Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 125934 | Gold therapy in rheumatoid arthritis. | 1975 Aug 30 | Forty patients with active rheumatoid arthritis were treated with intramuscular injections of gold salts. A significant response was shown by 67,5% of the patients. Treatment was discontinued owing to side-effects in 35%. Dermatitis and proteinuria from renal damage were the commonest complications of treatment. The method of treatment and its side-effects are discussed. | |
| 7128047 | Glycosaminoglycans produced by human synovial cell cultures. | 1982 Jul | Human synovial cells in culture are known to synthesize hyaluronic acid, but the production of sulfated glycosaminoglycans (GAG) has received less attention. Using 14C-glucosamine as a precursor, GAG content was studied in the medium, trypsin-solubilized pericellular layer, and cell residue fraction of cultured synovial cells derived from the synovial membranes of nonrheumatoid and rheumatoid joints. Over 90% of the total non-dialyzable counts appeared in the culture medium, for the most part in hyaluronic acid. The remaining nondialyzable counts were cell-associated, almost equally divided between the pericellular layer and cell residues. In these fractions, only part of the counts were in GAG susceptible to testicular hyaluronidase digestion, and GAG were significantly lower in the cell residue of the rheumatoid synovial cells compared to the nonrheumatoid cells. Analysis of the chondroitinase ABC and AC digestion products of these GAG indicated the presence of chondroitin-4 and -6 sulfates, and dermatan sulfate, but not heparan sulfate. Similar findings with respect to the identity of the GAG in nonrheumatoid and rheumatoid synovial cell culture media were obtained with 35SO4 as a precursor. | |
| 6405032 | Prevalence of eosinophilia during gold therapy for rheumatoid arthritis. | 1983 Feb | The prevalence of eosinophilia in 82 rheumatoid arthritis patients receiving gold sodium thiomalate (GSTM) and 30 patients receiving auranofin (AF) was determined in a retrospective study. Eosinophilia occurred in 21% taking GSTM and in 13% on AF. The simultaneous occurrence of toxicity and eosinophilia occurred in 14% receiving GSTM and in 10% receiving AF. In contrast, eosinophilia only occurred in 24% of those with suspected toxicity receiving GSTM and in 30% of those with suspected toxicity receiving AF. The value of eosinophilia as a marker of toxicity is discussed. | |
| 115078 | Cholestatic hepatitis induced by gold. | 1979 Aug | A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate. Hepatotoxicity in rheumatoid arthritis is well described following a variety of anti-inflammatory preparations but is now a rare complication of gold therapy and the literature on the subject is reviewed. | |
| 155958 | [Primary chronic polyarthritis with kidney involvement (mesangiocapillary glomerulonephrit | 1979 Mar | A 34 year old white male patient suffering from seropositive "probable" rheumatoid arthritis developed a severe hypocomplementemic mesangiocapillary glomerulo-nephritis. Rheumatoid factors (Latex test, Waaler-Rose titer) and IgM were markedly elevated in the serum. The third component of complement (C3) was markedly depressed, while the fourth component (C4) was within normal range. The rapid progression of the disease forced us to start an immunosuppressive drug therapy using azathioprine and steroids. Despite marked clinical improvement, e.g. normalisation of complement components, renal function, the disappearance of rheumatoid factor and proteinuria, the second biopsy taken two years later showed unchanged histological and immuno-histological changes of the glomerula. | |
| 6397802 | [Double-blind parallel clinical trial with tenoxicam in comparison with indomethacin in th | 1984 Sep | The comparative effects of tenoxicam and indomethacin are studied in 20 patients with rheumatoid arthritis. Ten evolutive parameters were studied after six weeks of treatment. Both drugs showed similar tolerance and efficacy on the evolution of the disease. | |
| 6378108 | Antibodies to cultured rat heart cells in sera of patients with rheumatoid arthritis. | 1984 Jun | Since heart lesions occur in many patients with rheumatoid arthritis (RA), sera from these patients were tested with an indirect fluorescent technique for antibodies reactive with rat heart cell cultures. Of 27 sera 22 had reactivity with non-muscle (nM) cells and 3 reacted with cultured beating muscle cells (M). Positive sera reactive with nM cells exerted complement-dependent cell cytotoxicity towards M cells. The nM antibodies were found to belong predominantly to the IgG class. They displayed no cross-reactivity with bovine collagen, human and bovine serum proteins, or human and sheep red blood cells. The relationship of these antibodies to the pathogenesis of RA heart lesions remains to be determined. | |
| 6975497 | [Demonstration of a subpopulation of T-lymphocytes by a monoclonal lymphocytotoxic antibod | 1981 Oct | The lymphocytes from 20 cases of mild rheumatoid arthritis have been explored thanks to a monoclonal antibody found in a murine hybridoma of specificity I-E/Ck, "cross-reacting" with the human molecules HLA-DR+. A slight increase in the lymphocyte subpopulation T-DR+ is found, representing 25.15% versus 18.5% of the lymphocytes T isolated by rosettes in the normal subject. These cells correspond to a subpopulation of T lymphocytes whose immunologic function remains to be defined. | |
| 385873 | Oxaprozin: a once-daily treatment regimen in rheumatoid arthritis. | 1979 May | The development of oxaprozin provided an opportunity to evaluate the control of inflammation in rheumatoid arthritis by a drug that can be administered once daily. A double-blind 12-week evaluation suggested comparable efficacy between 1,200 mg oxaprozin given as a single daily dose and 3,900 mg ASA given in 4 equally divided doses. A lower incidence of side effects was noted in the oxaprozin group. An open 6-month study substantiated the efficacy and safety of oxaprozin. | |
| 976101 | [Penicillamine-induced myasthenia in chronic rheumatoid arthritis (author's transl)]. | 1976 Jul 30 | A myasthenic reaction developed after an average latency of seven to eight months in 12 female patients (average age 51 years) treated with penicillamine for chronic rheumatoid arthritis. In most of them only the purely ocular form was noted, but generalisation of various degrees also occurred. When penicillamine had been discontinued the myasthenic signs were almost always fully reversible, recurring once again when treatment with penicillamine was started. In some instances a transitory symptomatic treatment with cholinesterase inhibitors was necessary. The occurrence of the myasthenic signs in these circumstances is probably similar to the anti-basal membrane nephropathy induced by penicillamine. | |
| 364608 | Prostaglandins and lymphokines in inflammation. | 1978 | It is suggested that the inflammatory process in rheumatoid arthritis (RA) results from activation of small lymphocytes to produce lymphokines, whose biological properties are appropriate to a mediator of chronic inflammation. Since prostaglandins (PGs) and allied products of arachidonic acid metabolism have properties pertinent to chronic inflammation, these compounds can also be regarded as potential mediators of chronic inflammation, a viewpoint supported by the capacity of steroids and non-steroidal anti-inflammatory drugs (NSAIDs) to suppress PG formation. Certain observations are inconsistent with PGs fulfilling this role. These anomalies may be resolved by considering PGE2 formation by macrophages to be a device for regulating lymphocyte activation. A defect of lymphocyte reactivity to PGE2 provides a basis for chronicity and has been demonstrated in multiple sclerosis (MS). Alternatively, should lymphocytes in lesions of RA be susceptible to PGE2 inhibition, one consequence of NSAID treatment may be exacerbation of joint destruction. | |
| 6160858 | Impaired antigen-specific suppressor cell activity in patients with rheumatoid arthritis. | 1980 Nov | Antigen-specific suppressor cell activity of peripheral blood mononuclear cells was investigated in 20 patients with rheumatoid arthritis (RA) and 16 age- and sex-matched healthy controls. Suppressor cell activity was generated by priming peripheral blood mononuclear cells with high dose antigen (ovalbumin) and adding the washed primed or control (unprimed) cells to autologous, optimally stimulated, target plaque forming cell (PFC) cultures. The ability of the primed cells to interfere with an optimal ovalbumin specific PFC response in the target culture was used as a measure of antigen-specific suppressor cell activity. The results demonstrated that the mean (+/- SE) PFC response of the rheumatoid patients (669 +/- 76 PFC/10(6) cells) was not statistically different from that of the normal controls (722 +/- 83 PFC/10(6) cells), P = 0.1. However, reduced suppressor cell activity was observed in the rheumatoid patients relative to controls (46.4 +/- 4.2% versus 64.6 +/- 2.7% suppression, respectively; P < 0.001). No correlation was demonstrated between suppressor cell activity in rheumatoid patients and disease activity or therapy. | |
| 938590 | Cellular hypersensitivity in rheumatoid arthritis, ankylosing spondylitis, and anterior no | 1976 May | The humoral and cellular responses to normal human ocular and joint tissue antigens were studied in rheumatoid arthritis, ankylosing spondylitis, and anterior non-granulomatous uveitis. No free-circulating autoantibodies could be detected by hemagglutination, immunodiffusion, and immunofluorescence. Uvea-retina, synovial membrane, and articular cartilage antigen preparations inhibited the migration of leukocytes from patients with rheumatoid arthritis. In ankylosing spondylitis inhibition could be induced only by synovial membrane antigens. Patients with anterior nongranulomatous uveitis were hypersensitive to uvea-retina antigens alone. | |
| 6185910 | [Rheumatoid factors]. | 1982 Oct | Rheumatoid factors (FRs) are auto antibodies which react with different antigenic sites on the Fc piece of human IgG. They appear in large amounts in serum and synovial fluid of patients with rheumatoid arthritis (RA) but they are not specific to this disease. Different methods of detection have been proposed but they induce a low threshold of sensibility and regularly give rise to a low specificity for RA diagnosis. Those auto antibodies have a weak affinity for their antigen. However, despite this weak affinity, they contribute to the formation of large and stable articular immune complexes which could induce inflammatory synovial processes during RA. Occurrence of RFs during various infectious diseases is an argument for a protective role of RFs. This protective role is supported by the findings that RFs structural genes are largely distributed in normal populations and, in part, inherited, and that normal peripheral blood lymphocytes are able to make IgM FR when in vitro polyclonally stimulated. | |
| 6438722 | [Soft-tissue changes in the metacarpal area in chronic polyarthritis]. | 1984 Nov | Rheumatoid arthritis causes changes in the soft tissues in the metacarpal portion of the hand which can be demonstrated by low Kv exposures. Indirect signs of inflammation consist of oedema extending from the synovial compartments to the skin, the subcutaneous tissues, the intermuscular fat septa and the peritendinous tissue. Increased blood flow leads to dilatation of veins. Direct signs of inflammation consists of tenosynovitis and synovitis of the joints, with enlargement of the corresponding compartments. Limited mobility of the hand over a long period, or improvement in motility are paralleled by changes in muscle mass. | |
| 6327982 | Gold induced encephalopathy: case report. | 1984 Apr | We describe a case with neurologic disease manifested as encephalopathy, generalized muscle fasciculations, and peripheral neuropathy occurring in a patient treated with therapeutic doses of gold for presumed rheumatoid arthritis. The illness remitted promptly during chelation therapy with dimercaprol (BAL). A review of the limited experience in the literature with the central nervous system toxicity of gold is given. | |
| 6669868 | Gas-like radiolucencies in a popliteal cyst. | 1983 | A 71-year-old man with rheumatoid arthritis complained of pain and swelling in the left calf. X-ray examination of the calf disclosed radiolucencies suggestive of soft tissue gas; however, subsequent investigation revealed no evidence of infection and an arthrogram showed a dissected popliteal cyst in the area of the gas. Gas-like radiolucencies in a popliteal cyst are an unusual finding which has not been previously reported. | |
| 7062299 | Schizophrenia and psychosomatic illness. | 1982 | In order to explore the possibility of a mutually exclusive relationship between schizophrenia and certain psychosomatic disorders, 354 adult schizophrenic patients, both acute and chronic, were studied with regard to lifetime prevalence of peptic ulcer, bronchial asthma, neurodermatitis and rheumatoid arthritis. Significant evidence to support the hypothesis of mutual exclusivity was found only in the case of peptic ulcer in the overall sample. Prevalence was higher in younger, more acute patients than in older, chronic patients, but this finding was difficult to interpret. Parallel enquiry into the prevalence of schizophrenia and the same disorders among close family members of the patients yielded inconclusive results. | |
| 6785435 | Penicillamine in rheumatic diseases: a prospective study of tolerance and efficacy. | 1981 Jan | Tolerance to D-penicillamine was studied prospectively over an 8-yr period in 318 patients with inflammatory rheumatic disorders. Adverse reactions, observed in 76% of patients, required permanent withdrawals in only 47% of the 318. Withdrawals could be reduced by lowering dosage and making increments extremely slowly. In 207 rheumatoid arthritis patients who had received gold thiomalate, adverse reactions to D-penicillamine were fewer than with the gold and, less often, caused permanent withdrawals. Of 164 nonresponders to gold thiomalate, 53% responded to D-penicillamine. Only 10% of nonresponders to D-penicillamine responded to gold thiomalate. | |
| 6968447 | [Cyclic nucleotides and enzymes of the synovial fluid in various rheumatic diseases]. | 1980 Jul | The authors measured the activities of four enzymes (L.D.H., acid phosphatase, B glucuronidase, and lysozyme) and the contents of AMPc and GMPc in the synovial fluid in 35 patients with rheumatic disease. In those with various forms of inflammatory rheumatism, they found negative correlation between AMPc and the enzymes, whereas in rheumatoid arthritis they observed a positive correlation between GMPc and these enzymes. |