Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 920251 | Lactoferrin and lysozyme in arthritic exudates. | 1977 | Lactoferrin (LF) has been assayed by radioimmunoassay in plasma and arthritic exudates and compared with lysozyme (LZ) levels and leukocyte counts. The mean LF concentration in 38 rheumatoid arthritis (RA) exudates was 9.1 mg/l (range 0.02-39.2). In 30 non-RA exudates LF was 3.3 mg/l (range 0.01-14.6). The corresponding LZ levels were 7.4 mg/l (range 2.5-18.5) in RA and 4.7 (range 1.0-12.5) in non-RA fluids. Exudate/plasma ratios were much higher for LF than for LZ and higher in RA than in non-RA exudates, whereas leukocyte counts did not differ. The LF/leukocyte count ratio was significantly higher in RA than in the non-RA group. The data suggest a more prominent release of neutrophilic granulocyte components in RA than in non-RA arthritis. | |
| 2864741 | Does sulphasalazine cause folate deficiency in rheumatoid arthritis? | 1985 | Sulphasalazine impairs folic acid absorption and metabolism but rarely leads to folate deficiency in inflammatory bowel disease (IBD). In rheumatoid arthritis (RA), however, serum and red cell folate concentrations are often low and sulphasalazine might stress folate metabolism. In a prospective study, 2 g sulphasalazine was compared with 500 mg penicillamine daily in 30 patients over 24 weeks. Pre-treatment serum and red cell folate concentrations were low-normal. Improvements in disease activity and haemoglobin occurred in both treatment groups, but MCV increased only in patients taking sulphasalazine. Serum and red cell folate concentrations did not change in either group. Increased MCV with sulphasalazine might therefore reflect reticulocytosis secondary to drug-induced haemolysis. The mechanisms by which sulphasalazine antagonizes folate metabolism are dose-dependent and, consequently, higher doses might precipitate folate deficiency. | |
| 6884415 | A phenylbutazone dose-finding study in rheumatoid arthritis. | 1983 | Different doses of phenylbutazone have been compared in a double blind study on 32 patients with rheumatoid arthritis in order to determine the minimum effective dose. Of 8 different dose levels studied (90 mg, 150 mg, 180 mg, 240 mg, 270 mg, 300 mg, 360 mg and 450 mg/day) the most efficacious was found to be 300 mg/day. Doses below this did not produce full benefit; no further improvement occurs with higher doses. Although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone. An attempt was made to distinguish 'responders' from 'non-responders'. We found no relationship between response and plasma levels of phenylbutazone or oxyphenbutazone. | |
| 7013055 | A double-blind study comparing sulindac with indomethacin in rheumatoid arthritis. | 1980 | Forty-two patients with definite or classical rheumatoid arthritis were included in a 6-week double-blind study to compare sulindac with indomethacin. Patients were randomly assigned to therapy, either sulindac 100 mg b.i.d. (plus indomethacin placebo) or indomethacin 25 mg t.i.d. (plus sulindac placebo). As required dosage was increased to either sulindac 200 mg b.i.d. or indomethacin 50 mg t.i.d. Efficacy of the two drugs was found to be equal but sulindac was better tolerated than indomethacin. | |
| 2999520 | Immunoglobulin G antibodies binding to a synthetic peptide deduced from the nucleotide seq | 1985 | A synthetic pentadecapeptide preparation, env 406-420, with an amino acid sequence deduced from the envelope glycoprotein gene of human T cell leukemia virus type I (HTLV I), was used as the antigen in an enzyme immunoassay for immunoglobulin G antibodies, exploring its usefulness for seroepidemiological purposes. The frequency of reactivity in the test groups, presented in decreasing order was: patients with rheumatoid arthritis; multitransfused nonleukemic patients; Japanese cases of adult T cell leukemia (ATL); HLA sensitized persons; Swedish cases of adult acute leukemia; and Swedish blood donors. Three American cases of ATL and 12 HTLV I seropositive monkeys did not react. In RF positive sera from patients with rheumatoid arthritis, no quantitative correlation between RF activity and anti-env 406-420 activity was seen. Anti-env 406-420 positive sera did not react or reacted only weakly with four control peptide preparations with different amino acid sequences. The experience with oligopeptide serology still is limited. Our results illustrate that unexpected cross-reactions which are hard to interpret can occur. Although absorption experiments indicated an HTLV I specific component of the reactivity, antibodies against epitopes of allo- and auto-immune specificity may also have participated. | |
| 6777766 | Acute renal failure due to gold. | 1980 May | A patient with rheumatoid arthritis is described who developed acute renal failure whilst receiving gold. This occurred despite the normal precautions of patient monitoring before each dose was given. The clinical picture suggests this was a hypersensitivity reaction to chrysotherapy. | |
| 966573 | [Ocular myasthenia caused by D-penicillamine (author's transl)]. | 1976 Mar | This report concerns a 55-year-old woman who developed ocular myasthenia after 12 months treatment with D-Penicillamine for her rheumatoid arthritis. In the last 2 years the literature contains reports of 22 similar cases. | |
| 6819360 | Terminations of treatment with gold sodium thiomalate in rheumatoid arthritis. | 1982 Nov | Treatment terminations with gold sodium thiomalate (GST) in 200 patients with rheumatoid arthritis (RA) were analyzed using the life table method. The termination rate was 27% at 6 months, 48% at 12 months and 84% at 48 months. The major reason for termination was mucocutaneous reaction. Pretreatment clinical and laboratory status of the RA did not influence terminations significantly. Concurrent administration of oral corticosteroids had no significant effect on gold terminations. Complete control of synovitis was achieved in 38% of patients by a median time of 6 months but sustained for greater than 12 months in only 19%. | |
| 128109 | Abnormalities of peripheral blood lymphocytes in rheumatoid arthritis. | 1975 | Peripheral blood lymphocytes from some rheumatoid arthritis (RA) patients show a reduced response to PHA when stimulated directly after isolation from blood. Cells which have been preincubated in medium with normal serum for 22 h before exposure to PHA show a relatively enhanced response, which approximates the normal. These findings could be compatible either with the blocking of surface PHA receptors of circulating RA lymphocytes, or with progressive maturation of these cells in vitro. Preincubation does not enhance the relatively reduced response of RA lymphocytes to allogeneic RA lymphocytes in one-way mixed lymphocyte cultures. An increased reduction in response to PHA following irradiation of RA lymphocytes suggests an increased radiosensitivity of the PHA-responsive subpopulation. This abnormally reduced response was not seen if the cells were preincubated in vitro prior to irradiation. | |
| 6618826 | Comparison of two detail screen-film systems using a rheumatoid erosion model. | 1983 Jul | Two detail screen-film systems, Lanex Fine/Ortho M and Lanex Fine/Ortho G, were evaluated using a radiographic model for rheumatoid erosions. Radiographs of hand bones with cortical defects using both screen-film systems were obtained. Seven observers analyzed 48 sites on each of 22 films for the presence of these cortical defects. Using analysis of variance techniques and receiver operating characteristic curves, no significant difference was found between the two systems for the detection of these subtle cortical defects. The authors conclude that although the Lanex Fine/Ortho M system provides better definition of laboratory test objects than Lanex Fine/Ortho G, the two systems do not differ when used for detection of cortical lesions. | |
| 6331974 | HLA haplotypes in multiple case families with rheumatoid arthritis. | 1984 Jun | In 9 families of which at least two members were affected by rheumatoid arthritis (RA), no specific combination of HLA genes, i.e., HLA haplotype was found to be associated with transmission of disease susceptibility. The results suggested an important role of HLA-DR4 in the etiology of RA, irrespective of other HLA markers. In addition, it may be concluded that genetic markers other than DR4 may act together with this HLA antigen in determining which individuals are at risk of developing this rheumatic disorder. | |
| 7089502 | The cytology of joint exudates in rheumatoid arthritis. Morphology and preparation techniq | 1982 | The cytology of joint exudates from patients with rheumatoid arthritis was examined by preparation of air-dried smears; a procedure that involved cytocentrifugation of synovial fluids following dilution in a balanced salt solution containing albumin. This procedure provided a monolayer of homogeneously distributed exudate cells with excellent preservation of morphological details. The dominant cell type in the exudates was polymorphonuclear leukocytes, often with signs of necrobiosis. The small and medium-sized mononuclear cells were lymphocyte-like and vital-looking. The large mononuclear cells displayed signs of extensive phagocytosis, especially phagocytosis of polymorphonuclear leukocytes. It is suggested that the granulocytes of the synovial fluid are cells which have reached their function compartment, where they work and die. | |
| 7441655 | Effect of oral zinc sulphate and penicillamine on zinc metabolism in patients with rheumat | 1980 Sep | Whole body zinc and zinc absorption were measured in 14 patients with classical rheumatoid arthritis (RA). Half of these patients were treated with penicillamine for a period of 8 wk and the other half received zinc sulphate orally for a similar period of time. Whole body zinc and zinc absorption were not significantly affected by either therapy. These observations suggest that any pharmacological effect of oral zinc sulphate or penicillamine on patients with RA is not mediated by their effect on zinc metabolism in such patients. | |
| 355954 | Naproxen in the treatment of rheumatoid arthritis. | 1978 Jun 28 | Naproxen, a new nonsteroidal anti-inflammatory analgesic drug was found to be better than placebo and as effective as indomethacin in the treatment of rheumatoid arthritis. The drug was well tolerated, and appears to be a useful alternative to more established medication such as aspirin. | |
| 796940 | Clinical evaluation of keto profen (Orudis) in rheumatoid arthritis: results of a multi-ce | 1976 | In a double-blind cross-over trial in rheumatoid arthritis, no difference was found between ketoprofen and phenylbutazone with regard to clinical efficacy at the dosages used. There was a higher incidence of side-effects reported during treatment with phenylbutazone. | |
| 6084867 | Polymorphonuclear granulocytes in rheumatic tissue destruction. VI. The occurrence of PMNs | 1984 | The meniscal surfaces from patients with and without inflammatory joint diseases were investigated for the presence of superficially located polymorphonuclear granulocytes (PMNs). In histochemically stained tissue sections as well as in electron microscopic investigations on previously paraffin-embedded menisci, PMNs were observed in cases with inflammatory rheumatoid joint diseases. The inflammatory cells were located in fibrin adhering to the meniscal surface and in the fibrous meniscal tissue just beneath the fibrin. From these observations it is concluded that PMNs in the inflammatory synovial fluid may gain access to the fibrous structures of the joint, thus participating in tissue destruction, as has been assumed from in vitro investigations by other authors. | |
| 823876 | Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'as | 1976 Aug | Using a radiometric technique, prostaglandin synthetase activity was measured in vitro in the microsomal fraction of 19 synovial tissues taken from 17 rheumatoid arthritis patients. The enzyme was inhibited in vitro by low concentrations of several 'aspirin-like' drugs, though paracetamol and salicylic acid were virtually inactive. While the synthetase preparations from patients receiving indomethacin, ibuprofen, or naproxen therapy exhibited considerable activity in vitro, we were unable to show any activity in preparations from patients taking aspirin, even in low doses. These findings suggest that in vivo aspirin may be unique in being an irreversible inhibitor of the enzyme, compared with other 'aspirin-like' drugs. | |
| 6362339 | Alveolitis during chrysotherapy for rheumatoid arthritis. | 1983 | A patient who developed dry cough and increasing breathlessness during chrysotherapy for seropositive rheumatoid arthritis is presented. Chest radiograms were repeatedly normal, but there was a moderate decrease in pulmonary diffusing capacity. Transbronchial lung biopsy showed alveolitis. No cellular immunity to gold salts could be demonstrated in vitro. Pulmonary function improved after withdrawal of gold, indicating that chrysotherapy rather than systemic rheumatoid disease was the cause of the alveolitis. | |
| 7221454 | [Results of the cytological examination of the synovial fluid in various arthropathies]. | 1981 Mar | 329 synovial fluids from various joint diseases were examined. 95% of the fluids from arthrosis contained less than 1 000 cells/ml, figure which seemed to us to be the limit which separates arthrosis from arthritis. Above 100.000 cells/ml, the diagnosis is always pyogenic arthritis. Between 50.000 and 100.000 cells/ml, one may find pyogenic arthritis but also a few cases of rheumatoid arthritis, psoriatic rheumatism, gout and pseudo-gout. In chondrocalcinosis, the fluid variable, often poor in cells. The percentage of polymorphs is of little diagnostic interest; it exceeds 50% in all cases of pyogenic arthritis. R.A. cells are almost constant in fluids with more than 1 000 cells/ml and their diagnostic interest is not great. | |
| 677357 | Group therapy with rheumatoid arthritic patients. | 1978 Apr | A husband-wife co-therapist team, in clinical collaboration with rheumatologists of the Phoenix Arthritis Center, has instituted a brief inpatient group therapy program in an arthritis unit of a general medical hospital. Problems of initiating the group are presented. Both preliminary findings and research possibilities are discussed. |