Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 921345 | Effect of penicillamine on complement in vitro and in vivo. | 1977 Oct | In most normal human sera the addition of penicillamine to a final concentration of 0-2 mmol/l and subsequent dialysis caused a slight reduction in serum haemolytic complement (CH50). At 200 mmol/l, CH50 activity was no longer demonstrable. Even high concentrations of penicillamine were needed to inhibit the ability of immunoglobulin to fix complement to preformed or forming immune complexes. This indicated that the reduction of CH50 observed in serum was due to an effect on the complement factors. In vivo, a dose of 240 mg penicillamine caused a slight transient reduction in CH50 in rabbit serum, while 1000 mg penicillamine had no effect on serum CH50 in patients with rheumatoid arthritis. In arthritis patients there was, however, some evidence for removal of complement deposits in synovial tissue during penicillamine treatment. Since it is theoretically possible that concentrations high enough to cause reduction of complement activity can be achieved locally in synovial tissue, the effect on complement may be one of the mechanisms by which penicillamine exerts its effect in rheumatoid arthritis. | |
| 629096 | [Mode of action of D-penicillamine in chronic polyarthritis. 1. Protein synthesis inhibiti | 1978 Jan | The influence of D-Penicillamine on protein synthesis in synovial fluid cells was investigated in 5 patients suffering from rheumatoid arthritis. Intra-articular injection of this substance at a dosage of 5 to 250 mg is followed by an inhibition of protein synthesis in the synovial fluid cells. | |
| 7006254 | [Enzyme histochemical demonstration of immunoglobulins in joint capsules in chronic polyar | 1980 Sep | In rheumatoid arthritis, immunoglobulins are detectable in joint capsules within the subsynovial space and in superficial cell layers in significantly greater frequency as compared with osteoarthritis. These extravascular immunoglobulins were demonstrated in good agreement by a three-step immuno-peroxydase technique and a two-step alkaline phosphatase technique, the former being preferable because of reduced unspecific background staining. Both techniques are at least as sensitive as conventional immunofluorescence while in addition rendering the histological evaluation of the entire joint capsule possible. Thus, the detection of extravascular immunoglobulins can be related to their activity as mediators of inflammation. Accordingly, hypertrophy and hyperplasia of superficial cells as well as stromal proliferation could be consequences of immunoglobulins or immune-complexes persisting in the joint capsule. The histochemical techniques described here are suitable to morphologically distinguish osteoarthritis from chronic polyarthritis in histological sections. The presence of immunoglobulins in superficial cell layers and/or extravascular spaces argues in favour of rheumatoid arthritis. | |
| 299864 | The immunology of arthritis: interpretation of serologic studies. (Summary of presentation | 1977 Feb | Results of serologic tests in rheumatic disease require good judgment in interpretation, based upon familiarity with the present knowledge of immunologic mechanisms, including the action of antibodies, auto-antibodies, T-cells and B-cells. | |
| 7149533 | Atlantoaxial instability revisited. An alert for endoscopists. | 1982 Nov | Atlantoaxial instability in rheumatoid arthritis patients presents a particular hazard for endoscopists. The basic pathology, while well known to orthopedists, is not common knowledge among bronchoesophagologists or anesthesiologists. The paper describes the syndrome, potential complications and possible approaches to avoiding serious neurologic sequellae. | |
| 423583 | Rheumatoid pericarditis. Clinical significance and operative management. | 1979 Apr | The incidence of subclinical pericarditis associated with rheumatoid pericarditis may be as high as 50 percent, but significant impairment of cardiac performance owing to this type of pericarditis rarely occurs. In the past 7 years, we have encountered eight men with congestive heart failure owing to rheumatoid pericarditis. Cardiac catheterization and echocardiography were useful in establishing the diagnosis of pericardial constriction. Pericardiocentesis was unsuccessful in relieving symptoms in the three patients in whom the procedure was performed. Seven patients underwent pericardiectomy; six had constrictive pericarditis and one patient had an acute pericarditis with the sudden onset of cardiac tamponade. The other patient died of cardiac tamponade prior to operation. All patients improved after operation and have remained free of cardiac symptoms 3 months to 4 1/2 years later. The frequent occurrence of adhesive and obliterative pericarditis with loculated effusions suggests the need for pericardiectomy rather than pericardiocentesis in the patient with rheumatoid arthritis and symptomatic pericardial involvement. Immediate and lasting relief of this unusual nonarticular manifestation of rheumatoid arthritis can be expected after pericardiectomy. | |
| 1079368 | [Value of HL-A groups in diagnosis in rheumatology]. | 1975 Feb | Since 1972, several relations have been demonstrated between some HL-A antigens and some articular diseases. The W27 antigen frequency is highly increased in ankylosing spondylitis (88%) and in Reiter disease (78%) compared with controls (5%). In peripheral forms of psoriatic rheumatism, the W17 and HL-A13 antigens are more frequent (24% and 15%) than in healthy subjects (4% and 5%). In central forms of psoriatic rheumatism, there is a relation with W27 (48%) and still, we do not know if this association concerns only spondylitis or also sacro-iletis. The HL-A typing may be useful for the diagnosis of some rheumatologic diseases, when for the diagnosis of ankylosing spondylitis. The relation between W27 and ankylosing spondylitis is cleanly stronger than that between Waaler-Rose reaction and rheumatoid arthritis. | |
| 6376325 | Reticulin and its related structural connective tissue proteins in the rheumatoid synovium | 1984 May | Argyrophilic reticulin fibres are an important component of the rheumatoid synovium and their distribution and that of their individual protein constituents have been studied in synovial biopsies from a series of 29 cases of rheumatoid arthritis. In acutely inflamed synovia they are predominantly found underneath the hyperplastic synovial lining layer and related to the inflammatory cell infiltrate. With developing chronicity the reticulin network is gradually replaced by mature collagen. This histological pattern is mirrored by changes in the individual components of reticulin fibres-fibronectin, the non-collagenous reticulin component of Pras and Glynn (NCRC) and collagen type III. | |
| 7458429 | Cellular immunity to possible synovial antigens in rheumatoid arthritis. | 1980 Dec | A reaction has been demonstrated between extracts of synovial cells removed from intact rheumatoid knee joints and autologous leucocytes. The cell mediated immunity test system used was leucocyte migration inhibition. Variable reactions were found with a spectrum of allogeneic extracts when donor leucocytes came from married or transfused females or transfused males. Leucocytes from healthy (nontransfused) males showed no reaction with any of the extracts. As a period of cell culture was used prior to preparation of this extract to remove nonspecific inhibitory substances, native immunoglobulins, and complexes, the data are best explained by the presence of a foreign pathogen or altered cell component in the synovial cells of these rheumatoid patients. | |
| 7114920 | Pyrophosphate arthropathy: a clinical and radiological study of 105 cases. | 1982 Aug | 105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and radiologically. There were 76 women (mean age 73) and 29 men (mean age 62). Of only 18 patients below the age of 60 at presentation 12 were men. The majority of the younger male group suffered from acute attacks of synovitis, and had no clinical or radiological evidence of joint damage. In contrast the older female group had widespread destructive changes. Associated joint disease included generalised osteoarthritis (45), rheumatoid arthritis (8), joint hypermobility (13), previous knee surgery (8), and gout 92). Sixteen patients had received long-term steroid therapy. Severe destructive joint changes were seen in 16 patients. The radiological features in those with rheumatoid arthritis by ARA criteria were atypical. The relationship between CPD deposition and arthritis is discussed in the light of these findings. | |
| 6719300 | Penicillamine therapy in rheumatoid arthritis. | 1984 May 5 | During the period 1976-1983, 67 patients with rheumatoid arthritis attending the arthritis clinics at Groote Schuur Hospital and Princess Alice Orthopaedic Hospital, Cape Town, were treated with penicillamine. The information obtained from a retrospective study showed that 47 patients (70,15%) gained some benefit from the therapy, and that 28 (41,79%) went into complete remission; 36 (53,73%) developed side-effects which resulted in termination of therapy in 24 (35,82%). Urinary abnormalities were the commonest side-effect (28,36%), the relatively infrequently described haematuria being the most frequent. Seven patients failed to respond to therapy. | |
| 1201106 | Ultrasonographic demonstration of popliteal cysts in rheumatoid arthritis. A noninvasive t | 1975 Nov | Ultrasound scanning techniques detected popliteal cysts in 14 of 24 knees affected with rheumatoid arthritis and associated with an anterior effusion. Serial scans demonstrated the persistence of cysts when effusion was not controlled by intraarticular steroid and lidocaine, and regression of cyst following control of effusion with anterior synovectomy. As the technique is noninvasive, painless, and reproducible, ultrasound scanning should be the technique of choice for the detection and assessment of popliteal cysts. | |
| 7131452 | Morphological and biomechanical studies of rheumatoid pannus and cartilage. | 1982 Jul | Invasive pannus or granulation tissue was observed in 0.2 mm thick slices of cartilage and adjacent subchondral bone taken from fresh metatarsal and metacarpal heads removed surgically from patients with rheumatoid arthritis. Application of stress to the slices showed "tracking" of pannus or invasive tissue between lacunae and through breaches in the subchondral plate. Softened regions in the cartilage matrix became creased and were easily distinguished from regions of normal consistency. The pannus-matrix interface was not disrupted by stresses as high as 30 g/mm2. | |
| 1242642 | The presence of alkaline phosphatase in the subchondral bone of the medial tibial condyle | 1975 Oct 27 | A study has been carried out on the alkaline phosphatase activity in trabecular bone in the normal state, rheumatoid arthritis and osteoarthritis. Samples were taken from the subchondral bone of the medial tibial condyle in all cases. The reason for this study was to investigate whether changes in rheumatoid bone like trabecular microfractures and healing reactions were parallelled by a mineralization process which could be demonstrated by an increased alkaline phosphatase activity and compared to that in osteoarthritic and normal bone. This investigation disclosed that the alkaline phosphatase activity in rheumatoid bone did not differ much from either osteoarthritis or normal bone. | |
| 7415585 | [Changes in the synovial membrane in early diagnosed cases of rheumatoid arthritis. II. Im | 1980 May | To extend the histologic-histochemical examinations on so-called early cases of rheumatoid arthritis (RA, Geiler and Emmrich 1980) additional immuno-histochemical and serological tests were carried out on the same subjects. The purpose was to find out to what extent the well-known humoral immunological abnormalities of RA cases with fully developed disease (so-called late cases) occur in the early stage of RA. It was also aimed to determine their diagnostic and pathogenetic significance. The synovial membranes were tested immuno-histochemically for rheumatoid factor, immunoglobulins, and complement fixation for the complement factors C3, C4 and C9. In the serum the rheumatoid factor was assayed by the latex test and its immuno-globulin class specificity by means of an immunofluorescence test. In contrast to observations in the late cases, rheumatoid factors, immuno-globulins and complement deposits are found less often. In the class specificity test of rheumatoid factor in the serum there are considerably more positive cases than with the latex test. In the synovial membrane and in the serum there are positive cases also in juvenile RA-cases. For the diagnosis of early cases the immuno-histochemical demonstration of the rheumatoid factor in the synovial membrane is of great importance. The diagnosis RA may thereby the secured. --In the pathogenesis the accumulation of vasculitides with deposits of immune-complexes may be important. Possibly a vasculitis induced by immune-complexes represents the initial reaction of the rheumatoid synovitis. Since in the early cases little synthesis and deposits of immuno-globulins, rheumatoid factors and complements are found, it may be assumed that the more active humoral immunological activity of the synovial membrane of the late cases develops slowly during the course of the disease. | |
| 4014820 | Cricoarytenoid arthritis presenting as cardiopulmonary arrest. | 1985 Jul | We describe a patient with a long history of rheumatoid arthritis who presented in full cardiopulmonary arrest. He was given intracardiac epinephrine. Fibroptic laryngoscopy determined the cause of the arrest to be upper airway obstruction from cricoarytenoid joint ankylosis, a complication of long-standing rheumatoid arthritis. The patient underwent a tracheostomy, recovered uneventfully, and was doing well nine months later. The literature is reviewed, and the pathophysiology, clinical findings, presentations, and treatment of this potentially fatal entity are described. | |
| 1191776 | [Circulation of antibodies to dispiral RNA and ribosomal RNA in patients with allergies, r | 1975 Apr | A study was made of the incidence of antibodies to bispiral synthetic polynucleotide (poly E, poly C). In patients with allergoses and in healthy persons antibodies to bispiral RNA were revealed in 14% of cases, in patients with rheumatism--in 40.9% and with rheumatoid arthritis--in 50% of cases. It is supposed that more frequent detection of antibodies to bispiral RNA in patients with rheumatism and rheumatoid arthritis is associated with persistence of the RNA-containing viruses. | |
| 1229739 | [Behaviour of synovial blood vessels in semi--thin sections in progressive chronic polyart | 1975 May | The synovial blood vessels of 17 patients with clinically definite rheumatoid arthritis (RA) were studied histologically and ultramicroscopically. No differences between seronegative and seropositive RA subjects were found. The abnormalities observed concerned mainly the endothelial cells, which showed changes varying in degree from swelling to fibroblastic transformation. The destruction of endothelial cells seemed to be linked with a positive test for C-reactive protein as a consequence of an acute relapse. Areas of cellular infiltration and partial homogenization were found in the tunica media of the vessel wall. There was a striking hyperemia of the capillaries and venules. | |
| 6180569 | [Diffusive interstitial pulmonary fibrosis in chronic polyarthritis]. | 1982 May | Among 167 in-patients with rheumatoid arthritis, 7 cases (4,2%) of diffuse interstitial pulmonary fibrosis of variable degree were revealed by chest X-ray examination. There was a predominance of the advanced functional classes according to Steinbrocker (where the duration of the disease was approximately the same as in patients without pulmonary fibrosis). There were higher 1-hour erythrocyte sedimentation rates and gamma-globulin valves and lower levels of hemoglobin and hematocrit in the patients with diffuse interstitial pulmonary fibrosis than in those without pulmonary changes. The etiological and pathogenetic aspects of several theories are discussed. The therapeutic possibilities are described and the importance of penicillamine therapy is emphasized. | |
| 369226 | [Methods and value of an immunofluorescence-optical determination of IgM, IgG and IgA rheu | 1979 Jan | Today the immuno-fluorescence technique is the simplest method to detect rheumatoid factors of all immuno-globulin classes. When applying sheep erythrocytes, standard sera may be used without exception. The airdried smear of the cells is to be incubated with rabbit anti-human-erythrocyte serum. The rheumatoid factors of the subsequently applied inactivated patients' sera localise above the amboceptor on the erythrocyte membrane. Only they bind FITC marked anti-human-gamma-globulin and cause a specific fluorescence. As a proof heteroagglutinines and crossreacting antibodies of the marked sera are first absorbed and corresponding controls are carried out. According to assessments of 101 sera approximately 20% of healthy people, approximately 50% of "definitely seronegative" patients with rheumatoid arthritis according to the agglutination method as well as 30% of other arthropathies had rheumatoid factors by these methods. A negative immunofluorescence optical test does not absolutely exclude the presence of rheumatoid factors in the serum. It is suggested that their occurrence are due to secondary reactions to the formation of immunogen antigen-antibody complexes. |