Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4478129 | [Clinical data on the use of estriol-testosterone combinations in small animal practice]. | 1974 | A combination of oestriol and testosterone oenanthate was tried in 14 different indications on 110 dogs and 5 cats of both sexes. Two formulations were used, containing in 1 ml either 0.15 mg oestriol and 2.25 mg testosterone or 1.15 mg of the former and 2.25 mg of the latter. Dosage was 0.2 ml per kg body weight, by i/m injection. The criterion for success was the degree of functional restitution, without taking into account pathological changes, which were generally unaffected. Good or very good results were obtained in hip dysplasia, arthitis and patellar luxation. None of the 50 bitches treated showed signs of oestrus or irregularities in the cycle. The formulation containing the lower drug concentration seemed to give the best therapeutic results. | |
| 970995 | Early rheumatoid disease. II. Patterns of joint involvement. | 1976 Aug | Data from the first research clinic visit (Fleming and others, 1976) have been subjected to factor analysis to identify early patterns of joint involvement. Nine patterns emerged. Two patterns, if present early, were found to have prognostic significance. An eventually more severe disease was associated with a pattern of large joint involvement (shoulder, elbow, wrist, knee) and a pattern based on metatarsophalangeal joints I and III. | |
| 7126294 | Human complement activation by self-associated IgG rheumatoid factors. | 1982 Sep | IgG rheumatoid factors (IgG-RFs) undergo concentration-dependent self-association into dimers and higher polymers, as previously reported. The interactions of purified IgG-RF from the plasma of 3 patients with rheumatoid arthritis, with guinea pig and human complement were studied. Self-associating IgG-RFs were isolated by affinity columns and gel filtration. These preparations contained no detectable IgM and were composed only of IgG subclasses known to fix complement. Complement utilization of IgG-RF was compared with that of monomeric IgG, heat-aggregated IgG, and soluble rabbit IgG immune complexes. Although incubation of IgG-RF or monomeric IgG with 3 units of guinea pig or human complement resulted in decreased hemolysis of sheep erythrocytes sensitized with IgM hemolysin, these substances were less than 100 times as effective as heat-aggregated IgG or soluble immune complexes. The ability of human or guinea pig complement that had been incubated with IgG-RF to restore hemolytic activity to C4-deficient guinea pig serum served to distinguish Clq binding from complement cascade activation. IgG-RFs and monomeric IgG did not activate guinea pig complement cascade in contrast to aggregated IgG. IgG-RFs, however, activated human complement cascade; monomeric IgG only bound human Clq. These results indicate that self-associated IgG-RFs can activate human complement in fluid phase, but less effectively than aggregated IgG or large-latticed immune complexes. | |
| 318718 | Ultrastructural study of human synovial membrane with immunoperoxidase. | 1977 Jan | An ultrastructural immunoperoxidase study of human synovial membrane biopsies performed in 16 patients with rheumatoid synovitis and in 14 control patients showed that: (1) plasma immunoglobulins have an intercellular distribution and seem to diffuse mainly by an intercellular rather than by a transcellular pathway; and (2) there is a difference in the distribution of plasma IgG and IgM. IgG was found in intravascular and extravascular spaces in all biopsies. IgM was found only in intravascular spaces in control biopsies, but in rheumatoid synovitis it was present in both intravascular and extravascular spaces. This difference in distribution may be due to increased vascular permeability in inflammatory synovitis. | |
| 6723121 | Methods for assaying D-penicillamine in a clinical setting. | 1984 | Penicillamine disulfides have been analysed by automatic amino acid analysis. Because the free thiol reacts poorly with ninhydrin, other detection methods are preferred, particularly high pressure liquid chromatography using an electrochemical detector or gas chromatography with a flame ionization detector. Pharmacokinetic studies have now been reported using these techniques. With patients on established penicillamine regimes, the concentration of free penicillamine in the plasma has been found to vary between 4 and 20 microM depending on dosage and time of administration. Disulfide concentration is higher than this by a factor of 3 or 4 and an even greater quantity is attached to plasma and tissue proteins. | |
| 109527 | Hanganutziu-Deicher antigen and antibody in pathologic sera and tissues. | 1979 Jun | Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test. | |
| 6861815 | Experience with piroxicam in general practice: results of a German multicenter study on 18 | 1983 | 18,888 patients with chronic or extra-articular rheumatic diseases were treated for an average period of 36.1 or 26.9 days with the new non-steroidal anti-rheumatic agent piroxicam. In particular, piroxicam had a positive effect in terms of providing relief from pain. Side effects were relatively rare and seldom required discontinuation of treatment. In about 75% of the patients the maintenance dose was 20 mg piroxicam in a single daily dose. No influence on the laboratory values or accompanying diseases were observed. | |
| 485580 | Myelotoxicity of D-penicillamine. | 1979 Jun | Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded blood counts on at least 5 of the patients showed a downward trend of the white cell and platelet counts while D-penicillamine was still being administered. One patient suddenly developed leucopenia and thrombocytopenia with a streptococcal septicaemia. | |
| 754387 | Cellular sensitivity to collagen in rheumatoid arthritis. | 1978 | Using an assay to measure antigen-induction of a lymphocyte mediator, LIF, we detected cellular sensitivities to native human types II and III collagens in three-quarters of a group of 50 patients with rheumatoid arthritis. There was no cellular response to type I collagen. Cellular reactivities to collagen were absent in a group of 41 patients who had other kinds of arthritis, such as osteoarthritis, crystalline-induced synovitis, or arthropathies associated with a high prevalence of the HLA-B27 antigen. Lymphocytes, responding to an unknown persistent antigenic stimulus, are thought to play a major role in the pathogenesis of rheumatoid arthritis. It has previously been hypothesized that collagen might function as an autoantigen in this disease. Based on the disease specificity of our findings and the tissue distribution of types II and III collagens, we propose that cellular sensitivities to these structural proteins may be involved in the pathogenesis of rheumatoid arthritis. | |
| 999620 | Clinical importance of the electro-oculogram with special reference to the chloroquine ret | 1976 | Examination of the EOG is surely worthwhile in cases of generalized pigment alteration and in juvenile foveal dystrophies. Its value in the control of chloroquine treatment is still doubted, but the method will become better if an EOG is made before treatment is started. EOGs made during the treatment can then be compared with those made earlier. As a result, the large interindividual variation is replaced by the much smaller intraindividual variation. In a group of normals and patients, the intraindividual standard deviation appeared to be about 10% of the original value of the EOG. Using this criterion, we think the EOG to be a valuable tool in preventing chloroquine retinopathy, although it is not yet certain if static perimetry with red light is still a better method. | |
| 1215875 | [Testing of the antirheumatic agent tolmetin for its interactions with oral anticoagulants | 1975 Jun 7 | In 15 patients on long-term oral anticoagulation the new antirheumatic drug tolmetin (Tolectin) was administered over a period of 10 days. Based on 11 parameters of coagulation, no interaction between the drug and phenprocoumon was found. A significant though clinically irrelevant prolongation of bleeding time was observed. | |
| 6583413 | Cellular mechanisms of bone damage and repair in the arthritic joint. | 1983 Dec | Trabeculae and subchondral bone have been studied by scanning electron microscopy (EM) and fluorescence microscopy from joints removed surgically in patients with rheumatoid arthritis (RA), osteoarthritis (OA), and "normals" who had leg amputations with no primary arthritis. In the arthritic specimens, inflammation, bone damage and repair varied in different areas of the same joint. Osteoclasts and mononuclear cells were associated with areas of resorption--together and separately. Scanning EM showed trabeculae in RA to be thinner, narrower, fewer, and with spindle forms compared with thicker trabeculae in OA. Attempts at repair were more successful in OA despite the higher bone turnover which occurred locally at the rheumatoid joint. | |
| 6419593 | Auranofin versus placebo in the treatment of rheumatoid arthritis. | 1983 Dec 30 | In a six-month, multicenter, double-blind study involving 340 patients, auranofin, 3 mg twice daily, was compared with placebo in the treatment of adult-onset rheumatoid arthritis. All patients were continued on a therapeutic regimen of salicylates and/or a newer nonsteroidal anti-inflammatory drug. Patients in both treatment groups who completed six months of therapy with coded medications showed significant improvement in the clinical features of rheumatoid arthritis (that is, number of tender and swollen joints, severity of pain, grip strength and duration of morning stiffness); however, the mean improvement was greater in the auranofin-treated group. Fifty-two percent of the auranofin-treated patients compared with 24 percent of the placebo-treated patients (p less than 0.05) were judged by their physician to have shown marked or moderate improvement. Only in the auranofin-treated patients was there significant improvement from baseline in the laboratory parameters of disease activity: erythrocyte sedimentation rate, IgA, IgG, and IgM. After at least three months of therapy, 30 percent (46 of 152) of the placebo-treated patients but only 9 percent (13 of 152) of the auranofin-treated patients (p less than 0.05) withdrew from coded medication due to insufficient therapeutic effect. Study medication was discontinued by 5 percent (eight of 152) of the auranofin-treated patients and 3 percent (four of 152) of the placebo-treated patients because of adverse therapy events (p = 0.24). This study demonstrates the efficacy of auranofin when added to salicylates and/or nonsteroidal anti-inflammatory drugs in the treatment of rheumatoid arthritis. | |
| 7111617 | Explicit incestuous motifs in psychosomatic patients. | 1982 | In this study, which is the first ever to deal with the issue of incestuous motifs in psychosomatic patients, the author reviewed the charts of all his psychosomatic patients, seen in at least 40 interviews between 1975 and 1980, and the charts of all his non-psychosomatic patients, seen in at least 40 interviews between 1970 and 1975, in order to determine the frequency of explicit incestuous motifs in each group. It was found that the motifs had been reported by more psychosomatic patients than non-psychosomatic patients. Also, it was found that the explicit incestuous motifs which had been reported by the psychosomatic patients were more intense and pervasive than those which had been reported by the non-psychosomatic patients. These findings are discussed with reference to the issue of failure of the ego's defense mechanisms in psychosomatic patients. | |
| 7398528 | Interpretation of the electro-oculogram of patients taking chloroquine. | 1980 Apr 15 | No significant differences in initial EOG were found between a group of RA patients using chloroquine, a group treated with gold and a normal group. Most probably this is due to the low dosage of chloroquine which is used nowadays. After six months, EOG values in the chloroquine group were reduced, while they were increased in the gold group. The differences were statistically significant, but most be carefully interpreted, because in the group of normal subjects the EOG was lowered as well. | |
| 6673094 | Median nerve compression complicating arthrodesis of the rheumatoid wrist. | 1983 | The frequency and pathogenesis of median nerve compression complicating the Rush pin method of fusing the rheumatoid wrist was evaluated retrospectively. This complication was encountered in 14/50 wrists (28%). In 7 hands the carpal tunnel was explored, mostly within 2 weeks after fusion. In addition to signs of acute entrapment of the median nerve the most constant finding was that the volar edge of the resected distal end of the radius was prominent and projected into the bottom of the carpal tunnel caused by too vigorous correction of the subluxed carpus. Obviously the median nerve was squeezed or angulated at the volar edge of the radius. After median nerve release and resection of the bony prominence all patients regained full sensibility within the period of observation (in average 2.5 years). It is concluded that this mechanism of nerve entrapment should be realized when fusion of a severely destructed rheumatoid wrist is considered. | |
| 681727 | Clinical and experimental studies on the effect of extensor carpi radialis longus transfer | 1978 Jul | Digital ulnar drift in the rheumatoid hand is a complex problem. The radial deformity of the wrist causes abnormal forces on the extrinsic flexor and extensor tendons which aggravate metacarpophalangeal ulnar drift. Analysis of the results of the transfer of the extensor carpi radialis longus to the extensor carpi ulnaris in 20 wrists showed that 13 of 20 had significant correction of the wrist deformity. The transferred tendon did not contract during active ulnar deviation. Laboratory studies of the transfer on cadaveric rheumatoid wrist models showed correction of the wrist deformity. The dorsal ulnar capsule was determined to be a stabilizer of wrist position, as evidenced by deformity after transection. | |
| 474303 | A comparison of the carrageenan edema test and ultraviolet light-induced erythema test as | 1979 Jun | Twelve non-steroidal anti-inflammatory agents (NSAI's) and one steroidal anti-inflammatory agent, dexamethasone, were examined in the carrageenan edema test (CET) in the rat and in the ultraviolet light-induced erythema test (UVE) in the guinea pig to evaluate the correlation between those models of inflammation and the clinical dose of the NSAI's in the treatment of rheumatoid arthritis. The regression of the logarithm of the clinical dose with the logarithm of the ED50 for UVE gave a slope of 0.54 implying a non-parallelism of assays and a difference in mechanism. Dexamethasone failed to inhibit the UVE thereby corroborating this point. The parallelism of the logarithm of the clinical dose with the logarithm of the ED50 for the CET was substantially better (slope = 0.86). Dexamethasone was active in CET and its dose would be predicted by the CET regression. When only one variable was used for a prediction, log(CET) was a better predictor of log (clinical dose) than log(UVE). Standard methods for best regression selection indicated that even when both predictor variables were considered, log(CET) alone gave the best regression equation for predicting clinical dose. The view that inhibition of prostaglandin biosynthesis is the primary anti-inflammatory mechanism of NSAI's in rheumatoid arthritis is discussed in terms of these findings. | |
| 4082680 | [Leukocyte agglomeration in synovial fluid]. | 1985 Oct 15 | The agglomeration of leucocytes serves as evidence of leucocytic activation. In rheumatoid arthritis it can be used as a very sensitive criterion of activity. Patients with rheumatoid arthritis with joint effusions showed a high agglomeration of leucocytes in 97%, i.e. a clear activation of leucocytes. In 74.3% the number of punctate leucocyte agglomerated increased. Punctates with a proof of a spontaneous agglomeration of leucocytes showed the most intensive inclination to agglomeration also after incubation. By synovial fluid normal but also leucergic granulocytes could be stimulated to increased agglomeration to leucocytes. In the synovial fluid also factors stimulating the agglomeration of leucocytes are found. They probably come from punctate granulocytes and stimulate also the chemotaxis and activation of the blood granulocytes. Since granulocytes essentially participate in the inflammatory reaction of the rheumatoid arthritis and in the joint destruction evoked by it, the therapeutic aspect should be directed also to the inhibition of such leucocyte-activating factors in the synovia. | |
| 355882 | Cellular sensitivity to collagen in rheumatoid arthritis. | 1978 Aug 17 | We examined patients with rheumatoid arthritis for cellular sansitivity to native human Types I, II and III collagens. Mononuclear cells from 50 patients with rheumatoid arthritis, 21 with other inflammatory arthritides, 20 with osteoarthritis and 20 normal subjects were evaluated for the in vitro production of leukocyte inhibitory factor in response to collagen and a control antigen, streptokinase-streptodornase. By this assay, cells from 37 (74 per cent) and 39 (78 per cent) of the patients with rheumatoid arthritis responded to Types II and III collagens, respectively. In contrast, cells from the 41 patients with other kinds of arthritis and the normal group did not produce this lymphokine to collagens. There was no response to Type I collagen or to denatured alpha chains of these collagens. All four groups responded equivalently to streptokinase-streptodornase. These data demonstrate that most patients with rheumatoid arthritis exhibit cellular sensitivity to Types II and III collagens. |