Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7060999 | Arthrodesis of the wrist in rheumatoid disease. | 1982 Feb | Twelve cases of wrist fusion for rheumatoid disease have been assessed pre and postoperatively in terms of symptoms, function, union, and complications. Improvement in hand function can be attributed to the provision of a painless stable wrist, and fusion in the straight position is in no way detrimental to personal hygiene. Delayed wound healing and pin migration are not uncommon complications but do not affect the end-results, which is radiological union from third metacarpal to radius - a definitive situation. | |
| 6950723 | Fibrositis and psychologic disturbance. | 1982 Feb | Thirty patients with fibrositis and 2 control groups, one of rheumatoid arthritis patients and the other of arthritis patients with other than rheumatoid arthritis, were compared on the basis of the Minnesota Multiphasic Personality Inventory (MMPI) to assess the role of psychologic factors in fibrositis. Patients with fibrositis differed in both elevation and variability in their MMPI profiles, indicating that they were more psychologically disturbed than patients with rheumatoid or other types of arthritis. The fact that almost all of the fibrositis patients' MMPI scales were higher suggests that we might be dealing with a number of different psychologic disturbances that have stiffness and musculoskeletal pain as principal and common symptoms. | |
| 490526 | Antecedent tonsillectomy and appendectomy in rheumatoid arthritis. | 1979 May | The prevalence of tonsillectomy and appendectomy was higher in 196 patients with rheumatoid arthritis (RA), prior to the onset of articular disease, than in their spouses and siblings. The estimated increased risk of developing RA with tonsillectomy was 1.5 and 3.5 times, with appendectomy 1.7 and 6.6 times, and with both surgical procedures 2.3 and 6.7 times, using patient-spouse and patient-sibling matched-pair data, respectively. However, only with patient-sibling data did the lower limits of the 95% confidence interval for the risk ratio exceed 1.0. Several hypotheses are offered to explain the possible association between these surgical procedures and RA. | |
| 6678695 | Relationship between clinical synovitis and radiological destruction, in rheumatoid arthri | 1983 Sep | The clinical synovitis and radiological destruction of wrist and subtalar joints were followed over a 3-year period in 107 patients with rheumatoid arthritis of no longer than 6 months' duration. The joints were examined clinically and by X-ray on entry to study, at one year and at three years of study. The progress of joint destruction was highly significantly correlated with the frequency of clinical synovitis at the three examinations in both wrist and subtalar joints. | |
| 591778 | Otoadmittance measurements in patients with rheumatoid arthritis. | 1977 Nov | Analysis of middle ear function has for many years been accomplished by acoustic impedance measurements and this has proved of great clinical value. The vectors which contribute to impedance are functions of mass, stiffness and resistance of the system and information about these components may be obtained by use of the otoadmittance meter. The shape of the tympanogram may be altered both by pathologies which change the relative magnitude of the vectors and by variation in the probe tone frequency. Patients with rheumatoid arthritis (55 ears) were compared with a series of controls (50 ears); 38% of 'rheumatoid ears' demonstrated a marked notch on the 660 Hz susceptance curve whilst only 8% of the control group showed this abnormality. The pattern suggests a decrease in the stiffness of the transducer mechanism in rheumatoid arthritis. | |
| 496450 | Relationship between erythrocyte sedimentation rate and serum C-reactive protein in rheuma | 1979 Aug | Serum C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were compared in 241 patients with rheumatoid arthritis (RA). There was a positive linear correlation between the 2 measurements with a high degree of variability. Neither age nor duration of RA had a detectable influence. The relationship between CRP and ESR was, however, altered by treatment with gold, penicillamine, or high doses of prednisone. It is suggested that serum CRP is the more sensitive measurement, but that CRP and ESR do not have identical clinical significance. | |
| 6965505 | Rheumatoid arthritis and B lymphocyte alloantigen HLA-DRw4. | 1980 Jan | Forty Caucasian patients with classical or definite rheumatoid arthritis were tested for 7 HLA-DR alloantigens and 37 HLA-A, B, and C antigens and compared with 125 and 450 healthy controls, respectively. HLA-DRw4 was significantly (corrected p = 10(-3) increased in rheumatoid arthritis (55%) compared with controls (23%). There was no significant correlation between clinical, radiological or serological disease parameters and HLA-DRw4. The frequency of HLA-B8 was increased in the patient group; however, the corrected p value was not significant. | |
| 7436580 | Cervical collars in rheumatoid atlanto-axial subluxation: a radiographic comparison. | 1980 Oct | Atlanto-axial subluxation occurs with a frequency varying from 6% to 45% in rheumatoid arthritis. Most patients are treated conservatively with a cervical collar. The effectiveness of different cervical collars in inhibiting anterior atlanto-axial subluxation was tested in 11 patients with classical rheumatoid arthritis. None of the collars had any major influence in inhibiting anterior subluxation of the atlas in maximal flexion. Furthermore, the harder collars with a stable cervical stand forced the atlas to subluxate anteriorly in some of the patients. | |
| 7436556 | Discriminatory indices of response of patients with rheumatoid arthritis treated with D-pe | 1980 Aug | A long-term study is being undertaken to classify drugs used as specific agents in the treatment of rheumatoid arthritis in terms of their effects on biochemical and clinical characteristics of the disease. In particular is hoped to establish those indices which are most relevant to the response of RA to treatment. Fifteen patients were treated with D-penicillamine after an initial period of 2 weeks on aspirin alone, when the baseline investigations were made. The dose of penicillamine was increased gradually to a maximum of 500 mg a day over the period of 6 months, and changes in 8 clinical and 25 laboratory indices were measured on 8 separate occasions in the 6-month period. Marked clinical improvement took place, and this was mirrored by changes in a wide range of biochemical parametaers. ESR and C-reactive protein were shown to be the most suitable indices of disease improvement with penicillamine treatment. | |
| 6864675 | Relationship between rheumatoid arthritis and monoclonal gammopathy. | 1983 Apr | The incidence of monoclonal gammopathy (MG) developing after the onset of rheumatoid arthritis (RA) was found to be 4.1%. Comparison of 12 patients with both diseases and a group of 215 control cases of RA showed the age of onset of RA was higher when MG was going to develop. In such cases, MG was heralded by lower or diminishing serum rheumatoid factor titers. Comparison of these 12 patients with 971 control cases of MG showed the same high frequency of patients with IgM-MG as that recently reported for a series in Western France. An unusually high but not significant incidence of patients with lambda light chains was observed. The reasons for this remain to be elucidated. | |
| 364636 | Chloroquine treatment in rheumatoid arthritis. Correlation of clinical response to plasma | 1978 | 15 patients with active RA were observed over a 3-month period after starting chloroquine treatment. Clinical condition, plasma levels of chloroquine and levels of 15 individual plasma proteins were checked monthly. Nine patients responded favourably to therapy, 6 failed to respond. The responders had lower initial CRP, orosomucoid and ceruloplasmin levels, whereas their IgA and IgM levels were slightly elevated. Significant reductions in the levels of CRP, haptoglobin, orosomucoid, fibrinogen and ceruloplasmin occurred in the responder group of patients. Alfa1-antitrypsin, antichymotrypsin C3 and C4 levels within the normal range were frequently encountered despite other clear-cut signs of activity. The chloroquine levels did not differ between responders and non-responders, the mean concentrations being 1.04 and 1.6 micromol/l respectively. This study has also demonstrated that in selected cases, despite active joint disease, all acute phase proteins may be normal. Finally, it was obvious that chloroquine, even when inducing remission, only brought about a partial normalization of the plasma protein pattern. | |
| 4032013 | Odontoid upward migration in rheumatoid arthritis. An analysis of 45 patients with "crania | 1985 Oct | Lack of correlation between the severity of rheumatoid subluxation of the upper cervical vertebrae and supposed absence of neurological damage has led to the erroneous supposition that this finding is innocuous. Incomplete autopsy studies in rheumatoid arthritis have failed to recognize the cause of death, despite previously proven dramatic occipito-atlanto-axial dislocations. The most feared entity of rheumatoid basilar invagination, namely "cranial settling," is poorly understood. Between 1978 and 1984, the authors treated 45 rheumatoid arthritis patients who were symptomatic with "cranial settling." This consisted of vertical odontoid penetration through the foramen magnum (9 to 33 mm), occipito-atlanto-axial dislocation, lateral atlantal mass erosion, downward telescoping of the anterior arch of C-1 on the axis, and rostral rotation of the posterior arch of C-1 producing ventral and dorsal cervicomedullary junction compromise. Cervicomedullary junction dysfunction has mistakenly been called "entrapment neuropathy," "progression of disease," or "vasculitis." Occipital pain occurred in all 45 patients, myelopathy in 36, blackout spells in 24, brain-stem signs in 17, and lower cranial nerve palsies in 10. Four patients had prior tracheostomies. Four previously asymptomatic patients with "cranial settling" presented acutely quadriplegic. The factors governing treatment were reducibility and direction of encroachment determined by skeletal traction and myelotomography. Transoral odontoidectomy was performed in seven patients with irreducible pathology. All patients underwent occipitocervical bone fusion (with C-1 decompression if needed) and acrylic fixation. Improvement occurred during traction, implying that compression might be the etiology for the neurological signs. There were no complications. Thus, "cranial settling" is a frequent complication of rheumatoid arthritis; although it is poorly recognized, it has serious implications and is treatable. | |
| 301940 | Antinuclear antibody: predictive of lymphocyte response in rheumatoid arthritis. | 1977 Spring | The phytohemagglutinin induced response of lymphocytes was studied in two groups of rheumatoid patients differing only in the presence or absence of antinuclear antibodies (ANA). The response was found to be depressed in 16 ANA positive and normal in 14 ANA negative patients. Antinuclear antibody screening may serve as a simple method to identify a subgroup of immunodepressed rheumatoid patients who may be potential candidates for immunostimulation therapy. | |
| 762241 | Different HLA-D associations in adult and juvenile rheumatoid arthritis. | 1979 Jan | HLA-D typing was performed in 126 patients with juvenile rheumatoid arthritis. HLA-DW4, the antigen found in previous studies to characterize adult rheumatoid arthritis, had a significantly lower frequency in children with arthritis than in normal controls (P less than 0.04). By contrast, in children the antigens HLA-DW7 (P less than 0.03) and HLA-DW8 (P less than 0.01) were increased compared to controls. The antigen TMo, detected with homozygous typing cells from a child with juvenile rheumatoid arthritis, was found to be related to the cross-reactive specificities HLA-DW7 and DW11. 46% of the patients with persistent pauciarticular arthritis of childhood typed for the antigen TMo, compared to only 1% of normal controls. Thus the relative risk for persistent pauciarticular arthritis in relation to the presence of TMo was 67.7 (P less than 0.0001). These results provide evidence of fundamental differences between adult rheumatoid arthritis and arthritis of childhood. The latter group appears to include a population distinguishable clinically and characterized in these studies by the HLA-D determinant TMo. | |
| 6728451 | Present approach to the severely involved rheumatoid wrist. | 1984 Apr | The wrist is a common target for rheumatoid arthritis, with the radiocarpal joint being involved more often than the midcarpal joint. The authors discuss the treatment modalities available for patients with advanced disease: total wrist fusion, flexible implant arthroplasty, and partial wrist fusion. The last procedure, utilized only since 1982 and limited to patients with only radiocarpal joint involvement, eliminates pain and corrects deformity while maintaining a significant range of motion. The indications and techniques for each procedure are described. | |
| 737409 | Lateral subluxation of the atlas in rheumatoid arthritis. | 1978 Dec | Two patients with lateral subluxation of the atlas resulting from rheumatoid disease involving the upper cervical spine have been described. The deformity can be suspected on clinical grounds and in one of our two patients spinal cord damage was a sequel. Erosion of the opposing surfaces of the odontoid and lateral masses of the atlas with detachment of the transverse ligament and deeper fibres of the posterior longitudinal ligament appear to underlie this deformity. Radiological confirmation may require AP views with the head tilted to one or other side. | |
| 294134 | Proliferative lesion of arthritis: a target for therapy? | 1979 | The term proliferative lesion refers to the increase in the amount of connective tissue and in the number of small blood vessels and mesenchymal cells with both phagocytic and synthetic functions, characterizing the rheumatoid synovium. This type of lesion is probably responsible for most of the joint destruction and synovial tissue fibrosis seen in this disease. In vitro data indicate that not only factors inducing bone resorption, for instance osteoclast activating factor and prostoglandins, but also connective tissue-degrading enzymes, can be produced locally in the joint, which suggests that these factors play a role in the destruction of articular structures. D-Penicillamine suppresses the immuno-inflammatory process of rheumatoid arthritis, which indirectly may lead to a depression of the stimuli perpetuating the proliferative lesion. As yet, there are no unequivocal clinical data indicating that D-Penicillamine has a direct suppressive effect on the proliferative lesion. | |
| 7290298 | [Membranous glomerulonephritis during rheumatoid arthritis. Probable toxicity of diclofena | 1980 | The development of membranous glomerulonephritis in a 51 year old patient suffering from rheumatoid arthritis suggested drug toxicity, and particularly of a recently developed anti-inflammatory agent, diclofenac. The toxicity is discussed in relationship to the biochemical and pharmacological properties of the molecule, the therapeutic setting and the positivity of serological tests for rheumatoid arthritis in this particular case. | |
| 7127956 | Hip fractures of rheumatoid arthritis. | 1982 Oct | The results of treatment of 73 transcervical and 49 extracapsular fractures of the femoral neck in patients with rheumatoid arthritis were compared with the results in 152 normal patients. In undisplaced transcervical fractures that were internally fixed and followed up for more than six months, there was no significant difference in results between the rheumatoid patients (5 acceptable results in 8 patients) and the control patients (8 acceptable results in 9 patients). In displaced fractures, when internally fixed, the rheumatoid group (8 acceptable results in 27 patients) did significantly less well than the control group (17 acceptable results in 30 patients). In hips affected by the disease, the results were worse (1 acceptable result in 9 patients). Hemiarthroplasty gave acceptable results in two-thirds of the rheumatoid patients with transcervical fractures, whether used as primary treatment of displaced fractures or as revision of failed pinnings. This was not affected significantly by the presence of disease in the joint. In extracapsular fractures, the presence of rheumatoid arthritis, whether or not it affected the hip, did not appear to affect the outcome. The presence of osteoporosis was associated with poor results. | |
| 7219803 | [Unilateral rheumatoid arthritis]. | 1981 Apr 14 | The authors describe a case of left monolateral rheumatoid arthritis of a patient who nine years previously presented ischemic cerebral lesion resulting in right emiparesis. It should be noted that rheumatoid arthritis appears clinically and radiologically monolateral, whereas from a histological viewpoint the lesions are always bilateral. This brings to mind previously advanced hypothesis to explain this rare expression of rheumatoid arthritis. In conclusion the main factor for articular protection is the rest period induced by the stroke. |