Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7257509 | Research in geriatric medicine in the Federal Republic of Germany. | 1981 May | The research in the field of geriatrics in the Federal Republic of Germany is based on the teachings of Max Bürger in Leipzig. Under the impulse of René Schubert, general geriatrics medicine could be investigated. A series of reasons are responsible for the relatively late development of rehabilitative geriatrics in the Federal Republic. The clinical gerontopharmacology has nevertheless achieved resounding results through the cooperation between pharmacologists and clinicans. Preclinical geriatric medicine developed only with little reference to gerontology, the concept originates from policlinical medicine, as inaugurated by Korth, 1967. The emphasis lies on prevention, with reference to the work of general physicians "outside of the clinical gates" of geriatrics. Within the special geriatrics age related angiocardiology, rheumatology, immunology and longevity are viewed as the most essential part of the research projects. Research activities in clinical geriatrics remained for a long time a domain of clinics and institutes outside the universities. There is a promising tendency yet, to establish the clinical geriatrics in the universities. | |
| 906524 | [Transport of salicylates from blood to joint fluid (author's transl)]. | 1977 Sep 16 | Samples of blood and joint fluid from thirty patients who had taken acetyl-salicylic acid were examined for occurrence of salicylates. The data were arranged in groups according to the diagnosis of the joint disease and did not show significant differences in the kinetics of salicylates into blood; the time of the first appearance averaged 6.4 minutes, and levels "close to maximum concentration" averaged 23 mg/l. In joint fluid, the time of first appearance of salicylates ranged from 10 to 31 minutes, and levels of maximum concentration of salicylates averaged 14.8 mg/l. Transport of salicylates from blood to joint fluid showed a pattern consistent with the type of joint disease. Support was found for the assumption that diffusion was the major factor in the movement of salicylates from blood to joint fluid. | |
| 152287 | [Favorable effects of estrogens and progesterones on general diseases]. | 1978 Oct 26 | Estrogens and progestagens exert positive effects on some general diseases as iron deficiency, anemia, premenstrual syndrome, intermenstrual migraine, akne, seborrhoea, hirsutism, androgenetic alopecia, slerodermia, rheumatoid arthritis, osteoporosis and depressive disorders. The mechanism of action and the mode of treatment in such cases are discussed. | |
| 929122 | Naproxen concentrations in serum, synovial fluid, and synovium. | 1977 | Naproxen levels in serum, synovial fluid and synovium of eighteen patients with "classical" or "definite" rheumatoid arthritis and chronic knee effusion were studied. After oral administration of 250 mg naproxen twice daily, naproxen levels in synovial fluid were found to be more than half as high as in serum. Even in synovium itself naproxen levels were appreciable. | |
| 6606307 | Magnetic resonance imaging of the cervical spine: technical and clinical observations. | 1983 Dec | Seventy-two patients were examined to determine the clinical potential for magnetic resonance imaging (MRI) of the spine. MRI using different pulse sequences was compared with plain radiography, high-resolution computed tomography, and myelography. There were 35 normal patients; pathologic conditions studied included canal stenosis, herniated disk, metastatic tumor, neurofibroma, trauma, Chiari malformation, syringomyelia, arteriovenous malformation, and rheumatoid arthritis. MRI provided sharply defined anatomic delineation and tissue characterization. It was diagnostic in syringomyelia and Chiari malformation and was useful in the evaluation of trauma and spinal canal block from any cause. MRI was sensitive to degenerative disk disease and infection. The spin-echo technique, with three pulse sequence variations, seems very promising. A short echo time (TE) produces the best signal-to-noise ratio and spatial resolution. Lengthening the TE enhances differentiation of various tissues by their signal intensity, while the combined increase of TE and recovery time (TR) produces selective enhancement of the cerebrospinal fluid signal intensity. | |
| 377448 | A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the managemen | 1979 May | In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day). Both drugs induced a clinically and statistically significant improvement of all the symptoms studied, except for pain at night during ibuprofen administration. Ketoprofen displayed a therapeutic efficacy significantly superior to ibuprofen in five of the eight symptoms studied. Side-effects were recorded in 10 patients receiving ketoprofen (one patient withdrew because of heartburn) and in nine patients receiving ibuprofen. | |
| 77134 | Basophil histamine release by RNA, DNA and aggregated IgG examined in rheumatoid arthritis | 1978 Feb | Basophils from patients with rheumatoid arthritis (RA) respond to RNA, DNA and immune complexes (aggregated IgG) with histamine release. The RNA response was well correlated to the clinical activity of the disease, since histamine liberation was found in all patients with severe activity, whereas no liberation was observed in patients with moderate or quiescent activity. A less significant correlation was obtained with DNA and aggregated IgG. In contrast, no response was obtained with RNA, DNA and aggregated IgG in patients with systemic lupus erythematosus (SLE) or in controls. In the RA and the SLE groups no significant correlation was found between the response of RNA, DNA and aggregated IgG and the serum titres of anti-DNA and antinuclear antibodies. No difference in basophil cell count in peripheral blood and basophil histamine content was found between RA, SLE and controls. Our results point to an involvement of an autoimmune type I reaction in the pathogenesis of RA directed against the nuclear components RNA and DNA and against immune complexes. | |
| 6614846 | Surgery of the rheumatoid foot. | 1983 Apr | The typical rheumatoid foot deformity is that of hallux valgus, bunion, hammer claw toes with contracted dorsal soft tissue, depressed metatarsal heads and associated painful callosities and corns both under metatarsal heads and on dorsal surfaces of cocked-up lesser toes. Deformity and pain will be amendable with surgery if patients are selected properly and correct surgery is performed to achieve a pain free weight-bearing foot. | |
| 932442 | A simple numerical method for the construction of isokinetic sucrose density gradients, an | 1976 Mar | A simple numerical method for calculating the parameters required for the production of isokinetic sucrose density gradients is described. Calculation is based on tables of viscosity and density of sucrose solutions at various concentrations. When density gradients prepared according to this method were used for centrifugation of a number of well characterised proteins, it was shown that isokinetic behavior occurs, and that sedimentation coefficients obtained are comparable to those determined by conventional analytical ultracentrifugation. The method was used to characterise polymers of IgM and IgG, and results suggest that IgM polymers up to the tetramer can occur in Waldenstrom's macroglobulinaemic serum, and that IgG polymers up to the pentamer can occur in stored specimens of ethanol precipitated human IgG. The sedimentation behaviour of 125I-IgE was studied by fractionating the gradients and counting the fractions, and it was shown that degradation of the labelled IgE took place during storage. It was also found that labelled IgE induces rapid breakdown of IgG with which it was mixed prior to centrifugation. The method has also been used to study immunoglobulin-containing complexes found in the knee joint fluids of patients with rheumatoid arthritis. The high degree of resolution of this method is demonstrated by the fact that many more of these components were detectable by density gradient centrifugation than by conventional analytical ultracentrifugation. | |
| 1036689 | Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and | 1976 Nov | The proteinase cathepsin D which degrades proteoglycan was never demonstrated in extracellular sites in tissues from patients with traumatized meniscoid cartilage, either before or after culture with an antiserum to human cathepsin D. In contrast, in synovia (but not usually cartilage) from the knees of 6 of 11 rheumatoid patients, extracellular cathepsin D was commonly detected by culturing tissues with an antiserum to this enzyme. | |
| 205223 | Hyporesponsiveness of lymphocytes to virus antigens in rheumatoid arthritis. | 1978 Mar | The immune response of peripheral blood lymphocytes to measles, rubella, parainfluenza types 1, 2, and 3 RNA virus antigens and to varicella-zoster and herpes virus type 1 DNA virus antigens was evaluated in 14 patients with rheumatoid arthritis (RA) and 14 matched controls by assessing 3H-thymidine incorporation. The results demonstrated hyporesponsivenss of lymphocytes from RA patients to virus antigens and phytohemagglutinin (PHA), which did not appear to be nonspecific because of a lack of correlation between response to virus antigens and response to mitogens. The patterns of decreased responsiveness was suggestive of a relative restriction of hyporesponsiveness to RNA virus antigens. | |
| 6367028 | [Is the demonstration of immune complex useful in the activity assessment of chronic polya | 1984 Jan 28 | In a prospective and controlled long-term study of 39 patients suffering from rheumatoid arthritis (RA), various blood parameters including the C1q-binding test (fluid phase) and the Rajicell test were performed. Blood samples were taken every three months during an observation period of eighteen months and compared with disease activity. According to these sequential analyses, immune complexes determined in the serum by these two tests do not always reflect disease activity expressed by addition of active joints. These results confirmed that the C1q-binding test often closely reflects disease activity. In patients with RA and extraarticular manifestations the C1q-binding test continuously showed increased concentrations of circulating immune complexes in the serum. In patients with predominant vasculitis the regular determination of circulating immune complexes is the best means of showing disease activity. This latter observation is especially true in patients with malignant RA. On the whole, the clinical significance of regularly performed assay for detection of immune complexes in RA appears questionable. | |
| 1095133 | Indomethacin--aspirin interaction: a clinical appraisal. | 1975 Jul 12 | Plasma profiles of indomethacin after a 50-mg oral dose were constructed in six healthy volunteers before and after a week of aspirin treatment. Aspirin did not interfere with indomethacin plasma levels. To examine the clinical effect of concurrent indomethacin and aspirin treatment 20 patients with seropositive rheumatoid arthritis were given indomethacin 100 mg/day, aspirin soluble 4 g/day, and the two drugs taken together in random order. Analysis of the clinical indices of inflammation--articular index and mean pain score--and of the efficacy of each treatment showed no significant differences between the three treatment groups. With the proliferation in the number of anti-rheumatic drugs available, the case for giving two or more nonsteroidal anti-inflammatory drugs concurrently remains unproved. | |
| 339851 | Immune reactants in cryoproteins. Relationship to complement activation. | 1977 Dec | Cryoproteins were isolated from the serum of 5 patients with essential cryoglobulinaemia 5 patients with rheumatoid arthritis, and 2 patients with Sjøgren's syndrome. These cryoprecipitates contained IgG, IgM, and IgA as well as complement proteins C1q, C4, C3, and factor B. The cryoprecipitates were analysed further for content of antibody and antigen, and were tested for their ability to activate complement. In the cryoprecipitates of 2 patients with Sjøgren's syndrome, nuclear antigen and antinuclear antibody characteristic of an immunological specificity found in Sjøgren's syndrome were shown. The cryoprecipitates of 6 other patients contained rheumatoid factor and antibody to a lymphocyte nuclear antigen. The solubilized cryoprecipitates were tested by in vitro assays for their ability to activate complement by the classical or alternative pathways. All 12 cryoprecipitates activated the classical pathway. 9 of the 12 cryoprecipitates also activated the alternative complement pathway under conditions which did not involve activation of C1 and C4. These studies show that a high percentage of cryoprecipitates consist at least in part of immune reactants. We discuss the relationship of these findings to pathogenetic mechanisms in disease. | |
| 311555 | The comparison of different rosette assay systems for the determination of T-lymphocytes i | 1978 Dec | The number of T-lymphocytes in the peripheral blood of 51 patients with different type of solid malignancies, 33 normal controls and 10 patients with rheumatoid arthritis was determined using different variations of the sheep red blood cell (SRBC) rosetting-technique (test temperature of 4 or 29 degrees C, medium substituted with or without fetal calf serum [FCS], SRBC treated or untreated with neuraminidase). No significant differences between cancer patients and normal controls were observed in the percentages of T-lymphocytes with the 4 degrees C incubation under any of the conditions tested. In absolute counts, however, a significantly decreased number of T-cells was observed in cancer patients, most likely due to the observed significant lymphopenia in this group. When the test temperature was raised to 29 degrees C, a significantly lower rosette formation was obtained in both percentages and absolute counts of peripheral T-cells in the group of cancer patients as compared to normal individuals only when both neuraminidase treated SRBC and FCS substituted medium were used. The question of whether the observed differences in the percentages and absolute counts of peripheral T-lymphocytes between cancer patients and normal controls using this rosette assay are due to a loss of a T-cell subpopulation or to an alteration in the metabolic state of T-cells in cancer patients remains open. | |
| 396214 | [Current aspects of rheumatoid arthritis]. | 1979 Oct 25 | According to recent investigations two factors might play an essential role in the pathogenesis of rheumatoid arthritis (R.A.). Besides genetic components, i.e. the HLA-system and familial aggregation, the immune processes, mediating tissue inflammation and injury, are acknowledged as having established roles in the pathogenesis of R.A. The present report reemphasizes recent data concerning the autoimmunity and the immunologic network with trends of therapy in R.A. In view of the effectiveness of new nonsteroidal antiinflammatory drugs, a double-blind study of suxibuzon vs. indomethacin in 30 patients with active R.A. is described in detail. Both drugs were active and similar in their efficacy at 4 weeks as judged by clinical and laboratory measurements. No serious toxic side-effects were observed in both treatment regimens. | |
| 6379832 | Fibronectin in the synovium of chronic inflammatory joint disease. | 1984 | The localisation of fibronectin in the synovial membrane of rheumatoid arthritis (RA) and other chronic inflammatory joint diseases has been studied using a peroxidase-antiperoxidase immunohistochemical method. Synovia were studied from seven cases of seropositive RA three cases of seronegative RA, six cases of ankylosing spondylitis, four cases of Reiter's syndrome and five of psoriatic arthritis. Six were small biopsies and the remaining tissues were obtained at open surgery for orthopaedic procedures or biopsies. Fibronectin was demonstrated in all of the synovia examined and was present in intimal cells, synovial giant cells, the walls of small blood vessels, basement membrane of larger vessels and deposits of fibrin. No difference in this distribution of fibronectin was found in seropositive and seronegative RA, ankylosing spondylitis, Reiter's syndrome or psoriatic arthritis, neither was there any difference in the amount of fibronectin at various sites. | |
| 160092 | Rapidly fatal pulmonary fibrosis: the accelerated variant of interstitial pneumonitis. | 1979 Oct | We sought to explore immunological factors in patients who died with rapidly fatal fibrosing lung diseases (Hamman-Rich syndrome). A retrospective review of cases of interstitial lung disease showed 12 recent deaths from Hamman-Rich syndrome. The mean age was 62, men outnumbering women 3 : 1. Five patients had proved collagen vascular disease (rheumatoid arthritis three, lupus two). Four others had a history of allergic disorders, syphilis, chronic eosinophilia, or hypersensitivity reactions. One patient showed disappearance of immunofluorescence as fibrosis advanced, which has not previously been reported. The study suggests a possible aetiological link between disorders of immunity and Hamman-Rich syndrome. The evidence also supports the notion that Hamman-Rich syndrome is an accelerated variant of the more indolent interstitial pneumonias. | |
| 1093551 | Effect of ibuprofen dosage on patient response in rheumatoid arthritis. | 1975 Mar | In a 4-week double-blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups. | |
| 4140154 | Stimulation of lymphocyte transformation by autologous serum fractions from patients with | 1974 Nov | In vitro lymphocyte transformation was used in an attempt to demonstrate hypersensitivity reaction to gamma-globulin in patients with rheumatoid arthritis. Peripheral blood lymphocytes from Latex-positive rheumatoid patients were cultured in TC 199 fluid for 3 days in the presence of autologous gamma-globulin preparations (concentrations of 0.01–11 mg/ml), and the percentage blast formation determined microscopically on 1000 cells. Negative controls and phytohaemagglutinin controls were included. Transformation of 10 per cent or more was considered significant. Whole gamma-globulin obtained by ammonium sulphate precipitation failed to stimulate autologous lymphocyte transformation. IgM and IgG fractions obtained by gel filtration on Sephadex G-200 at pH 4.05 stimulated transformation in five out of ten and eight out of ten autologous lymphocyte cultures. The activities of the IgM and IgG fractions could be distinguished by their specificities (homo- and auto-specificity, respectively). Controls including IgM and IgG fractions from healthy persons, Latex-negative rheumatoids, and patients with other connective tissue diseases in autologous culture and IgG from rheumatoids in homologous culture failed to stimulate transformation. Further fractionation of blasto-genically active IgG fractions on DEAE—cellulose and on goat antihuman IgG coupled to Sepharose, in order to determine if the activity was associated with IgG, was unsuccessful, since most of the activity was lost during the procedures. |