Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6469162 | [Effect and tolerance of naproxen. Testing of a new Galenic preparation of an anti-rheumat | 1984 Jun 7 | The non-steroidal antirheumatic drug naproxen has been available in capsule form since 1974. A new formulation, a film-coated tablet, has recently been developed and has various advantages, namely rapid release and absorption of the active substance, a lower volume, and a score-line. The efficacy and safety of the new tablet in a dose of 1000 mg daily was investigated in 30 patients in an open study. The substance was well tolerated, and there was no need to discontinue treatment in any patient. In the majority of patients the efficacy of the preparation was very good to good. An unsatisfactory effect was only obtained in two cases. | |
| 6546120 | Total condylar knee arthroplasty for valgus and combined valgus-flexion deformity of the k | 1984 | Total condylar knee arthroplasty was performed on 64 knees with fixed valgus or valgus/flexion deformities. The technique for release of tight lateral and posterior structures is important to balance the ligament. Clinical results were rated good and excellent in 95% of the knees. Four patients with excessive flexion deformities required 6 weeks of cast bracing in the immediate postoperative period for instabilities caused by an imbalance in the spacing in flexion and extension. In no joint in the entire series did stability deteriorate with time. There were no patellar complications or nerve palsies noted. Radiographic evaluation revealed well-fixed components in 92% of the arthroplasties. None has required revision for mechanical loosening to date. With proper technique the total condylar prosthesis can be employed in knees with valgus or valgus/flexion deformities to give predictably good results. The total condylar III prosthesis may be required in severe combined deformities for added stability. | |
| 3922462 | Practical results of treatment with disease-modifying antirheumatoid drugs. | 1985 May | Reappraisal of disease-modifying antirheumatoid drug (DMARD) therapy in rheumatoid arthritis (RA) has raised the possibility that the risks of treatment outweigh the benefits. To provide more information a retrospective survey of the case-notes of 325 patients with RA was performed. The case-notes were randomly selected from the 2320 RA patients indexed in one department. Improvement was defined by the contemporary written notes of the managing physician. Analysis employed the life-table technique. A total of 247 case-notes could be adequately analysed: 154 patients had received one or more DMARDs constituting 251 drug-patient exposures. Improvement followed drug-patient exposure in 57% of cases after a delay of between one and seven months. Nine per cent occurred within one month and 22% within two months. Of those patients withdrawn from treatment after less than two months, the 'early withdrawal' group, 25% subsequently improved without further DMARD therapy. The probability of still receiving a specific DMARD 8 months, 24 months and 36 months after the start of treatment was 50%, 25% and 10%, respectively. The majority of withdrawals resulted from adverse reactions. There was no evidence for a relationship between patient responses to sequential DMARDs. | |
| 6458085 | Con A-induced suppressor cell activity and T-lymphocyte subpopulations in peripheral blood | 1981 | Suppressor cell activity was investigated in peripheral blood lymphocytes from twenty patients with rheumatoid arthritis (RA) and twenty patients with juvenile rheumatoid arthritis (JRA) using a concanavalin A/mixed lymphocyte culture assay. The mean suppression in the RA patients was slightly reduced compared with the suppressor cell activity in adult controls (25 +/- 5% suppression compared with 37 +/- 5%; P less than 0.05, Student's t test), whereas the JRA patients had normal suppressor cell activity (mean 46 +/- 5% versus 43 +/- 5% in healthy children matched for age and sex). The RA patients had normal proportions of T-cell subpopulations, 13.3% T gamma cells and 49.8% T mu cells, compared with 13.8% and 58.0% in controls. The JRA patients, however, had a significantly reduced mean percentage of T gamma cells, 6.6%, compared with 13.8% in healthy children (P less than 0.05, Mann-Whitney U-test). The mean percentage of T mu cells was 53.7%, versus 56.2% in the controls. The relation between suppressor cell activity and suppressor cells enumerated by membrane markers is discussed. | |
| 3891167 | Studies on fibronectin in inflammatory vs non-inflammatory polymorphonuclear leucocytes of | 1985 May | Using indirect immunofluorescence and flow cytometry, we studied the reactivity of an antibody to human fibronectin with human polymorphonuclear leucocytes (PMNL). Our main objective was to compare the intensity of reaction of this antibody with inflammatory vs non-inflammatory PMNL. We used peripheral blood PMNL as a source of non-inflammatory cells and PMNL isolated from the synovial fluid of patients with rheumatoid arthritis as a source of inflammatory cells. Our findings revealed considerably brighter staining of the inflammatory PMNL. Using flow cytometry as a method of measurement, a difference in fluorescence intensity of at least 40 channels (log scale) was observed in all 12 patients studied when comparing peripheral blood with synovial fluid PMNL. In inflammatory PMNL, fibronectin was found both at the intracellular and membrane levels of the cell whereas fibronectin could be detected only intracellularly in non-inflammatory PMNL. | |
| 7258747 | Evaluation of lymphocyte populations and their mitogenic activity in relation to serum cop | 1981 Aug | Purified mononuclear cells from the peripheral blood and sera from 30 patients with active rheumatoid arthritis (RA) were compared to the control or standard values in respect to the total number of B (EA) and T (E) rosette forming lymphocytes, their responsiveness to phytohemagglutinin (PHA) and pokeweed (PWM) mitogen, and serum immunoglobulins, (C3) complement and copper levels. The RA patients had significantly lower values for EA cells, PWM stimulation index, hemoglobin and hematocrit. Significantly higher values for serum copper and sedimentation rates were found. Relatively higher values for IgG, M, A and C3 were found in RA patients with lower values for E cells. | |
| 190647 | Cyclic AMP response to prostaglandin E1 in mononuclear cells from peripheral blood and syn | 1977 Jan | The cyclic AMP response to prostaglandin E1 (PGE1) was studied in peripheral blood (PB) and synovial fluid (SF) mononuclear cells from patients with rheumatoid arthritis (RA). The PGE1 induced accumulation of cyclic AMP was consistently (7 of 8 patients) less in cell suspensions derived from SF than in suspensions of equivalent numbers of mononuclear cells obtained simultaneously from PB. The high PB/SF cyclic AMP ratio was seen most clearly at the lowest concentration (10(-6)M) of PGE1 tested. There was no correlation between the patients' therapy and cyclic AMP response to PGE1. The high PB/SF cyclic AMP ratio was not accounted for by the presence of platelets in PB cell suspensions. | |
| 6380835 | C3 receptors on granulocytes from patients with rheumatoid arthritis and Felty's syndrome. | 1984 Sep | The expression of receptors for the third component of complement (C3R) on polymorphonuclear cells (PMN) from patients with rheumatoid arthritis (RA) or Felty's syndrome (FS) and healthy controls (HC) was studied by means of a rosetting technique using ox erythrocytes coated with rabbit IgM and mouse complement. The percentage of rosette forming PMN (RF-PMN) was found to be increased in patients with FS (59%) and patients with RA (47%) compared to HC (18%), when measured directly after cold isolation of PMN. Incubation at 37 degrees C of cold isolated cells increased the percentage of RF-PMN in all three groups, although the values were significantly higher during the first 45 min of incubation in both patient groups. When incubated with serum from patients with FS at 37 degrees C, cold isolated donor PMN formed significantly more rosettes than after incubation with donor serum. This increase was shown to be due to the presence of circulating immune complexes in the patient sera and could be mimicked by incubating donor PMN with aggregated human IgG. As a result of these experiments it was demonstrated that the increased percentages of PMN with C3R in patients with FS or RA are most likely caused by a previous in vivo activation of PMN by immune complexes. The possible effect of such an increase in C3R expression in relation to PMN function in these patients is discussed. | |
| 389039 | State of the art. Primary biliary cirrhosis and the immune system. | 1979 Sep | The immunologic features of diseases associated with primary biliary cirrhosis (PBC) such as Sjörgren's syndrome, scleroderma, rheumatoid arthritis and others are reviewed. Immunologic abnormalities involving both humoral and cell mediated immunity have been found in PBC. The morphologic and immunologic data have been used to propose a pathogenetic mechanism for PBC. Recent studies of penicillamine indicate that the drug may influence liver copper content and the deposition of immune complexes. | |
| 1201105 | Antibodies to DNA in patients with rheumatoid arthritis and juvenile rheumatoid arthritis. | 1975 Nov | Antibodies to double-stranded DNA (DSDNA) were found in 18 patients with RA, in 5 patients with JRA, and in 5 patients with undiagnosed connective tissue disease. Five patients had clinical features consistent with both RA and SLE, 11 with only RA, and 5 with only JRA. Based on these observations, the presence of serum anti-DSDNA antibodies should not be used as a sole criterion in the diagnosis of SLE. | |
| 975666 | Guepar hinge prosthesis: complications and results with two years' follow-up. | 1976 Oct | Experience with the GUEPAR prosthesis in 292 cases of which 103 have been followed for more than 2 years, suggests that: implanting a hinge prosthesis is major surgery on elderly patients in whom severe complications have occurred and for this reason, the operations should be reserved for extremely damaged and unstable knees; the most important local complications have been deep sepsis for which we have noted a rate of 6.6 per cent; in the treatment of sepsis, everything must be done to preserve the prosthesis because arthrodesis is difficult to obtain; pain relief has been significant as a result of the operation. The prosthetic design allows flexion of more than 90 degrees in 85 per cent of the cases and 120 degrees in 26 per cent; after two years, the results seem relatively stable. We have not observed aseptic loosening after this period but a longer observation period is necessary to be reassured on this point; patellar pain remains a major concern because this arthroplasty has not solved the problem, and other solutions will have to be found. | |
| 1105774 | IgG rheumatoid factor in dental periapical lesions of patients with rheumatoid disease. | 1975 | To detect "hidden" IgG rheumatoid factor in tissues from dental periapical lesions, 26 rheumatoid and 14 control patients were examined by the direct immunofluorescence technique for binding of FITC-labelled IgG before and after pepsin digestion. Whereas free rheumatoid factor was detected in only 1 rheumatoid tissue before digestion with pepsin, this tissue as well as 8 other rheumatoid tissues strongly bound heat-aggregated IgG after the digestion procedure. Six of these 9 tissues also bound native IgG. In no control tissue was free rheumatoid factor detected and in only 1 was "hidden" rheumatoid factor revealed after pepsin digestion. Hence, presence of IgG rheumatoid factor correlated positively with the presence of rheumatoid disease, and evidence was established that certain features of rheumatoid inflammation occur in dental periapical lesions of many patients with rheumatoid disease. | |
| 405730 | An initial report on a double-blind trial comparing small and large doses of gold in the t | 1977 May | A double-blind clinical trial on 60 patients with rheumatoid disease comparing 10 mg sodium aurothiomalate weekly to 50 mg weekly is continuing. An initial report on thirty of these patients, who had completed a year of treatment, shows no statistically significant difference in the response between the two groups. No conclusions can be drawn about toxic reactions in this number of patients having received treatment for only one year. | |
| 1236747 | A neutral protease in rheumatoid synovial fluid capable of attacking the telopeptide regio | 1975 Sep 9 | Fluorescent-labelled polymeric collagen fibrils have been prepared which contain three fluoresein residues in the telopeptide regions and four fluorescein residues in the helical region of each tropocollagen unit within the polymer. This material has been used as a substrate for the study of enzymes present in the synovial fluid of inflamed rheumatoid joints which are capable of degrading polymeric collagen fibrils. Two enzyme systems were observed, one inhibited by EDTA and having the properties of the known synovial collagenase, the other having the properties of a neutral protease. The neutral protease was found to be present in sonicates of the polymorphonuclear leucocytes in the synovial fluids of inflamed joints. This enzyme attacked the telopeptides of fluorescein-labelled polymeric collagen fibrils and was similar to trypsin in removing two residues of fluorescein-labelled peptides per tropocollagen molecule within the polymeric collagen fibrils but did not depolymerise the polymeric collagen fibrils. | |
| 4034451 | Ocular and oral problems in arthritis. How to recognize, when to refer. | 1985 Sep 1 | Recognition of oral and ocular problems is important in the management of arthritis. Although the focus of attention is usually on joint problems, patients with these chronic disorders require a comprehensive approach to their total medical care. Physicians need to watch for physical signs of significant inflammation and should alert their patients to watch for significant symptoms. | |
| 597373 | Pleural fluid complement, complement conversion, and immune complexes in immunologic and n | 1977 Dec | Forty-four pleural fluids and 41 blood specimens from patients with various diseases were examined for concentration of whole complement, C4, C3, conversion products of C3 and C3PA, and immune complexes. C3 conversion was found in all eight pleural fluids from patients with rheumatoid arthritis, five of seven with lupus erythematosus, two of six with congestive heart failure, and nine of 23 with malignant diseases. Conversion of C3PA correlated closely with C3 conversion and both were significantly inversely related to whole complement, C4, and C3. Concentration of immune complexes was highest in patients with rheumatoid arthritis. Pleural fluid immune complex concentrations correlated positively with conversion of C3 and C3PA. These findings suggest that the reduced levels of pleural fluid complement in rheumatoid arthritis and lupus erythematosus may be secondary to complement conversion by immune complexes. | |
| 6340495 | From experiment to experience: side effects of nonsteroidal anti-inflammatory drugs. | 1983 May | As part of the approval process, new drugs are first studied in controlled clinical trials with carefully selected patients. After gaining approval, however, these drugs are often used in the general community under widely different circumstances. This report explores the effects of such differences on the frequency and severity of side effects using the nonsteroidal anti-inflammatory drugs as a prototype. A review of clinical trials is compared with the accumulated experience at the Stanford and Phoenix Arthritis Centers. Statistical analysis of patient records was accomplished using the American Rheumatism Association Medical Information System Computer Data-Base System. To overcome potential biases in different methods of detecting side effects, a questionnaire was mailed directly to 390 patients, including subjects who were and were not participants in formal drug studies. Agreement between experiment and experience was generally quite good. However, a tendency for severe side effects to occur more frequently in community use than would be predicted from clinical trials was noted. | |
| 824722 | Long-term treatment with ketoprofen in rheumatoid arthritis. A clinical trial with special | 1976 | The tolerance of ketoprofen (2-(3-benzoylphenyl)-propionic acid) was studied in sixteen patients with rheumatoid arthritis during a treatment period up to seven months. The drug was well tolerated with only a few minor side-effects and showed a clear anti-rheumatie effect with a dose of 150 mg/day. This effect may equal that of 4.0 g/day of acetylsalicylic acid or even exceed that, and may be somewhat smaller than that of 600 mg/day of phenylbutazone. | |
| 529247 | Correlative studies of lymphocyte transformation and plasma protein levels in ankylosing s | 1979 Nov | Lymphocyte transformation was studied in 24 patients with ankylosing spondylitis (AS), 21 with rheumatoid arthritis (RA) and 23 control subjects (CS). Enhanced transformation was found in response to phytohemagglutinin (PHA) (p less than 0.01) and human aggregated gamma globulin (p less than 0.025), but not to inulin, for AS patients. Correlation coefficients between the concentrations of each of 8 AS plasma proteins and PHA-induced lymphocyte transformation in autologous plasma showed significance only for C-reactive protein (CRP). However, co-culture experiments with PHA in autologous and allogeneic (AB) plasma, and in CRP-devoid AB serum showed no specific enhancing effect by AS plasma on lymphocyte responses. Although these studied demonstrate that AS is frequently characterized by enhanced in vitro transformation to T lymphocyte dependent mitogens, this response does not appear to be related to the known immunoregulatory properties of CRP. | |
| 375604 | [Immunopharmacology of levamisole]. | 1979 May 1 | Levamisole, a simple chemical, first introduced as a broad spectrum anthelmintic, is an immunotherapeutic agent with anti-anergic properties. It is the first member of a potential new class of immunologically active, probably thymomimetic compounds. The present knowledge from studies on isolated cells, experimental animals, healthy volunteers and patients with various diseases shows that levamisole behaves physiologically as a thymus hormone and restores to normal the functions of phagocytes and T-lymphocytes in compromised hosts and induces T-cell differentiation. The biochemical mechanism of action remains still unclear. The various mechanisms by which levamisole might act are not mutually exclusive. Levamisole is well tolerated in doses of 2,5 mg/kg. Side-effects are markedly more frequent in patients with rheumatoid arthritis than with other diseases. The only potentially fatal adverse reaction is agranulocytosis. |