Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7370512 | A follow-up study of the earliest radiological changes in rheumatoid polyarthritis. | 1980 Feb | After more than 20 years devoted to the search for the earliest demonstrable radiological signs in polyarthritis, the author now offers proof that the very faint and tiny juxta-articular erosions described for the first time in 1963 (Nørgaard, 1963) are the earliest positive signs of rheumatoid polyarthritis. In the follow-up study of 153 cases which showed these fine erosions on the initial X-ray examination, 148 have subsequently had proven polyarthritis confirmed by clinical or radiological methods or both. The fate of the other five is discussed. | |
| 3904438 | Six-month, double-blind comparison of isoxicam with buffered aspirin in rheumatoid arthrit | 1985 Oct 18 | The results of a six-month, double-blind comparison of isoxicam (Maxicam), 200 mg once a day, with buffered aspirin, 3,600 mg per day (900 mg four times a day), showed that isoxicam was statistically significantly better than aspirin in eight of 12 measures of efficacy. The study was carried out in 15 centers around the United States in 191 patients with classic or definite rheumatoid arthritis. The measures for which improvement with isoxicam was significantly better than aspirin were number of tender joints, sum of tenderness scores, number of swollen joints, sum of swelling scores, number of joints involved, grip strength, and overall assessment of the patient's condition by physician and patient. The measures for which the difference favoring isoxicam was not statistically significant were duration of morning stiffness, time to walk 50 feet, and global assessment of change in the patient's condition by physician and patient. The results indicate that 200 mg of isoxicam once daily is effective for treating rheumatoid arthritis. Compared with 3,600 mg of buffered aspirin daily, isoxicam is better in relief of symptoms and at least as effective regarding improvement in function. | |
| 7263127 | Aspirin effect on cataract formation in patients with rheumatoid arthritis alone or combin | 1981 May | The prevalence of cataracts is significantly lower in patients with rheumatoid arthritis receiving aspirin (mean of 2,700 mgs daily for an average of 10.4 years) as compared to the matched population not receiving aspirin. Similarly, fewer cataracts were found among a population with diabetes and rheumatoid arthritis receiving aspirin (mean of 2,340 mgs daily for an average of 8.8 years) as compared to the matched population on no aspirin. The effects of aspirin on cataract formation may result from 1) lowering of plasma tryptophan levels and increased excretion of tryptophan metabolites, 2) inhibition of aldose reductase and sorbitol formation in the diabetic lens, 3) inhibition of tryptophan or kynurenine binding to lens protein. | |
| 359887 | Medical treatment of Serratia arthritis with trimethoprim-sulfamethoxazole. | 1978 Oct | A patient with moderately severe rheumatoid arthritis and diabetes mellitus receiving steroids developed septic arthritis due to Serratia marcescens. Treatment with a new cephalosporin analogue, intra-articular and intramuscular gentamicin, and chloramphenicol alone and in combination proved ineffective. Finally, trimethoprim-sulfamethoxazole therapy, given for a protracted period, eradicated the infection without the need for surgical drainage. | |
| 501062 | Compression of the ulnar nerve at the wrist secondary to a rheumatoid synovial cyst: case | 1979 Sep | Compression of the ulnar nerve within or near the canal of Guyon has been ascribed to numerous intrinsic and extrinsic factors. The anatomy of the region is discussed, and a review of the reported causes of ulnar nerve compression is presented. A case of ulnar nerve compression at the wrist secondary to a rheumatoid synovial cyst is reported. Prompt decompression resulted in clinical and electromyographic recovery of sesory and motor function. | |
| 4065719 | [Tenosynovitis in chronic inflammatory joint diseases and its sequelae in the area of the | 1985 Sep | The synovial lining of tendons may participate early in chronic rheumatic diseases. As a result of the inflammatory activity degenerative changes of tendons may occur. Increasing damage to tendons ends in their rupture. At 775 tenosynovectomies, 395 of them in chronic rheumatic diseases, in 68 patients (78 hands) 173 ruptures of tendons (14 flexors, 159 extensors) were found. The value of early tenosynovectomy as a preventive measure is emphasized. | |
| 6712294 | Synovial synthesis of rheumatoid factors and immune complex constituents in early arthriti | 1984 Apr | Synovial synthesis of immune complex constituents and rheumatoid factors has been estimated in rheumatoid arthritis (RA) and in unclassifiable inflammatory arthritis (IA) and related to duration of symptoms. Within 6 months of onset of symptoms both RA and IA patients synthesised (or trapped) immune complexes locally. However, local synthesis of the rheumatoid factors was almost exclusive to RA patients and mainly in patients with symptoms of more than 6 months' duration. Thus all arthritis patients may respond immunologically to an initial trigger in the affected joint but only RA patients develop localised chronic autoimmunity later. | |
| 309927 | Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid | 1978 Dec 1 | Increasing evidence has been obtained of the special value of Ia-like B-cell alloantisera for demonstrating disease associations with histocompatibility antigens. This was particularly evident for the study of the immunogenetics of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), two conditions frequently considered related. The profiles of antigens recognized by the alloantisera in patients from each disease group was distinctive. Two types of alloantisera were obtained that illustrated the divergence between the twod iseases. One type showed a higher than normal incidence in RA but lower than normal in SLE; the other showed a higher incidence in SLE. While these sera were not totally defined, evidence was obtained that the SLE-reactive alloantiserum related to two alleles of the major histocompatibility complex DRw2 and DRw3, while the RA-reactive alloantiserum related to a common specificity shared by cells positive for either DRw4, DRw7, or DRw10. The data indicate that immunogenetic factors are relevant to the development of both RA and SLE, but that these are distinct for each disease. | |
| 981993 | Follow-up study of synovectomies of the knee joint in patients suffering from rheumatoid a | 1976 | Synovectomies of the knee joint that were performed during the years 1960-65 at the Rheumatism Foundation Hospital because of rheumatoid arthritis have been re-examined after the lapse of 9.5 years in 156 patients and 202 knee joints and 110 non-operated knee joints of the same patients. Track of motion was helped both in synovectomized and in control knees. Deficiency of extension decreased only in the synovectomized knees; track of motion of the knee was improved by the operation. Swelling and pain appeared less often in operated than in control knees. The patient's own assessment of the operating results was good in 71% and poor in 12% of the cases. Radiological deterioration continued during the follow-up period both in the operated and in the control knees, though it was more severe in the latter. There is a distinct negative correlation between severity of disease and the patients's ability to work. Within the limits of this survey it is not possible to prove that synovectomy halts the radiological destruction of the knee joint; it is mainly a question of a measure that retards the rate of deterioration. One of the chief advantages of synovectomy of the knee is that it helps the patient to live a normal life and makes it possible for him to participate in working life. | |
| 408921 | A study of the variable heavy chain (VH) regions in human polyclonal IgM rheumatoid factor | 1977 | Ten IgM polyclonal rheumatoid factor (RF) preparations isolated from sera from various patients with rheumatoid arthritis (RA) were investigated with respect to their variable heavy chain (VH) subgroups. They were tested in a haemagglutination inhibition system using red cells sensitized with myeloma proteins with known chemical VH subgroups and anti-VH subgroup specific antisera. Most of the preparations showed a considerable degree of restriction to one VH subgroup. Seven of the IgM-RF preparations were restricted to the VHIII subgroup, two to the VHI subgroup and one to the VHII subgroup. However, a weak reaction in other VH subgroup systems was seen in several instances. Two normal IgM fractions from healthy persons showed no VH subgroup restriction, and showed a rather similar degree of reaction in all the three subgroup systems. | |
| 6890408 | Multiple squamous cell carcinoma treated with intra-arterial cisplatin in a patient with r | 1982 Nov | A 64-year-old woman, who had had rheumatoid arthritis controlled for many years by prednisone, developed multiple biopsy-proven squamous cell carcinoma of the skin extending from the left elbow to the hand. She was treated with intra-arterial cisplatin (90 mg/m2) maintained (8+ months) until she died of an unrelated cause. We believe that arterial infusion of cisplatin as treatment for advanced regional squamous cell carcinoma of the skin should be pursued further as part of a multimodal approach and as definitive therapy. | |
| 1135613 | Effect of short-term physical training on patients with rheumatoid arthritis. a six-month | 1975 | Twenty-three patients with rheumatoid arthritis were retested about 6 months after 5 weeks' physical conditioning and 7 patients from a former control group were also retested. Former training group patients, who had continued to train about 4 times or more per week, had maintained the improved physical status obtained during the initial conditioning, while those patients who had trained less than that or discontinued training, had lost some or most of their improvement. The physical status in the former control group was virtually remained unchanged. Joint status in the former training group was no different at re-test than at post-training or pre-training examinations. A questionnaire, given to the training group patients. Four patients from this group returned to work had positively affected the daily physical activity of these patients. Four patients from this group returned to work after the hospital training program. | |
| 132143 | Synthesis of glycosaminoglycan in adult human articular cartilage in organ culture from pa | 1976 Feb | Hyaline cartilage was obtained from patients undergoing synovectomy of the knee joint for rheumatoid arthritis. Eroded cartilage from beneath the invading pannus and relatively normal cartilage from the same joint were maintained in organ culture for three days. During the first 48 hours in culture the explants were exposed to 35SO4 in the medium. The equivalent layers of normal and eroded cartilage were analysed for DNA uronic acid and 35SO4 incorporation. There was a decrease in the DNA and uronic acid of the eroded cartilage, although only the latter reached statistical significance. The uptake of radioactive sulphate was significantly greater in explants taken from the eroded site than from normal areas. This increase in metabolic activity could well be a protective phenomenon. | |
| 849363 | Enhancement of in vitro immunoglobulin synthesis of rheumatoid lymphocytes by aggregated h | 1977 Mar | In vitro immunoglobullin synthesis by lymphocytes of patients with rheumatoid arthritis (RA) was enhanced by the addition of heat-aggregated human IgG. Stimulation occurred in the presence of fresh seropositive autologous plasma and was abolished by heat inactivation. By contrast, no significant stimulation was induced in lymphocytes from patients with miscellaneous arthritides and normal subjects cultured in the presence of either fresh autologous plasma or fresh normal AB serum. Although stimulation of RA lymphocytes did not occur in the presence of fresh AB serum, it did when purified IgM rheumatoid factor was added to this serum. These results suggest that immune complexes formed between aggregated IgG and rheumatoid factor in the presence of complement stimulate immunoglobulin synthesis in the peripheral blood lymphocytes of patients with RA. | |
| 4051399 | New mobilization and laterofixation procedure for cricoarytenoid joint ankylosis in rheuma | 1985 Sep | Ankylosis of the cricoarytenoid joints due to rheumatoid arthritis can cause severe laryngeal obstruction. With a mobilization and laterofixation procedure, five of six patients were successfully operated upon. Documented improvement of breathing was achieved and the voice function was acceptable after decannulation. | |
| 6229181 | Parenteral gold in the treatment of rheumatoid arthritis. | 1983 Dec 30 | For over 50 years, gold therapy has played an important role in the treatment of rheumatoid arthritis. Since 1932, many clinicians and investigators have confirmed the beneficial effects of the water-soluble gold salts, aurothioglucose and gold sodium thiomalate. Gold therapy is indicated for patients with active disease who are not responsive to conservative therapy. To minimize patient risks, contraindications must be considered, and careful clinical and laboratory monitoring must be performed under close supervision by the physician during therapy. Side effects may include vasomotor reactions, dermatitis, stomatitis, leukopenia, proteinuria, nephrosis, and thrombocytopenia. During therapy, one of six patients may have an adverse reaction requiring suspension or termination of therapy. Of the five tolerating gold, one will not benefit, three may have marked improvement, and one may have a remission. The usual recommended dosage schedule is intramuscular injection of 25 to 50 mg of gold salt at weekly intervals until a total of 1,000 mg has been achieved. At this level, gold injections may be spaced biweekly, triweekly, and then monthly for an indefinite period. | |
| 6751241 | Clinical response to therapy with thymopoietin pentapeptide (TP-5) in rheumatoid arthritis | 1982 Oct | The effect of thymopoietin pentapeptide (TP-5) was evaluated in patients with rheumatoid arthritis (RA). Ninety-two patients were divided into 3 groups, namely, placebo, TP-5 intramuscularly (IM) 1 mg, TP-5 intravenously (IV) 50 mg, and were evaluated for 6 measures of disease activity at the beginning of the study and at 3 and 6 months. No difference was observed between the placebo group and the group treated with TP-5 IM 1 mg. However, in the group treated with TP-5 IV 50 mg a statistically significant improvement of all parameters except the ESR was observed. | |
| 7247473 | Characterisation of activated lymphocytes in the peripheral blood of patients with rheumat | 1981 Jun | The extent and nature of lymphocyte activation in the circulation in rheumatoid arthritis (RA) was investigated. Peripheral blood lymphocytes (PBL) from RA patients and healthy controls were separated into a number of discrete fractions by density in discontinuous Ficoll density gradients. Low density (activated) lymphocytes were found at significantly higher levels in RA, particularly in patients with clinically active disease. Conversely, patients with clinically inactive RA had normal levels of activated lymphocytes. Lymphocyte populations within the ficoll gradient fractions were detected by E rosettes, staining for surface Ig, and by different avidities of EA binding. The activated population in RA was shown to be relatively depleted of T cells, enriched in surface Ig-bearing lymphocytes, and depleted of lymphocytes with high avidity EA binding. The evidence suggests that many of the activated PBL in RA are B blasts. | |
| 337940 | [Study of an articular cartilage in rheumatoid arthritis by the immunofluorescence method] | 1977 | The immunomorphological examinations of 20 biopsy specimens of articular cartilage in rheumatoid arthritis at various stages of the pathological process showed immunoglobulins of different classes and complement (C'3) to penetrate into the articular cartilage. In early stages mostly IgG was detected, and with increasing destructive processes in the matrix IgM was found. A certain tropism in the distribution of immunoglobulins in the cartilage matrix to the zones of chondrocytic capsules was observed which could be associated with the direction of immune reactions towards chondrocytes. The articular cartilage tissue may be the basis for the development of the autoimmune process and maintain permanent inflammatory process in the synovial membrane of the joint with local antibody synthesis. The process of phagocytosis of the antigenic substances of the articular cartilage or immune complexes deposed in it underlies the distribution of pannus. | |
| 1220709 | [Pemphigus induced by D-penicillamine in rheumatoid arthritis. Study of 5 cases and system | 1975 Dec 20 | The authors present 5 cases of pemphigus induced by D-penicillamine in a series of 180 cases of rheumatoid arthritis treated with this medication. In addition, anti-epidermal intercellular substance antibodies were sought in 40 asymptomatic patients. No antibodies were found in this group. The notion of induced pemphigus seems well established, as is the value of testing for antibodies in the surveillance of D-penicillamine treatment. |