspected retinal damage. This is in agreement with earlier studies. Hydroxychloroquine seems to be a safe alternative among the antimalarial drugs as far as eyes are concerned. | |
| 64410 | [Behavior of the heparinocytes after gold therapy]. | 1976 | A reduction of the total leukocytes as well as a significant decrease of heparinocytes and BAI (basophilic age index) can be observed in rheumatoid arthritis in the course of a gold therapy. As some coagulation parameters simultaneously speak in favour of an enhancement of the intravasal coagulation, a partial blocking of the endogenous heparin caused by gold may be supposed. A combined heparin or heparinoid therapy in a low dosage is being recommended for risk patients of the vascular and coagulation system. | |
| 786007 | Aspirin-induced hepatic dysfunction in a patient with adult rheumatoid arthritis. | 1976 Sep | A patient with classical rheumatoid arthritis receiving high doses of aspirin developed significant elevation of serum glutamic oxaloacetic transaminase. This patient had recently been on phenylbutazone and an initial liver biopsy, at the time of elevation of the transaminase revealed nonspecific mild fatty infiltration of the liver compatible with the pathology seen with rheumatoid disease. Because of the severity and activity of her rheumatoid arthritis, and thus the need to know whether aspirin was the etiologic factor in liver dysfunction, the patient was challenged with aspirin. SGOT elevation occurred after a 4-6 day lag period, which promptly remitted when salicylates were discontinued. A liver biopsy at this time revealed evidence for degeneration, regeneration, and mild focal mononuclear infiltration. Although previous reports note salicylate-related hepatocellular dysfunction in patients with systemic lupus erythematosus and juvenile rheumatoid arthritis, these data clearly demonstrate the relationship of ASA to liver dysfunction in a patient with adult onset rheumatoid arthritis. This histologic picture as well as the clinical course of this patient's hepatic abnormality suggest a toxic rather than hypersensitivity etiology for this syndrome. | |
| 6155692 | Degradation of protein SAA to an AA-like fragment by enzymes of monocytic origin. | 1980 | On incubation in cultures of blood mononuclear leucocytes from normal individuals, protein SAA is gradually degraded and yields an intermediate fragment with the same molecular weight as that of protein AA. This protein fragment has the same antigenic properties as protein AA, as judged from double-immunodiffusion analysis. Cell fractionation studies attribute the degrading capacity to the monocytes. Evidence was also found that the proteolytically active substances was released to the medium by cells in culture. The proteolytic substance, which also degraded protein AA, could be inhibited by diisopropyfluorophosphate and phenylmethyl sulfonylfluoride. This suggested that the enzyme might be a serine protease. | |
| 6486133 | Pain and inflammation. | 1984 Sep 10 | The traditional "aspirin first" approach to the treatment of osteoarthritis and rheumatoid arthritis is undergoing serious reappraisal. Aspirin and acetaminophen are equipotent in their analgesic efficacy; however, aspirin is associated with a higher incidence of side effects. Acetaminophen should therefore be used as first-line therapy for the treatment of osteoarthritis since reduction of pain is the primary therapeutic objective. Analgesic doses of aspirin (up to 3,900 mg per day) do not produce an anti-inflammatory effect and thus are not beneficial in the treatment of rheumatoid arthritis. Only high doses of aspirin (4 to 6 g per day) used for a sustained period produce an anti-inflammatory effect. Since many patients with rheumatoid arthritis cannot tolerate long-term use of anti-inflammatory doses of aspirin, it may be preferable to initiate therapy with one of the newer nonsteroidal anti-inflammatory drugs. | |
| 7389202 | Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis. | 1980 Feb | Immune complexes were isolated from the synovial effusions of patients with seropositive definite or classical rheumatoid arthritis by centrifugation over a sucrose-polyethylene glycol gradient. Physiochemical and immunochemical analysis showed IgG and IgM to be the predominant molecular species with lesser amounts of Clq and moderate amounts of IgA and activated C4 and C3. Very low concentrations of Clr, Cls, factor B and beta 2-microglobulin were detected. Trace amounts of four other components totalling less than 4% of the total protein, were seen and their molecular weights established. Reasons were advanced for thinking that fibrinogen, human serum albumin and alpha 2-macroglobulin were only secondarily associated with the complexes. The data are consistent with the hypothesis that IgG is the main, if not the only antigen, responsible for provoking and maintaining the pathological changes in rheumatoid arthritis. | |
| 7316292 | [Dermatologic aspects of collagen disease (author's transl)]. | 1981 Jul | In this brief review the dermatologic aspects of collagen diseases are stressed. Cutaneous manifestations are the main clinical features from the standpoint of diagnostic evaluation of these disorders. Juvenile rheumatoid arthritis, lupus erythematosus, dermatomyositis and scleroderma are considered. | |
| 6651366 | Relationship between finger and wrist deformities in rheumatoid arthritis. | 1983 Dec | The present study was undertaken to test the hypothesis that there is a significant correlation between the position of the wrist and metacarpophalangeal angulation in the common rheumatoid hand deformities. Measurements were carried out on radiographs of the hand from 2 comparative groups: 67 patients (134 hands) with classical or definite rheumatoid arthritis (RA), and a control series of 50 adults (100 hands) attending the routine fracture clinic. Rheumatoid patients were unselected and included those with a variety of hand deformities. The results showed a statistically significant relationship between finger and wrist deformities in patients with RA but not in the normal controls. | |
| 866800 | [Rehabilitation of rheumatoid arthritis and ankylosing spondylitis: a study of the pre-req | 1977 May | Rheumatoid arthritis/chronic polyarthritis and ankylosing spondylitis belong to the most common inflammatory rheumatic diseases. Owing to their progressive character they can result in morphological and functional defective conditions making rehabilitation procedures necessary. In contrast to other diseases calling for rehabilitation treatment the rehabilitation of these two diseases is in the majority of cases a life-long process, during which a change in rehabilitation goals and procedures is not seldom. Hence, rehabilitation is a dynamic process which requires flexible adjustment. A positive rehabilitation outcome is dependent upon the following factors: (1) the patient's disease (duration, stage, type of affection, progression, inflammatory and immunological activity, general condition and drug tolerance), (2) the patient's personality (age, intelligence, motivation), (3) the patient's home and vocational environments. In addition to technical pre-requisites, which are also important, the following medical ones have to be outlined: early diagnosis and initiation of therapy and the availability of a comprehensive treatment programme embracing drug, surgical, physical and balneological therapies, also as an in-patient. A further pre-requisite is the high rheumatological qualification of the responsible physician, who must maintain good contacts with the other members of the rehabilitation team. In the long run, this qualification can only be achieved with the provision of adequate training programmes, and if rheumatology is accepted as an independent discipline. | |
| 7433352 | [Rheumatoid pleurisy with cholesterol pleural effusion. A single case. Literature review ( | 1980 May | The authors report a new case of rheumatoid pleurisy proved by the clinical contest and the biological samplings of pleural fluid: a pleurisy with cholesterol pleural effusion. Six observations of rheumatoid pleurisy with cholesterol pleural effusion were found in the literature. This new case confirms this biological peculiarity of rheumatoid pleurisies and the authors insist on the existence of acute pleurisies with cholesterol pleural effusion. | |
| 3874608 | Are disease duration and degree of functional impairment determinants of bone loss in rheu | 1985 Jun | One hundred and five patients with rheumatoid arthritis treated with a variety of antirheumatic drugs, excepting glucocorticoids, were stratified according to the degree of functional impairment (functional classes I to IV) and duration of the disease (0-3 years; 4-8 years; and greater than 8 years). The variables investigated were distal forearm bone mineral content (BMC), biochemical markers of bone formation: serum alkaline phosphatase and serum bone gamma-carboxyglutamic acid containing protein (BGP) and biochemical markers of bone resorption: fasting urinary calcium and fasting urinary hydroxyproline. Significant relationships were found between BMC and functional impairment and duration of the disease. Indices of bone formation and bone resorption rose with increasing functional impairment, particularly those of bone resorption. It is concluded that disability induces osteopenia in rheumatoid arthritis by increasing the bone turnover with a more marked increased in resorption than in the formation processes. The effect of the disease duration is merely that of adding more years of functional impairment. | |
| 6939887 | Autoantibody formation in D-penicillamine-treated rheumatoid arthritis. | 1981 Jan | One hundred and two rheumatoid arthritis patients were tested before treatment for the presence of 16 autoantibodies. Low titers of antinuclear factors appeared, but there were no antitissue antibodies. At different intervals during the treatment of a 2nd series of 176 patients, elevations of antinuclear factors were observed that correlated slightly with either autoimmune or toxic side effects. Antitissue antibodies were seen only in pemphigus and myasthenia after the onset of these complications. The practical value of systematic evaluation for autoantibodies in penicillamine-treated rheumatoid patients is questionable. | |
| 6582268 | Prevalence of primary and secondary fibrositis. | 1983 Dec | Of 1,473 consecutive new patients seen in an outpatient rheumatology clinic, 3.7% met criteria for "primary fibrositis." Secondary fibrositis was diagnosed in 12.2% of patients with rheumatoid arthritis (RA), 15.7% of patients with primary neck and back pain syndromes and 6.7% of patients with osteoarthritis (OA). When conditions presumed to be associated with secondary fibrositis were excluded, primary fibrositis was identified in 55 of 405 patients or 13.6%. Two hundred fifteen or 14.6% of all patients had either primary or secondary fibrositis. Fibrositis may be the most common disorder seen in rheumatic disease practice after OA and RA. | |
| 49444 | Transurethral prostatectomy in patients with severe hip deformity. | 1975 Sep | The use of a modified lithotomy position and perineal urethrotomy has permitted transurethral prostatectomy in patients with severe hip disease. The procedure is described. | |
| 6887168 | Pseudogout masking other arthritides. | 1983 Jun | Of 314 patients with proved pseudogout, 9 had a separate serious disease in the same joint: 5 had septic arthritis, 2 rheumatoid arthritis, 1 psoriatic arthritis, and 1 hypertrophic pulmonary osteoarthropathy. In every instance but one, the episode of crystal synovitis appeared to be provoked by the new inflammatory process, disturbing previously asymptomatic chondrocalcinosis. Pseudogout attacks, although generally idiopathic solo events, can mask septic and chronic inflammatory arthritis. | |
| 102654 | Capillary column gas chromatography--mass spectrometry in studies on rheumatoid arthritis. | 1978 Oct 1 | A method is described for determining the organic acid profile of synovial fluid. The method requires 50--100 microgram of sample and involves ion exchange for isolation of the acids followed by combined capillary column gas chromatography--mass spectrometry. Normal synovial fluid and synovial fluid from patients with rheumatoid arthritis show a similar qualitative pattern of acids (mainly fatty acids) resembling the pattern found in serum. The concentrations of the organic acids in the abnormal synovial fluids are 5--10 times higher than those in the fluid from the normal joints. In patients receiving treatment with gold thiomalate, free thiomalate was excreted in the urine. The release of this thiol upon gold therapy is of consequence for the further understanding of the mechanism of action of certain drugs against rheumatoid arthritis. | |
| 1096275 | A double-blind cross-over trail of Prenazone and aspirin in the management of rheumatoid a | 1975 May | A double-blind cross-over trial of Prenazone 600 mg and Aspirin 4 g daily was carried out on 20 patients suffering with rheumatoid arthritis. The analgesic and anti-inflammmatory activity was indistinguishable from that of aspirin under the conditions of the trail. Twelve patients expressed a general preference for Prenazone and six for aspirin. Prenazone appeared to be well tolerated and free from serious side-effects. These results suggest that it will be a useful drug in the management of rheumatoid arthritis. |