Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7364140 | [D-penicillamine-induced pemphigus]. | 1980 | The authors describe a new original observation of a D-penicillamine-induced pemphigus in a patient with rheumatoid polyarthritis. It begins in two steps: the first crisis of blisters having subsided after withdrawal of D-penicillamine, there is a recurrence 7 months later. Clinical and histopathological aspects of pemphigus vulgaris are discussed. Existence of intercellular antisubstance antibody in the serum and in the skin. Evolution identical to that of a classical pemphigus requiring an important corticotherapy. Review of the literature on the previous cases of D-penicillamine-induced pemphigus and other pemphigus attributed to the action of other drugs, namely pyritinol, rifampicine and practolol. Discussion of the pathogenesis. | |
| 3896664 | Differential dosing study of pirazolac, a new non-steroidal anti-inflammatory agent, in pa | 1985 | Twenty-four patients with classical or definite rheumatoid arthritis participated in a 4-week double-blind crossover study to compare the effectiveness of two different dosage regimens of pirazolac. Patients were allocated at random to receive 2-weeks' treatment with either 300 mg pirazolac in the morning and 600 mg at night or 450 mg pirazolac given morning and evening, and were then crossed over to the alternative regimen for a further 2 weeks. Physician assessments of disease activity were carried out on entry and at the end of each treatment period, and patients kept a daily record of visual analogue scale scores for pain and stiffness. The results showed that both dosage regimens of pirazolac produced a significant improvement in the parameters assessed, but the difference between the two regimens was not significant. However, overall assessment at the end of the trial by the 23 patients who completed the study showed that 14 preferred the 300/600 mg regimen compared with 7 who preferred the 450/450 mg regimen: 2 patients considered both regimens equally effective. Pirazolac was relatively well tolerated, only a few patients reporting gastro-intestinal (2) and skin (3) side-effects during the trial period. | |
| 7124288 | Lack of influence of the anabolic steroid nandrolondecanoate on bone metabolism. | 1982 Sep | Eleven male patients with rheumatoid arthritis were treated with the anabolic steroid nandrolondecanoate and parameters of calcium and bone metabolism were studied. No changes were found in the concentrations of calcium, phosphorus or hydroxyproline in serum and urine (corrected for the creaturia). A significant decrease (P less than 0.01) was observed in the levels of alkaline phosphatase, but this was attributed to a change in liver enzymes, because the gamma glutamyl transpeptidase fell. Acid phosphatase levels showed an increase, possibly as a result of an effect of nandrolondecanoate on the prostate. No change was found during treatment in the serum levels of parathyroid hormone, calcitonin, 25 hydroxyvitamin D, 24, 25 dihydroxyvitamin D and 1.25 dihydroxyvitamin D. A seasonal fluctuation was observed for 25 hydroxyvitamin D and 24, 25 dihydroxyvitamin D, but not for 1,25 dihydroxyvitamin D. It was concluded that short-term treatment with the anabolic steroid nandrolondecanoate did not result in changes in parameters of calcium and bone metabolism. | |
| 6794794 | Assessment of iron stores in inflammation by assay of serum ferritin concentrations. | 1981 Oct 31 | A serum ferritin concentration of below 15 microgram/l is accepted as indicating diminished iron reserves in an otherwise normal person. In patients with inflammatory disease this lower limit of normality may be inappropriate as inflammation may directly stimulate the production of ferritin protein. Results obtained in a survey of 150 patients with early inflammatory joint disease suggest that a ferritin concentration of 55 microgram/l is a more appropriate lower limit of normality. | |
| 2988961 | Radio-synovectomy in chronic synovitis of the knee joint in patients with rheumatoid arthr | 1985 | The influence of intra-articular (i.a.) colloidal 198Au (5 mCi) or 90Y-silicate (5 mCi) on synovitis of the knee joint in patients older than 45 years with rheumatoid arthritis (RA), who had been treated since 1970 in our hospital, was investigated. Of the 89 knee joints of 77 patients studied, 65 had no or minimal radiological abnormalities of the knee joint treated (group I), whereas 24 patients had moderate to severe changes (group II). Before and at regular intervals after radio-synovectomy the clinical response was scored using pain, hydrops and warmth as parameters. The results indicated that 1 year after treatment the percentage of knee joints with a favourable response was greater in group I than in group II (58% versus 25%, P = 0.001). This difference was still present 3 years after treatment. Clinical response showed no correlation with initial inflammatory activity as measured by 99mTc-pertechnetate uptake measurements. However, in group I, those patients with an ESR below 60 mm/h, measured just before radio-synovectomy, more often had a favourable response than those with an ESR in excess of 60 mm/h (P = 0.01). No or only slight complications of radio-synovectomy were noted, whereas leakage of radioactivity from the knee joints was minimal. It is concluded that radio-synovectomy is an effective and safe procedure in those patients with rheumatoid synovitis of the knee joint without the presence of significant radiological damage and the absence of active systemic disease. | |
| 7469526 | Incidence and correlation between serum IgG and IgM antibodies to native type II collagen | 1981 Feb | Raised serum IgG and IgM antibody levels to native type II collagen were found in patients with rheumatoid arthritis and in patients with juvenile chronic arthritis. There was a good correlation between the serum IgG and the IgM antibody levels in rheumatoid arthritis and a weaker correlation in juvenile chronic arthritis. Raised serum IgM antibody levels to native type II collagen were found in only 1 patient each with ankylosing spondylitis and psoriatic arthritis, and in these groups here was no correlation between the serum IgG and the IgM antibody levels. The highest serum IgG and IgM antibody levels to native type II collagen were found in rheumatoid arthritis. These results, together with the results on serum antiglobulin levels, indicate that patients with rheumatoid arthritis produce antibodies of both IgG and IgM immunoglobulin class which may have pathogenetic significance in the more severe arthritis found in this condition. | |
| 6767559 | [Interactions between rheumatoid factors and antinuclear autoantibodies: their occurrence | 1980 Feb 25 | In this paper it is demonstrated that IgM rheumatoid factor (RF) can inhibit the detection of antinuclear antibodies (ANA) by the classical rat liver cryostat section method. This "inhibition" of IgG-ANA by IgM-RF may be due to the formation of high molecular weight complexes. It would be the same in vivo. This masking effect can explain interesting similarities and dissimilarities observed in the clinico-immunological profiles of rheumatoid arthritis and systemic lupus erythematosus. D-Penicillamine can restore ANA activity by dissociating ANA-RF complexes. A new technique is described for the detection of these masked ANA. | |
| 849849 | [Principles of the therapy of osteoporosis. 1. Definition, classification, diagnosis]. | 1977 Feb 17 | More and more the treatment of osteoporotic changes of the skeleton becomes a topic of discussion of an emotional nature. Whatever reasons may exist, it can be taken for granted that a considerable interest can be found in the pertinent problems coming up, and that a difference of opinion exist on some issues. However, certain principles should not be disputed, since nowadays there is hardly any doubt as to their validity. To represent these and to compare them with the methods of treatment of an osteoporosis discussed today is the purpose of this information. This first part contains definition, classification and diagnosis. | |
| 7143306 | [Stress fractures of the pelvis]. | 1982 Aug | Stress fractures of the pelvic ring should be suspected everytime a patient complains of hip pain. These stress fractures are more likely to occur in elderly, obesity, rheumatoid arthritis, osteoarthritis of the hip and after total hip replacement. A bone scan should be performed for early diagnosis, for roentgenolographic evidence of stress fracture often one ago two or three weeks behind the onset of symptoms. | |
| 701343 | Total hip arthroplasty in chronically dislocated hips. Follow-up study on the protrusio so | 1978 Oct | The so-called protrusio socket technique of total hip arthroplasty was shown to be very effective in a series of twenty-two chronically dislocated or subluxated hips. In seventeen patients with follow-up of sixteen to fifty-nine months, excellent results were obtained in all but two hips. Obesity and rheumatoid arthritis or other systemic causes of osteopenia are considered contraindications to the procedure. | |
| 1151980 | 4-Amino-5-arylpyrimidines as antiinflammatory agents. | 1975 Jun | 4-Amino-5-arylpyrimidines were synthesized by a variety of methods and have demonstrated antiinflammatory activity in the carrageenan-induced edema in the rat but displayed little activity against adjuvant-induced arthritis in rats or against uv-induced erythema in guinea pigs. | |
| 6861814 | Clinical and laboratory changes produced by piroxicam in rheumatoid arthritis. | 1983 | Twenty-five patients with active rheumatoid arthritis received treatment with piroxicam during 12 weeks in an open, non-comparative trial. In addition to improvement of clinical parameters, a significant diminution of the erythrocyte sedimentation rate and a decrease in rheumatoid factor titers was noted in both serum and synovial fluid. | |
| 4460204 | [Articular manifestations of cryoglobulinemias]. | 1974 Oct | Manifestations are found in the joints in 27-50 percent of patients with cryoglobulinaemia. They include arthralgia, or less frequently arthritis of distal oligo-articular topography, predominantly in the lower limbs. These manifestations consist of pure synovitis - nonexudative, nondestructive, and usually recurrent. Cold is rarely a precipitating factor. The manifestations are indicative of cryoglobulinaemia when they are associated with other symptoms of the disorder, among which Raynaud's disease and purpura of the lower limbs are the most frequent. Cryoglobulin is demonstrated only if the blood is centrifuged at 37 degrees C before being held at 4 degrees C. Different immunochemical forms of cryoglobulins exist. The list of disorders that accompany cryoglobulinaemia includes multiple myeloma, Waldenström's disease, idiopathic glomerulonephritis, and, in particular, autoimmune diseases, such as the Sjögren syndrome and disseminated lupus erythematosus. In cases of rheumatoid arthritis, cryoprecipitable proteins are found in the synovial fluid and in the serum. Almost half the cases of cryoglobulinaemia are idiopathic cryoglobulinaemias and constitute the purpura-arthralgia-asthenia-cryoglobulinaemia syndrome. Immunological studies indicate that the mixed cryoglobulins that are characteristic of the idiopathic forms, are the circulating immune complexes that are responsible for the visceral lesions. The mechanism of cryoprecipitation remains unknown. Treatment is mainly symptomatic, as immunodepressants give variable results. | |
| 6334742 | Left-handed "Z" DNA antibodies in rheumatoid arthritis and systemic lupus erythematosus. | 1984 Oct | A solid phase radioimmunoassay was used to evaluate antibodies to 13 nucleic acid antigens for their ability to distinguish between systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and control sera. The antigens included 5 synthetic duplex DNA, several single-stranded nucleic acids and 2 left-handed "Z" DNA. Many of the 45 SLE patients' sera showed distinctive patterns of binding to the various antigens, but this could not be correlated with disease type or activity. In general, the duplex DNA antigens gave the best sensitivity and specificity for the detection of SLE but the antigen poly(dA) may be superior. Antibodies to "Z" DNA were found in some SLE patients but surprisingly, the binding was significantly higher in the RA group than in the SLE group. This is the first nucleic acid antigen to show more specificity for RA than for SLE. | |
| 6442225 | The activity of natural killer cells in patients with rheumatoid arthritis: I. The effect | 1984 Jul | The role of natural killer (NK) cells in vivo remains uncertain, but they have been implicated in a number of protective and aggressive host responses. We have found the NK activity of most patients with rheumatoid arthritis (RA) to be significantly depressed below the values for a control healthy population. This depression is not related to the use of myochrysine, methotrexate or penicillamine. Auranofin, which has a stimulatory effect in vitro, seemed in vivo to cause a further depression. ASA and indomethacin, when given to normal subjects, stimulated NK activity. The reduced NK activities seen in patients with RA taking these and other non-steroidal anti-inflammatory agents remains unexplained. | |
| 6091771 | Latent collagenase of rheumatoid synovial fluid is not of granulocytic origin. | 1984 Oct 16 | The physicochemical properties of three latent collagenases derived from rheumatoid synovial fluid, polymorphonuclear leucocytes and culture medium of rheumatoid synovium were compared. It has been shown that synovial fluid enzyme is similar to that of synovium collagenase from tissue culture and differs significantly in molecular size and protein charge from granulocyte collagenase. The results indicate that the latent, trypsin-activable collagenase present in rheumatoid synovial fluid is not of granulocytic origin and seems to derive from the synovial membrane. | |
| 3925540 | [Controlled prospective study of clinical and biological thyroid parameters in rheumatoid | 1985 May | 15 patients with rheumatoid arthritis (14 women and 1 man aged between 30 and 75 years) were compared to a control group of 12 women and 1 man (aged between 22 and 77 years) admitted to the rheumatology unit at the same time for benign diseases. Both groups were examined for: the presence of a goitre, family history and/or clinical hormonal dysfunction, the plasma levels of total cholesterol, free thyroxin (FT4), free triiodothyronine (FT3), before and 2 hours after 50 micrograms of thyrotropin IV, thyrostimulin half an hour before and one hour after thyrotropin and the levels of the antimicrosomal anti-thyroid antibodies and the anti-thyroglobulin antibodies. None of the patients with rheumatoid arthritis had any clinical hormonal dysfunction. However, 6 of the 15 patients presented a homogeneous goitre, 5 of these 6 patients had a family history of goitre and 2 had positive antibodies. In comparison with the control group, the 15 cases of rheumatoid arthritis had a significant decrease (m +/- sd) in the FT4 (13.20 +/- 2.50 pmol/l vs 15.60 +/- 2.47; p less than 0.02), FT3 (3.80 +/- 1.12 pmol/l vs 5.50 +/- 0.93; p less than 0.001) and a rise in the T3 with low thyrotropin (5.70 +/- 1.60 vs 8.50 +/- 1.50; p less than 0.001), while the levels of thyrostimulin and the thyrostimulin peak under thyrotropin were not modified.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 1117025 | Link arthroplasty of the metacarpo-phalangeal joints. A preliminary report of a new method | 1975 Feb | Link arthroplasty is a system of joint replacement in which the joint is left almost intact with no great removal of bone. It is based on a two-piece self-locking hinge slotted into the metacarpal head and phalangeal shaft. The operation is simple and no special instruments are needed. The preliminary follow-up of fifty-four metacarpo-phalangeal joint replacements showed thirty-five good and sixteen fair results. | |
| 6601708 | The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid a | 1983 Feb | It has been shown that synovial tissues and fluids contain activated T lymphocytes. We examined the synovial fluids of rheumatoid arthritis patients and control (noninflammatory) fluids for the presence of interleukin 2 (IL-2) activity, a lymphokine essential to maintaining cells in an activated state. Using an IL-2 dependent T cell line it was found that 10/14 (71%) of rheumatoid synovial fluids contained IL-2 like activity while 0/8 control fluids demonstrated activity. The active material was resistant to heat (56 degrees C for 1h), was less than 50,000 molecular weight by gel filtration fractionation and was not precipitated by 50% saturated ammonium sulphate. It is therefore not immune complex in nature. | |
| 305925 | Suppressor cell-mediated neutropenia in Felty's syndrome. | 1978 Mar | The mechanism of neutropenia in Felty's Syndrome (FS) was tested. The suppressor capacity of mononuclear cells from patients with FS on normal bone marrow granulopoiesis was tested by the in vitro colony forming unit in culture assay. Peripheral blood, bone marrow, and spleen cells from FS patients with marked neutropenia (less than 1,000 neutrophils/mm3) suppressed the colony forming unit in culture of normal bone marrow. Cells from rheumatoid arthritis patients without neutropenia, cells from patients with drug-induced neutropenia without rheumatoid arthritis, or plasma from FS patients failed to suppress the colony forming unit in culture. Though suppressor cells were predominantly thymus-derived (T) cells, monocytes were also effective in suppression. The suppressor efficiency of cells from the various compartments were spleen greater than bone marrow greater than peripheral blood. Splenectomy in FS transiently corrected the neutropenia and eliminated suppressor cell activity. Hyperactive suppressor cells may be responsible for the neutropenia in some patients with FS. Correction of neutropenia in these patients should be directed at modulating the suppressor cell subpopulation. |