Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 323292 | Detection of immune complexes. The use of radioimmunoassays with Clq and monoclonal rheuma | 1977 May | This study describes two sensitive, rapid, relatively simple, competitive inhibition radioimmunoassays for detecting immune complex. The tests are based on the inhibition of I125-Clq or I125-monoclonal rheumatoid factor (mRF) binding to an insoluble substrate, IgG-Sepharose. The assays can be performed in 5 h utilizing 10 micronl of serum. Heating of serum is not required and polyclonal rheumatoid factors do not interefere. With the two assays, a wide range of complexes of various size and complement fixing activity can be detected. The Clq test can detect complement fixing Ig complexes larger than 19S, while the mRF tests detect complexes of IgG as small as 8S irrespective of their complement fixing activity. Mouse, rabbit, and human aggregated IgG (agg IgG) can be detected in the Clq test, and human and rabbit agg IgG in the mRF test. As low as 4 microng/ml of isolated human agg IgG can be detected in the Clq test and 0.5 microng/ml in the rheumatoid factor test. Sensitivity is greater for mouse agg IgG. For pathologic sera which must be diluted to eliminate interfering factors, the sensitivity of the assay is approximately 10 times less. The Clq test showed marked inhibition by systemic lupus erythematosus sera with close correlation with CH50 levels and disease activity. The mRF test showed better correlation with rheumatoid arthritis sera. In addition, anionic macromolecules known to react with Clq and other Clq reactants that occur in pathologic sera such as the "low molecular weight" substances in systemic lupus erythematosus are also detected. These reactants are not detectable in the mRF test and can be eliminated in the Clq test by performing the test at higher ionic strength. The tests can be applied to the study of a variety of pathologic states where immune complexes appear to play a role. | |
| 823121 | Synergism of immunogenic and adjuvant-active components of mycobacterial wax D in the indu | 1976 | Two derivatives of wax D, one possessing immunogenicity and the other adjuvant activity, were tested for the possible role in the induction of adjuvant arthritis (AA) in rats. The former, a water-soluble arthritogenic and immunogenic component (WAC), in incomplete Freund's adjuvant, was able to induce delayed hypersensitivity (DH) and mild AA, but failed to function as an adjuvant in rats. The latter, an acetylated wax D (AD) and its subfraction, AD6, did exert adjuvant activity, but were free from immunogenicity and arthritogenicity. The addition of AD or AD6 to the WAC in incomplete Freund's adjuvant, when injected into inguinal lymph nodes, resulted in the production of severe AA with high incidence. Other adjuvants such as pertussis vaccine and lipopolysaccharide could not replace AD6; they failed to enhance AA when combined with the WAC. Also, other mycobacterial antigen, PPD, could not replace wax D-derived WAC; it did not induce AA when coupled with AD6, although it did induce DH to PPD. | |
| 1081376 | Eosinophil-specific and other granulocyte-specific antinuclear antibodies in juvenile chro | 1975 Aug | Sera from 151 children of whom 112 had juvenile chronic polyarthritis (JCP), and from adults with rheumatoid arthritis (RA), and from healthy pregnant females were tested for the presence of granulocyte-specific antinuclear antibodies (GS-ANA). These were detected in 20% of sera from cases of JCP, in 68% of adult RA, but in none of the controls. Eosinophil-specific ANA were the only ANA present in 18% of positive children and 54% of the positive adults. GS-ANA in children were predominantly IgG and of low titre. Heat-stable GS-ANA were detected in sera from eight children but none bound complement. The presence of GS-ANA was not significantly associated with sex, age of onset, duration of disease, mean active joint count, mean ESR, nor with the presence of fever, rash, splenomegaly, amyloidosis, pericarditis, or rheumatoid factor. | |
| 7217121 | Spherocentric arthroplasty of the knee. Clinical experience with an average four-year foll | 1981 Apr | We studied eighty-two consecutive spherocentric total knee arthroplasties with an average follow-up of four years (range, two to six years). All patients had either severe preoperative instability or deformity, or both. The over-all functional improvement and symptomatic relief were excellent. Knees with preoperative instability did as well as those with preoperative deformity that were stable. The knees with preoperative valgus deformity were the most likely to have postoperative wound problems or transient nerve palsy, while those with preoperative varus deformity were much more likely to have loosening. Postoperative limb alignment of 7 to 9 degrees of valgus angulation protected against lucency and loosening. No new cases of lucency or loosening appeared after two and one-half years. The infection rate was 4 per cent and the rate of failure due to loosening was 5 per cent. The over-all reoperation rate was 9 per cent. Nine patients (with eleven arthroplasties) died during the follow-up period. | |
| 6422017 | Glucocorticosteroids and oral medicine. | 1984 Feb | The article deals with the use of glucocorticosteroids in the treatment of the oral manifestations of Systemic Lupus Erythematosus (SLE), Discoid Lupus Erythematosus (DLE), Rheumatoid Arthritis (RA) in the temporomandibular joint, Pemphigus Vulgaris, Pemphigoid, Erythema Multiforme Exudativum (EME), Lichen Planus (LP), and Recurrent Aphthous Ulcerations (RAU). The benefit from steroids is discussed on the basis of current knowledge of etiology and pathogenesis of the various disorders. All of them are characterized by inflammation which appears secondary to a hypersensitivity reaction against autocomponents. Glucocorticoids do not interfere with the primary disease mechanisms. But it is concluded from the literature, that because of anti-inflammatory and immunosuppressive effects of the hormones, it seems reasonable to profit from steroids as palliatives in acute phases of the diseases and/or as long-term suppressors of the general host defense. | |
| 3909380 | Immunoperoxidase assay for anti-dsDNA antibodies using Crithidia luciliae substrates. | 1985 | In studies on 779 fresh, unselected ANA+ sera, 50 (6.4%) were found to have anti-dsDNA antibodies, by using CIP (C. luciliae immunoperoxidase), and 84% of the 50 patients met the criteria for definite SLE. After freezing 36 of these sera for 13 +/- 1 months, only 52.8% were again positive by CIP. Using CIF (C. luciliae immunofluorescence), 16.7% and 52.8% of the same stored sera were anti-dsDNA+, with transmitted and epi-illumination, respectively. We favour CIP to CIF because: slide files are permanent, overcoming any lability of antibodies in frozen sera; kinetoplast, flagellum and nucleus are easily distinguished; perikinetoplast staining is avoided; specialized microscopic equipment is not needed. | |
| 501186 | Gait patterns of the diseased knee joint. | 1979 Jul | Biomechanical gait analyses were carried out on 21 patients in whom 11 had bilateral and 10 unilateral disease of the knee joint. Similar studies, for use as controls were made on 7 normal volunteers. The data, on which the analyses were based, were obtained using a force plate, a xylophone plate, electromyography and electrogoniometry. The equipment and methods used are described. The results suggest that the locomotion mechanism in patients with disease of the knee joints is affected adversely by severity of pain and instability. Alterations observed in the gait characteristics of such patients comprise decreased sagittal plane knee motion during stance phase, increased electromyographic activities of the quadriceps and the hamstrings during stance phase and increase in the lateral component of ground reaction force. Functional requirements of the knee joint include stable support of body weight and a wide range of movement. These features make the knee particularly susceptible to the deleterious effects of traumatic injury, inflammatory and degenerative disease. The purposes of this study are to characterise the gait patterns of patients with such disease of the knee joints and to identify the mechanisms of these abnormal patterns. With these intentions, biomechanical analyses were carried out on information obtained from the use of force plates, electrogoniometry and electromyography. | |
| 671980 | [Cor pulmonale in various collagen diseases]. | 1978 May | The early manifestations of cor pulmonale and their dependence on the functional and morphologic changes in the lungs as well as on the collagen disease were studied on 186 patients with various collagenoses. Besides undergoing routine methods of examination all patients were tested for the function of external respiration and subjected to X-ray examination of the lungs and heart and electro-, phono-, vector- and kinetocardiography. There was no parallelism between the clinical manifestations of respiratory insufficiency and the functional and X-ray signs of affection of the lungs. Despite the chronic changes in the lungs, the configuration of the heart is altered only in singular cases. In the diagnosis of the involvement into the process of the right parts of the heart kinetocardiography and changes in the PV1 angle on the ECG proved to be most informative. Instrumental methods of examination revealed that the right parts of the heart were already involved in the stage of functional changes in the lungs. | |
| 6728268 | [Proglumetacin for the treatment of inflammatory and degenerative arthropathies]. | 1984 May 12 | Twenty patients with inflammatory (15) or degenerative (5) joint disorders had been treated with 450 mg/day of proglumetacin during 35 +/- 18 days. Articular symptoms showed a definite and continued improvement, particularly evident during the initial 15 days of treatment on both painful and inflammatory components. The final physician's evaluation rated 75% of results as excellent or good, versus 15% of poor (3 patients, one of whom already refractory to diclofenac). The tolerance was defined as excellent to good in 90% of patients: one (5%) was dropped out upon the onset of sweating and palpitation, already observed with other drugs. Overall, only one case each of heartburn, anorexia and diarrhoea were considered as possibly related to the treatment. Laboratory tests did not show any variation that could be attributed to the drug. Proglumetacin therefore, by force of its efficacy and safety, appears to be particularly suited as a first-choice drug for the management of both inflammatory and degenerative joint disorders. | |
| 7083426 | [Total hip-joint prosthesis. Critical long-term review of the new McKee Arden CAD stem pro | 1982 Feb | The article makes a comparison between the results of total arthroprosthesis operation of the hip with traditional Mckee Arden prosthesis (50 cases operated in the two-year period 1976-77) and those with the new McKee Arden model with C.A.D. stem (52 cases operated in the two-year period 1977-78). All operations were performed at the "G. Pini" Orthopaedic Institute by the same team and with the same surgical technique. The results are based mainly on three parameters (according to McKee): pain, amplitude of movement, and need to use supports. THe Authors conclude by stressing the efficiency of the new model of prosthesis and noting a decrease in intra and post-operative complications. | |
| 409162 | On the nature and significance of bony proliferation in "rheumatoid variant" disorders. | 1977 Aug | Radiographic and pathologic abnormalities of the peripheral joints in a cadaver with ankylosing spondylitis are described. Bony proliferation about involved articulations is is characteristic of all "rheumatoid variant" disorders and results from subchondral bony hyperplasia and periosteal new bone formation. Such proliferation may be related to the presence of the histocompatibility antigen B27 in these diseases. | |
| 722421 | Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis. | 1978 Dec | Encephalopathy secondary to aspirin-induced hepatoxicity developed in three patients with JRA. In each patient clinical and biochemical resolution occurred after discontinuing the drug, but toxicity appeared on rechallenge. Liver biopsies in two patients showed mild nonspecific changes. Acute hepatic decompensation and encephalopathy may occur as a consequence of aspirin hepatoxicity in JRA and justify sequential observations of liver function tests and salicylate levels in such patients. | |
| 6697645 | Low-dose methotrexate kinetics in arthritis. | 1984 Mar | Twelve patients with either rheumatoid or psoriatic arthritis were injected with a 10-mg bolus dose of methotrexate (MTX) either intramuscularly (n = 6) or intravenously (n = 6) and the MTX concentration in their sera was determined by radioimmunoassay. MTX concentration--time data fitted triexponential equations. Doses injected intramuscularly were rapidly and completely absorbed. There were no significant intergroup differences in drug mean t 1/2, volume of distribution, and total body clearance. In nine patients serum MTX concentrations remained above the suggested critical level of 0.01 mumol throughout the 24-hr study irrespective of the route of administration, but MTX did not cumulate in the serum. We conclude that the behavior of low doses of MTX in patients with arthritis closely resembles the pattern in patients receiving intermediate and high doses for the treatment of neoplasia. | |
| 886802 | [Reiter's disease in an infant (author's transl)]. | 1977 Apr | A case of Reiter's disease in a 15-month-old child is presented. The manifestation of this syndrome in childhood is an extraordinary event, so far few cases only have been observed. The symptoms of the syndrome are urethritis, arthritis and iritis. A specific infection could not be demonstrated. The typical clinical features are discussed and compared with earlier reports. Speculations on the etiology are made. | |
| 6701529 | Association of parvoviruses with rheumatoid arthritis of humans. | 1984 Mar 30 | A small virus resembling parvoviruses in its morphological and physicochemical properties was derived from synovial tissue of a patient with severe rheumatoid arthritis. This virus, designated RA-1, elicits a syndrome in neonatal mice that includes neurological disturbances, permanent crippling of limbs, dwarfism, alopecia, blepharitis, "masking," and a rigid curvature of the thoracic spine. Polyclonal antibodies against RA-1 display high virus neutralizing activity and in immunoassays detect reactive antigen in synovial cells from different rheumatoid arthritis patients but not persons with osteoarthritis. Putative parvoviruses isolated from several other rheumatoid arthritis patients are only weakly pathogenic for newborn mice but can generate RA-1 virus-specific antigens in tissues of these animals. It has not been established that RA-1 and existing parvoviruses of mammalian species are related. | |
| 3863522 | The role of non-prosthetic surgery in the treatment of rheumatoid arthritis by fusions and | 1985 | After the introduction of modern artificial joints the classical operation methods, such as osteotomies, arthrodeses and auto-arthroplasties, have been forced aside little by little. Irrespective of the late complications following replacement surgery, the patients today expect a movable, painless endoprosthesis, which at it best seems to benefit the patient. The question arises whether the classical methods still have a role in the surgical treatment of rheumatoid arthritis. The reply is "yes", they do have a fair share of rheumatoid surgery, indeed. They still compete with the modern endoprosthetic surgery for the place of the primary operation in many cases. To give instances, tarsal reconstruction by subtaloid arthrodesis is superior to other methods and arthrodesis of the wrist is often only reasonable way to get a strong, painless key joint to the hand. Even the shoulder arthrodesis may successfully compete with an endoprosthesis. Also classical auto-arthroplasties such as resection arthroplasties of the metacarpophalangeal and elbow joints are serious rivals of respective endoprostheses. The practice of Rheumatism Foundation Hospital (RFH) in the golden mean between the endoprosthesis enthusiasts and their opponents will be described in this article. The practice varies greatly from clinic to clinic and is progressing--and regressing--all the time. | |
| 6480632 | Kinematic total knee replacement. | 1984 Sep | We reviewed 124 consecutive kinematic condylar total knee replacements (in ninety-one patients) at two to four years postoperatively. One hundred and eleven (90 per cent) were rated as good or excellent. The average active postoperative flexion was 106 degrees (range, 94 to 120 degrees). Twenty-two knees (18 per cent) had incomplete, non-progressive radiolucent lines, less than one millimeter in width, at the tibial bone-cement interface; these were considered insignificant. Restriction of stair-climbing ability in this series appeared to be a function of involvement of multiple joints rather than of patellar replacement, as the rheumatoid patients with resurfaced patellae performed the worst. The osteoarthritic patients with involvement of a single joint performed the best, regardless of whether the patella was resurfaced or not. When compared with a similar series of total knee replacements in which the tibial component was made entirely of plastic, less reaction at the bone-cement interface was found with the metal-backed kinematic tibial component. We suggest that this finding is clinical confirmation of in vitro studies that demonstrated the advantage of metal-backed tibial components. We concluded that this procedure, if meticulously performed, will give predictably good to excellent results with a low complication rate, a good postoperative range of motion, and a favorable-appearing bone-cement interface at two to four years. | |
| 328880 | Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of | 1977 Summer | A double-blind parallel multi-centre study of 102 patients with rheumatoid arthritis (RA) was performed, comparing ibuprofen (1200-2400 mg daily) and ketoprofen (150-300 mg daily) a new non-steroidal, anti-inflammatory agent, over a three month period. Ketoprofen was well tolerated and shown to have comparable efficacy with ibuprofen. Longterm efficacy and tolerance studies are indicated. | |
| 3970670 | Knee arthrodesis for failed total knee arthroplasty. | 1985 Mar | The use of arthrodesis to salvage failed total knee arthroplasty is reviewed in nine patients. Prosthetic failure was due to infection in six cases, aseptic loosening in two cases, and instability in one case. The techniques of arthrodesis included six Hoffman external fixators, two fluted intramedullary rods (3M-Orthopedic Products Division, St Paul), and one pulsing electromagnetic field stimulator. Arthrodesis was successful in eight of nine patients, averaging 5.4 months to union. All eight patients resumed a painfree functional level of activity. Meticulous surgical technique and appropriate method of arthrodesis are emphasized. | |
| 7084286 | An interaction study between benoxaprofen and digoxin. | 1982 | The influence of maintenance therapy with benoxaprofen, 600 mg daily, on digoxin steady-state plasma levels was studied in 12 patients with rheumatic disease. No difference could be shown during concomitant therapy or after withdrawal of benoxaprofen (p greater than 0.10 and p greater than 0.90, respectively). Toxic concentrations were not observed. There were no changes in renal function values. |