Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 868499 | Compression neuritis of the ulnar nerve treated with simple decompression. | 1977 | The purpose of this investigation was to test the hypothesis submitted by Osborne (1957), which proposed that the symptoms of compression ulnar neuritis, in most cases, result from compression on the ulnar nerve at the proximal border of the aponeurosis of the flexor carpi ulnaris muscle. Thirty-two simple decompression operations were performed on 31 patients, diagnosed as suffering from compression neuritis of the ulnar nerve. They were subsequently examined over a period of 5 years. Relief from symptoms was achieved in 28 cases, whilst four patients derived no improvement from the operation. Three of the four unsuccessful cases were judged to have been incorrectly diagnosed and were not suffering from compression of the ulnar nerve in the elbow. A second operation was required in two patients, in one a second decompression and in the other anteposition. No surgical or post-surgical complications occurred. | |
| 6914866 | [Complement (C3)-activating material in synovial fluid from patients with rheumatoid arthr | 1981 Sep | Synovial fluid from patients with the following diagnoses was investigated: - rheumatoid arthritis (RA) - rheumatoid arthritis with benign development (BRA) - osteoarthrosis (A) The sediment was isolated by ultracentrifugation, its C3 cleaving activity measured by 2-dimensional electrophoresis and its concentration if IgG, IgM, IgA, C3, C4 and C3-proactivator by immunoprecipitation. There is evidence that there is more C3 cleaving activity in RA than in osteoarthrosis. Activity levels of BRA were between those of osteoarthrosis and RA. Although there was no significant difference in the IgG-, IgM- or IgA-level of the 3 mentioned diagnoses after 21 minutes of centrifugation (133 000 g), it was possible to demonstrate more C3 breakdown products in RA than in osteoarthrosis and BRA. Very big molecules seem to be responsible for the generation of C3 cleaving products. These observations are not only of theoretical interest but seem also to be useful diagnostically. | |
| 7306426 | A chronic dose-ranging study of the pharmacokinetics of phenylbutazone in rheumatoid arthr | 1981 Aug | Phenylbutazone in doses of 200, 300 and 400 mg/day was administered chronically to six rheumatoid arthritic patients. At each steady-state the plasma levels of phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone as well as the extents of binding of phenylbutazone and oxyphenbutazone to plasma proteins were measured. 2 Plasma concentrations of phenylbutazone did not increase proportionally with dose but when corrected for protein binding unbound concentrations of phenylbutazone did show a proportional increase with dose. 3 Plasma concentrations of oxyphenbutazone decreased with an increase in phenylbutazone dose suggesting either that the elimination of oxyphenbutazone is stimulated or its formation inhibited after chronic administration of phenylbutazone. 4 Binding studies with human serum albumin demonstrated the ability of phenylbutazone and oxyphenbutazone to mutually displace one another. Neither saturation of the protein binding sites nor displacement interactions could account for the changes in binding shown by phenylbutazone with increased dose. 5 gamma-hydroxyphenylbutazone concentrations increased proportionally with phenylbutazone dose reaching 68% of the phenylbutazone concentration in one patient. There was a large inter-subject variation in the gamma-hydroxyphenylbutazone concentrations. | |
| 197621 | [Parasitic rheumatism]. | 1977 Jun 9 | The joint manifestations of parasitic diseases are rare. They may be due to the presence of a parasite within one or severed joints, to involvement of a neighbouring joint, or distant involvement due to an immuno-allergic mechanism. The latter category constitutes what one may call parasitic rheumatism. The latter is characterised by arthropathies of inflammatory type with raised sedimentation rate, marked but inconstant hypereosinophilia, and total inefficacy of antirheumatic treatments. The diagnosis of parasitic rheumatism depends on these criteria, on the diagnosis of the parasitic disease in question, above all filariasis but also other parasitic diseases, and above all the great efficacy of specific anti-parasitic treatments. | |
| 7027681 | [Lonazolac-Ca-a non-steroidal antirheumatic agent. Long-term clinical study in chronic pol | 1981 Jul | During a controlled open long-term study, Lonazolac-Ca, a new nonsteroidal antiphlogistic substance, has been tested in 35 patients with rheumatoid arthritis (stage I-III, according to Steinbrocker). The patients took 600 mg Lonazolac-Ca daily in three equal doses. The observation period was one year. Clinical and laboratory controls were carried out in monthly intervals. In more than 50% of the patients the tested parameters pain, swelling and active mobility improved significantly. Because of acute deterioration of the basic disease which necessitated the application of steroids, therapy with Lonazolac-Ca was discontinued in some cases. Lonazolac-Ca is well tolerated. But also as with other non-steroidal antiphlogistics, administration of the substance may be restricted in individual cases due to gastric symptoms. No adverse effect on blood count, liver and kidney function was seen. | |
| 7009757 | Three polyethylene glycol dependent methods for the detection or circulating immune comple | 1981 | A composite method using polyethylene glycol (PEG) and different markers for detecting circulating immune complexes (CIC) is described. The markers used are bovine conglutinin (RK-BA), C1q (C1q-BA) and IgG, IgM quantitation of PEG precipitate (RID-Ig). A composite scoring system is used in interpreting results from individual assays. The sensitivity of multiple PEG methods (MPM) was determined in 418 serum samples and compared with Raji cell assay in 204. Correlations between individual assays, viz., RK-BA-C1q-BA, RID-Ig and Raji cell test in several disease conditions including rheumatoid arthritis, glomerulonephritis, post-renal transplantation, maintenance haemodialysis, multiple sclerosis and normal pregnancies were computed. The relative discriminatory ability of a single PEG technique to differentiate normal from pathological sera in these disease states was observed in comparison with the composite PEG index. This index gives an improved assessment of abnormal sera, is simple and sensitive and has some advantages over biological techniques such as the Raji cell assay.U | |
| 775605 | [Early isotopic synoviorthesis during rheumatoid polyarthritis (RP)]. | 1976 May | The authors report the results of 1258 chemical synovectomies carried out in subjects with rheumatoid polyarthritis on joints at Steinbrocker stage I and of 470 chemical synovectomies carried out during the first year of evolution of rheumatoid polyarthritis. Comparison with the results of chemical synovectomy carried out later demonstrate the superiority of early chemical synovectomy. | |
| 4057194 | Grading of tenderness as a source of interrater error in the Ritchie articular index. | 1985 Aug | To assess the effect of grading of tenderness on the interrater reliability of the Ritchie articular index (RAI), 3 physicians recorded independent joint scores on each of 18 patients, examined in random order. Our results indicate that close agreement (Intraclass Correlation Coefficient = 0.85) can be achieved on global RAI scores, and that raters can achieve reasonable agreement (kappa = 0.40-0.59) on the absolute presence or absence of tenderness of individual joints. By contrast, interrater agreement hardly exceeds the chance level (kappa = 0.008-0.148) when degree of tenderness is independently assessed. The grading system of the RAI may thus be implicated as an important source of the instrument's interrater error. | |
| 6662180 | The binding of ibuprofen to plasma proteins. | 1983 | The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty acid contamination of the human serum albumin. The fraction of ibuprofen not bound to normal plasma rose significantly from a value of 0.0128 at an ibuprofen concentration of 2 mg X l-1 to 0.0155 at a concentration of 50 mg X l-1. Ibuprofen was less strongly bound to rheumatoid plasma than to normal plasma but this difference can be accounted for by the difference in albumin concentration between the two plasmas. It was found that salicylic acid can displace ibuprofen from protein binding sites, in vitro, and that this is the probable cause of the pharmacokinetic interaction between the two drugs. | |
| 6463523 | Rheumatoid factors in psoriatic arthropathy and in Waaler-Rose negative rheumatoid arthrit | 1984 | Serum levels of IgG, IgA and IgM rheumatoid factor (IgG RF, IgA RF and IgM RF) were determined by means of the diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA) in 42 Waaler-Rose negative patients with psoriatic arthropathy (PsA) type 1 (arthritis with involvement of distal interphalangeal joints) and type 3 (polyarthritis of rheumatoid type) according to the criteria of Moll and Wright as well as in 53 patients with Waaler-Rose negative rheumatoid arthritis (RA). Elevated levels of RF were found in 22% of patients with PsA type 3 and 45% of patients with Waaler-Rose negative RA. In contrast, none of the patients with PsA type 1 had detectable amounts of RF. It is suggested that the presence of IgG, IgA or IgM RF in patients having psoriasis in conjunction with inflammatory polyarthritis indicates the RA nature of the joint disease and should be considered as exclusion criterion for the diagnosis of PsA. | |
| 818450 | Animal models of arthritis. | 1976 Apr | The criteria for selecting and establishing a animal model for arthritis were described. Rats are the most frequently used animals. Adjuvant and Myocobacterium induced arthritis provide a model of chronic joint inflammation, although significant differences exist when compared with human disease. A better model of arthritis in rats and mice can be induced by the injection of one strain of Mycoplasma arthritidis. An even better model is presented by rabbits first immunized against a protein such as heterologous fibrin or albumin, and then challenged by the same protein injected directly into a joint. This results in a localized chronic arthritis pathologically similar to that of man. Arithritis can also be induced in rabbits by the injection of polymers such as chitinor or Concanavalin A into the joint. Although there is no lack of arthritis animal models, there is no animal model which gives a true replication of rheumatoid arthritis. | |
| 475874 | IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in se | 1979 Sep | IgG rheumatoid factor was detected in the sera of the majority of patients with seropositive rheumatoid arthritis. Values suggestive of IgG rheumatoid factor were noted in one-quarter of patients with seronegative inflammatory arthropathies. These determinations were always low and correlated with elevated IgG concentrations, suggesting nonspecific adherence of IgG rather than a true antigen-antibody reaction. In support of this conclusion, nonrheumatoid factor IgG was capable of concentration-dependent nonspecific adsorption to the solid phase. IgG, but not IgM, rheumatoid factor corresponded with disease activity in patients with seropositive rheumatoid arthritis, suggesting that IgG rheumatoid factor may be important in the pathogenesis. | |
| 1084244 | Antibody-dependent direct cytotoxicity of human lymphocytes. II. Studies on peripheral blo | 1976 May | Antibody-dependent direct cytotoxicity (ADDC) by human lymphocytes was evaluated in patients with rheumatoid arthritis and normal controls. Purified peripheral blood and synovial fluid lymphocytes mediated normal ADDC when compared to control subjects. No correlation could be obtained between the percentages of T, B and null cells in effector cell populations and the degree of 51Cr released from target cells. Sera from 50% of patients with rheumatoid arthritis inhibited ADDC by normal lymphocytes; the degree of inhibition did not correlate with the titre of IgM rheumatoid factor. The pathogenic implications of these findings are discussed. | |
| 229778 | Fate of herpes simplex virus in lymphocytes from inflammatory joint effusions. ii. Mechani | 1979 Oct | Mononuclear cells which were isolated from rheumatoid synovial effusions and cultured without prior separation failed to support the growth of herpes simplex virus (HSV). However, subpopulations of T lymphocytes separated on the basis of cell size or receptors for sheep red cells were, in isolation, permissive for this virus. Virus growth in these permissive cells was blocked by cocultivation with the remaining mononuclear cell populations. | |
| 6750780 | Low-dose penicillamine treatment of RA. Comparison of 600 mg and 300 mg regimens. | 1982 | Results and side effects were compared in 100 patients with rheumatoid arthritis treated with 600 mg penicillamine daily and 100 patients given 300 mg daily. While haemoglobin rose and erythrocyte sedimentation rate dropped in both the 300 mg and the 600 mg cohort, no significant improvement in clinical measure could be demonstrated for the low-dose patients. Medication was discontinued because of side effects in 30 patients on the low dose and 41 patients on the higher dose. Only 8 renal complications were seen among the low-dose patients, vs. 26 in the 600 mg cohort. However, 6 patients on the low dose vs. none on the higher dose dropped out because of inadequate therapeutic effect. Further downward adjustment of currently used daily dose, though desirable because of the relationship between dosage and side effects, seems doomed by unacceptable loss of therapeutic efficacy in most cases. | |
| 1094964 | MIF production of lymphocytes from patients with rheumatoid arthritis with antigen-antibod | 1975 Apr | Immune complexes, human erythrocytes coated with human IgG antibody, inhibit the migration of lymphocytes from rheumatoid arthritis (RA) patients. No correlation could be observed between migration inhibition and Waaler-Rose titre (sheep cell agglutination titre) in inidvidual patients. Production of migration inhibitory factor (MIF) could be detected in 16 of 20 cultures of RA lymphocytes incubated with antigen-antibody complexes, when the supernates were tested with guinea pig macrophages. Only two supernates of healthy persons showed migration inhibition activity under these conditions. The results suggest that migration inhibition by antigen antibody complexes in RA represents a true reaction of delayed hypersensitivity. | |
| 6333061 | Relation of clinical activity of rheumatoid arthritis to immune complexes, complement comp | 1984 | Circulating immune complexes by fluid phase Clq binding assay, complement components and anti-immunoglobulin levels were studied in sera of 35 patients with rheumatoid arthritis (RA). In 23 of the 35 sera (65.7%), circulating immune complexes were positive, and the mean +/- SD of Clq binding activity (ClqBA), 44.5 +/- 19.4%, was significantly high compared to that of healthy persons, 17.4 +/- 8.2%. Antigenic determination of complement components revealed that Clq, C3, C5, C9, factor B and Cl esterase inhibitor (ClINH) were significantly high in sera of RA, but C4 and properdin were not. The disease activity correlated with ClqBA, IgG- and IgM-anti-immunoglobulins, C9 and serum IgG. On the other hand, ClqBA correlated with both IgG- and IgM-anti-immunoglobulin levels but not with complement components. | |
| 6831768 | Stimulation of murine macrophage cathepsin B by serum from patients with rheumatoid arthri | 1983 Jan | Cultures of non-elicited mouse peritoneal macrophages were used as a test system to study the effect of sera from patients with rheumatoid arthritis (RA) on intra-cellular cathepsin B activity of macrophages. Sequential sera obtained during and after pregnancy from six RA patients, and sera from six actively ill, non-pregnant RA patients were compared to six healthy female controls and 3rd trimester healthy women. Sera from actively ill RA patients (both pregnant and non-pregnant) caused macrophage cathepsin B levels significantly above normal controls, while intra-cellular activities of beta-glucuronidase and N-acetyl-glucosaminidase did not differ from the controls. A significant correlation between activity of RA and intracellular cathepsin B was found in pregnant patients. It is suggested that a factor (or factors) present in serum from patients with active RA causes a rise of intracellular cathepsin B in macrophages. | |
| 387324 | Silicone implant arthroplasty of the great toe. A review of single stem and flexible hinge | 1979 Jul | One hundred sixty-five feet were reconstructed with the single stem silicone implant, including patients with hallux regidus, hallux valgus due to degenerative and osteoarthritic joint changes, hallux valgus secondary to rheumatoid arthritis and patients with previous unsuccessful "bunion" procedures. Preoperative pain and intolerance to shoe wear were relieved in the great majority of patients. The amount of correction of the hallux valgus angle was directly related to the preoperative deformity. Infection occurred in 2 patients, and inflammatory reaction to the implant occurred in one patient. One hundred five feet were reconstructed with a flexible hinge implant; 94 of the feet had joints destroyed by rheumatoid arthritis. Dramatic improvement in the hallux valgus angle resulted in these feet which had relatively severe preoperative deformities. No implant fractures were recorded. The present survey of our cases, and experiences reported by others, encourage the use of these implants by surgeons who follow the suggested indications, surgical technique, and follow up care. | |
| 4781515 | An improved method for the extraction of prostaglandins. | 1973 Nov |