Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3876665 | [Personality structure of chronic rheumatically ill females]. | 1985 Jul | 80 female patients were tested for personality differences by the Freiburg Personality Inventory and the Giessen Test Self Image. They were divided into four groups with 20 patients each, suffering from rheumatoid arthritis, ankylosing spondylitis, spondylosis and coxarthrosis. While RA patients did not significantly differ from AS patients, nor spondylosis patients from coxarthrosis patients, certain personality differences were detected between the patients with inflammatory and those with degenerative rheumatic diseases. These results, however, do not allow us to draw the conclusion that a "degenerative or inflammatory rheumatic personality" exists. Besides the Giessen Test Self Image the Giessen Test Self Ideal was also administered to all of the patients. In all four groups the desire for a better basic mood and less depression was prevailing. RA patients also wanted more "social resonance" and "predominance". AS patients wanted significantly less "control" and more "responsiveness". These components should be given special consideration in the psychological care of rheumatic patients. | |
| 1224930 | [Non-steroidal antirheumatic therapy and the liver]. | 1975 | In 161 patients with rheumatoid arthritis a raised activity of alkaline serum phosphatase was found in 37.3% and identified as hepatic phosphatase by means of heat inactivation, and partly by determination of isoenzymes using the Polyacrylamidgel-electrophoresis. This relatively frequent finding may be explained as toxic hepatic damage due to antirheumatic therapy, and a drug-induced cholestasis. This is caused by several non steroidal antirheumatic drugs, especially upon longer administration, or in higher dosage or both, may be acting as potential hepatotoxic. Therefore, the control of alkaline serum phosphatase and gamma-GT before and during the antirheumatic treatment is recommended. | |
| 6722409 | Structural requirements for activity of certain 'specific' antirheumatic drugs: more than | 1984 May | The relationship between chemical structure and the clinical activity and toxicity of several second-line antirheumatic drugs is examined. The presence of a thiol group in many of these agents has previously been noted, but most of the compounds additionally either possess, or form metabolites containing, the ethanethiol backbone or a similar ring structure. This applies not only to penicillamine and disodium aurothiomalate but also to thiola , 5- thiopyridoxine , levamisole and captopril. The presence of free circulating thiols has recently been shown for several of these compounds including free thiomalate in the case of disodium aurothiomalate, which on a molar basis is the most potent agent of all. Further study of thiomalate and related compounds in vitro and in vivo may clarify the pathogenesis of rheumatoid arthritis as well as allowing the development of more effective and less toxic second-line agents. | |
| 7417036 | On-line separation of macromolecules by membrane filtration with cryogelation. | 1980 Aug | The use of cold filtration in the removal of macromolecules from disease state plasma is safe and simple. It overcomes the disadvantages of plasma exchange in chronic treatments and is specific in removal of those causative factors implicated in the disease. | |
| 407458 | [Cardinal radiological signs of the most important rheumatic diseases of joints in adults | 1977 Jun 3 | The assessment of roentgenograms in rheumatology is frequently complicated because all forms of the disease have lesions of connective tissue structures in common. A reliable classification of a particular rheumatic disease is sometimes only possible on the basis of repeated examination during the course of the disease. Certain cardinal radiological signs are useful aids to diagnosis. Thus arthritis is characterized by concentric reductions in the height of the joint cavity and the bone lesion, arthrosis by excentric reduction of height and osteophytes. Special pointers to rheumatoid arthritis, psoriatic arthritis, the degenerative diseases, ankylosing spondylitis and related diseases are given. | |
| 1184744 | Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for b | 1975 Nov | Synovial tissue from patients with rheumatoid arthritis was maintained in organ culture for 3-14 days. Conditioned media from these synovial cultures contained bone resorption-stimulating activity, measured in vitro by using calcium release from mouse calvaria as the assay system. The synovial cultures also produce prostaglandin E2 (PGE2) as measured by serologic methods. The production of both the bone resorption-stimulating activity and PGE2 was inhibited by more than 90% by treatment of the synovial cultures with indomethacin (5 mug/ml). In contrast, treatment of the synovial cultures with colchicine (0.1 mug/ml) caused a marked and parallel increase in the concentration of both bone resorption-stimulating activity and PGE2 in the conditioned media. The bone resorption-stimulating activity was quantitatively extracted into diethyl ether. Within the limits of experimental error, all of the bone resorption-stimulating activity in medium was accounted for by its content of PGE2, itself a potent osteolytic factor. We conclude that the bone resorption-stimulating activity produced by rheumatoid synovia in culture is PGE2. | |
| 734382 | Release of lysosomal enzymes from human polymorphonuclear leukocytes by soluble intermedia | 1978 | The efficacy of soluble immune complexes (1C) of different sizes prepared in vitro or present in RA sera and synovial fluids to induce the release of beta-glucuronidase (BG) and neutral protease (NP) from PMN has been examined. Immune complexes of human HGG-rabbit anti-human HGG prepared in 5, 10 and 20 times excess of antigen equivalence were fractionated into three pools, PI (22S--13S), PII (13S--7S) and PIII (7S) using Sephadex G-200 column chromatography. NP and BG-releasing activity was mostly associated with PII. Similar fractions were obtained from RA sera and synovial fluids. BG-releasing activity was again predominantly associated with PII. PII fractions from normal sera and from 2 non-RA IC disease sera showed less BG-releasing activity than the RA PII fractions. Negligible NP release was observed with all three serum pools. Further investigation demonstrated the presence of NP inhibitor(s) in PI and PII from human sera. | |
| 1153978 | The content of calcium, magnesium, copper, zinc, lead and chromium in the blood of patient | 1975 | The blood concentrations of calcium, magnesium, copper, zinc, lead and chromium were measured in patients with rheumatoid arthritis and in a "normal" control group. The values of hemoglobin and the effect of some drugs on the metals studied were also estimated. In metal analyses the atomic absorption spectrophotometric technique was used. The mean concentration of copper in the blood of patients with rheumatoid arthritis was significantly higher than in the control group. This was not true in females taking conteceptive drugs that cause elevated serum copper concentrations. Chromium concentrations were significantly lower in patients with rheumatoid arthritis. The mean concentrations of zinc was higher in rheumatoid females than in female controls. The concentrations of calcium, magnesium and lead were not found to be different in patients with rheumatoid arthritis from those in the control group. | |
| 7214989 | Non-steroidal anti-inflammatory drugs and the Sigma SR in rheumatic diseases. | 1981 | Sigma SR and erythrocyte sedimentation rate (ESR) were compared before and after treatment with non-steroidal anti-inflammatory agents in 6 patients with rheumatic diseases. No evidence was found that either was altered by this kind of drug therapy, though there was considerable variation in the shape of sedimentation rate curves (obtained by plotting erythrocyte sedimentation rate every 5 minutes over 150 minutes), between individuals with the same disease. | |
| 6810578 | Prostaglandins and their precursors in rheumatoid arthritis: progress and problems. | 1982 May | Evidence is presented to support the hypothesis that prostaglandins and their precursors, collectively termed prostanoids, have an important role to play in the pathogenesis of joint destruction in arthritis, with particular reference to rheumatoid arthritis. After discussion of the role of prostanoids as mediators of inflammation, evidence is given that prostanoids are present in the joints of patients with rheumatoid arthritis, that these substances are capable of causing joint damage in vitro and in vivo, and that drugs which are able to arrest the progress of the arthritic condition or bring symptomatic relief possess the ability to inhibit prostanoid synthesis in vivo and in vitro. | |
| 6295670 | Antibodies to EB virus- and cytomegalovirus-induced antigens in early rheumatoid disease. | 1982 Nov | Early rheumatoid arthritis patients were identified in a group of people, presenting for the first time with symptoms of joint disease. Antibodies to the rheumatoid arthritis nuclear antigen (RANA) and the early antigen of cytomegalovirus (CMV-EA) were determined in serum samples by indirect immunofluorescence. The results indicate that elevated titres of RANA antibodies are present in early rheumatoid patients, but are not a good diagnostic marker of rheumatoid disease, due to the high incidence in normal subjects and disease control patients. Strong reactions to CMV-EA were seen in a proportion of the early patients but were rare in established disease, suggesting that recent infection with this virus might be an early feature. | |
| 377154 | A comparison of sulindac with ibuprofen in the management of rheumatoid arthritis. | 1979 Apr 25 | Sulindac 200mg b.i.d. was compared with ibuprofen 400mg t.d.s. in a double-blind controlled trial in patients with rheumatoid arthritis. Both drugs produced a measurable and significant improvement from baseline levels, in both objective and subjective parameters. All parameters favoured sulindac but the differences were not statistically significant. Side effects were infrequent with both drugs and in all but three cases did not necessitate withdrawal from the trials. Sulindac appears to be an effective anti-inflammatory analgesic drug for the management of rheumatoid arthritis with a low incidence of side effects. | |
| 6409481 | Changes in T-cell subsets in patients with rheumatoid arthritis treated with total lymphoi | 1983 May | Patients with intractable rheumatoid arthritis (RA) were treated with total lymphoid irradiation (TLI, 2000 rads). We previously reported long-lasting clinical improvement associated with marked suppression of in vitro lymphocyte function in this group. In an attempt to better understand the mechanism of immunosuppression and clinical changes observed after TLI, we studied in greater detail changes in peripheral blood T-cell subsets identified by monoclonal antibodies. Before TLI, RA patients had a higher percentage of Leu-3 (helper subset) cells and a lower percentage of Leu-2 (suppressor/cytotoxic subset) cells than normals. Immediately after TLI, the absolute numbers of both Leu-2 and Leu-3 cells were reduced by at least 90%. Within 6-12 weeks, the number of Leu-2 cells returned to the pretreatment levels, but the levels of Leu-3 cells remained depressed for months thereafter. The lack of repopulation of Leu-3 cells resulted in a marked increase in the ratio of Leu-2 to Leu-3 cells as compared to pretreatment values (1.73 +/- 0.23 vs 0.39 +/- 0.06), and in a decrease in the percentage and absolute number of total T (Leu-1 and Leu-4) cells. The failure of Leu-3 cells (which mediate predominantly helper/inducer functions) to repopulate the peripheral blood may contribute to the prolonged clinical immunosuppression observed after TLI. Similar changes in T-cell subsets were not observed in RA patients given remittive drugs or low doses (200 rads) of radiotherapy. Thus, TLI differs from other treatment modalities with regard to its prolonged selective effect on the Leu-3 subset. | |
| 6316521 | [Pseudophlebitic forms of popliteal cysts]. | 1983 Oct 27 | We report five observations of popliteal cysts responsible for clinical features of phlebitis of the calf. In each case, thrombosis of deep veins was outruled by phlebography. Clinical manifestations, which did not respond to efficiently dosed anticoagulant therapy, consistently resolved quickly after treatment of the cyst. Rheumatoid arthritis was the most frequent etiology. These observations induce us to look for a popliteal cyst in patients with signs of phlebitis. The negative phlebography rectifies the clinical diagnosis, thus avoiding prolonged anticoagulant therapy. | |
| 460842 | The use of arthroscopy for follow-up in knee joint surgery. | 1979 Jul | Fifty-three joints in 48 patients were examined arthroscopically after surgery in order to evaluate postoperative results and particularly to reveal the causes of poor results. The chief arthroscopic findings in unsatisfactory cases were the following: recurrence of synovitis or osteoarthritic changes after synovectomy for rheumatoid arthritis, residual meniscal or osteoarthritic changes after meniscectomy, loose ligamentous or meniscal lesions after ligamentous repair or reconstruction, and poor regeneration of cartilage after high tibial osteotomy. | |
| 1178840 | [The enlarged saccular recess of the distal radio-ulnar joint shown of low Ke V film (auth | 1975 Apr | There is a widening of the saccular recess of the distal-radio-ulnar joint, the radiocarpal joint with altered articular disk, and most often in rheumatoid arthritis due to effusion or synovial proliferation. In the latter case typical localized pressure erosions and periosteal new bone formation of the radius and ulna may be observed. | |
| 7398523 | Ophthalmological examination of patients taking chloroquine. | 1980 Apr 15 | EOGs have been routinely measured once a year in rheumatoid arthritis (RA) patients treated with chloroquine derivatives. Criterion for the advice to stop the treatment was a decrease in the EOG of more than 20% of the value obtained before treatment was started or, where this value had not been determined, a decrease in the EOG to below 1.85, i.e. the Arden criterion. Evaluating the results, it appears that in RA patients, examined once a year, the variability of the EOG is approximately 30% of the value obtained. Furthermore, instead of a lower limit for the normal value of 1.85, we found in the rheumatism group 1.6. If these new criteria were to be applied, less than 4% of the patients would be advised to stop chloroquine treatment. We wounder whether check-ups of these patients remain necessary when dosage of chloroquine or its equivalent is below 75 g per year. | |
| 7136592 | Influence of hip arthroplasty upon chemotactic behaviour of leucocytes. | 1982 Oct | Fourteen patients treated with total hip endoprosthesis were investigated for leucocyte defects. A chemotactic assay was used as an indicator of leucocyte function. Tests were carried out preoperatively and on postoperative days 1, 3 and 6. The chemotactic index started to decline on the first postoperative day, reached a peak on the third day after surgery and returned to almost preoperative values on the sixth day. The results might provide a clinical explanation for the data showing a high postoperative infection rate in total hip surgery. | |
| 877825 | Banked autologous blood in total hip replacement. | 1977 Jul | Transfusion of banked autologous blood was used in 61 patients requiring a total hip replacement. Up to 3 units of blood may be removed by phlebotomy within three weeks of the operation. Hemoglobin levels of less than 7 milligrams and hematocrit levels below 29 had no adverse effect on wound healing or resistance to infection. Autologous transfusion avoids many of the problems associated with homologous blood transfusion, especially serum hepatitis. | |
| 4808815 | Effect of several drugs on gastric potential difference in man. | 1974 Jan 5 | Measurement of gastric mucosal potential difference was used to study the effect on the gastric mucosal barrier in six volunteer subjects of several drugs known to provoke ulcers. Potential differences were also recorded in nine patients with rheumatoid arthritis being treated with long-term aspirin and five patients on long-term prednisone. Unbuffered aspirin and ethanol "broke" the barrier as shown by a rapid fall in potential difference. The effects of aspirin were dose related, with 600 mg causing a greater reduction than 300 mg. The effects of aspirin and ethanol given together were additive and caused the greatest fall in potential difference. Sodium acetylsalicylate did not alter the normal potential difference. Indomethacin, phenylbutazone, and prednisone all failed to cause any change in potential difference. The patients on long-term aspirin and prednisone had readings within the normal range and responded the same as normal subjects to an acute challenge. These studies show that aspirin and ethanol will damage the gastric mucosal barrier but that indomethacin, phenylbutazone, and prednisone do not. |