Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6747237 | Arthrodesis of the wrist by internal fixation in rheumatoid arthritis: a follow-up study o | 1984 Jul | Between 1972 and 1981, 59 wrists of 44 patients destroyed by rheumatoid arthritis were arthrodesed by internal fixation with a Rush pin. This study comprises 45 wrists of 38 surviving patients--nine men and 29 women, aged 20 to 72 years. The follow-up time ranged from 1 to 11 years with a mean of 3.9 years. The surgical technique used in this study is simple and safe, and a good position of the wrist in both frontal and lateral projections can easily be achieved. The Rush pin is passed down the third metacarpal and into the radius. It stabilizes the wrist adequately. All the wrists operated on obtained a strong bony fusion of the radiocarpal joint. The complication rate was low. Five of 45 Rush pins were removed because the subcutaneously located distal tip between the metacarpals irritated tendons and skin. In one male patient a thin Rush pin broke and a pseudoarthrosis of the intercarpal joints developed; there was, however, no need to remove the pin. | |
| 308252 | [Study of cellular immunity in rheumatoid arthritis]. | 1978 Jun | The responsiveness to mitogens of the in vitro cultural peripheral blood lymphocytes from 60 patients with rheumatoid arthritis (RA) and from controls was evaluated in terms of H3 TdR uptake. The size of the response was tested for a correlation with the percentages of T and B lymphocytes, determined by E and EAC rosette test, as well as with the various alterations of the clinical and biological parameters. In the RA cultures an elevated level of spontaneous H3 TdR uptake was found, which could be an in vitro carry-over of an activation in vivo. No significant statistical differences were found between rheumatic and control groups as regards: 1 degrees--the H3 TdR uptake induced both by PHA and SLO; 2 degrees--the proportion of the circulating T and B lymphocytes. The only positive correlation evidenced by this study in RA patients was that between the proportion of B lymphocytes and the gammaglobulin level in the plasma. | |
| 743023 | Rheumatic diseases and the eye. | 1978 Nov | The ocular complications of the rheumatic diseases are common, frequently insidious and sight threatening, and deserve review to heighten awareness and facilitate earlier diagnosis and treatment. | |
| 6179010 | [Acupuncture in rheumatology. Case contribution]. | 1982 Jul 31 | Results obtained by acupuncture treatment of patients with rheumatic diseases were analysed. Clinical, serological and psychological parameters were evaluated at the beginning and end of treatment. Results showed variations in pain intensity, articular function, inflammation, anxiety and bodily condition. The results are accompanied by a description of the limits of the research conducted. | |
| 2931799 | T-lymphocyte subsets and HLA-DR-expressing cells in the osteoarthritic synovialis. | 1985 | Rheumatoid and osteoarthritic synovial membranes biopsied at operations were analysed in frozen sections with an immunohistochemical monoclonal antibody technique. It is evident from this investigation that immunocompetent inflammatory cells such as HLA-DR-expressing non-T cells and T cells in general occur even in the osteoarthritic synovial membrane, though to a lesser degree than in rheumatoid arthritis. In about half of the osteoarthritic synovial membranes these T cells were clustered in follicle-like formations. In both diseases, most of the T cells were helper/inducer T cells whereas cytotoxic/suppressor T cells occur sparsely and almost exclusively in rheumatoid arthritis. | |
| 6334354 | Unusual T cell proliferations and neutropenia in rheumatoid arthritis: comparison with cla | 1984 Oct | 4 patients are described with rheumatoid arthritis, splenomegaly, neutropenia and an unusual proliferation of T cells in the blood and marrow. These patients are clinically similar to patients with classical Felty's syndrome but can be distinguished from them by staining blood and marrow mononuclear cells with a panel of monoclonal anti-T cell antibodies. The T cells from patients with T cell proliferations stain with UCHT1 (OKT3 equivalent) and UCHT4 (OKT8 equivalent but do not stain with a panel of OKT1-like antibodies. In 7 patients with classical Felty's syndrome there was no increase of UCHT4 cells in the blood and the large majority of T cells stained with OKT1-like antibodies. The marrows from the patients with T cell proliferations contain plentiful haemopoietic progenitor cells and it is probable that the T lymphocytes suppress their normal maturation. There was a poor response to splenectomy in 2 patients with T cell proliferations, and single cytotoxic drug therapy may be more appropriate when therapy is required. The literature is reviewed and it is suggested that the T cell proliferations may be secondary to the rheumatoid process. | |
| 824725 | Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 pati | 1976 | During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and safety of treatment with diftalone in a per oral dosage of 500 mg/day were compared with those of indomethacin given orally at doses of 50-75 mg/day initially and 100 mg/day subsequently, for a treatment period of 24 months. In this long-term study, diftalone demonstrated that its effectiveness and safety in the treatment of rheumatoid arthritis are clearly comparable to those of indomethacin. | |
| 60841 | [Studies on the mechanism of L-agglutination (author's transl)]. | 1976 Aug | The mechanism of L-agglutination (LA) was studied by fractionating human sera by means of Sephadex G 200 gel filtration. LA was found to be mediated by 2 factors: the rheumatoid factor (RF) as a macroglobulin, occuring only in sera from patients with rhematoid arthritis, and an IgG globulin, found also in normal sera, probably a highly prevalent incomplete streptococcal antibody. RF-containing IgM fractions, by themselves devoid of LA activity, can be rendered positive not only by IgG from the same serum, but also by IgG from normal sera or by commercial human IgG. After absorption of sera containing the RF with streptococci LA disappears; by addition of normal serum, IgG from normal serum or human IgG LA titers were attained similar to those of the respective native serum. A treatment of RF-containing sera with mercaptoethanol leads to a largely parallel disapperance of LA and latex fixation. Three substrains of Streptococcus pyogenes SF 130 (type) 1), Varying in their endowment with type-specific antigens, reacted similarly in LA. | |
| 4023171 | Systemic lupus erythematosus and infection: a controlled and prospective study including a | 1985 Jun | An epidemiological group of 60 SLE patients was studied; 162 infections were observed prospectively for an aggregate of 1366 months. Bacterial infection was more frequent in the SLE patients than in matched controls but only slightly more frequent than in matched rheumatoid arthritis patients. The rheumatoid arthritis patients, also matched with regard to corticosteroid dosage, showed a tendency towards an increased infection rate only. Lower urinary tract infections were comparable in all three matched groups. In a total of 102 SLE patients studied, including the epidemiological group, clinical SLE activity was accompanied by an increase in the frequency of bacterial infection. In 49 patients bacterial infections were more common after flare than before. There was a high incidence of mucocutaneous infections induced by S. aureus, where skin traumatisation was an added risk factor. No increase of opportunistic infections was found in matched groups, but 26 such infections occurred in the subjects as a whole, and they were seen to be more frequent in conjunction with steroid-treated active SLE. Admission to hospital because of suspected infection was common, and infection was the cause or a contributory factor in five of the seven deaths among SLE patients. | |
| 109055 | Effects of gold, dapsone, and prednisone on serum C-reactive protein and haptoglobin and t | 1979 Apr | Sequential measurements of serum C-reactive protein (CRP), serum haptoglobin (Hp), and erythrocyte sedimentation rate (ESR) were made in 209 patients with rheumatoid arthritis (RA); 78 of them were treated with gold, 71 with dapsone, and 60 with prednisone. The results were expressed as proportional changes in the measurements at 28-day intervals after treatment began. The period of study was 140 days. During treatment with gold and dapsone there were statistically significant gradual and progressive falls of similar magnitude in serum CRP and ESR. During treatment with prednisone serum CRP and ESR fell abruptly by 28 days and thereafter altered little. At 140 days prednisone had had the largest proportional effect on both measurements. During gold treatment the fall in serum Hp was similar to that of the ESR. In contrast, prednisone had little effect on Hp levels despite large falls in serum CRP and the ESR. Either prednisone stimulates Hp synthesis or the divergence is an expression of the difference in type of effect between gold and prednisone on RA. The effect of dapsone on serum Hp was large and progressive; it partly reflects haemolysis and, since the haemolysis was not progressive, partly improvement in the RA. The results show the relative efficacy of the drugs and suggest that dapsone may be a useful alternative treatment for RA. | |
| 156393 | Penicillamine in rheumatoid arthritis: adverse effects. | 1979 | The use of penicillamine in rheumatoid arthritis (RA) is limited by the incidence of adverse effects, some of which are potentially hazardous. However, adverse effects are dose-related and the advantages and disadvantages of different fixed and flexible dose regimes are discussed. The incidence of adverse effects is significantly greater in patients previously treated with gold who developed toxicity to that drug--no such increase being found in gold treated patients whose only reason for stopping gold was ineffectiveness. Rashes which develop after several months of treatment are variants of pemphigus and their various presentations are described. Fatal reactions, fortunately rare, are predominantly associated with aplasia of the bone marrow. Monthly haematological checks coupled with meticulous charting of the results may reveal trends as well as numerical changes and serve as an early warning of marrow damage. | |
| 979163 | Indentations of the glomerular basement membrane in renal diseases. A light and electron m | 1976 Oct | Indentations of the glomerular basement membrane were observed by light microscopy in ultrathin Epon-embedded serial sections from the renal biopsies of patients who had membranous glomerulonephritis, minimal change glomerulonephrits, acute or resolving exudative glomerulonephritis and focal glomerulonephrits, interstitial nephritis, amyloidosis, rheumatoid arthritis, or ankylosing spondylitis. In patients with membranous glomerulonephritis, acute or resolving exudative glomerulonephritis, amyloidosis, or rheumatoid arthritis, the occurrence of indentations in the glomerular basement membrane differed significantly from that in controls. The presence of indentations did not correlate with proteinuria, hematuria, leukocyturia, arterial hypertension, or with the nephrotic syndrome or its treatment with steroids. Examination of alternate serial sections by light and be electron microscopy showed that the indentations that were light microscopically visible corresponded to craters on the epithelial surface of the glomerular basement membrane seen in the electron microscope. These craters contained protruding portions of the epithelial cells, extracellular electron-lucent material or electron-dense amorphous or striated membranous material. They were often surrounded by spikelike protrusions of the lamina densa. These indentations might represent solitary remnants of former subepithelial deposits. | |
| 1082634 | Elution and characterization of lymphocytes from rheumatoid inflammatory tissue. | 1975 | Lymphocytes were eluted from the synovial tissue of 19 patients with classical rheumatoid arthritis. The tissue was minced and dissociated by treatment with crude collagenase and DNase. The cell suspension obtained was filtered and incubated in plastic culture flasks overnight at 37 degrees C. The cells that did not adhere to the plastic surface were harvested and the lymphocytes further purified by the Ficoll-Isopaque gradient centrifugation technique. The lymphocyte yield varied from 0.64 to 32 times 10(6) cells. Differential counts showed on the average 85% lymphocytes, 12% mocrophage-like cells, and variable proportions of polymorphonuclear granulocytes, unclassified cells, and dead cells. An average of 77% of the cells were viable as assessed by the trypan blue exclusion test. This cell suspension was investigated for lymphocyte populations. T lymphocytes were predominant in all experiments (mean, 73.6%). The mean percentage of B lymphocytes was 9.7%, whereas the proportion of Fc-receptor-bearing lymphocytes was on the average 6.0%. | |
| 354028 | A long-term study of diclophenac sodium in the treatment of rheumatoid arthritis and osteo | 1978 Mar 25 | One hundred and two patients with either rheumatoid arthritis or osteo-arthrosis were treated for prolonged periods with diclophenac sodium (Voltaren; Geigy) to evaluate the efficacy and tolerability of the drug. Fifty-seven patients completed a trial of 12 months. A total of 70% showed an improvement in functional class, and 40% of the total had complete functional capacity by the end of the trial. The drug was well tolerated. The side-effects (heartburn, abdominal cramps, headache and dizziness) were mild and in most cases did not require cessation of treatment. In 9 patients the Coombs test became positive during the trial, but this did not require cessation of therapy. | |
| 185972 | Demonstration of antibodies to collagen and of collagen-anticollagen immune complexes in r | 1975 Oct | Twenty-nine synovial fluids from patients with rheumatoid arthritis (RA) and 10 synovial fluids from patients with other joint diseases were investigated with regard to the presence of antibodies to denatured human collagen and of collagen-anticollagen immune complexes. 12 of the 29 RA synovial fluids showed anticollagen titres from 1:16 to 1:512 in passive haemagglutination. Only one patient in the group with no arthritis had a significant anticollagen titre of 1:32. Digestion of the synovial fluids with bacterial collagenase resulted in an anticollagen titre increase from two to four dilution steps in 9 of the RA fluids, while 6 previously negative RA synovial fluids showed anticollagen titres from 1:32 to 1:28 after digestion with collagenase. These results indicate the existence of collagen-anticollagen immune complexes in 15 of the 29 RA synovial fluids investigated. | |
| 6989545 | Tiopinac in rheumatoid arthritis: a three-phase dose-ranging, efficacy, and aspirin-withdr | 1980 May | We designed a clinical trial to obtain dose-ranging, efficacy, and aspirin-withdrawal data on tiopinac in patients with rheumatoid arthritis. To accomplish this without exposing the patients to risk of disease exacerbation and avoiding type II error, we used a 3-phase protocol adding tiopinac to current therapy. The 3 phases-open-label dose ranging, double-blind tiopinac versus placebo, and aspirin withdrawal-began after a single-blind run-in period. The manufacturer withdrew tiopinac from investigation because of toxicity at higher doses, but with only 13 patients we found that tiopinac (up to 300 mg/day) decreased walking time, painful joints, and morning stiffness and increased grip strength (p less than 0.05). Both the global evaluation by the investigators and patient ratings of their activity showed superiority of tiopinac (tiopinac: 5 better, 1 worse; placebo: 1 better, 6 worse; p = 0.028 by Fisher's exact test). Complete aspirin withdrawal could be accomplished in only 3 patients, although in 10 of 13 the dose could be reduced 50% of baseline or less. The 3-phase protocol indicated effectiveness, a dose range, and partial aspirin replacement with minimal patient risk. | |
| 7384722 | [Our experience with surgery of the rheumatoid metatarsus. 150 cases]. | 1980 Jan | The authors report on the results of their experience with surgery of the rheumatoid metatarsus (95 patients operated on--150 operations). The operation most frequently performed was the Lelievre metatarsian resection-alignment. They confirm the advantage of this type of surgery, which provides very handicapped patients with substantial relief, both of pain and of the functional troubles, despite the nature of the disease involved. Out of 80 patients operated on and followed up over a period of 2 to 14 years, and considering the correction of the deformities, the effect on pain and functional troubles, the authors report 103 very good and good results, and 18 poor results and failures. The good results obtained deteriorate only very little in the long run: after 10 years, the very good and good results involving effect on pain, has gone from 96 to 90%. On the other hand, as far as functional troubles are concerned, very good and good results go from 90% to 70%. The authors underline the advantage of a very through examination, in order to look for post-operatory risk factors (peripheral circulatory deficiency and poor resistance to infection). They insist for exercising great prudence when advising an operation consisting of the interposition of an endoprosthesis (Swanson's implant). Indeed, in subjects who are in any way fragile, delays in scarification, related to hematomas complicated or not with skin necrosis appear with increased frequency after interposition of the implant. | |
| 830776 | Activation of complement components C3 and factor B in synovial fluids. | 1977 Jan | Synovial fluids from 106 patients with various types of arthritis were examined for the presence of conversion products of C3 by means of crossed antigen-antibody electrophoresis and for products of factor B by immunoelectrophoresis. C3 conversion was found in all 15 fluids from patients with seropositive rheumatoid arthritis, in 11 of 15 with seronegative rheumatoid arthritis, in the majority with probable and possible rheumatoid arthritis, juvenile rheumatoid arthritis, SLE, pseudogout, gout, Reiter's syndrome, and frequently in other arthritides studied, but in only one of 15 with degenerative arthritis. In 53 synovial fluids a single C3 conversion peak was seen in addition to the native protein and in 18 others two conversion peaks were present. In many synovial fluids showing conversion whole-complement titers and C3 protein concentrations were normal. In both rheumatoid arthritis and crystal synovitis the per cent of C3 conversion, as estimated by planimetry, correlated with synovial fluid leukocyte counts, Factor B conversion was found in 31 fluids and usually occurred in fluids also showing C3 conversion. The findings indicate that in vivo activation of components of the classical and alternative considered mediated by immune complexes. Activation is also commonly present in a wide variety of other inflammatory arthritides and ofter would not be recognized by measuring only concentrations of hemolytic whole complement or C3 by immunodiffusion. The positive association between C3 conversion and synovial fluid polymorphonuclear leukocytes suggests that chemotactic factors generated from complement may be responsible for the attraction of leukocytes into the synovial space in these diseases. | |
| 3993419 | Transpharyngeal radiography of mandibular condyle. Comparison with other conventional meth | 1985 Mar | Transpharyngeal examination of the mandibular condyle was compared with transcranial and transmaxillary examinations in 22 patients with mandibular pain/dysfunction. All projections were supplementary and a combination of at least two methods seemed preferable. When a single examination was used, underestimation of abnormalities was evident. In demonstrating condylar destruction, the transpharyngeal examination seemed to be superior to the more commonly used transcranial, but inferior to the transmaxillary examination. | |
| 7310776 | Hidden 19S IgM rheumatoid factor in synovial fluid. | 1981 Sep | Synovial fluid (SF) of 16 adult patients with rheumatoid arthritis (RA) and 9 children with juvenile rheumatoid arthritis (JRA) was investigated for the presence of hidden 19S IgM rheumatoid factor (RF). SF was incubated with 500 IU hyaluronidase/g of SF, dialyzed against acetate buffers at decreasing pH, centrifuged and subjected to chromatography on a Sephadex G-200 column. The resulting IgM-containing fraction of SF from 5 seropositive patients (3 adult RA, 2 JRA patients) demonstrated RF activity by the complement-dependent hemolytic assay. Hidden 19S IgM RF was not found in the IgM-containing fractions of SF from 13 adult seronegative RA patients. Hidden 19S IgM RF was shown in the IgM-containing fraction of SF in 4 of 7 children with seronegative JRA. |