Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4034961 | Supraacetabular insufficiency fractures. | 1985 Oct | Insufficiency fractures in the supraacetabular region were identified in five women, aged 55-83 years. Factors contributing to the diminished resistance of their bones included postmenopausal osteoporosis, steroid therapy, radiation therapy, and rheumatoid arthritis. The supraacetabular fractures were seen on routine radiographs as hazy bands of sclerosis located immediately above and parallel to the acetabular roof. All five patients had additional fractures in the spine or pelvis. Supraacetabular insufficiency fractures may be an unsuspected cause of hip pain, especially in older women. | |
| 6385276 | Giant synovial cysts. | 1984 | Giant synovial cysts (GSC) are large, well-defined cavities, containing synovial fluid and lined by a synovium-like membrane, which extend for a variable distance outside the joint cavity. We are reporting 15 cases of GSC of various joints. Rheumatoid arthritis is the most common disease process reported in association with GSC. We suggest that trauma may be a more important cause of GSC than has previously been described. Arthrography and ultrasonography are both helpful in diagnosing these large cysts, especially in the knee to aid in differentiating GSC from thrombophlebitis. | |
| 644233 | [Synoviorthesis of the knee using osmic acid: apropos of 61 injections]. | 1978 Feb | The authors report their experience of 61 injections of osmic acid into the knee during the course of rheumatoid polyarthritis. The results stated to be very good and good, are classified by the disappearance of pain, swelling and stiffness, or a improvement in any one of these criteria. As observed in 67% of cases at the third month the result following changed with time. While these favourable results persisted into the fifth month, there was a remarkable maintenance of them to the 30th month in those patients who it was able to follow so long. The most distinct and lasting results were seen in those joints which showed the least radiological change. Tolerance of the injection of osmic acid was satisfactory apart from several painful reactions which improved in the 24 hours following injection. Two cases of thrombo-phlebitis were seen and one case of rupture of the synovium. If the results obtained with osmic acid appear less impressive than those obtained with isotopes, the simplicity of the method attracts attention as it needs no complicated equipment and is applicable to young invalids. | |
| 6608424 | Anti-perinuclear and rheumatoid factor in different forms of autoimmune thyroid disease. | 1984 Mar | Anti-perinuclear factors (APF), IgM-, IgG- and IgA-rheumatoid factors have been detected in six, five, one and three out of 20 patients with primary myxoedema, respectively. We were unable to find APF in 22 patients with Hashimoto's thyroiditis nor in 20 patients with Graves' thyrotoxicosis. APF appears to be a marker for non-organ specific autoimmune diseases. | |
| 7359683 | Spontaneous skin tearing during systemic corticosteroid treatment. | 1980 Mar 28 | A 52-year-old woman with rheumatoid arthritis experienced painless spontaneous hemorrhage, tearing, and necrosis of the skin on the lower laternal aspect of both legs. Thereapy with systemic prednisone had been used to suppress active synovitis for almost four years and was associated with moon facies, hirsutism, truncal obesity, thinning of the skin, extensive purpura on the extremities, and other manifestations of hypercortisolism. There was no evidence of rheumatoid vasculitis, trauma, or blood dyscrasia. The leg lesions may represent an exaggerated type of steroid-induced purpura resulting in localized areas of gangrenous skin. | |
| 4083937 | Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients w | 1985 Dec | The molecular weight distribution of hyaluronate (HA) in synovial fluid (SF) from 10 patients with rheumatoid arthritis (RA), from six patients with other joint disorders, and from five recently deceased persons without joint affections was investigated by a gel chromatographic procedure. A new and highly specific radioassay was used for determination of the HA concentration in the effluent from the chromatographic column, and this allowed analyses on 0.5 ml or less of untreated synovial fluid. The results confirmed the findings by others that the weight-average molecular weight (Mw) of HA in SF from patients with RA (4.8 X 10(6)) was similar to that in other joint diseases (5.0 X 10(6)) and moderately but significantly (p less than 0.001) lower than that of normal SF (7.0 X 10(6)). Furthermore, the molecular weight distribution of HA in the pathological SF was generally broad and varied considerably between individuals. The HA concentration in the pathological SF varied between 0.17 and 1.32 g/l, which is in accordance with previous reports and considerably lower than that of normal SF. Neither the nature of the arthropathy and the extent of the inflammatory process nor the pharmacological treatment had a tendency to influence the HA concentration in the SF, the mean molecular weight of HA, or its molecular weight distribution. Although the concentration of HA in SF drops in joint disease, the total amount of the polysaccharide is greatly enhanced. Also the amount of high molecular weight polysaccharide (Mw greater than 6 X 10(6)) is in excess in joint disease. The pathological state is therefore characterised not by lack of high molecular weight hyaluronate but by a dilution of it. | |
| 956267 | Roentgen features of the rheumatoid mid- and hindfoot. | 1976 Jun | The roentgen features of rheumatoid involvement of the mid- and hindfoot are analyzed utilizing anatomic and pathologic material from "control" and rheumatoid cadavers and a detailed radiographic study of a rheumatoid population. Characteristic findings include diffuse abnormalities predilecting the calcaneus, talocalcaneonavicular and tarsometatarsal joints with joint space narrowing, bony fusion and reactive sclerosis. Rheumatoid localization in the mid- and hindfoot is not unusual, particularly in long-standing disease, and is almost universally associated with metatarsophalangeal alterations. | |
| 1082030 | Cellular and humoral immune parameters of synovial fluid and blood in rheumatoid arthritis | 1975 Dec | Thymus derived (T) and bone marrow derived (B) cells from joint fluid and peripheral blood of 15 patients with rheumatoid arthritis and 10 controls with other inflammatory joint diseases were studied. High absolute numbers and high percentages of T cells in the synovial fluid, T plus B cell sums exceeding 100 per cent in synovial fluid or blood, and fewer complement receptors compared to surface Ig bearing cells in joint fluid or blood was found only in rheumatoid arthritis. T and B cell numbers did not correlate with disease activity. No differences in T and B cells were found between patients positive or negative for rheumatoid factor. (J Rheumatol 2: 363-372, 1975). | |
| 7152377 | Tendon ruptures in the hand with particular reference to attrition ruptures in the carpal | 1982 Oct | The mechanisms of tendon rupture in the hand are reviewed. Attrition ruptures of tendons in the carpal tunnel, other than those due to rheumatoid arthritis, are rare. A case is reported where Kienböck's avascular necrosis of the lunate caused rupture of flexor policis longus. This is the second case reported in the literature and serves as a model of attrition rupture. | |
| 7056117 | D-Penicillamine-induced severe pneumonitis. | 1982 Mar | We report the first histologically described case of severe D-penicillamine-induced pneumonitis. It occurred in a 73-year-old woman who suffered from rheumatoid arthritis and had previously demonstrated gold intolerance. Pathologic study disclosed marked interstitial and alveolar damage resembling that described with certain chemotherapeutic agents. We assess the drug's responsibility, discuss possible pathogenetic pathways, and provide suggestions regarding the patient on a D-penicillamine schedule. | |
| 114641 | Gold in the treatment of rheumatoid arthritis -- why, when and how? | 1979 | The use of gold salts is reviewed and discussed in terms of rationale (Why), indications and side-effects compared to other disease suppressives (when), and different types of gold and their modes of administration (How). | |
| 213903 | [Degradation of C1q, the first subcomponent of the complement sequence, by synovial collag | 1978 Oct 27 | Human C1q is shown to be degraded by high concentrations of RA synovial collagenase (enzyme : substrate ratio 2 : 1). The collagen-like sequence of C1q is attacked by the enzyme. A possible cleavage site is described and compared with the cleavage site in collagen. | |
| 901027 | Rheumatoid synovial cells from intact joints. Morphology, growth, and polykaryocytosis. | 1977 Aug | Synovial cell lines were isolated by instillation of trypsin or chymotrypsin into intact knee joints of patients with persistent rheumatoid effusions resistant to conventional therapy. Morphology and growth in the primary phase were compared with rheumatoid cells isolated from excised synovium and nonrheumatoid synovial cells obtained from intact joints of cadavers or amputated limbs. Cell populations from all sources included varying proportions of macrophage-like and fibroblast-like cells, with only 1-3% multinucleated cells. In medium supplemented with calf serum alone, rheumatoid cells from intact joints showed negligible changes in morphology. However, in the presence of nonrheumatoid, autologous rheumatoid or homologous rheumatoid serum a rapid increase occurred in size of the macrophage-like cells and numbers of polykaryocytes, including some giant syncytial cells. These effects were directly proportional to serum concentration and were identical in fresh or heat-inactivated serum. In most of these rheumatoid cell lines no multiplication occurred, regardless of serum type or concentration. In rheumatoid synovial cells from excised synovium, human serum induced both polykaryocytosis and rapid growth of fibroblasts. Nonrheumatoid synovial cells grew rapidly but few polykaryocytes developed, mostly with less than 6 nuclei. Evidence of viral infection in rheumatoid synovial cells was sought by electron microscopy after stimulation of polykaryocytosis by human serum. In one of the cultures many cells were found with intranuclear particles possessing characteristics of the adenovirus group. | |
| 1138673 | Jaccoud arthritis. | 1975 Apr | Jaccoud polyarthritis is thought to be a rare complication of rheumatic fever. It is characterized by severe rheumatic fever, with repetitive or prolonged attacks, associated with a painless, but deforming arthritis affecting the small joints of hand and feet. Radiologically, erosion of the metacarpal heads may be present. All described cases have shown obvious rheumatic heart disease. Two patients had the clinical and radiographic features of Jaccoud arthropathy who had no antecedent history of rheumatic fever. Jaccoud arthropathy may have diverse causes. | |
| 136882 | Stimulation of lymphocytes from rheumatoid arthritis patients by mitogens and IgG. | 1976 | In the first part of this work patients with rheumatoid arthritis (RA), 36 cases and normal subjects, 49 cases have been studied by lymphocyte cultures stimulated by phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and Con A convalently bound to sepharose 4 B (Con A-S). The comparisons between the two groups have shown a significant difference between the RA lymphocytes and the control lymphocytes stimulated by PHA and Con A. However no statistical difference has been found between the two lymphocytes populations stimulated by PWM and Con A-S. In view to determining the lymphocyte population stimulated by each mitogen, separations of B- and T-cells from peripheral blood have been performed according to the ability for the T-cells population to bind the sheep red blood-cells (rosette forming cells). The T-cell rich population was only stimulated by PHA, Con A and PWM. Although the T-cell depleted one has shown no response to these mitogens, a response to Con A-S was elicited. In the second part of this work, patients with RA, patients with positive tuberculin (PPD) skin-tests and controls were studied. The lymphocytes from these groups were cultured in serum-free medium to obtain cell-free supernatants. These lymphocyte cultures were preincubated with the appropriate antigen or reconstituted after removal of the cells. Supernants from RA lymphocytes stimulated in vitro by undenaturated IgG induced an inhibition of the leucocyte migration, as well as the supernatants from tuberculin-sensitized lymphocytes. However, supernatants from non-RA lymphocytes or tuberculin-unsensitized lymphocytes did not show such an inhibition. These MIF like supernatants have been studied by Sephadex G-100 gel filtration. A MIF like activity has been found for PPD and IgG supernatants between the chymotrypsinogen (MW 23,000) and the lysozyme (MW 17,000). This MIF like activity could be due to RA lymphocytes stimulated by undenatured IgG. | |
| 6361968 | R2 anti-reticulin antibody in a mixed hospital population. | 1983 Oct | R2 anti-reticulin antibody was detected in 15 of the 9,500 serum samples examined (0.16%) from a mixed hospital population. The antibody titre varied from 1:40 to 1:320, and the R2 was of the IgG class in 13 of the 15 positive samples. All the 15 serum samples with R2 were negative on human liver, confirming the lack of cross reaction of this antibody. The reactivity of R2 was not absorbed by soluble fractions of type I collagen, showing that this antibody is not directed against this antigen. R2 was confined to two groups of pathological conditions: connective tissue and digestive tract diseases. Four of 15 patients with R2 had rheumatoid arthritis and in two of these four cases the antibody was of the IgA class. | |
| 6646039 | Human amnion in the treatment of chronic ulceration of the legs. | 1983 Sep 17 | A prospective study to evaluate the efficacy of human amniotic membrane dressings in the treatment of chronic leg ulcers was conducted on 15 patients. Patients with two ulcers were selected. One ulcer was treated with human amnion and the other, treated with standard dressings, served as a control. The rate of healing of the two ulcers was observed and compared. Chronic ulcers of post-phlebitic, post-irradiation and post-burn origin responded to treatment with human amnion and healed more rapidly than the control ulcer. Ulcers associated with rheumatoid arthritis and vasculitis showed no improvement. It was observed that all ulcers treated with human amnion quickly became pain-free. | |
| 7102272 | Arthrodesis of the wrist by the method of Mannerfelt. A follow-up of 19 patients. | 1982 Aug | Twenty-four wrists in 21 patients were treated with arthrodesis by the Mannerfelt method. Seventeen patients had rheumatoid arthritis and 4 osteoarthrosis. Stable radiocarpal ankylosis was obtained within 3 months in all cases. Postoperative complications were few and slight. Fusion of the carpo-matacarpal joints occurred spontaneously in a number of the patients. Minor mobility in the carpo-metacarpal joints of the transfixed digit was not the cause of essential complaints. It was not necessary to remove the osteosynthesis material in any patient. At follow-up all patients but 3 were satisfied with the position of the wrist, aimed to be close to neutral. | |
| 500755 | A review of 100 Attenborough stabilised gliding knee prostheses. | 1979 Nov | We have reviewed 100 Attenborough total knee replacements in eighty-two patients with a follow-up of one to four years and conclude that this prosthesis has a valuable place in the surgical management of patients suffering from rheumatoid arthritis and osteoarthritis with severe involvement of the knee. In 85 per cent of these knees a good result was obtained with relief from pain, and in 77 per cent a useful range of movement with a stable knee. Only two patients with loosening and three with deep infection were seen in this series. | |
| 649636 | Intra-articular pressure as a factor in initiating ulnar drift. | 1978 Apr | To determine the possible relevance of intra-articular pressure in the production of ulnar drift, metacarpophalangeal joints of fresh cadaver specimens were injected with water to increase the intra-articular pressure. Of the thirty-two joints tested, ulnar deviation was produced in twenty-three, flexion in twenty-four, and simultaneous ulnar deviation and flexion (ulnar drift) in nineteen. In two or three instances, the displacement was in extension or radial deviation. These results suggest that elevated intra-articular pressure may be a factor in the initiation of ulnar drift in patients with rheumatoid arthritis. |