Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7272159 | Circadian variations in the signs and symptoms of rheumatoid arthritis and in the therapeu | 1981 May | 1 Seventeen patients with rheumatoid arthritis were studied in a double-blind crossover trial contrasting three different times of administration of twice-daily flurbiprofen. 2 Twelve of these patients were also studied when taking the same dose of flurbiprofen as a split dose four times a day. 3 Symptoms and signs of the disease were self-assessed throughout the day for several days on each regimen and the information was analysed for rhythmicity. 4 Twice a day flurbiprofen may be more effective than four times daily flurbiprofen, and the regimen without an evening dose was the least effective of three twice-daily treatments tested. 5 Circadian rhythms of grip strength and finger joint size were demonstrated, and were similar on all treatment regimens. 6 These rhythms have a similar pattern to those detected during studies of immune responses, and it is suggested that morning stiffness in rheumatoid arthritis is not only the result of nocturnal inactivity, and may respond to appropriately timed medication given to decrease inflammation or to suppress other aspects of the immune response. | |
| 6831147 | Gallium 67 scanning in rheumatoid arthritis. | 1983 Apr | Gallium 67 scans were performed on both knees of 38 patients with rheumatoid arthritis. There was a significantly higher level of 67Ga accumulation in those knees with clinically active synovitis (p less than 0.001). Synovial white cell concentration was also elevated in the group with active synovitis. The white cell concentration correlated with the 67Ga knee/femoral ratio at the p less than 0.001 level. 67Ga activity in the synovial fluid was predominantly in the supinate and activity was also present in the synovium. The findings indicate that 67Ga uptake occurs in rheumatoid joints and reflects the degree of synovial inflammation. | |
| 374144 | Pemphigus foliaceus in a patient with rheumatoid arthritis and Sjögren's syndrome. A case | 1979 | A 74-year-old male patient with rheumatoid arthritis and Sjögren's syndrome developed pemphigus foliaceus. Clinically healthy skin tissue revealed a fluorescent band of IgM along the basal membrane and an intercellular deposit of C3 and IgG in the deepest areas of the epidermis. Similar investigations of diseased skin revealed no deposits of IgM, and C3 and IgG were spread over a large area of the epidermis, though following the same pattern. In sero-positive rheumatoid patients with and without vasculitis, C3 and IgM are frequently found in small dermal vessels immediately below the epidermis in apparently normal skin. The fluorescent band of IgM along the basal membrane is thought to be an expression of the patient's rheumatoid arthritis, in spite of the fact that this IgM site is not typically associated with rheumatoid arthritis. The change in the pattern of deposition is thought to be due to pemphigus foliaceus. | |
| 758922 | Coexistent gout and rheumatoid arthritis. Case report and literature review. | 1979 Jan | A 73-year-old woman with Felty's syndrome and arthritis mutilans of long duration presented with tophaceous gout. The 7 previously reported cases of coexistent gout and rheumatoid arthritis (RA) are critically reviewed. Possible explanations for the rare coexistence of RA and gout are discussed: if uric acid is an inhibitor of the immune response, then hyperuricemia and gout could protect against development of RA. Conversely, crystalline protein binding may be a critical factor in the pathogenesis of gout, and the presence of abnormal proteins in RA could protect against gout. | |
| 907801 | The use of the radioimmunoprecipitation-PEG assay (RIPEGA) to detect anti-IgG antibodies. | 1977 Jul | A new procedure, the radioimmunoprecipitation--P.E.G. assay (RIPEGA) is proposed for the detection of anti-IgG antibodies (anti-IgG Ab). This sensitive and reproducible test was performed by incubation of radio-labelled human IgG (125I-IgG) with patient's sera. Separation of free from complexed 125I-IgG was achieved by a 7% P.E.G. precipitation. Preliminary results demonstrated anti-IgG Ab in 84.4% of the cases of sero-positive rheumatoid arthritis (R.A.), 85% of seronegative R.A., 43% of other forms of inflammatory arthritis, 50% of unclassified arthritis and in 10.5% of the control subjects. | |
| 7280897 | Penicillamine-induced myasthenia gravis in a patient with rheumatoid arthritis. A case rep | 1981 Sep 19 | This article reports some observations made in a woman who developed myasthenia gravis after treatment with D-penicillamine. Withdrawal of the drug was not followed by spontaneous remission of the myasthenic syndrome. | |
| 6858276 | [Reactive dynamics of immunologic parameters in healthy humans and in patients with rheuma | 1983 Mar 1 | Investigations of three immune components (IgG, CRP, alpha 1 sGP) in 500 patients with rheumatoid arthritis at the beginning and the end of a spa treatment lasting 4 or 6 weeks as well as in 29 healthy test persons in monthly intervals over 2 years make clear that these immune components represent biorhythmologically regulated functions which underly a different dynamics related to the initial value. By means of the so-called "cross-over-point method" the adequate conditions can be figured. In these cases under the influence of the spa therapy a significant decrease of the dispersion at the end of the significant decrease of the dispersion at the end of the cure develops for the parameters CRP and IgG. These findings as well as the typicality of the course of the empiric regression between the beginning of the cure and the end of the cure represent criteria which are of importance for the demarcation of the dependence of the initial value to a statistical a: (a-b) effect. It is shown that the pathologically reactive dynamics of the immune components can be demarcated from the biorhythmically undisturbed dynamics. | |
| 6106453 | A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis. | 1980 Jun | In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis. | |
| 920239 | Radiographic evaluation of rheumatoid arthritis and related conditions by standard referen | 1977 Jul | A review of radiographic evaluation of rheumatoid arthritis is given. Standard reference films are introduced for evaluation of rheumatoid arthritis and related conditions in the extremity joints. In this system, numerical evaluation of arthritis is given for individual joints in a patient. | |
| 6878082 | The physician and the arthritis patient: informed partners in therapy. | 1983 May | By creating an environment for treatment and rehabilitation which is simultaneously functional, attractive, and clearly responsive to the arthritis patient's medical, functional and emotional needs, the physician sends the message that he is concerned about all aspects of care and willing to do his share in promoting and maintaining the therapeutic partnership with the patient. | |
| 3978364 | Methods of X-ray assessment in rheumatoid arthritis: a re-evaluation. | 1985 Feb | We have re-examined the value of hand radiographs in the assessment of joint damage in rheumatoid arthritis in a series of related studies. Our objectives were: to assess the reproducibility of scoring hand radiographs and the relationships between different types of changes; to analyse the correlations between radiographic changes and hand function; and to assess the inter-relation between hand changes and overall joint damage. We confirmed the reproducibility of radiological assessments and showed that two observers can reproducibly score hand radiographs separately for joint space loss and erosions; both of these correlated with the Larsen score derived from standard radiographs. However, hand radiographic changes were not closely related to hand function; nor did they predict damage to large joints. Finally, examination of changes in 13 joint groups showed that there is a weak relationship between damage and disease duration, and the rate of damage is greatest in the initial years. We conclude that the status of hand radiography as a measure of overall outcome in rheumatoid arthritis remains an open question. | |
| 7138748 | Variations in responses to non-steroidal anti-inflammatory drugs. | 1982 Nov | 1 This paper assesses the variability in the response of patients with rheumatoid disease to a group of non-steroidal anti-inflammatory drugs (NSAID). 2 Thirty six patients were divided into three groups and each group received a set of four NSAID. The different drugs were each given three times daily for a week and the treatment order was randomised. 3 The study demonstrated marked variability and unpredictability in patient responses and cast doubt on the value of comparative trials of different NSAID. | |
| 1180177 | Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induce | 1975 Feb | Liver function alterations, in the adjuvant induced polyarthritis procedure in rats, has been demonstrated by many investigators. We observed a significant inhibition of the polyarthritis with phenylbutazone but we were unable to find any changes in the relative liver weights of SGPT, AP or BUN in polyarthritic or phenylbutazone treated rats. However, we did observe that polyarthritic rats maintained a significantly higher plasma phenylbutazone concentration than the corresponding non-arthritic controls. This appears to futher substantiate the influence of 'pathopharmacodynamics' on the disposition and activity of drugs. | |
| 481181 | [Rheumatoid polyarthritis in Madagascar (author's transl)]. | 1979 May | Report of 11 cases of rheumatoid arthritis observed in Malagasy. Frequently, a single joint is concerned at the on-set period and this may raise some questions to differetiate rheumatic fever, gout and osteo-articular tuberculosis, as these three diseases are of high and almost equivalent frequency in the country. Clinical, biological and radiological features are the same as observed in Europe. Evolution is often severe as a consequence of requently delayed diagnosis and difficulties encountered in treatment of out-patients. | |
| 3924262 | Ten year mortality and causes of death in patients with rheumatoid arthritis. | 1985 Jun 15 | Five hundred men and 500 women, aged 40 or over, with rheumatoid arthritis, together with a control population matched for age and sex, were observed over 10 years. During that time 352 patients with rheumatoid arthritis (208 men, 144 women) and 221 controls (148 men, 73 women) died. The overall mortality was significantly higher (p less than 0.0001) in both men and women with rheumatoid arthritis than in the controls. Infections and cardiovascular and renal diseases (especially amyloidosis) appeared to be the main causes of death in rheumatoid arthritis. | |
| 301031 | Chronic polyarthritis associated with hypogammaglobulinemia. A study of two patients. | 1977 Apr | Two adult patients with hypogammaglobulinemia and chronic synovitis were studied. Synovial tissue and fluid were examined by histologic, virologic, and immunologic methods. The synovium lacked characteristic histologic features of rheumatoid arthritis, and B lymphocytes were absent from the synovial tissue, fluid, and peripheral blood. These 2 patients may represent a form of chronic synovitis produced in the absence of any B lymphocyte response. | |
| 6613752 | Serum biochemistry in relation to the action of azathioprine in rheumatoid arthritis. | 1983 Jun | In a long-term study we have been comparing biochemical changes in the blood of patients with classical or definite rheumatoid arthritis (RA) when groups of patients are treated for the first time with specific anti-rheumatoid drugs for a six-month period. One such group was treated for 26 weeks with azathioprine. Biochemical and clinical assessments were made at each of 10 clinic visits during the treatment period. Side-effects prevented six patients completing the study. Clinical improvement in the remaining patients was accompanied by a reduction in acute phase proteins, increases in total serum sulphydryl and serum histidine, but little or no change in immunological variables. Comparison of correlation matrices constructed between clinical and laboratory variables for azathioprine and drugs previously tested suggests that azathioprine is more effective than a control group on aspirin alone and in some ways comparable with D-penicillamine. | |
| 5080706 | Peroxidase arthritis. II. Lymphoid cell-endothelial interactions during a developing immun | 1972 Oct | The interaction of lymphoid cells with vascular endothelium was studied during the development of immunologic synovitis in response to repeated intraarticular injections of a heterologous protein antigen. Lymphoid cells emigrated in venules and small veins, both by penetrating the endothelial cytoplasm and by traversing intercellular junctions. Frequent endothelial mitoses were coincident with lymphoid cell emigration. Endothelial cells in the involved vessels increased in number and bulged prominently into the vascular lumen. Endothelial nuclei contained dispersed chromatin and prominent nucleoli; the cytoplasm contained many vacuoles and abundant polyribosomes and rough-surfaced endoplasmic reticulum. Intercellular junctions were numerous and complex. These phenomena were prominent in rabbits studied after 12 to 16 daily injections; they then receded, despite continued antigenic stimulation. In animals studied after 35 or 37 daily injections, the venules appeared relatively normal, and lymphoid cell emigration was observed infrequently. Growth of new vessels was prominent at this stage. The present data do not establish whether the endothelial changes were the cause or the result of lymphoid cell emigration, although the latter seems more likely. Further studies are needed to elucidate the exact nature of these interactions. | |
| 6606208 | Antiperinuclear factor in an Italian series of patients with rheumatoid arthritis. | 1983 Jul | Serum samples from 90 cases of rheumatoid arthritis (RA), 218 control patients and 100 healthy controls were tested by indirect immunofluorescence for the presence of the antiperinuclear factor (APF), an autoantibody to the keratohyaline granules of human buccal mucosal cells. The sensitivity and specificity of the APF test for RA were 82 and 90%, respectively, slightly higher than those obtained when the same serum samples were tested for rheumatoid factor (RF) using a latex agglutination method. The diagnostic gain of APF in the RF-negative RA cases was greater than that of RF in the APF-negative cases (54% vs. 37%). In spite of a few technical disadvantages, the APF test should be therefore performed in the serological routine examination of rheumatic diseases. As APF was also found in 11% of degenerative joint disease (DJD) cases and the estimated prevalence ratio RA/DJD is, in Italy, 1/11, the predictive value of a negative APF test proved to be much higher than that of a positive test (98% vs. 40%) for the diagnosis of RA. APF was significantly associated with other autoantibodies (RF and antinuclear antibody). | |
| 672138 | [Possible influence of plasma factors on lymphocyte blastigenesis and E rosette forming in | 1978 Jul 1 | The lymphocytes blastigenesis to PHA in culture with autologous or normal plasma, the formation of E rosettes and the presence of immunoglob-lins on the lymphocytes surface were evaluated in 51 patients with chronic primary polyarthritis. While the percentage of T and B cells was almost normal (52.1 +/- 2.1% and 18.1 +/- 2.1%, N.V. 55.6 +/- 2.0% and 16.2 +/- 0.8%), the blastigenesis was significantly reduced in cultures with a 25% autologous plasma (5399 +/- 709 cpm compared to 13,182 +/- 920 cpm of the normal standard) and returned towards normal values when it was replaced by the plasma of a normal subject (12,189 +/- 1081 cpm). The rheumatoid plasma was capable of reducing the blastigenesis in 11 normal subjects (7395 +/- 750 cpm). The preincubation for 90' of the lymphocytes of 14 controls in rheumatoid or autologous plasma induced a significant reduction in the formation of spontaneous rosettes (40.8 +/- 1.4 % and 56.2 +/- 1.7%). These results suggest that the reduced function of the T lymphocytes in this disease is due to plasma factors. |