Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7336798 | [Pulmonary side effects of gold treatment]. | 1981 Dec 15 | On the basis of more than 35 cases from literature a survey of clinical and paraclinical findings, diagnostic criteria, differential diagnosis, therapy and prognosis of the pulmonary reaction evoked by gold is given. The first symptoms mostly appear within the initial phase of the treatment, after several weeks to months. Unexpectedly increasing dyspnoea, weakness, cough and feeling of sickness in patients who are treated with gold salts are warning signals which refer to the possibility of a lung injury by gold. The differential-diagnostic demarcation from rheumatoid lung, a rare extraarticular manifestation of the rheumatoid arthritis, may render difficulties. The latter, however, usually refers to a slower progressing, is not or only incompletely able to involution and scarcely reacts to cortisonoids. The gold-conditioned pulmonary changes in most cases completely involve after a well-timed finish of the treatment with the gold-preparation. Cortisonoids are given for the acceleration of the remission. The prognosis is in general good. However, it depends on the fact, how long the gold treatment is still continued after the appearance of the pulmonary side-effect. | |
| 441641 | The pharmacological properties of ketoprofen and its place in antirheumatic therapy. | 1979 | The anti-inflammatory effects of ketoprofen (Alrheumat) in inflamed areas are achieved by antagonizing inflammation mediators or blocking their synthesis. In addition to this peripheral effect, central analgesic and antipyretic effects also are detectable. The pharmacodynamic and pharmacokinetic properties of ketoprofen clearly distinguish it from other non-steroidal anti-inflammatory agents. These properties could also explain the low number of side-effects. | |
| 6331829 | Serum C1q levels as a prognostic guide to articular erosions in patients with rheumatoid a | 1984 Aug | C1q was measured serially by single radial immunodiffusion in 54 rheumatoid arthritis (RA) patients over a period of more than 5 years, and values were correlated with laboratory, radiographic, and clinical findings. The number of joints with erosion (NJE) was determined retrospectively from radiographs of patients who had RA of greater than 7 years duration. In patients with clinically "burned out" RA, C1q levels were not statistically different from those of healthy adults. During the period of active disease, each patient's C1q level remained very constant, irrespective of erythrocyte sedimentation rate, C-reactive protein (CRP) level, or whether the RA was active or in remission. No sustained correlation was found between the C1q level and the other 2 acute phase reactants, but patients with C1q levels of at least 250 micrograms/ml showed a positive CRP over a period of years, in contrast to those with C1q levels below 250 micrograms/ml. Patients with an initial C1q above 250 micrograms/ml had more erosive RA when compared with those having C1q levels below 250 micrograms/ml. These data suggest that active RA can be classified into two subsets by C1q levels, one with persistent inflammation and a high NJE and another without persistent inflammation and with a low NJE. | |
| 6394613 | Double-conjugate enzyme-linked immunosorbent assay for immunoglobulins G and M against Tre | 1984 Dec | An enzyme-linked immunosorbent assay (ELISA) for the simultaneous measurement of immunoglobulin G (IgG) and IgM was developed to detect antibodies to Treponema pallidum. Wells of polystyrene microtiter plates were coated with T. pallidum antigen, diluted patient serum was added, and IgG and IgM which bound to the T. pallidum antigen were measured by the simultaneous addition of alkaline phosphatase-labeled anti-human IgG and horseradish peroxidase-labeled anti-human IgM. Bound IgG was detected first, followed by bound IgM. After development of the procedure, 145 categorized sera were evaluated: 60 from individuals without syphilis; 62 from patients with syphilis, including 22 with primary, 20 with secondary, and 20 with latent phases of syphilis; and 23 from patients with rheumatoid arthritis. Of the 60 sera from individuals without syphilis, 100% were nonreactive for IgG antibody and 16% were reactive for IgM. Of the 23 sera from patients with rheumatoid arthritis, 3 were reactive for IgG and 3 were nonreactive for IgM. Of the 62 sera from patients with syphilis, 61 (98%) were reactive for IgG antibody with increased titers as the stage of syphilis increased, whereas IgM reactivity decreased. This enzyme-linked immunosorbent assay appears to be a simple method for the simultaneous measurement of antibodies under equal assay conditions. | |
| 6230450 | Synovial T lymphocytes in rheumatoid arthritis. | 1983 Dec | The presence of interleukin-2 (IL-2) like activity has been demonstrated in synovial fluids from rheumatoid arthritis patients. Continuous T cell lines (CTL) generated from such fluids respond to the synovial IL-2, exhibit a predominant suppressor/cytotoxic cell phenotype and release immunoregulatory mediators. | |
| 356763 | Intra-articular methotrexate. Clinical and laboratory study in rheumatoid and psoriatic ar | 1978 Aug | The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory effect in the psoriatic arthropathies; the percentages of polymorphonuclear cells and pyroninophilic mononuclear cells in synovial fluids fell sharply. Intraarticular hydrocortisone acetate was not anti-inflammatory in 2 psoriatic patients treated subsequently. The anti-inflammatory action of MTX in joints may resemble its effectiveness in controlling the rash of psoriasis. | |
| 356246 | Diclofenac sodium (Voltaren) and indomethacin in the ambulatory treatment of rheumatoid ar | 1978 | In a double-blind crossover trial conducted on a multicentre basis, 109 patients with "classic" or "definite" rheumatoid arthritis were treated for two weeks with diclofenac sodium (Voltaren, 25 mg t.i.d.) and indomethacin (25 mg t.i.d). Both drugs led to a clear-cut decrease in morning stiffness, as well as to a significant improvement in pain at rest and on movement. In these respects no significant difference between the two-drugs was observed. As regards their effect on status of rheumatoid condition, however, a trend towards a significant improvement was discernible, in the investigator's opinion, only in response to diclofenac sodium. "Unwanted effects" were mentioned by 25 patients before the trial, by 31 during treatment with diclofenac sodium, and by 33 during treatment with indomethacin. While the patients were receiving indomethacin, five of them discontinued treatment on account of side effects (headache in three cases, headache and tiredness in one case, and an allergic skin reaction in one case) and one of them, who complained of headache, lowered the dosage; treatment with diclofenac sodium was discontinued because of side effects by only one patient, who had developed an allergic skin reaction. | |
| 6400419 | Foot abnormalities in rheumatoid arthritis. | 1984 | By anticipating the deformities that can occur in the rheumatoid foot and by carefully and compulsively looking for them, we can more effectively deal with the pathologic conditions. Although we usually equate conservative care with nonoperative treatment, and shoe corrections are certainly important, early operative intervention may be essential. Procedures we must use early if indicated are as follows: decompression of the posterior tibialis tendon and other medical structures in the tarsal tunnel, excision of intermetatarsal bursae, and talonavicular arthrodesis. Furthermore, relating forefoot to hindfoot deformities is important. A valgus hindfoot should be corrected before laterally dislocated MTP joints. A great deal can now be accomplished in treating the remaining weight-bearing joints of the lower extremity. The possibility of combining some of these procedures while hips or knees are undergoing surgery also exists. For example, it may certainly be reasonable when performing a knee arthroplasty to consider a hindfoot arthrodesis or a forefoot arthroplasty on the opposite side. | |
| 7025171 | Dental study in patients with rheumatoid arthritis. | 1981 May | Twenty-one patients with rheumatoid arthritis took part in a comparison of three toothbrushes, each used for one month in a randomized trial. The three toothbrushes were a conventional toothbrush with modified handle to allow ease of gripping, an electric toothbrush, and thirdly a finger-stall attached to a normal toothbrush. There was no change in the patients' rheumatoid status during the trial. The patients were scored for plaque and gingival changes but no difference was found between the three toothbrushes. We recommend a standard toothbrush with a modified grip for the rheumatoid hand; the extra expense of an electric toothbrush cannot be justified. | |
| 737906 | Leucocyte migration inhibition with IgG-IgG complexes and rabbit IgG fragments in patients | 1978 Nov | The interaction of leucocytes from patients with rheumatoid arthritis and from healthy control subjects with IgG–IgG complexes and IgG fragments has been assessed in vitro using leucocyte migration inhibition. IgG–IgG complexes were prepared in vitro and fractionated by gel filtration on Sepharose CL-6B. Significant inhibition of rheumatoid leucocyte migration was observed in the presence of IgG–IgG complexes at a protein concentration of 5 μg/ml. This concentration of complexes had no effect on control cells. The rheumatoid leucocytes showed a twenty- to forty-fold increase in reactivity to complexed IgG as compared with the native protein. The inhibitory effect was mediated through the Fc region of the IgG molecule but was independent of complement. Native rabbit IgG inhibited both rheumatoid and control leucocyte migration. Rabbit F(ab')(2) was inactive however, whereas the Facb fragment (from plasmin digestion) caused specific inhibition of rheumatoid cells. Little reactivity was seen with Fab or with Fc fragments. The present study demonstrates that rheumatoid leucocytes react abnormally to IgG and provides the first direct evidence that this reactivity is directed largely against determinants in the C(H)2 region of the molecule. The response of rheumatoid leucocytes to this region is significantly increased if the IgG is complexed to antigen or subjected to limited proteolysis. Both these processes are associated with inflammatory reactions and may be responsible for producing the altered IgG structure which induces the antiglobulin response in rheumatoid arthritis. | |
| 7178764 | The lumbar interspinous bursae and Baastrup's syndrome. An autopsy study. | 1982 | This study describes the prevalence, distribution, pathology and pathogenesis of lumbar interspinous bursitis (described as a clinical syndrome by Baastrup in 1933). It is based on an anatomic study of 152 lumbar spines derived from routine and random postmortem material, together with selected specimens from autopsies on patients with various rheumatic diseases. From a statistical study of 50 randomly chosen spines, bursae are found when the interspinous distance is small compared with the total height of the lumbar spine ('bursal index'): nearly all bursal spaces show some sign of inflammation and a few show severe bony erosion. Crystal deposits therein are also described. | |
| 6167273 | A preliminary ferrographic survey of the wear particles in human synovial fluid. | 1981 Jul | The technique of ferrography has been applied to the analysis of wear particles in human synovial fluid aspirates. A number of discrete, identifiable classes of wear particles were found, including particles indicative of cutting wear and rubbing wear. The spectrum of particles varied among different groups of patients, suggesting an eventual diagnostic use for this method. | |
| 277809 | Doctor-patient communication in patients with arthritis. | 1978 Jun 28 | Fifty patients with a chronic form of arthritis were given a standard interview concerned with establishing what knowledge they had of their disease and the drugs they were receiving for its treatment. Eighty-six percent of patients overall knew the name of their disease and 74 percent, the names of the drugs which they were receiving. Seventy-three percent of patients receiving non-steroidal anti-inflammatory drugs were unaware that these drugs were likely to have gastro-intestinal side effects even though about half of these patients were receiving either soluble aspirin or indomethacin. Younger patients were more likely to be aware of potential gastro-intestinal side effects (46 percent) than older patients (19 percent). Thirteen patients with rheumatoid arthritis were receiving myocrisin or penicillamine which are more likely to be associated with severe side effects than non-steroidal anti-inflammatory drugs. Four of five younger patients had some knowledge of the likely side effects of these drugs but none of the eight older patients knew this information. Written instructions should be given to older patients receiving these potentially toxic drugs. | |
| 301046 | Some immunological parameters in rheumatoid arthritis from India. | 1977 Mar | The present study describes the immune status of 41 patients with rheumatoid arthritis from India. The results showed a high level of immunoglobulins, normal levels of C3, less proportion of seropositivity (54%) than that reported from the west and 26% having antinuclear antibody in their serum. T lymphocyte proportion in the blood was found to be low in acutely ill patients only. Mantoux and streptokinase-streptodornase skin tests for delayed hypersensitivity were positive only in about 50% of that of controls. However, all the patients could be sensitized to DNCB. For testing the humoral antibody response TAB vaccine was given. The levels of antibody produced against O and H antigens of "Salmonella typhi" were comparable in patients and controls. However, the level of IgM rose significantly in the patients in comparison to that of controls. The cause of this, at least partially, was found to be due to a very significant rise of rheumatoid factor after TAB vaccine in the patients. Also 3 out of 8 patients converted to a seropositive state after TAB vaccination. Controls did not show the development of rheumatoid factor. | |
| 3914146 | [Plastic repair of the acetabular floor for acetabular protrusion in total endoprostheses | 1985 Nov | The authors describe the early results of the acetabular floor replacement procedure introduced by them. The surgical technique and the exact method of preparing the autograft are described in detail. The authors consider the use of autologous bone preferable to other methods. This technique results in guaranteed bony consolidation. No complications occurred during the three-year observation period, and none of the patients have any complaints. | |
| 4038016 | Long-term results of wear of plastic hip prostheses. | 1985 | The Oscobal-Daubenspeck hip prosthesis was used in 19 hemiarthroplasties and 38 total hip arthroplasties in 1973-1975 and the 10-year experience is presented. Pain recurred some years after the operation. The reason was wear of the high-density polyethylene prosthesis head, most pronounced in the hemiarthroplasties, resulting in wear-debris synovitis, resorption of bone, and mechanical loosening of the prosthesis. This design of prosthesis should not be used. | |
| 7416811 | Incidence of serum antibodies to native type I and type II collagens in patients with infl | 1980 Jun | Using a new solid-phase double-antibody radioimmunoassay we have determined the incidence of serum IgG antibodies to native bovine type I and type II collagens in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis. Raised serum IgG antibody levels to native type I collagen were present in 49% of patients with RA, 30% with AS, and none of the patients with psoriatic arthritis. Raised serum IgG antibody levels to native type II collagen were present in 42% of patients with RA, 30% with AS, and none of the patients with psoriatic arthritis. In rheumatoid arthritis there was a lack of correlation between IgG antibody levels to collagen and the erythrocyte sedimentation rate, IgG rheumatoid factor, and circulating immune complexes measured by the Clq-binding activity. In ankylosing spondylitis IgG antibody levels to native type II collagen were raised only in patients with peripheral joint involvement. The significance of IgG anticollagen antibodies is not certain, but parallels with rheumatoid factor are discussed. | |
| 950627 | Impaired blastogenic response of lymphocytes from synovial fluid and peripheral blood of p | 1976 Jun | Synovial fluid lymphocytes from patients with rheumatoid arthritis demonstrated a markedly diminished blastogenic response to both phytohemagglutinin and pokeweed mitogens, when compared to normal peripheral blood lymphocytes. The blastogenic response to rheumatoid peripheral blood lymphocytes to both mitogens was also depressed, when compared to the response of normal lymphocytes, but the difference was less marked and was within limits which could be accounted for by recent salicylate therapy. Lymphocytes of both peripheral blood and synovial fluid of rheumatoid patients showed a delayed response to PHA (five days to achieve maximum thymidine incorporation vs four days for normals). | |
| 6497466 | Synovial fluid lactate levels in septic and non-septic arthritides. | 1984 Oct | Lactate concentration was studied in 383 synovial fluid specimens from patients with various arthritides. The highest concentrations of lactate occurred in non-gonococcal septic synovial fluids. High values were recorded in seropositive rheumatoid arthritis and crystal-induced arthritides, medium values in synovial fluids from seronegative rheumatoid arthritis, seronegative spondylarthritides, gonococcal arthritis and haemarthrosis, and the lowest values in aspirates from osteoarthrotic joints. There was a positive correlation between synovial pH and lactic acid concentration. These data suggest that determination of lactate in synovial fluid can be valuable in the rapid exclusion of septic arthritis. Its value for differentiating between other inflammatory arthritides is discussed. | |
| 2933045 | Total lymphoid irradiation in patients with refractory rheumatoid arthritis. | 1985 Nov | Eleven patients with rheumatoid arthritis that had been refractory to conventional drug therapy were treated with total lymphoid irradiation (TLI). Followup continued for 6 months in 9 patients, 12 months in 6 patients, and 24 months in 3 patients. At 6 and 12 months post-TLI, a significant improvement in clinical disease activity was demonstrated. Side effects noted during TLI included fatigue, nausea, diarrhea, and vomiting. One patient died of cardiorespiratory arrest, 2 patients died of kidney failure secondary to generalized amyloidosis, and 1 patient died of septic shock secondary to a multilocular septic arthritis. One patient experienced 2 episodes of septic arthritis; 2 patients manifested delayed wound healing. Immunologic assessments showed consistent lymphopenia in all patients. T lymphocyte subsets decreased after TLI, and showed a transient increase at 6 months post-TLI. The suppressed mitogen responsiveness, which was noted 2 months after irradiation, was found to increase almost to the pre-TLI levels at 12 months. The observed increase in morbidity and mortality after TLI is evidence that discourages the use of this therapeutic technique, at least in its present form. |