Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6149715 | Clinical and prognostic significance of vasculitis as an early manifestation of connective | 1984 Dec | The courses of 18 patients with arthritis and vasculitis in the first 2 years after onset of disease (mean follow-up, 54 months) were studied. The patients were categorized as having rheumatoid vasculitis, systemic vasculitis, and undifferentiated connective tissue syndrome. These patients cannot be distinguished on basis of organ involvement by vasculitis or histopathologic findings on biopsy, but can be separated clinically by the extent of joint involvement and the presence or absence of rheumatoid factor and antinuclear antibody. Early onset of vasculitis is associated with a poor outcome, especially in patients with rheumatoid arthritis, with rapid progression to vasculitic involvement of the viscera, resulting in death. On the basis of the 54-month follow-up period involving this selected series, the prognosis of patients with systemic vasculitis and undifferentiated connective tissue syndrome appears more favorable than that of patients with rheumatoid vasculitis. | |
| 6411434 | Hypoxemic respiratory failure in rheumatoid arthritis: gold related? | 1983 Sep | This report describes a patient with rheumatoid arthritis, treated with gold salts, that led to hypoxemic respiratory failure and rapid death, in an otherwise healthy adult with no cardiopulmonary history. The unique clinical, radiologic, pathologic, and therapeutic aspects of this case are discussed. | |
| 6318342 | [Pharmacokinetics of ketoprofen in the synovial fluid]. | 1983 Dec 12 | Serum and synovial fluid concentrations of ketoprofen were studied after administration of 50 or 100 mg in a single oral dose to patients with rheumatoid arthritis. Results show that ketoprofen is rapidly absorbed. Serum concentrations are similar in patients and healthy subjects. During the initial phase, plasma half-life, which averaged 1.5 to 2 hours in study patients, was similar to that recorded in controls. Significant accumulation of ketoprofen in synovial fluid of patients was demonstrated. | |
| 176958 | Activation of human leucocyte procollagenase by rheumatoid synovial tissue culture medium. | 1975 Dec | Production of a factor activating leucocyte procollagenase by tissue culture of rheumatoid synovium was shown. The activator was isolated, partly purified, and shown to be thermolabile, nondialysable, and had no activity toward casein, haemoglobin, histones, and PZ-peptide. The activity of the activator was partly decreased by trypsin. | |
| 137185 | [The radiological and scintigraphic findings in psoriatic arthropathy (author's transl)]. | 1976 Nov | The radiological and scintigraphic findings in the skeletons of patients with psoriasis and psoriatic arthropathy are described. The results indicate that is it possible to detect inflammatory disease in joints by scintigraphy in patients who have not yet developed symptoms. The effect of treatment can be satisfactorily followed by serial scans. Further investigations and observations will be required to show whether the paravertebral calcification and syndesmophyte formation which has been described is really pathognomonic for psoriatic arthropathy. | |
| 6158390 | The action of aspirin on plasma kininogen and other plasma proteins in rheumatoid patients | 1980 Jul | 1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid patients received aspirin therapy for 1 week, their mean plasma kininogen concentration fell by 31% to 6.3 +/- 0.8 microgram Bk eq/ml. This was accompanied by a 20.4% fall in mean plasma alpha 2-globulin level. Haematocrit and total plasma protein were not significantly altered (P > 0.05). 3. The fall in kininogen was very rapid, the main reduction occurring within the first hour. 4. Aspirin therapy greatly reduced the pain assessments but had no effect on plasma concentrations of IgG, IgA, IgM, complement component C3, nor on ESR, haemoglobin, leucocyte count, nor ring size. Left hand grip strength was increased while right hand grip strength was unchanged. 5. The action of aspirin on plasma kininogen and alpha 2-globulin was similar to that of indomethacin. Plasma kininogen has been considered to be an acute phase reactant. The possible diagnostic value of plasma kininogen estimation is discussed. | |
| 402889 | Precipitation of 125I-labelled IgG aggregates by factors in sera of healthy individuals an | 1977 Feb | Several factors in human serum are capable of precipitating soluble 125I-labelled heat aggregated IgG (agg IgG*). A study of the nature of these factors resulted in the development of two new methods for the detection and assay of anti-IgG-immunoglobulins (rheumatoid factors) in serum. One method detected rheumatoid factors of the IgG and the IgA classes which are capable of binding and coprecipitating with Clq and agg IgG* in an EDTA milieu. In a second method the serum was first heat inactivated and the assay was then made in a polymeric milieu where rheumatoid factors of the IgM as well as the IgG and IgA classes could be detected. 67 sera from patients with rheumatoid arthritis were tested with this method and rheumatoid factors were detected in all seropositive (as assayed with conventional rheumatoid factor tests) sera and in 58% of the seronegative sera. In the presence of certain anti-IgG-immunoglobulins or polymers, the precipitation of Clq and soluble agg IgG* is greatly enhanced, and we suggest that this can be used as a basis of a sensitive method for the assay of agg-IgG-binding activity of Clq. | |
| 808229 | Depressed synovial fluid levels of properdin and properdin factor B in patients with rheum | 1975 Jul | Two proteins in the properdin system, properdin and factor B, and complement components C4 and C3 were measured by radial immunodiffusion in serums and synovial fluids from 21 patients with rheumatoid arthritis (RA) and positive tests for rheumatoid factor, 9 patients with seronegative RA, and 10 with degenerative joint disease. In addition to depressions of synovial fluid C4 which correlated with lowered C3 in seropositive RA, consistent with activation of the classic pathway, low synovial fluid levels of factor B and properdin in seropositive RA indicate intraarticular activation of the properdin pathway as well. | |
| 6986443 | In vitro response of peripheral blood lymphocytes from patients with rheumatoid arthritis | 1980 Mar | The effect of several LPSs on the thymidine uptake of lymphocytes from patients with RA was investigated. In contrast to normal controls, the mitogenic response to E. coli 026 B6 LPS by lymphocytes from patients with RA was significantly (2p less than 0.05) diminished. This effect was seen with Con A but not with PHA or PWM. No correlation with peripheral B or T cell percentages or with antibody titers to the LPS was found. The response to LPS was dependent on the species and strain of bacterium from which it was isolated. | |
| 7230166 | Whither Westergren--the sedimentation rate reevaluated. | 1981 Mar | The term "Westergren sedimentation rate" implies that a standardized test is being performed. Questionnaires sent to 177 rheumatologists and 150 clinical laboratory directors showed that a variety of techniques are used to perform the sedimentation rate by the "Westergren" method. A comparative study revealed that the most reproducible results could be obtained with the classical Westergren technique or with a modified Westergren technique using EDTA anticoagulated blood and saline diluent. The use of undiluted whole blood in a Westergren tube was less reproducible and compared poorly with the classical Westergren technique. The results confirm that the undiluted Westergren technique should not be used and that in clinical studies the technique employed for determining the sedimentation rate should be specified. | |
| 3878640 | [Significance of interleukin 1 and related monokines in the pathogenesis of chronic polyar | 1985 Sep | Activated monocytes/macrophages secrete monokines, regulatory proteins which are capable of initiating and maintaining immune processes as well as having an effect on other non immunocompetent cells. In rheumatoid arthritis the monokine Interleukin-1 (IL-1) was detected in the synovial fluid. IL-1 activates immunocompetent cells in the synovial membrane. It also stimulates rheumatoid synovial cells to markedly increase the collagenase-production and release of prostaglandin E2 and lysosomal acid hydrolase. The proliferation of fibroblasts is enhanced by IL-1. IL-1 has also been shown to be responsible for stimulating the production of cartilage-degrading enzymes and to lead to degradation of the cartilage matrix. It can enhance the rate of Ca++-release in the bone, but may also stimulate the production of collagen and glycosaminoglycans by osteocytes. Drug-induced inhibition of secretion, release or function of IL-1 may have an immune-modulating, antiinflammatory and antiproliferative effects. | |
| 1121638 | N-acetyl-beta-d-glucosaminidase activity in synovial fluid. | 1975 Feb | N-acetyl-beta-D-glucosaminidase activity in the synovial fluid of different articular diseases was studied and statistical investigations were carried out after logarithmic transformation of the data. The enzyme activity in the synovial fluid of rheumatoid arthritis is increased when compared with osteoarthrosis and traumatic effusions. The enzyme activity in traumatic effusions is also increased in comparison with osteoarthrosis. A linear relation was found between the enzyme activity in cell-free fluid and the polymorphonuclear leucocyte (PMN) count in rheumatoid arthritis osteoarthrosis and in miscellaneous synovitis. The activity per PMN cell was determined and found to be relatively constant in the synovial fluid of inflammatory diseases (rheumatoid arthritis, chondrocalcinosis, miscellaneous synovitis). The N-acetyl-beta-D-glucosaminidase activity per PMN cell in serum was found to be significantly lower than in synovial fluid. | |
| 6401389 | Nonexudative diarrhea after gold salt therapy: case report and review of the literature. | 1983 Jan | A case of fulminant watery diarrhea after therapy with 485 mg of gold thioglucose in a 78-yr-old woman suffering from rheumatoid arthritis is presented. Evaluation failed to reveal evidence of infection, malabsorption, or mucosal inflammation. Treatment, after stopping therapy, was supportive over several months and the patient recovered completely. A comparison with other presentations of gold induced diarrhea is made through a review of all known cases reported in the literature. Although these cases have many points in common, it is apparent that there is a spectrum of disease from fatal hemorrhagic diarrhea to nonexudative diarrhea. Any diarrhea in a patient receiving gold salt therapy must be thoroughly investigated before continuing therapy. | |
| 6979136 | [The effect of basic therapeutic procedures on the immunoregulatory T-cell apparatus in pa | 1982 Jan | Five by five patients with rheumatoid arthritis were treated with gold salts, D-penicillamine and cyclophosphamide. The T-lymphocyte subpopulations were measured. In patients, treated with gold salts or D-penicillamine, we did not find alterations of the number of TG- and TM-lymphocytes. The daily treatment with 100 mg cyclophosphamide will result in a significant reduction of TG-lymphocytes. | |
| 6939882 | Pyrithioxine and thiopronine: new penicillamine-like drugs in rheumatoid arthritis. | 1981 Jan | Two new SH-CH3-containing drugs have been studied as penicillamine-like agents. Pyrithioxine--retrospectively compared to a D-penicillamine series--was associated with fewer side effect-related withdrawals (14 vs 39) but with more non-responses and withdrawals for relapse. A review of the literature shows that thiopronine and D-penicillamine have a similar "score" of side effects and good responses. More extensively-controlled trials are needed for a better assessment of these new drugs. | |
| 779340 | [Gold treatment of progressive chronic polyarthritis--a clinical study]. | 1975 May | In an intraindividual series of investigation consisting of 30 patients with rheumatoid arthritis the effect of gold therapy (Aurothioglucose) has been proved controlling biochemical and clinical parameters. Controls of the function-index by Steinbrocker et al. have shown a significant improvement in comparison with the stage before gold treatment. Futhermore a significant decrease of erythrocyte sedimentation rate (Westergren) as well as a significant increase of albumins and a significant decrease of gamma-globulins in proteinelectrophoresis provoked by gold treatment could be demonstrated. Side effects during gold treatment were observed in 5 patients; therapy was stopped in 2 patients. | |
| 7017917 | Additive clinical effect of indomethacin suppositories during salicylate therapy in rheuma | 1981 | Twelve rheumatic patients were given 2.0 and 4.5 g acetylsalicylic acid daily in two 3-week periods. On days 13 and 20 of each period the patients took a suppository containing either placebo or 50 mg of indomethacin. The study was performed double-blind. Indomethacin had a significant additive effect during ASA therapy with 2 g daily as estimated by articular index and subjective ratings of pain and morning stiffness. On the 4.5 g ASA dose there was a significant improvement only for articular index. The patients experienced less pain during maintenance therapy with 4.5 g of ASA compared with 2.0 g daily. Both ASA doses induced complete inhibition of prostaglandin PGF2 alpha release from platelets. Thus the suppression of PGF2 alpha release does not reflect the therapeutic response of these drugs. Side effects observed comprised tinnitus, dizziness and gastritis. In 2 of the patients the aminotransferase levels increased, indicating hepatotoxicity. The protein binding of salicylate decreased with increasing salicylate concentration. As the dose was increased from 2.0 to 4.5 g/day the unbound concentration increased 5 to 24 times. This reflects the combined effect of capacity-limited metabolism and capacity-limited protein binding of salicylate. | |
| 6851315 | Charnley low-friction arthroplasty in patients with psoriasis. | 1983 Jun | A retrospective study of 38 patients with established psoriasis treated by 55 Charnley low-friction arthroplasties showed a superficial infection rate of 9.1% and a deep infection rate of 5.5%. All of the operations were carried out in the Charnley clean-air enclosure, without prophylactic antibiotic therapy. The incidence of postoperative sepsis in psoriatic patients was significantly higher than in patients with osteoarthritis (p less than 0.001) and rheumatoid arthritis (p less than 0.05). Hence, prophylactic antibiotic therapy appears beneficial in psoriatic patients. | |
| 1225384 | Soluble complexes and antiglobulin factors detection by immunofluorescence and immunoadsor | 1975 Nov | In this report is was demonstrated that in rheumatoid factors (RF) positive sera, 19 S IgM rheumatoid factor can form soluble complexes with different proteins (IgG, albumin) of sera. In these complexes the antiglobulin activity of IgM is not inhibited. When immunofluorescence and immunoadsorption procedures are used for the detection of antiglobulin activities of rheumatoid sera, the proteins which are bound to IgM rheumatoid factor, even if they are devoid of any antiglobulin character, may be revealed simultaneously with IgM. Moreover in some cases the detection of IgM may be hindered, while the linked proteins remain detectable. In these conditions, these complexes in RF positive sera may give false negative results for IgM rheumatoid factor, and may give rise to artefactual appearance of IgG and other proteins (albumin antiglobulin-like activities. This paper points out that before investigating IgG and IgA antiglobulin activities, IgM rheumatoid factor should be previously eliminated, for example by immunoadsorption. | |
| 1099958 | Lymphokines in rheumatoid synovitis. | 1975 Jun 13 | In antigen-induced experimental arthritis of rabbits, a macrophage migration inhibitory factor was released from the inflamed synovial tissues. A migration inhibitory factor, blastogenic factor, and B-cell-stimulating factor were also found in human rheumatoid synovial fluids and culture supernatants of rheumatoid tissue explants. Joint fluids from patients with inflammatory conditions other than RA sometimes also displayed these activities. OA fluids were usually inactive. At present, little is known of the origin or role in vivo of the lymphokine-like activities observed in the joints of rheumatoid patients. In related experiments, injection of lymphokine-rich antigen-free lymphocyte supernatants into normal rabbit knee joints produced a synovitis characterized by lining layer hyperplasia and infiltration of the sublining layer by macrophages. The lymphocytic and plasmacytic components seen in active antigen-induced synovitis were absent. It seems likely that some of the changes observed in active chronic synovitis are mediated by soluble factors of the lymphokine variety. |