Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 512369 | Anomalous reactions in the haemagglutination assay for anti-collagen antibodies: studies o | 1979 | Sera from 23 patients with chronic low back pain, 20 rheumatoid patients and 16 normal controls were tested for antibodies to collagen types I, II and III, both native and denatured, by haemagglutination. Weak reactions against denatured collagen types I and II were found in 30-40% of the sera. Sera from individuals with rheumatoid arthritis or chronic low back pain behaved similarly, while only one normal serum showed any positive reaction. Reactions to denatured collagen type III and to native collagen of all 3 types were largely negative. Non-antibody serum components were thought to be responsible for these haemagglutination reactions since weakly positive reactions were abolished by cryoprecipitation and could not be confirmed by a solid-phase fluorimetric assay. Using the latter technique sera from 62 rheumatoid patients were screened for antibodies to type II collagen (native and denatured) and only one positive serum found. We conclude that haemagglutination is subject to false positive reactions and that the incidence of anticollagen antibodies in sera from patients with rheumatoid arthritis or chronic low back pain is low. | |
| 6870403 | Group G streptococcal arthritis. | 1983 Jul | Five patients were seen in the UCLA hospital system with septic arthritis due to group G Streptococcus. All had prior joint disease or surgery on the affected joint. Findings from physical examination and laboratory evaluation were typical for pyogenic arthritis. Response to antimicrobial therapy was slow and marked by recurrent sterile joint effusions. Group G streptococcal arthritis may be diagnosed more frequently if routine serologic grouping of streptococcal isolates from joint fluid samples is performed. Such identification may also have prognostic significance. | |
| 366718 | Pyogenic arthritis and rheumatoid disease: the importance of the infected foot. | 1978 Nov | During a nine-year period (1968--76) 75 patients were admitted to Coventry Hospitals becaues of pyogenic arthritis. Of these patients, 22 suffered from pre-existing rheumatoid disease, and in these the foot was the most common site of primary infection. Adequate and energetic management of foot problems and associated skin sepsis in patients suffering from rheumatoid disease appears to offer the best opportunity of reducing the incidence of superimposed pyogenic arthritis. | |
| 3978945 | Silastic condylar arthroplasty. | 1985 May | Interpositional Silastic condylar arthroplasty of the first carpometacarpal joint was used in 40 patients with disabling arthritis. Limiting bone resection at the base of the thumb improves prosthetic stability. Pain was lessened and function improved in most cases. Technical modifications and their rationale are discussed. | |
| 6134094 | Case-control study of rheumatoid arthritis and prior use of oral contraceptives. | 1983 Jun 11 | This study was designed to determine whether oestrogens in oral contraceptives and other drugs have a protective effect against development of rheumatoid arthritis. The medical records of 229 women with rheumatoid arthritis and 458 individually matched controls identified through the comprehensive records system for the population of Rochester, Minnesota, were examined for current and prior use of oestrogens. No association was found between rheumatoid arthritis and the use of oral contraceptives, or the use of oestrogens for menopause-related or postmenopausal symptoms. | |
| 404715 | Treatment of rheumatoid arthritis with gold. | 1977 May | There have been three important double-blind studies evaluating the use of gold therapy in rheumatoid arthritis. Patients treated with gold have decreased number of joints with synovitis, decreased ring size, increased grip strength, and roentgenographic evidence of arrest or decrease in the progression of skeletal lesions. If a patient with active synovitis does not respond to nonsteroidal anti-inflammatory drugs after four months of treatment, he is a candidate for gold therapy. Maintenance gold therapy has been shown to sustain clinical improvement. Patients must be monitored with appropiate laboratory tests. | |
| 8837 | Benorylate: a report on 2 years' experience of its use in rheumatoid arthritis and other c | 1975 | 52 outpatients with rheumatoid arthritis or osteoarthritis were given benorylate (as the 40% suspension) in doses of up to 8 g daily. Peroids of medication were varied but some patients were given the drug for nearly 2 years. Assessments of clinical progress were made at regular intervals by recording both subjective and objective measurements including duration of morning stiffness, grip strength, joint size. Laboratory investigations include renal function tests, liver function tests, blood picture and occult blood. No serious side effect, attributable to benorylate was reported and it was concluded that the drug is satisfactory for the long term treatment of rheumatic diseases. | |
| 6388514 | Technique-related variation in results of FANA tests. | 1984 Oct | We compared the reliability and reproducibility of three tests for fluorescent antinuclear antibodies (FANA) that are routinely performed in our laboratory. Sera from 72 patients, selected according to diagnosis (SLE in 28, RA in 12, and other connective-tissue diseases in 33), and from 32 healthy controls were tested with all three assays. There were wide variations between the results obtained with these tests. The variations did not reflect sensitivity or degree of standardisation (reproducibility on retesting was greater than 95%) and appeared to be inherent in the techniques. Clinicians should be aware of the technique-related differences in FANA assays. | |
| 6343924 | [Clinical study of patients with primary polyarthritis. Cross-over comparative study of pr | 1983 Jun 23 | Proglumetacin at low-dose (300 mg/day) and naproxen (500 mg/day) were used in a crossover study in 20 patients with primary polyarthrosis. Each drug was administered during 1 week without between drugs. Both drugs resulted effective in the management of the most disturbing symptoms, without significant differences. Tolerance was also superimposable, as the few reported complaints were recorded under both treatments and appeared rather related to the patient than to the drug. Proglumetacin therefore, even when given at low dose, resulted at least as effective as an established treatment for polyarthrosis, while confirming its very good tolerance, so as to appear well suited for the general management of patients with such degenerative-reactive disorders. | |
| 6512367 | Metacarpophalangeal joint arthroplasty eleven year follow-up study. | 1984 Oct | During a period from April, 1972 to May, 1983, 339 Swanson silastic implants were implanted in eighty-two hands of fifty-five patients. A follow-up study was performed to evaluate the long-term function of these implants. Our follow-up study indicates that metacarpophalangeal joint arthroplasty can relieve pain, correct deformity, improve appearance and improve hand function by providing functional motion and stability. Few long-term problems were noted and the functional benefits gained by surgery decreased little with time. Patient satisfaction was high. | |
| 6413683 | I. Unbound serum gold: procedure for quantitation. | 1983 Aug | The unbound fraction of many drugs appears to be the therapeutically active component. However, the major problem encountered in following unbound serum gold (UBSG) concentration during chrysotherapy has been the ability to quantitate such a small quantity of gold reliably without matrix interference. The methodology detailed here overcomes these difficulties and provides an effective means of monitoring the UBSG fraction during chrysotherapy. We have observed that the unbound fraction of gold dissipates quickly after gold sodium thiomalate administration and constitutes less than 2% of the total serum gold concentration. | |
| 930242 | [Replacement of the knee-joint (author's transl)]. | 1977 Oct | Survey of methods. In first part new classification of prostheses. Discussion of some biomechanical problems, mainly on hinge-prosthesis which can only be compromises for various periods. Replacement to be considered only for elderly or very old patients, when conservative treatment offers no chances, other operations are not promising or have failed, arthrodeses cannot be done and pain and loss of function are severe. Indications for hinge- and slide-prostheses are given. In the second part two statistics of results from the literature are discussed and experience with 130 own cases using own model is described. Infection occurred in 3 cases where removal of prosthesis had to be done. Examples of the need for reversal operations are given. | |
| 7037996 | [Studies on degradation of cartilage proteoglycan by rheumatoid synovial tissue. Part II: | 1981 Nov | 1. Proteolytic enzymes are likely to play the main role on the proteoglycan (PG)-degrading activity of rheumatoid synovium. In this paper, the presence of cathepsin D, cathepsin B, lysosomal elastase and cathepsin G in rheumatoid synovium is established by isolation, purification, and characterization of these proteases. 2. The degradation of MgCl2-extracted PG from bovine nasal cartilage was performed by using these proteases and the property of the products was studied by the viscosity, Sepharose CL-4B chromatography, Agarose/polyacrylamide-gel electrophoresis, hexosamine analysis and amino acids analysis. 3. These proteases reduced the viscosity of PG solutions and the reaction was inhibited by addition of pepstatin, antipain, elastatinal and chymostatin for each protease. 4. The size and chemical composition of the degradation products varied with the different proteases. Of the four proteases, cathepsin G produced the largest glycosaminoglycan multi-chain peptides and cathepsin B produced the smallest contained chondroitin single-chain peptide. Each protease specifically split PG core protein and the degradation products particularly indicated the characteristic structure of core peptides. 5. The results suggest that these proteases may be contributed to the breakdown of cartilage PG in rheumatoid arthritis. | |
| 708316 | The place of surgery in rheumatoid arthritis. | 1978 Aug | The medical and surgical management of patients with rheumatoid disease has improved over recent years. Despite the improvements, much disability and pain arise from the condition. The major surgical advances in recent years have been in the field of joint replacement, and these advances are continuing. Joint replacement units have evolved, allowing further specialization in this rapidly advancing field. Close liaison between the general practitioner, rheumatologist, orthopaedic surgeon and allied health professionals is most important in achieving the best possible results in the management of these patients. | |
| 6342784 | Fenbufen and indomethacin: a comparative study in rheumatoid arthritis. | 1983 | Fenbufen and indomethacin were compared in the treatment of 30 patients with rheumatoid arthritis. In a randomized, double-blind crossover study patients received 75 mg of indomethacin daily or 600 mg of fenbufen daily for six weeks and then were treated with the alternate regimen for a similar period. The drugs were equally efficacious. The erythrocyte sedimentation rate of patients who had received fenbufen was significantly lower than that of patients who had received indomethacin. More side effects were reported by the indomethacin-treated patients. A further 24-week open evaluation of fenbufen in rheumatoid patients indicated that fenbufen is a useful anti-inflammatory analgesic in the long-term management of mild and moderate rheumatoid arthritis. | |
| 7331807 | Deformation and loosening of the tibial component in knee arthroplasty with unicompartment | 1981 Dec | Roentgenological signs of deformation and loosening of the tibial component in knee arthroplasties with unicompartmental endoprostheses occurred in one-third of 87 rheumatoid (RA) knees within 2 years and in one-fifth of 107 osteoarthritic (OA) knees within 3 years after the operation. Compared with thicker components significantly more 6 mm components in RA, and 6 and 9 mm components in OA became deformed and loose. There was no difference in the clinical assessment of the knees with and without deformed tibial components. Reoperations were recorded during an extended follow-up. In the group with initially asymptomatic loosening twelve RA knees within four and a half years and three OA knees within four years developed pain on weight-bearing and had to be reoperated. One patient (OA) had loose components without any roentgenological signs; the loosening was first discovered when the unoperated compartment was revised because of secondary osteoarthrosis. Knees fitted with 6 mm components more often required reoperation because of loosening than did those with thicker components. | |
| 7288759 | Plasma exchange in rheumatoid vasculitis. | 1981 May | Plasma exchange (PE) was used to treat 9 patients with rheumatoid vasculitis. The immediate development of new lesions was arrested in 7 patients. Two patients continued to develop new lesions. One responded to additional cyclophosphamide plus methyl prednisolone but the other died within days from severe systemic vasculitis. Prolonged PE alone, or PE followed by cyclophosphamide plus methyl prednisolone was associated with healing of existing lesions without relapse. Short term PE, alone or followed by azathioprine, failed to heal existing lesions and relapses occurred within 3 months. IgG rheumatoid factor and anticomplementary activity fell with PE and correlated best with clinical response. | |
| 6495890 | [Effect of histamine-blocking substances on mitogen-induced lympho proliferation in rheuma | 1984 Jul | Peripheral blood lymphocytes of patients with rheumatoid arthritis, psoriatic arthritis and healthy controls, isolated by a ficoll density gradient, were incubated with different concentrations of histamine, cimetidine and diphenhydramine (DPH) and simultaneously stimulated with phytohemagglutinine (PHA). In comparison to healthy control persons the lymphoproliferation rate in arthritic patients could be increased about 20% by addition of the histamine-blocking agents cimetidine and DPH. This suggests the existence of in vivo histamine-induced suppressor cells in arthritic patients, which can be inhibited by receptor blocking agents. | |
| 170758 | [Destruction of cartilage in the adjuvants disease of the rat]. | 1975 Jul | The structure of cartilage in rats with adjuvant disease was investigated lightmicroscopically and by scanning electron microscopy. Severe destruction of the cartilage with formation of lacunae only was observed in areas previously covered by pannus. However, outside the pannus differences between normal animals and animals with arthritis also were observed. In adjuvant treated animals a more fibrillar structure of the surface was seen as compared with untreated rats. This more fibrillar structure may be due to a loss of mucopolysaccharides. The severe destruction of cartilage must be related to the action of collagenase which only acts in areas with a close contact between cartilage and pannus. | |
| 7044801 | A comparison of benoxaprofen and sulindac in patients with rheumatoid arthritis and osteoa | 1982 | The efficacy and safety of benoxaprofen and sulindac were compared in patients with rheumatoid arthritis and osteoarthritis. A double-blind, crossover protocol was used with three placebo periods. Fixed doses--600 mg of benoxaprofen once a day and 200 mg of sulindac twice a day--were used. Rheumatoid arthritis patients showed significant improvement in most measurements with both drugs, but overall results favored benoxaprofen, particularly in erythrocyte sedimentation rate and physician's global assessment. Results were fairly equal in osteoarthritis patients. Propoxyphene consumption was less during the benoxaprofen therapy period for both groups of patients. Adverse reactions in combined rheumatoid arthritis and osteoarthritis patients generally were mild to moderate. Gastrointestinal complaints were more common with sulindac, while skin reactions were more common with benoxaprofen. No serious abnormalities in laboratory values were noted. |