Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 938311 | [Kienböck's disease. Follow-up studies and therapeutic considerations (author's transl)]. | 1976 Jun 18 | This paper presents a follow-up of patients with Kienböck's disease up to 30 years after their first symptoms. Only the shortening of the radius and the grafting of the lunate with cancellous bone offers some kind of basic therapy. The intercarpal arthrodesis, the arthrodesis of the wrist and the operation named after Steinhäuser should only be considered in cases with severe deformation and disabling pain. | |
| 809225 | Interaction of sudoxicam and aspirin in animals and man. | 1975 Oct | In rats, both the plasma concentrations and the anti-inflammatory activity of sudoxicam are depressed by concurrent administration of aspirin, being similar to that reported for other nonsteroidal agents, whereas, in man and monkey, plasma concentrations of sudoxicam are not affected by concurrent administration of aspirin. In this respect sudoxicam differs from such other nonsteroidal anti-inflammatory agents as indomethacin and naproxen. | |
| 3997507 | Inhibition of collagen II arthritis by simultaneous administration of concanavalin A and o | 1985 Apr | Several pharmacological agents, some of which are known to have effects on the immune system, decrease the incidence of collagen II-induced arthritis when added to the antigen emulsion. Concanavalin A, which has been reported to exert suppressive effects on the immune system in vivo, consistently reduced the immune response to the collagen antigen. These effects were dose and time dependent. The suppressive effects of pokeweed mitogen, tilorone and carrageenan on anti-collagen II responses were somewhat variable. Suppressive activity could be observed with concanavalin A and levamisole when the drugs were injected at a site distant from the collagen emulsion. These studies indicate that local administration of drugs is an effective approach for demonstrating the activity of some agents that may alter the course of collagen II disease through an effect on the immune system. | |
| 6833733 | Compression arthrodesis of the thumb. | 1983 Mar | A retrospective study of all patients who had undergone thumb arthrodeses at the Denver Orthopedic Clinic since 1972 was undertaken to determine the incidence of satisfactory results with the Micks External Compression Fixator. Sixty-six patients underwent 82 metacarpophalangeal or interphalangeal arthrodeses that resulted in bony fusion in 81 cases. Indications for surgery included pain, instability, and collapse-type thumb deformity. Complications in the 81 successful cases included three that required a second procedure, one for nonunion and two for loss of position. There were eight cases of pin track drainage that cleared with removal of the device and did not adversely influence the outcome. Joints arthrodesed with external compression formed bony union in approximately half the time required for bony unions with Kirschner wire fixation. The fused position of either metacarpophalangeal or interphalangeal joints did not influence patient satisfaction, and all patients were satisfied with their surgery and demonstrated satisfactory use of the thumb. | |
| 3900395 | Penicillamine induced pemphigus. | 1985 Jun | Three cases of penicillamine induced pemphigus are described and compared to 35 previously reported cases with typical direct immunofluorescence. The incidence in our clinic was 0.57%. The penicillamine dose ranged from 250 to 1500 mg/day and the mean duration of treatment was 11 months at the onset of pemphigus in the 38 cases. Morphology and immunopathology was indistinguishable from spontaneously occurring pemphigus. The majority of cases resolved within 4 months after stopping, penicillamine; however, 8 cases, including 2 in this report, have persistent pemphigus. | |
| 175459 | [Detection of anti-DNA antibodies by electroimmunodiffusion. Comparison of the results wit | 1975 Mar 20 | The detection of anti-DNA antibodies was carried out by the electroimmunodiffusion method. The results were compared to those of the immunofluorescent method for anti-nuclear factors. Positive results were obtained with the electroimmunodiffusion method in 86% of the lupus erythematosus cases, 77% of the sero-positive rhumatoid polyarthritis cases and 67% of the scleroderma cases. They are comparable to those obtained by other methods. The electroimmunodiffusion method allowed in 3 out of 54 sera to defect anti-DNA antibodies although no anti-nuclear factor was found. | |
| 7188500 | Investigations concerning vitamin A transport in rheumatic diseases. | 1982 Sep | The investigation concerned changes in vitamin A derivatives (retinol and retinyl) content in serum of patients suffering from two types of rheumatic diseases--rheumatoid arthritis (RA) and osteoarthrosis. Healthy women of similar age served as control. It was found that the retinol content of the serum in the group suffering from RA was significantly (P less than 0.001) lower than that of the control group, while in the group suffering from osteoarthrosis it was significantly higher (P less than 0,01). The serum retinol content of the group with RA was similar and was not an effect of the corticosteroid treatment. Significant differences were found (P less than 0,01) between the groups suffering from RA and osteoarthrosis in the serum content of the retinol. The retinyl content of the serum showed a significant (P less than 0.05) difference between the groups afflicted with RA and osteoarthrosis. | |
| 7012342 | Decreased numbers of monocytes in inflammatory exudates in systemic lupus erythematosus. | 1981 Jan | Rebuck skin windows and delayed hypersensitivity testing were performed on patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Patients with SLE had a decreased appearance of mononuclear/macrophage cells in the inflammatory exudate compared to patients with RA and normal controls. This abnormal response was unrelated to corticosteroid therapy, but appeared to correlate with activity of disease. Impaired ability to react to skin test antigens was also demonstrated in patients with SLE. The defective mononuclear/macrophage response in patients with SLE may contribute to the impaired cell-mediated immunity and increased susceptibility to infection which occur in this disorder. | |
| 573508 | Splenectomy for hematologic disease. | 1979 Oct | One hundred and thirty splenectomies were performed at the University Hospital in Birmingham for hematologic disorders during a 12 year period. There were seven deaths of which four were related to sepsis in patients with malignant growths which probably impaired immune competence. Splenectomy was found to be uniformly satisfactory for hereditary hemolytic anemia, for hypersplenism complicating rheumatoid arthritis and for the rare instance of primary hypersplenism. Splenectomy was usually salutary in didopathic thrombocytopenic purpura and in antoimmune hemolytic anemia. When done for diagnosis, splenectomy was definitive in about 50 per cent of the instances. Individual patients with thrombotic thrombocyeosinophilia syndrome benefited. Splenectomy for hypoplastic or aplastic anemia in an actual circulation offered only questionable benefit and is rarely necessary for hyperplenism secondary to portal hypertension. | |
| 309534 | HLA-B27, antinuclear antibodies and drug-induced agranulocytosis. | 1978 Dec 1 | Eight female patients with drug-induced agranulocytosis (five patients with definite seropositive rheumatoid arthritis (RA), three patients with upper respiratory infections) were studied for the presence of HLA-B27 and antinuclear antibodies (ANA). Five of eight patients were found to be HLA-B27 positive and all RA patients had ANA in their serum. The frequency of HLA-B27 and ANA was found to be significantly different from control groups. It is concluded that the occurrence of HLA-B27 and ANA was found to be significantly different from control groups. It is concluded that the occurrence of HLA-B27 in female patients with seropositive RA (especially in those with ANA) and of HLA-B27 alone in other individuals could reflect an increased risk for drug-induced agranulocytosis. | |
| 968355 | Cyclophosphamide, gold and penicillamine--disease-modifying drugs in rheumatoid arthritis- | 1976 Aug | Gold appears to be the disease-modifying drug of first choice for two reasons: response and absence of long-term toxicity. Although cyclophosphamide produces results as good or better than gold, the possible long-term toxicity outweighs the clinical benefit except in the unusual case. Penicillamine appears to be an acceptable drug of second choice. | |
| 4584053 | Polyarthritis associated with Salmonella infection in rats. | 1973 Nov | Rats infected intravenously with Salmonella enteritidis develop a chronic destructive polyarthritis. The joint lesions resemble those of human rheumatoid arthritis in distribution and pathology. On the basis of histological and microbiological studies, involvement does not appear to be the result of intra-articular sepsis. Instead, the data favor the view that transient infection incites an immunological response that localizes in the joint and becomes destructive. | |
| 421847 | Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells. | 1979 Feb 15 | Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C. | |
| 162222 | Auto-reaction phenomenon detected by enzyme electrosyneresis in the serum of patients with | 1979 Jan 31 | The use of modified electrosyneresis by making 760 sera of healthy persons or persons suffering from various diseases with immune complexes to react with their own pronase-treated serum has shown the following results: - One of 220 sera of healthy persons, 11 were positive in ESE (5%); - Out of 123 sera of HBsAg carriers, 23 were positive (18.6%); - Out of 135 sera of patients with acute viral type B hepatitis, 132 were positive (97.7%); - Out of 168 sera of patients with acute HBsAg negative hepatitis, 127 were positive (75.5%); - 4 cases of fulminant hepatitis were all strongly positive; - 54 cases of patients with rheumatoid arthritis were 100% positive; - 2 cases of patients with systemic lupus erythematosus were positive; - Out of 6 patients with glomerulonephritis 3 were positive; - Out of 34 patients with carcinoma of various organs, 19 were positive (55.88%). The Authors believe, on the basis of the research work set forth partly in the present report, that this interaction is connected with the presence of immune complexes. The method used has been called Enzyme Electrosyneresis (ESE) and the detected antigen "Auto antigen exposed by protease and by electrosyneresis" (AEPE). | |
| 3878880 | Profiles of antibodies to histones, DNA and IgG in patients with systemic rheumatic diseas | 1985 Oct | The occurrence of antibodies against the total histone complex and the histone fraction H1, antibodies against denatured (ss) DNA and the synthetic double stranded polynucleotide poly dAT, as well as rheumatoid factors (RF) was determined in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) using enzyme linked immunosorbent assays (ELISA). Antihistone antibodies could be demonstrated at a frequency of about 17% in the patients with systemic rheumatic disease with no differences between the groups, even if there was a tendency for anti-H1 antibodies to occur more often in the SLE and SS patients than in the RA patients. Some of the antihistone antibody activity seen in the RA patients seems to be due to crossreactive RF. All patient groups showed significant IgG anti-ssDNA antibody activity compared to the controls, but the highest antibody levels were seen in the SLE patients. IgG antipoly dAT antibodies occurred significantly more often and at higher levels in the SLE patients than in the other patient groups. Although the individual tests did not readily distinguish the 3 diseases from each other, the antibody profiles were different. Patients with SS had the broadest reactivity, and the SLE patients had antibodies predominantly restricted to polynucleotides. | |
| 7127902 | Immune complexes in early arthritis. II. Immune complex constituents are synthesized in th | 1982 Jul | Synovial fluids and paired sera taken from patients either before, after or at the time of diagnosis of definite rheumatoid arthritis (RA) were compared with samples from patients with unclassified inflammatory arthropathies (IA). Raised levels of immune complexes (IC) were detected in some RA patients by C1q binding activity but in the majority of both RA and IA patients by the platelet aggregation test; levels were usually higher in joint fluids than in sera. IgM rheumatoid factors (RF) and IgA RFs were lower in synovial fluids but IgF RF levels were similar in matched samples. Synovial fluid to serum albumin ratios were used to estimate synovial permeability (inflammation) and then to calculate which patients synthesized macromolecules locally in the synovium. Local synthesis of RFs was detected in a greater proportion of RA than IA patients and only two patients formed RFs locally in the first months of symptoms. Half the patients in both groups however appeared to synthesize or trap IC constituents and in many patients there was evidence of local synthesis within 6 months after their symptoms had started. We conclude that local synthesis of large amounts of RFs is uncommon in the early stages of RA but that IC of unknown composition are synthesized or localized in the affected joints of many patients with RA and inflammatory arthropathies shortly after their symptoms appear. | |
| 6813485 | A comparative study of auranofin, gold sodium thiomalate, and D-penicillamine in rheumatoi | 1982 Jul | We compared auranofin (AF) in a single blind multi-centre study with gold sodium thiomalate and D-penicillamine in the treatment of rheumatoid arthritis. Adult patients with disease duration 6-60 months without previous treatment with gold salts with persistent active disease, were included. Thirty-nine patients, 13 in each treatment group, have so far been entered. Cumulative toxicity data and some results of efficacy assessments in those completing 9 months of treatment are presented. AF is very well tolerated, judgment concerning efficacy must await the end of the trial. | |
| 7085116 | Quantification of the C3 breakdown product C3d by rocket immunoelectrophoresis. | 1982 | The levels of the C3 breakdown product C3d were measured in plasma, serum, and synovial fluid by the technique of rocket immunoelectrophoresis. Serum and plasma from 22 healthy donors, 4 patients with rheumatoid arthritis, 1 patient with systemic lupus erythematosus, and 1 patient with cryoglobulinemia were used. The synovial fluid was studied in 3 other patients with rheumatoid arthritis. Normal values for the 22 healthy donors in plasma were within a narrow range of 3.25--5.75% as compared to the standard pool that was prepared. Storage of plasma to -80 degrees C during 7--15 days did not modify the results of the test. Significant differences in C3d values were observed between serum and EDTA plasma samples. Patients with immunological diseases showed higher values of C3d in the samples (from 5 to 30% of activity as compared to the standard pool). Measurement of C3d by rocket immunoelectrophoresis showed to be an easy, satisfactory and reliable procedure able to be incorporated to routine immunological evaluations. | |
| 412451 | Hepatic toxicity associated with gold therapy. | 1977 Dec | Three patients with rheumatoid arthritis developed jaundice after initiation of chrysotherapy. Gold sodium thiomalate had been administered in dosages of 37.5, 60, and 110 mg in these patients before the onset of jaundice. Liver function studies indicated a cholestatic jaundice in all subjects. One patient underwent exploratory laparotomy because of progressive jaundice. Liver biopsy was done in two patients. In one patient significant bile stasis and thrombi were seen in the biliary tree. In another patient liver biopsy showed ballooning of hepatocytes with minimal cholestasis. All patients recovered spontaneously. Awareness of this rare complication may prevent unnecessary diagnostic and surgical procedures in patients with rheumatoid arthritis who may develop jaundice while receiving chrysotherapy. | |
| 6610689 | Antibodies to heterogeneous nuclear ribonucleoproteins in sera from patients with rheumati | 1984 May | Ribonucleoprotein (RNP) particles sedimenting at 40 S in sucrose gradients were prepared from calf thymus nuclei. They were identified as heterogeneous nuclear RNP (hnRNP) on the basis of size, electron microscopic examination, buoyant density, and protein electrophoretic patterns. Sera from patients with systemic lupus erythematosus, rheumatoid arthritis, and mixed connective tissue disease were found to interact with hnRNP by counter-immunoelectrophoresis and enzyme-linked immunosorbent assay (ELISA). Small nuclear RNP (snRNP) were purified by immunoaffinity using a monoclonal anti-snRNP antibody immobilized on Sepharose beads. Inhibition of the ELISA assay for snRNP with anti-hnRNP Fab fragments and cross-over experiments revealed that the autoantibodies detected in human sera recognize common epitopes present on snRNP and hnRNP. |