Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 628654 | Nonsteroidal antiinflammatory drugs: new alternatives for rheumatic disease. | 1978 Mar | New antirheumatic drugs which are moderately effective clinically and less toxic than similarly acting, previously available drugs are believed to act by blocking certain mediators of inflammation. At present, there is no evidence that they influence the release of lysosomes, inhibit the action of complement, or modify immune mechanisms. | |
| 342691 | Piroxicam (CP 16171) in rheumatoid arthritis: a controlled clinical trial with novel asses | 1977 Winter | Piroxicam (CP 16171), a new nonsteroidal anti-inflammatory agent, decreased pain, stiffness, and inflammation and increased the patient's ability to perform tasks in a double-blind study of patients with active, definite rheumatoid arthritis, poorly controlled despite standard therapy. Clinically and statistically significant improvement occurred in grip strength, walking time, and morning stiffness, and in patient and physician evaluation. Seventy-five per cent of the piroxicam-treated patients increased their daily activities. Three patients treated with the tablet form of piroxicam developed gastrointestinal ulcerations. Another patient developed iron deficiency anemia. | |
| 6974932 | [(Fab')2-antiglobulins in serum and synovial fluid in patients with chronic polyarthritis] | 1981 Jul | In addition to the well-known rheumatoid factors or antiglobulins belonging to different immunoglobulin classes, a new type of antiglobulin has been found in serum and synovial fluid from patients with rheumatoid arthritis. 15/20 sera and 6/6 synovial fluids contained serologically active material with a molecular weight of approximately 95.000 Daltons. Using chromatographic and affinity chromatographic methods as well as specific precipitation techniques, the (Fab')2 character of these antiglobulins could be ascertained. These antiglobulins may arise through enzymatic degradation of IgG or monomeric IgM antiglobulins, or may be the product of partial intracellular degradation of phagocytosed immune complexes with subsequent extrusion of such material. An in vitro blocking effect of (Fab')2 type antiglobulins on SCMC or ADCC reactions was not found. | |
| 6785437 | Other penicillamine-like drugs. | 1981 Jan | Drugs like penicillamine act slowly, benefit extraarticular features of the disease as well as the joints, reduce erythrocyte sedimentation rate and rheumatoid factor titer and may slow the progression of radiographic changes and alter the outcome of the disease. Their action is to some extent disease-dependent. The 1st choice of drugs of this type is now penicillamine. It compares favourably with other drugs of the same type including gold, azathioprine and levamisole. A number of compounds in the development stage offer potential advantages over currently available drugs of this class. A compound which was safe enough to be recommended for widespread use would take over the role of first-line treatment of rheumatoid arthritis. | |
| 200037 | An epidemiological study on paramyxovirus antibody titers in multiple sclerosis, systemic | 1977 Aug | The present epidemiological study concerned and evaluation of the level of measles antibodies (hemagglutination inhibition (HI) assay) and para-influenza-1 (Sendai) antibodies (complement fixation (CF) test) in serum of 107 control individuals (38 women), 176 multiple sclerosis (MS) patients (93 women), 717 relatives to MS patients (361 women), 9 patients with systemic lupus erythematosus (SLE) (all women), 46 relatives to SLE patients (28 women), 57 patients with rheumatoid arthritis (RA) (37 women), and 143 relatives to RA patients (85 women). In MS and their relatives the HI titer value was significantly raised and the CF titer only insignificantly increased. In SLE the HI titers were insignificantly raised but the CF values significantly decreased. In RA HI values were insignificatly raised, but the CF values were significantly decreased among females lacking rheumatoid factor in serum. In the individuals under study, HI values did not correlate with CF values. In MS two groups of patients could be treated, i.e. one group with raised HI values and one with normal distribution of titers. The data obtained are discussed in light of the theory, that all three disease entities may be "Slow Virus Diseases". | |
| 6378463 | Antibodies to gliadin, gluten and reticulin glycoprotein in rheumatic diseases: elevated l | 1984 Jul | An enzyme immunoassay was used to measure circulating antibodies to gluten, gliadin and to 'reticulin glycoprotein' in 25 patients with Sjögren's syndrome (SS), in 20 patients with rheumatoid arthritis without SS and in 19 patients with systemic lupus erythematosus without SS. Antibody levels to these three antigens were significantly higher in SS than in the other groups. In SS the level of antibodies to 'reticulin glycoprotein' correlated positively with the levels of antibodies to both gliadin and to gluten but not with the level of antibodies to SS-B antigen. Patients with primary SS had higher antibody levels to 'reticulin glycoprotein' than had patients with secondary SS, whereas no significant difference between primary and secondary SS was found in the levels of the antibodies to gliadin or to gluten. Circulating antibodies to gliadin, gluten and 'reticulin glycoprotein' have not been previously recognized in SS. Their occurrence suggests that small bowel injury may be a common finding in SS. | |
| 4015200 | Studies on the interaction of rheumatoid factor with monosodium urate crystals and case re | 1985 Jun | Gout and classical rheumatoid arthritis rarely coexist. We report a patient with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumatoid factor (RF). This was studied with a purified monoclonal rheumatoid factor (mRF) with specificity for IgG. The mRF bound preferentially to MSU coated with IgG in contrast with the IgM control. Inhibition of the neutrophil chemiluminescence (CL) response to IgG-coated MSU was observed at concentrations of mRF that had no effect on the CL response to uncoated crystals. Neutrophil activation was not altered by coating crystals with an IgM control at the same concentration. These data suggest that RF may bind to antigenic determinants on exposed Fc of adsorbed IgG and block the interaction of crystal-bound IgG with Fc receptors. Although crystal coating by RF may modify the expression of gouty arthritis, it is unlikely to be the sole explanation for the dissociation between gout and RA. | |
| 170907 | Thermography and rheumatic diseases. | 1975 | The common factor in most of the rheumatic diseases is an arthritis. Radiometry and thermography have been shown to indicate and measure heat resulting from localised inflammation. In rheumatoid arthritis, juvenile arthritis, osteoarthrosis, gout and ankylosing spondylitis abnormal heat distribution has been recorded over affected joints. Experimental evidence has shown that temperature change reflects the inflammatory state of the joint, and that this may be used to measure the effect of therapy by oral, systemic and local drug therapy, and also surgery, i.e. synovectomy. | |
| 47952 | Antiglobulin production to altered IgG in rheumatoid arthritis. | 1975 Mar 15 | Conformationally altered IgG molecules have been detected in the serum of patients with rheumatoid arthritis. A hypothesis is presented that specific T-cell unresponsiveness to autologous IgG can be bypassed through the recognition of the altered IgG by competent B lymphocytes. The recognition of altered IgG is mediated through membrane Fc receptors (which may themselves be different in rheumatoid arthritis) and this favours stimulation of those cells carrying a specific receptor for an antigenic part of the molecule. A particular cellular arrangement may be required for complete antigenic stimulation and antiglobulin production. The resultant antiglobulin can have the same binding affinity for autologous and homologous IgG since the antigenic part of the molecule need not be a structurally altered site. | |
| 6372799 | HLA-DR4 is not a requisite for autoimmunity to collagen in rheumatoid arthritis. | 1984 May | Immunogenetic studies in rheumatoid arthritis have demonstrated an increased frequency of the HLA-DR4 alloantigen in individuals with both the sporadic and familial forms of the disease. To investigate the significance of this association, we ascertained whether the possession of DR4 is necessary for the expression of cellular and humoral immunity to native human type II collagen. Our results indicate that the presence of DR4 is not required for the development of autoimmunity to collagen in rheumatoid arthritis. | |
| 6219220 | Evaluation of T cell subsets with monoclonal antibodies in synovial fluid in rheumatoid ar | 1982 Nov | Monoclonal antibodies that react with all T cells (OKT3), the inducer-helper T cell subset (OKT4), and the suppressor-cytotoxic T cell subset (OKT8) have been used to evaluate T cell and T cell subpopulations in synovial fluid (SF) from patients with rheumatoid arthritis (RA). We found that the immunoregulatory ratio of SF lymphocytes ranged from normal values to extremely low values indicating normal to excess numbers of OKT8+ cells. The rheumatoid synovium in patients with RA is characterized by the presence of lymphoid aggregates in which HLA-DR+ interdigitating cells form close contacts with a large number of OKT4+ T cells, while the OKT8+ T cells are sparse. It may be that the localizing mechanisms for OKT8+ suppressor cells in lymphoid aggregates are deficient in RA and the cells are thus permitted to pass into synovial exudates, resulting in an increase of OKT8+ cells in the SF. | |
| 938589 | Induction of peripheral blood lymphocyte transformation by autologous synovial fluid lymph | 1976 May | Synovial fluid lymphocytes and synovial fluid from most patients with rheumatoid arthritis induced blastogenesis of autologous peripheral blood lymphocytes. In vitro transfer of the mitogenic activity of the synovial fluid to peripheral blood lymphocytes was not accomplished, but diminished response of the peripheral blood lymphocytes to phytohemagglutinin stimulation after incubation in synovial fluid was demonstrated. These findings suggest that a similar blastogenic response in vivo may induce the lymphoid hyperplasia regularly observed in rheumatoid arthritis. | |
| 1099957 | T- and B-cell interactions in autoimmune syndromes. | 1975 Jun 13 | We have reviewed briefly some of the individual capabilities of T and B cells and how these can be modified by interactions between the two cell lines. Evidence that T cells have their own distinct receptors for antigens, yet under certain circumstances may bind IgM or IgG produced by B cells, has been particularly emphasized. The probability that B cells, in turn, may bind the antigen receptor of T-cell origin reflects the balanced nature of an intricate communication system in which interactions between antigens, antigen receptors, and binding sites for these receptors all serve to modulate the integrated functioning of T and B cells. It is suggested that this communication system is disturbed in patients with rheumatoid arthritis; specifically, it is proposed that defective feedback activity of IgG-antigen complexes on activated T cells may exist in some patients and could result in unchecked and harmful T-cell activity in the joint. Therapeutic implications of this idea are mentioned. | |
| 1092727 | Naproxen and aspirin in rheumatoid arthritis: a multicenter double-blind crossover compari | 1975 Apr | One hundred nineteen adults with active definite or classical rheumatoid arthritis were studied in a multicenter double-blind crossover study of naproxen (500 mg/day) and aspirin (3.6 Gm/day). Each drug was given in sequence for a six-week study period. Patients already receiving corticosteriod and/or gold therapy were maintained at constant dose throughout the study, but analgesics and other nonsteroidal antiinflammatory agents were discontinued at baseline. Objective and subjective evaluations by both investigator and patient were carried out at two-week intervals. No significant difference in global evaluation of efficacy or individual measures of efficacy was observed between aspirin and naproxen therapy, although physicians' global evaluation tended to favor naproxen. Sedimentation rate was lower on aspirin (naproxen 43.1 mm/hr; aspirin 38.7 mm/hr; P=0.02). Naproxen, 250 mg twice daily, was significantly better tolerated than aspirin, 900 mg four times daily. Mild, moderate, and severe side effects were less frequent with naproxen. The incidence of heartburn was significantly lower on naproxen, and significantly fewer patients terminated their six-week study period on naproxen than on aspirin. There were no significant deviations from baseline values in hematocrit, white cell or differential counts, or in tests of renal and hepatic function during the course of the study. | |
| 7334212 | Detection of differentiation antigens by use of monoclonal antibodies. | 1981 | Various monoclonal antisera placed at appropriate dilutions in a microcytotoxicity typing tray can be used to characterize different cell types with the aid of a simple 2-h microcytotoxicity test. With this simple assay, T and B lymphocytes, granulocytes, monocytes, blast cells, and platelets can readily be distinguished. In addition, spleen cells contained 25-50% T cells, half of which expressed Ia antigens. The presence of Ia-bearing T cells in peripheral blood lymphocytes of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients can also be detected using this cytotoxicity tray. | |
| 4265382 | Immunopathologic studies in relapsing polychondritis. | 1973 Mar | Serial studies have been performed on three patients with relapsing polychondritis in an attempt to define a potential immunopathologic role for degradation constituents of cartilage in the causation and/or perpetuation of the inflammation observed. Crude proteoglycan preparations derived by disruptive and differential centrifugation techniques from human costal cartilage, intact chondrocytes grown as monolayers, their homogenates and products of synthesis provided antigenic material for investigation. Circulating antibody to such antigens could not be detected by immunodiffusion, hemagglutination, immunofluorescence or complement mediated chondrocyte cytotoxicity as assessed by (51)Cr release. Similarly, radiolabeled incorporation studies attempting to detect de novo synthesis of such antibody by circulating peripheral blood lymphocytes as assessed by radioimmunodiffusion, immune absorption to neuraminidase treated and untreated chondrocytes and immune coprecipitation were negative. Delayed hypersensitivity to cartilage constituents was studied by peripheral lymphocyte transformation employing [(3)H]thymidine incorporation and the release of macrophage aggregation factor. Positive results were obtained which correlated with periods of overt disease activity. Similar results were observed in patients with classical rheumatoid arthritis manifesting destructive articular changes. This study suggests that cartilage antigenic components may facilitate perpetuation of cartilage inflammation by cellular immune mechanisms. | |
| 7461554 | [Therapy of degenerative joint diseases of a rheumatic nature. Effectiveness of naproxen a | 1980 Oct 23 | 40 patients with degenerative joint diseases were treated with a new application form of naproxen (Proxen 500 film-coated tablets). The patients received one tablet daily in the evening for a period of 4 weeks. The therapeutic efficacy was demonstrated clinically on swelling of the joints, reduction of mobility, pressure pain, muscular stiffness and by improvement of pain symptoms: pain during day and night, pain at rest, movement pain. During therapy 75% of the cases showed marked improvement of the subjective and objective symptoms. The once daily application in the evening did not only influence favourable nocturnal and rest pain, but also reduced diurnal and movement pain significantly. In accordance with these findings 23 hours after application in the evening nearly constant serum levels of naproxen were found for the whole duration of treatment. The fast release of the active substance from the film-coated tablets leads to a rapid onset of the analgesic activity. | |
| 126552 | Antibodies to peptidoglycan in the sera from population surveys. | 1975 Jul | A recently described latex agglutination test was used to determine peptidoglycan antibody titers in sera from healthy human subjects and in sera from patients with a history of streptococcal infections or rheumatoid arthritis. Using latex particles coated with group A streptococcal peptidoglycan 32.8% of the sera from 961 healthy donors reacted positively with titers ranging from 1 : 5 to 1 : 320. Peptidoglycan antibodies were more frequently present in the younger population (45.1% in the 20-29 years old) and considerably decreased in advanced age (15.7% in the 70 years or older). Sera from 82 patients with elevated ASO-titers showed detectable peptidoglycan antibody levels in 40.2%; a statistically significant correlation between ASO and peptidoglycan antibody titers could not be substantiated. Sera from 25 patients with rheumatoid arthritis gave a high incidence (56-92%) of positive results. However there was evidence that this may be due to the action of rheumatoid factor present in such sera. | |
| 230650 | [Scintigraphic study of the sacroiliac joints]. | 1979 | Scintigraphic and radiometric investigation with 99mTc-pyrophosphate was carried out on the sacro-iliac joints of 79 patients: 48 with positive form of Behterev disease, 26 -- with probable form of the disease, 2 -- with Reiter syndrome and 2 -- with rheumatoid arthritis. Scintigraphy was combined with radiometric investigation (determination of sacro-iliac -- sacral index) with a view to obtaining quantitative information about the degree of accumulation of pyrophosphate in sacro-iliac joints. The data from the scintigraphic and radiometric investigations were juxaposed to clinical laboratory and X-ray investigations. Forty of the patients examined were HLA-B27 positive and 38 of them-HLA-B27 negative. Sacro-iliac index, determined in 13 healthy subjects (26 sacro-iliac joints) was within the limits of 1.18 +/- 0.094. The average value of the index of the 78 patients examined was 1.41 +/- 0.20. The index, during the first and second X-ray stage was 1.43 +/- 0.13 and 1.45 +/- 0.19 resp. The values decreased to 1.39 +/- 0.18 during the third X-ray stage, whereas in the fourth stage with completely ankylosis of the joints, the index was 1.20 +/- 0.07, being close to that of the control group of healthy subjects. | |
| 6972764 | Selective lymphocyte deficiency in seronegative rheumatoid arthritis. | 1981 Jun | Prior studies have shown that in vitro infection with the Epstein Barr virus (EBV) is able to induce IgM rheumatoid factor production by normal lymphocytes, with a higher degree of production by seropositive rheumatoid arthritis lymphocytes. The present investigation demonstrates that EBV-infected lymphocytes from patients with seronegative rheumatoid arthritis produce in vitro significantly less IgM rheumatoid factor than do normal lymphocytes. The results suggest that the peripheral blood of seronegative patients is deficient in the rheumatoid factor precursor B cells responsive to stimulation by Epstein Barr virus. |