Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6880857 | Glucose intolerance in patients with chronic inflammatory diseases is normalized by glucoc | 1983 | Nine of 16 patients with inflammatory connective tissue diseases (rheumatoid arthritis, polymyalgia rheumatica, scleroderma and mixed connective tissue disease) had glucose intolerance defined a a K-rate less than one but a normal early insulin response to intravenous glucose loading. The degree of the impaired glucose handling was related to the degree of inflammatory activity as defined by acute phase reactants. Glucocorticoid therapy induced within three days an improved and normalized glucose tolerance and an augmented early insulin response (p less than 0.001). The glucocorticoid effect was still present up to six months of ongoing therapy. It is suggested that glucose intolerance in chronic inflammation is a consequence of a peripheral insulin antagonism and an inhibition of insulin secretion. This inhibition may be mediated directly or indirectly by inflammatory cell products and may be sensitive to glucocorticoids. | |
| 6520495 | [Geometric total knee arthroplasty--follow-up for an average of six years]. | 1984 Oct | Geometric total knee prosthesis was applied for reconstruction of 70 destructive knee joints in 56 patients from November 1973 through March 1979. The average follow-up period extended to six years and seven months. Eleven patients had died and four could not be located. Eighty-one percent of the remaining arthroplasties disclosed little or no pain at the time of the review. Pain in the patellofemoral joints was an insignificant problem in this series. The absence of radiolucent zone at the tibial cement-bone interface was noted in only 20.4% of the roentgenograms. New formation or progression of radiolucent zone after six months was found in 36.7%. Displacement of the marker wires seen in serial roentgenograms existed in 51.0% of the knees. The tibial component was fractured in one patient. | |
| 781231 | Comparison of benefit-to-risk ratios of aspirin and fenoprofen: controlled multicentre stu | 1976 | The benefit-to-risk ratios of fenoprofen (2.4 gm/day) and aspirin (3.9 gm/day) were compared in a randomized, double-blind, 26-week parallel study involving 216 patients. Criteria for inclusion, exclusion, subjective, and objective evaluations were based on the PMA-FDA Nonsteroidal Anti-Inflammatory Drug Clinical Testing Guidelines. Thirty-four of 109 aspirin-treated patients and 23 of 107 patients on fenoprofen dropped out of the study. Both fenoprofen and aspirin brought about improvement in most efficacy parameters measured, but fenoprofen was superior to aspirin (p less than 0.05) in reduction of swollen joints, grip strength, activity index, and patients' preference of medication. The number and frequency of complaints and the incidence of abnormal SGOT levels, were greater with aspirin than with fenoprofen. The study suggests that fenoprofen has a better benefit-to-risk ratio than aspirin, when given in equally effective doses. | |
| 3967427 | Total joint arthroplasty of the knee. | 1985 Jan | The total knee experience at a hospital in Baltimore with the Universal Instruments and Total Condylar and Kinematic prostheses in 1978 and 1979, and with the PCA prosthesis with and without cement since 1980, has led to the development of the philosophy that impacts on all aspects of total knee arthroplasty. In most instances, if the patient is a suitable risk for surgery and symptoms are sufficiently disabling to justify knee fusion, the authors would first attempt a total knee arthroplasty regardless of age, weight, or other factors. Technical perfection of alignment and component position are their goals. The vast majority of total knee components can be mechanically fixed rigidly without the addition of methylmethacrylate. In general, clinical examinations (up to four years) suggest that the cementless results were equally as good as the cemented results and did not have a tendency to deteriorate with time. | |
| 6318350 | [Open clinical trial of a new oral galenic form of ketoprofen]. | 1983 Dec 12 | Thirty-two patients with rheumatoid arthritis and several other rheumatic diseases were entered into a randomized study to investigate the correlation between the pharmacokinetics and clinical effectiveness of Bi-Profenid 150 mg. Each patient was given, in a variable order, one 150 mg Bi-Profenid tablet twice daily for 2 days, and two 50 mg Profenid capsules each morning and noon with one 100 mg suppository each evening for 2 days. Dosage convenience, effectiveness on pain during the second part of the night and resolution of morning stiffness were considered better with Bi-Profenid by 23 patients and with conventional forms by four, while five reported no preference. In 15 patients treated for one month, only 5 reported mild side-effects which did not require withdrawal from the study. The patients' preference appears to be a result of the bioavailability of Bi-Profenid. | |
| 6263097 | Survival of rheumatoid synovium implanted into nude mice. | 1981 Jun | The gross morphologic features, histologic features, and synthesis of collagenase and prostaglandin E2 by rheumatoid synovial cells injected into athymic nude mice were studied. A single cell suspension of 2 X 10(7) cells was inoculated subcutaneously into the dorsum of each mouse. In 8 out of 9 mice injected with cells from 6 different patients, rheumatoid synovial cells remained at the injection site for 20-30 days. During this time they became organized into a pannuslike structure with fibroblasts, occasional multinucleated cells, numerous blood vessels, and diffuse collagen fibers. No lymphocytes were seen. Compared with cells cultured in vitro at Day 0, removal, dissociation, and culture of the implanted material at Day 21 revealed a decrease in the percentage of dendritic (stellate) cells known to be associated with collagenase and PGE2 production. However, cells passed through nude mice retained the ability to synthesize both of these compounds. Implantation of rheumatoid synovium into nude mice may provide a way of studying factors influencing the proliferative and destructive lesion of rheumatoid arthritis. | |
| 6670282 | [Effect of chloroquine diphosphate on the superhelix structure of DNA and protein synthesi | 1983 Dec 23 | The influence of chloroquine diphosphate on protein synthesis in synovial fluid cells was investigated in 8 patients suffering from rheumatoid arthritis. Intraarticular injection of chloroquine diphosphate at a dose of 25 mg and 50 mg is followed a small decrease in incorporation of 3H-marked amino acids into the synovial fluid cells. Above a dose of 100 mg the protein synthesis is significant reduced. In a second experiment the supercoiled structure of DNA under C1Q was lost. After 2 hours the chain breaks were repaired. | |
| 6652967 | Reduced complement-mediated immune complex solubilizing capacity and the presence of incom | 1983 Nov | Reduced complement-mediated solubilization (CMS) of pre-formed immune complexes (IC) was demonstrated in sera from 11 out of 12 SLE patients. The presence of incompletely solubilized endogeneous IC in SLE sera was indicated by the following findings: (1) When IC positive SLE sera with reduced CMS capacity were mixed with normal donor sera they inhibited the CMS of the latter sera. (2) Resuspended PEG (2.75%) precipitates obtained from SLE sera inhibited the CMS of normal donor sera. (3) Non-solubilized or incompletely complement solubilized IC in SLE sera give a strong response in the PEG-CC assay for IC. The IC activity of SLE sera was clearly reduced in this assay when the endogeneous IC were solubilized prior to testing. In contrast, sera of 14 rheumatoid arthritis (RA) patients exhibited normal CMS. IC which could be further solubilized by complement were not demonstrable although all RA sera were IC positive. | |
| 7256143 | [Primary biliary cirrhosis as seen by the rheumatologist. Apropos of 2 cases]. | 1981 Apr | The authors report 2 cases of primary biliary cirrhosis associated with scleroderma (calcinosis, Raynaud's syndrome, sclerodactyly, telangiectasia) in one case, and associated with pseudopolyarthritis in the other; they recall the conditions under which the rheumatologist may be led to make the diagnosis of this disease. Apart from liver diseases including acute or chronic rheumatic signs, one may observe in primary biliary cirrhosis without symptoms certain other rheumatological syndromes: e.g. scleroderma, Sjögren's syndrome, rheumatoid arthritis, Charcot's joint. The laboratory examinations may give unexpected results: e.g. high levels of IgM, the presence of antinuclear antibodies or may give unexpected results: e.g. high levels of IgM, the presence of antinuclear antibodies or cryoglobulins which sometimes orient wrongly the diagnosis in other directions. One may thus note that a high level of alkaline phosphatase should suggest in any case of inflammatory rheumatism, primary biliary cirrhosis, and attempt to prove this by seeking antimitochondrial antibodies. | |
| 373989 | A double-blind, crossover trial of mefenamic acid, sulindac and flurbiprofen in rheumatoid | 1979 | A double-blind crossover trial was carried out in 24 patients to compare the effects of mefenamic acid, flurbiprofen, sulindac and placebo. Each drug was given for 2 weeks, the treatment sequence being randomized. Daily doses were 1500 mg mefenamic acid, 150 mg flurbiprofen or 150 mg sulindac. All of the active drugs were significantly superior to placebo in terms of pain score, patients' assessment, articular index of joint tenderness, and duration and severity of morning stiffness. There was improvement in grip strength compared with placebo, but the differences were not statistically significant with sulindac. There was slight reduction in joint circumference but this was only statistically significant in the right hand with flurbiprofen and sulindac. No significant differences were found in technetium uptake in knee joints. The three drugs appeared to be equally effective and tolerated, and no significant differences were noted. | |
| 6467859 | The nature of urogenital involvements in female uro-arthritis, with special reference to c | 1984 Jun | To study the nature of urogenital involvements in female uro-arthritis 73 consecutive patients with arthritis concomitant with any type of urogenital involvement were examined. The controls were 281 females interviewed only and an additional 83 also gynaecologically examined. A history of cervicitis, salpingitis, dysuria and pyelocystitis/-nephritis occurred significantly more often in patients than in controls. Clinical gynaecological examination revealed cervicitis in 26,8% (19/71) of the patients and 15.7% (13/83) of the controls (p less than 0.05). Aseptic pyuria was definitely more frequent in patients (19/73) than in controls (0/63). The isolation of Chlamydia trachomatis was positive in 14.7% (10/68) of the patients and 3.7% (3/81) of the controls (p less than 0.025). Serological evidence (titre greater than or equal to 64) for chlamydial infection was obtained in 53.4% (39/73) of the patients and 18.2% (14/77) of the controls (p less than 0.00025). The results indicate the importance of urogenital history and findings in females with rheumatic attacks. The most prominent and persistent urogenital involvements were cervicitis, salpingitis, pyuria and dysuria. Chlamydial infection appears in any case to be responsible for part of these involvements (42/73). | |
| 4436351 | A humeral replacement prosthesis for the elbow: results in ten elbows. | 1974 Sep | A stainless-steel or titanium prosthetic replacement for the trochlea and capitellum was developed and used in ten elbows, five with post-traumatic lesions, three with rheumatoid arthritis, and two with ankylosis secondary to hemophilia. After followups of from one to seven years, the results were found to be unpredictable or poor in the patients with inflammatory arthritis or hemophilia, while a stable, painless elbow with a functional range of motion was achieved in four of the five patients with post-traumatic lesions. | |
| 3831143 | Nifedipine and Raynaud's phenomenon associated with connective tissue diseases. | 1985 Apr | We have evaluated the therapeutic effect of the calcium-channel blocking agent nifedipine in Raynaud's phenomenon associated with connective tissue diseases and in idiopathic digital vasospasm. Thirty patients were included in this study: Raynaud's phenomenon was associated with progressive systemic sclerosis (PSS) in ten patients, systemic lupus erythematosus (SLE) in five and rheumatoid arthritis (RA) in three; it was idiopathic (I) in twelve patients. Each patient received, in a double-blind manner and random order, on two consecutive weeks, nifedipine (20 mg three times daily) and placebo. Nifedipine proved to be effective: the mean number of digital vasospastic attacks per week decreased from 20.30 to 5.83 (p less than 0.01). The results in the SLE and RA groups were similar and were pooled. The improvement (in percent decrease) was better in the idiopathic group (90.95) than in the SLE and RA group (78.63, p less than 0.02) and the PSS group (64.02, p less than 0.01). | |
| 6652966 | Inhibition of complement-mediated solubilization of antigen-antibody complexes by sera fro | 1983 Nov | Sera and synovial fluids from patients with seropositive rheumatoid arthritis inhibit the ability of normal serum to prevent immune precipitation. Sera from patients with seronegative forms of arthritis contain little inhibitory activity. Studies of the mechanism of action of the inhibitor show that it reduces C4 consumption by antigen-antibody complexes. These findings suggest that the binding of C1 to complexes or activation of C1 is impaired. The possibility that the inhibitory activity may be mediated by rheumatoid factor is discussed. As inhibitory activity is more prevalent and of a higher level in patients with extra-articular features, it is possible that it may play a pathogenetic role. | |
| 4026405 | Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and activ | 1985 Jul | In patients with rheumatoid arthritis high levels of prostaglandin E1 have been found in the joint fluid, and its increased production by adherent synovial cells and macrophages clearly supports the notion that this arachidonic acid metabolite is involved in the pathology of the disease. Besides its known inflammatory qualities and the suppressive effects on various lymphocyte functions prostaglandin E2 has proved to be an essential cofactor in the secretion of the lymphokine osteoclast activating factor. In this study we have discovered an enhanced release of prostaglandin E1 and thromboxane B2 from a subpopulation of blood monocytes from patients with rheumatoid arthritis and active systemic lupus erythematosus. No correlation between prostanoid release from monocytes and inflammatory activity of the disease was found. However, even monocytes from patients with early stage or mild inflammatory activity displayed a 'stimulated' arachidonic acid metabolism. In contrast only patients with active systemic lupus erythematosus showed in this respect comparable secretory activity or monocytes. Our findings may point to a possible pathogenic role of prostanoids in rheumatoid arthritis, which may also have some implication for the early diagnosis of this disease and for its differentiation from other chronic inflammatory rheumatic conditions. | |
| 4082740 | [Follow-up of hip endoprostheses following completion of true stress conditions over a 10- | 1985 Sep | Results of a long term followup with total hip-replacement of the Endo-Klinik are presented. The analysed data-material exhibits a relative homogeneity because of a large series of one system of prostheses and homogeneous technique in surgery. Thus, analytic statistical methods (life-tables and regression models) could be used. In this way, prognostic factors on the durability of total hip replacement could be determined. These are essentially: long practical experience of the surgeon with one matured prosthesis-system, type of hip-joint disease, and the age of the patient. It is assumed, that in well organized special centres for joint replacement the failure rate could be reduced generally. | |
| 6411920 | High dose, low frequency parenteral gold administration. | 1983 Jun | A dosage plan of up to 200 mg of aurothioglucose at approximately 4-week intervals was tested. Moderate or major improvement occurred in 20 of the 30 patients entered. Mean erythrocyte sedimentation rate fell from 46 to 26 mm/h, mean grip strength rose from 99 to 179 mm Hg (best hand) and mean number of swollen joints declined from 10.9 to 3.3. Maximum improvement occurred at a mean cumulative dose of 649 mg and after an average of 18 weeks and 5 visits. These data suggest that more efficient strategies for gold administration can be devised. | |
| 6456528 | [A follow up study of "geometric" total knee arthroplasty with special reference to the im | 1981 | The authors have analyzed the results obtained with 63 "Geometric" total knee arthroplasties with a follow-up of more than five years. Four septic complications and nine loosenings were observed. Three main causes that have been noted were 1) unsatisfactory operative indications, 2) poor positioning of the prosthesis, 3) poor design of the prosthesis. The last point has led to a new design of prosthesis called "anametric" because its design is closer to that of normal anatomy. The "geometric" model should be considered as a first generation of prosthesis. | |
| 4219839 | Specific antisera to Clr. Quantitation of Clr in normal and pathological human sera. | 1974 Mar | Monospecific neutralizing and precipitating antisera to C1r, a subunit of the first complement component, were obtained. These antisera neutralized C1r activity in purified preparations and in macromolecular C1 and did not react with C1q or C1s. They formed one line of precipitation in the β-globulin region with normal human serum, C1(hu) and C1r at various stages of purification. Using anti-C1r antiserum and a radial immunodiffusion technique, the concentration of C1r was determined in normal, SLE and RA sera. It was 101 μg/ml in normal sera and lower in sera of active SLE patients (69·7 μg/ml). No significant variations from normal were found in sera of SLE patients in periods of remission or in RA patients. | |
| 3892646 | [Preponderant synthesis of rheumatoid factors by synovial plasma cells in rheumatoid polya | 1985 May | Plasma cells synthesising rheumatoid factor have been identified by immunofluorescent studies of sections of cells eluted from synovial membranes poor in macrophages. More than 90% of the IgM plasma cells produce rheumatoid factor, while 50 to 60% of IgG plasma cells and only 10% of IgA plasma cells produce rheumatoid factor. The equivalent results obtained in patients with sero-positive and sero-negative rheumatoid arthritis suggest that auto-immunisation between the IgG plays the same determinant role in the pathophysiology of the two types of rheumatoid arthritis. |