Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 139094 | [Glomerulopathy in rheumatic patients due to penicillamine]. | 1976 | This paper describes four cases (where rheumatoid arthritis is the basic ailment of the patients involved) of immune complex nephritis and stage I membranous glomerulonephritis, respectively. Treatment was by means of penicillamine. Also discussed are light-microscopical, immunohistological, and electron-optical results. | |
| 7174786 | Activation of human complement by immunoglobulin G antigranulocyte antibody. | 1982 Dec | The ability of antigranulocyte antibody to fix the third component of complement (C3) to the granulocyte surface was investigated by an assay that quantitates the binding of monoclonal anti-C3 antibody to paraformaldehyde-fixed cells preincubated with Felty's syndrome serum in the presence of human complement. The sera from 7 of 13 patients with Felty's syndrome bound two to three times as much C3 to granulocytes as sera from patients with uncomplicated rheumatoid arthritis. The complement-activating ability of Felty's syndrome serum seemed to reside in the monomeric IgG-containing serum fraction. For those sera capable of activating complement, the amount of C3 fixed to granulocytes was proportional to the amount of granulocyte-binding IgG present in the serum. Thus, complement fixation appeared to be a consequence of the binding of antigranulocyte antibody to the cell surface. These studies suggest a role for complement-mediated injury in the pathophysiology of immune granulocytopenia, as has been demonstrated for immune hemolytic anemia and immune thrombocytopenia. | |
| 6432411 | An European open multicentre trial with auranofin in rheumatoid arthritis. | 1984 Mar | In 8 European countries a multicentre trial was started in 672 patients with RA. The safety and efficacy of Auranofin (oral gold), was evaluated. There seems to be no difference in response to treatment between patients treated with Auranofin 3 mg twice daily or 6 mg once daily. From the fourth month of treatment there is a statistically difference in improvements for following parameters : activity index of Chalkins, articular index of Lansbury, ESR, pain, morning stiffness, grip strength, number of swollen joints and number of tender joints. These data suggest that Auranofin can be considered as a valuable disease modifying antirheumatic drug (DMARD) in RA and that early onset of therapy can be advised. In most cases the treatment is well tolerated. | |
| 413499 | Immunofluorescence of the skin in gold rashes - with particular reference to IgE. | 1977 Dec | Immunofluorescence studies have been carried out on rashes from 36 patients with rheumatoid arthritis receiving gold therapy. 24 of the rashes were clinically attributed to gold and 12 were diagnosed as coincidental rashes. IgE was found in 6 of the gold rashes and in 4 of the coincidental rashes. Immunofluorescence changes of immune complex vasculitis, lichen planus, or pemphigoid were found in 9 gold rashes while 2 coincidental rashes showed vascular fluorescence for immunoglobulins but nor for complement. Two definite gold rashes showing no changes on immunofluorescence showed perivascular infiltration with lymphocytes on light microscopy. Thus, while immunofluorescence is only marginally helpful in the diagnoses of gold rashes, evidence of an immunological reaction tends to favour a diagnosis of a gold-induced rash. | |
| 6969958 | T-lymphocyte subpopulations in rheumatoid arthritis. | 1980 Sep | We studied 24 patients with rheumatoid arthritis and 24 age- and sex-matched controls for lymphocyte subpopulations in the peripheral blood. Patients with rheumatoid arthritis had a significantly lower relative lymphocyte count (p < 0.005) and a higher percentage of T lymphocytes bearing Fc-receptor for IgM (TM) (p < 0.05). The proportion of B lymphocytes, total T lymphocytes and T lymphocytes with Fc-receptors for IgG (TG) in patients with rheumatoid arthritis was not different from that in controls. In 1 of 5 cases tested incubation of T lymphocytes in autologous rheumatoid factor positive serum instead of FCS resulted in significant reduction of TM and increase in TG cells. These results are discussed in relation to possible immunological factors involved in the etiology of rheumatoid arthritis. | |
| 7112023 | [Protein binding of salicylates in rheumatoid arthritis]. | 1982 May | Protein binding of salicylates was determined in 16 control subjects and 27 patients suffering from rheumatoid arthritis. Results obtained after separation of the free and bound fractions by dialysis to equilibrium and measured by spectrofluorometry were analyzed using a new mathematical model. In correlation with the decrease in plasma albumin concentrations, a decrease was found in the protein binding of salicylates in patients with rheumatoid arthritis. This phenomenon was less marked in therapeutic zones and was related to the degree of severity of the inflammatory syndrome. The binding capacity per albumin molecule at saturation was decreased in patients suffering from advanced forms, suggesting that the changes seen were not due solely to quantitative variations in serum albumin levels. This study confirms the value of the determination of free salicylate levels in patients suffering from inflammatory rheumatic disorders. | |
| 1082748 | Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membr | 1976 Jan | The perivascular infiltrates of the rheumatoid synovium were examined in the electron microscope. Lymphocyte-rich, plasma cell-rich, and transitional areas were observed. The transitional areas contained lymphocytes, plasma cells, blast cells, macrophages, and fribroblasts. Although lymphoblasts were frequent, the blast cells were predominantly plasmablasts. Marked degeneration of fibroblasts in the vicinity of lymphoblasts suggested the liberation of a lymphotoxin by the lymphoblasts. There was close contact between blast cells and macrophages and between macrophages and lymphocytes. The close association of lymphoblasts, plasmablasts, and macrophages in the transitional areas suggests that these are sites of T- and B-cell interaction in the rheumatoid synovial immune response. | |
| 6403279 | Ferroxidase and ascorbate oxidase activities of caeruloplasmin in synovial fluid from rheu | 1983 May | 1. The protein caeruloplasmin inhibits certain free radical reactions, in part probably due to its ability to oxidize Fe2+ into Fe3+ (ferroxidase activity). Since caeruloplasmin is present in synovial fluid from rheumatoid patients, we investigated its properties in relation to protection of the joint from damage by oxygen radicals produced by activated phagocytes. 2. The ferroxidase and ascorbate oxidase activities of serum from both normal and rheumatoid patients could be accounted for by the caeruloplasmin present, as determined immunologically. More caeruloplasmin is present in the serum of rheumatoid patients than in normal serum. 3. Synovial fluid from rheumatoid patients contains caeruloplasmin protein but its ferroxidase and ascorbate oxidase activities are abnormally low. It is suggested that ferroxidase deficiency contributes to radical damage in the rheumatoid joint. | |
| 6740268 | Xanthoma tendinosum in a normolipemic ectodermal dysplasia patient. | 1984 | A female patient with congenital ectodermal dysplasia is described, who developed xanthoma tendinosum in her hands simulating rheumatoid arthritis. The serum lipids of this patient were normal. Both ectodermal dysplasia and xanthoma tendinosum in a normolipemic patient are rather uncommon and to our knowledge have not been previously reported in one and the same patient. | |
| 6625704 | Leucocyte superoxide dismutase in rheumatoid arthritis. | 1983 Oct | Superoxide dismutase (SOD) activity was measured in polymorphonuclear leucocytes (PMNLs) and mononuclear cells (MNCs) from 60 patients with rheumatoid arthritis (RA) and in 15 controls. In all patients and controls SOD activity (U/mg protein) in MNCs was twice that in PMNLs. SOD activity in PMNLs and in MNCs from patients with RA was significantly higher than that in controls. SOD activity in PMNLs (but not in MNCs) from patients treated with corticosteroids was significantly higher than that from patients treated with nonsteroidal anti-inflammatory drugs. There was no relation between SOD activity in both PMNLs and MNCs and either the patients' age, sex, duration of disease, serum immunoglobulin concentration, IgM rheumatoid factor, and copper level, or the degree of disease activity. | |
| 7183583 | Surgical rehabilitation. | 1982 | There is hardly any other disorder where the possibility of replacing destroyed joints by artificial ones has transformed the functional outcome so decisively as in rheumatoid arthritis. The advances achieved in surgery may even be regarded as the most important result of any research on rheumatoid arthritis as published in recent years. Arthroplastics account for almost half of all interventions in our own statistics which cover almost 6000 operations on patients with this disease. Surgical synovectomies account for more than 40 per cent, and various other techniques are used in only 10 per cent of operations. Indications and contra-indications are discussed first in a more general way, and the need for close collaboration of family doctor, rheumatologist, orthopaedic surgeon and highly qualified therapeutic staff is emphasized. In the following sections the most rewarding methods used for rehabilitation of the upper limbs are described, including pre- and post-surgical management as well as the results to be expected. Subsequently our standard programme for the surgical rehabilitation of the affected joints of the lower limbs is presented. Special reference is made to a new technique for the fixation of the arthroplasty in cases of rheumatoid acetabular protrusion. | |
| 237493 | A double blind trial to assess the value of alclofenac compared with phenylbutazone in the | 1975 Apr | A double-blind cross-over study using a double placebo technique was employed to compare the effectiveness of daily alclofenac 3 g and phenylbutazone 300 mg in rheumatoid arthritis. (2) Thirty-one patients with classical or definite rheumatoid arthritis entered the trial. Twenty-three patients completed the trial; eight patients were withdrawn while on alclofenac, six developing a rash and two having inadequate analgesia. (3) Relief of pain on both drugs was comparable. (4) When questioned at the end of the trial, sixteen patients preferred phenylbutazone, four preferred alclofenac. (5) No significant changes in laboratory values were found, apart from a slight mean fall in haemoglobin on phenylbutazone. (6) There were significantly more side effects on alclofenac and rashes were particularly prominent. | |
| 6466396 | Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory d | 1984 Aug | Synovial fluid fibronectin from normal subjects and from patients who have rheumatic inflammatory diseases has been studied and compared with plasma fibronectin. The average fibronectin concentration in synovial fluids from normal subjects was 172 +/- 69 micrograms/ml; it was 721 +/- 315 and 556 +/- 349 micrograms/ml in synovial fluids from patients with rheumatoid arthritis and osteoarthritis, respectively. This is the first report on fibronectin concentrations in normal synovial fluids. Synovial fluid fibronectin from healthy subjects and patients with rheumatoid arthritis or osteoarthritis showed a molecular weight identical to that of plasma fibronectin. All normal and pathologic synovial fluid fibronectins showed a remarkably lower electrophoretic mobility compared with that of plasma fibronectin, when separated according to net molecular charge on agarose gel. Peptides from thermolysin digests of fibronectin from plasma and synovial fluid, when compared on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, showed distinct differences. These data demonstrate that synovial fluid fibronectin represents a molecular form which is structurally different from that of plasma fibronectin. This suggests that synovial fluid fibronectin is locally synthesized, possibly by a cell type which differs from that responsible for the production of the plasmatic fibronectin pool. | |
| 6398184 | Assessment of hand function. | 1984 Dec | Hand assessment involves analysis of developing deformities and the pathological changes causing them, and a study of how these changes affect the various components of hand function both individually and combined into activities required by the patient. A detailed recording of this information helps in the planning of treatment, and is essential for reliable evaluation of the effects of treatment. | |
| 4470919 | Osmium: an appraisal of environmental exposure. | 1974 Aug | In the U.S., the chief source of new osmium is copper refining, where this metal is produced as a byproduct. Probably less than 10% of the osmium in the original copper ore is recovered, and 1000-3000 oz troy of osmium is lost each year to the environment as the toxic, volatile tetroxide from copper smelters. In 1971, about 2000 oz troy of osmium was domestically refined, most of which was from secondary sources. An additional 4169 oz troy of osmium was toll-refined. Major uses for osmium tetroxide identified are for catalysis, especially in steroid synthesis, and for tissue staining. Minor uses of osmium metal are for electrical contacts and for imparting hardness to alloys for mechanical pivots, etc. Unreclaimed osmium tetroxide that reaches wastewater streams is probably rapidly reduced by organic matter to nontoxic osmium dioxide or osmium metal, which would settle out in the sediment of the water course. Waste osmium metal, itself innocuous and chemically resistant, would be oxidized to the toxic tetroxide if incinerated. Because of the small amounts used and their wide dispersal, the amounts of osmium tetroxide in wastewater and air should pose no hazard to man or the environment. The chief acute toxic effects of osmium tetroxide are well known and include eye and respiratory-tract damage. Few data are available that provide information on possible effects of nonacute exposure resulting from environmental contamination by osmium. However, workers continually exposed to osmium tetroxide vapors (refiners and histologists) and rheumatoid arthritis patients who have received intra-articular injections of osmic acid solutions have shown no apparent damage from exposure to low levels of osmium. | |
| 4203129 | Determination of IgG antiglobulins in rheumatoid disease using insolubilized human IgG. | 1973 Sep | IgG antiglobulins in human sera were measured by single radial diffusion in agar after elution from ethyl chloroformate insolubilized immunosorbents of rabbit or human IgG. With both immunosorbents seronegative and seropositive rheumatoid sera contained significantly higher levels of IgG antiglobulins than did sera from healthy adults. Attempts to measure antiglobulins interacting specifically with the pFc' half of the Fc region were not successful due to an unacceptably high degree of non-antibody binding. | |
| 6980101 | A proposed criteria for diagnosis of systemic lupus erythematosus used in Veterans General | 1982 May | An eight-point diagnostic criteria for SLE was proposed and evaluated at the Veterans General Hospital (VGH), Taipei. It consists of 8 points and 12 items, 3 points being required for an accurate diagnosis. All of 94 cases of SLE whether they could or could not be diagnosed with the ARA criteria fulfilled 3 or more points of the VGH criteria. None of the 17 cases of rheumatoid arthritis fulfilled 3 or more points of the VGH criteria. | |
| 7237670 | [Essential deformans osteolysis. Report of a case with progressive and generalized evoluti | 1980 | The authors report a clinical and radiographic course of a 16 years old caucasian girl with a progressive deformation of her skeleton. The primary lesions occur in knees and wrists. This disease was at first considered as a rheumatoid arthritis, then as a dysplasia epiphysialis multiplex, and now as essential deformans osteolysis (with carpal lysis, shortening of the forearm bones, dislocation of the elbows, disparition of the humeral and femoral heads, contracture of hips and knees, posterior tarsal lysis, and kypho-scoliosis). The clinical (particularly ophtalmologic), biological (including inflammatory, phospho-calcic and nephrologic evaluation with mucopolysaccharidosis urinary excretion) and histological (skin, muscle and bone) check-up were normal. They review the different classification established on lesion topography, on association or not with a nephropathy, finally on an dominant or recessive autosomal inheritance. Then the authors think that their case is similar to the ones of Winchester and Hollister. They discuss the etiopathogenic factors, and do not consider their case as a new mucopolysaccharidosis, but rather as a generalized disease of the collagen of bones. | |
| 623681 | Kinetic studies of phagocytosis. I. The serum independent particle uptake by PMN from pati | 1978 Jan | The initial phagocytic rate of IgG coated polyvinyl toluene latex particles was assayed for isolated PMN cells. The kinetic studies of phagocytosis were performed in serum-free medium using an electronic particle counter. The mean phagocytic rate for the reference group of apparently healthy individuals was 0.60 min-1. PMN cells from 5 of 26 patients with rheumatoid arthritis (RA) had subnormal values of particle ingestion rate, although the mean of the group was not significantly reduced compared to the controls. Correlation coefficient between the log of rheumatoid factor titer and phagocytic rate was 0.58 (P less than 0.001). During penicillamine treatment an increased rate of phagocytosis was observed in patients with RA. Granulocytes isolated from 17 patients with systemic lupus erythematosus (SLE) had a significantly increased (P less than 0.001) mean initial rate of phagocytosis (0.91 min-u). Two patients in this group had an acute exacerbation of disease activity and were treated with large doses of prednisone. An appreciable decline in phagocytic rate was observed during the intensive corticosteroid therapy. | |
| 7302350 | [Respiratory complications in the course of treatment with D-penicillamine : alveolitis an | 1981 | D-penicillamine has proved to be an effective treatment of rheumatoid arthritis, but adverse effects of this drug are frequent. The authors report 4 cases of respiratory disease in the course of treatments with D-penicillamine for which the drug may probably be held responsible. Two patients presented with diffuse alveolitis which improved on stopping D-penicillamine. Two patients presented with rapidly progressive dyspnea; chest X-ray showed distended lungs; lung function tests showed severe airflow obstruction with air trapping : treatment with bronchodilators and corticosteroids was ineffective. Several cases of patients with such features have been reported during the last few years; pathologic studies which were performed disclosed bronchiolitis. Clinicians should be aware of the severity of this type of bronchiolitis and stop D-penicillamine immediately in patients presenting with early respiratory symptoms. |