Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 19205 | Treatment of rheumatoid arthritis with tolmetin: a comparison with alclofenac. | 1976 | A double-blind between-patient trial over 6 weeks to compare the effects of 1.6 g tolmetin daily with 4 g alclofenac daily was completed by 37 out of 44 out-patients with rheumatoid arthritis. Tolmetin proved as effective as alclofenac in relieving pain and in reducing both the articular index score and the number of inflamed joints. However, alclofenac produced a significantly greater reduction in the duration of morning stiffness, which could have been related to the timing of the initial daily dose of tolmetin. Onset of fatigue was significantly improved by both drugs. Neither treatment group exhibited any significant changes in the serum levels of IgG, IgA, and IgM, nor in the latex and sheep-cell agglutination titres. Although neither drug gave rise to serious side-effects, 3 patients (2 on tolmetin, 1 on alclofenac) were withdrawn because of skin rash, 2 (on tolmetin) because of gastro-intestinal upsets, and 1 from each group because of lack of analgesic effects. | |
| 4001974 | Rheumatoid arthritis: skeletal manifestations observed on portable chest roentgenograms. | 1985 | This report describes the thoracic skeletal radiographic findings of rheumatoid arthritis, observed on portable chest examinations of 21 patients. Their pathophysiology is reviewed and additional examples of a recently described finding are illustrated: erosion of the medial surface of the proximal humerus with subsequent pathologic fracture, associated with superior and medial migration of the humeral head. It has been proposed that erosion of the medial aspect of the proximal humerus is due to impingement wear, and that pathologic fracture results from the fulcrum effect of the inferior lip of the glenoid on the humerus. Rheumatoid arthritis is often diagnosed by the clinician rather than the radiologist. However, in acutely ill patients receiving portable chest radiographs, complete history and laboratory findings are often unavailable. Attention to the thoracic skeleton may clarify pleural and/or parenchymal lung disease in these patients. | |
| 7044795 | Radiologic assessment of benoxaprofen therapy in rheumatoid arthritis. | 1982 | Our study of 39 patients with rheumatoid arthritis suggests a trend for benoxaprofen therapy given over a prolonged period to retard the rheumatologic process when measured radiologically by both osseous defect and joint space narrowing rates. After a mean duration of 21 months, the progression of osseous defects (OD) and/or joint space narrowing (JSN) was decreased in 28 of 39 patients (72%) who qualified for this study. Fourteen patients (36%) had both OD and JSN rates decreased. An additional 8 patients had OD rate diminished alone and another 6 patients had JSN decreased alone. Clinical evaluation of benoxaprofen has previously revealed a low risk factor and an ability to improve clinical symptoms and signs. Because there is also a trend for this drug to retard or arrest radiologic progression, it becomes a promising agent for the long-term treatment of rheumatoid arthritis. | |
| 595910 | [Control of penicillamine therapy in patients with chronic polyarthritis through urine dis | 1977 Nov | D-penicillamine treatment of 50 patients with rheumatoid arthritis with negative ANF tests, was followed by means of protein disk electrophoresis of the urine. In the beginning the urine proteins were analysed every 4 weeks, later at intervals of 3 to 6 months. A glomerular proteinuria, caused by an immune-complex nephritis, can be recognized very early by this method. A glomerular proteinuria was the reason for discontinuing the treatment in 10 of the 50 patients (8 seropositive, 2 seronegative), drug fever occurred in one case with seropositive arthritis. Protein disk-elektrophoresis of the urine is an appropriate method to recognise renal damage earlier than with any other known routine method. | |
| 881690 | Free DNA in the serum of rheumatoid arthritis patients. | 1977 Summer | Seventy patients with classical or definite rheumatoid arthritis (RA) were studied in an attempt to correlate the serum levels of free DNA with other features. In 26 patients (37%), levels of DNA ranging from 100-540 ng/ml, with a mean of 187 ng/ml, were found. In additional seven patients with a mean of 257 ng/ml, low levels of anti-DNA-antibody were observed. The remaining of 37 patients (53%) had levels of 0-80 ng/ml in their sera, with a mean of 39 ng/ml. All three groups differed significantly (p less than 0.01) from the control group of 61 healthy individuals, who had levels of 0-80 ng/ml with a mean of 13 ng/ml. The high levels of free DNA were commonly found in patients with more severe symptoms who had active RA for less than 10 years, whereas patients with longer duration of disease showed lower levels of DNA. In addition, elevated DNA levels were found more commonly in patients seronegative for rheumatoid factor (RF). Other clinical features did not show significant differences among these patients. The implications of these findings to the pathogenesis of the disease are discussed. | |
| 7361027 | Knee-joint temperature measurement using a differential thermistor thermometer. | 1980 Feb | A simple method for measuring joint inflammation with a differential thermistor probe thermometer was applied to acute synovitis of the knee. Temperature assessments were made immediately before and serially after intra-articular steroid therapy. The method was capable of showing a significant difference in temperature between inflamed and normal knees. Knee temperature assessments correlated well with clinical parameters and were essentially independent of room temperature. | |
| 7354699 | Laryngeal rheumatoid arthritis. | 1980 Feb | The classic sequence of pathologic changes associated with rheumatoid arthritis as they affect the cricothyroid and cricoarytenoid joints of five larynges is described. Although several previous reports have drawn attention to the presence of rheumatoid arthritis in the larnx, the current study emphasizes that the small joints of the larynx may be involved by the full spectrum of pathologic changes and that both cricothyroid and cricoarytenoid joints are equally prone to the various stages of inflammation, joint destruction and ankylosis that characterize the disease elsewhere. Rheumatoid nodules were seen in two cases and granulomatous areas surrounding cricothyroid joints were noted in two others. | |
| 6932712 | [HLA-DR and rheumatoid arthritis in adults. Study on the south of France]. | 1980 Jul | In a homogenous group of 31 cases of adult rheumatoid arthritis treated with gold salts and belonging to a caucasoid race in the South of France, HLA-DR groups were determined. The association with HLA-DR 4 was confirmed. DRw4 was present in 32.2 % of patients as against 12.9 % in 116 controls (p < 0.015). The relative risk of rheumatoid arthritis for DRw4 subjects is 3.3. This association is even more significant statistically in men, in spite of the small number studied (p < 0.005). The frequency of the DRw4 antigen is lower in the South than in the North of Europe (12.9 % as against 24 % respectively). The incidence of the disease and the problems of grouping for HLA-DRw4 and associated antigens are discussed. | |
| 429738 | Rheumatoid arthritis in the elderly, presenting as polymyalgia rheumatica. | 1979 Apr | Two elderly patients presented with generalized aches and pains (particularly in the shoulders and the pelvic girdle), stiffness, fatigue, anemia, and an elevated erythrocyte sedimentation rate, but there were no signs or symptoms directly referable to the joints. Two and five months later respectively, pain, swelling, and signs of synovitis appeared in several joints in a symmetrical pattern, and a diagnosis of rheumatoid arthritis was made. Rheumatoid arthritis in the elderly may resemble polymyalgia rheumatica. On the other hand, synovitis in many patients with polymyalgia rheumatica may resemble rheumatoid arthritis. In the elderly, the differentiation of these two entities may be difficult. Moreover, patients initially presenting with the signs and symptoms of polymyalgia may eventually manifest typical rheumatoid arthritis. | |
| 6525435 | "The pill" and rheumatoid arthritis: benefits for the future? | 1984 | The paper firstly reviews the recent epidemiological literature on the apparently protective effect of oral contraceptive use on the onset of rheumatoid arthritis. This epidemiological evidence is then placed in the wider context of both old and recent clinical observations on the influence of pregnancy, the menstrual cycle and exogeneous sex hormones on the course of rheumatoid arthritis. Finally, possible hints for underlying biological mechanisms are discussed. | |
| 6395534 | [Active acetabulum base stabilization as a supplement to endoprosthesis in polyarthritis-i | 1984 Nov | In many cases, rheumatoid arthritis results in protrusio acetabuli. In order to effect a durably stable support over the whole extent of the acetabulum, the active stabilization of the socket base in an endoprothetic joint replacement through a corticospongy plastic is more promising than the application of passive measures. Rheumatoid arthritic persons underwent 127 hip-joint replacements as first-time surgeries. In 47 operations out of the 127, we also carried out the active stabilization of socket bases because of protrusio acetabuli. Through the implantation of corticospongy bone material into the protrusions, socket bases with enough strain capacity could be recreated. Loosenings or reprotrusions were not observed over a period of up to 5 years. | |
| 3831162 | [Specific protein in the plasma of rheumatoid arthritis patients]. | 1985 Nov | A unique protein was detected in the plasma of rheumatoid arthritis patients by two-dimensional electrophoresis. We named it rheumatoid arthritis specific protein (RASP). According to the pattern and concentration of its spot, RA patients were classified into three groups as RASP+, RASP +/- and RASP-. RASP+ was detected only in RA and its occurrence was 45/120 (38%). The occurrence of RASP including RASP +/- was 84/120 (70%) in RA, 6/13 (46%) in SLE, 2/8 (25%) in PSS, 11/51 (22%) in liver disease and 4/44 (9%) in normal. RA patients with RASP+ indicated significantly high level of ESR, CRP and platelet counts comparing with RA patients with RASP-. These results suggested that RASP might be a good indicator for the diagnosis and evaluation of the activity of RA. RASP was purified with gel chromatography repeated three times. RASP was very similar with immunoglobulin G in its biochemical and immunological properties. | |
| 6528182 | Bilateral peroneal nerve palsy secondary to posterior dislocation of the proximal tibiofib | 1984 | Bilateral peroneal nerve palsy due to posterior dislocation of the proximal tibiofibular joint in a 72-year-old rheumatoid patient is described. Operative findings showed thickening of the synovial membrane of the proximal tibiofibular joint and a neuroma at the peroneal nerve at the fibular head. The cause of posterior dislocation of this joint in the wake of rheumatoid inflammation is discussed. | |
| 3007756 | The immunopathogenesis of rheumatoid arthritis. | 1985 Dec | Rheumatoid arthritis (RA) may represent a T cell dependent immune response to a restricted antigen(s) within the joint, with inflammatory pathways reflecting secondary recruitment. The nature of the inciting antigen is unknown--the stimulus could be an infectious agent or a host constituent. In patients with RA, the centrality of antiself reactivities and immunogenetic influences is apparent. Further clarification of these mechanisms would result in a potential for antigen-specific immunosuppressive therapy. | |
| 6520840 | Nodular regenerative hyperplasia of the liver in a patient with rheumatoid vasculitis: a m | 1984 Dec | Nodular regenerative hyperplasia (NRH) of the liver commonly occurs as a complication of Felty's syndrome but the pathogenesis of the hepatic lesion is not certain. We present a patient with rheumatoid arthritis, leukopenia, glomerulonephritis, NRH and portal hypertension who had histologic evidence of widespread intrahepatic arteritis and paucity of arteries less than 40 micron diameter. We postulate that in this patient the arterial lesions caused secondary portal venous obliteration, portal hypertension, and nodular transformation. | |
| 498630 | Surgery of the wrist in rheumatoid arthritis. | 1979 Jul | One hundred four patients with rheumatoid arthritis of the wrist were evaluated a minimum of 12 months post-operatively (average of 34 months). Seventy patients had 87 arthroplasties and 34 patients had 41 arthrodeses performed on the Arthritis Service of Rancho Los Amigos Hospital (Downey, California), from 1962 to 1975. Seventy-eight per cent of the arthrodeses fused, yet only 69% were painfree. Of the 22% that did not fuse, 67% were pain-free. Carpal and/or intercarpal synovitis recurred in 16% of the fused group and 33% of the nonfused group. Eighty-three per cent of the arthroplasties were pain-free, 91% were stable, and all lost motion which averaged 40 degrees (55%). Spontaneous fusion occurred in 16%). Synovitis recurred in 8.0%. | |
| 6456516 | Surgery of the rheumatoid foot: preferable procedures. | 1981 | Management of patients who have rheumatoid arthritis is best accomplished by a team approach utilizing the help of the family physician, the rheumatologist, the physical therapist and the orthopaedist. Such an approach insures careful screening and proper selection of those who can be helped by surgical procedures. Those who have painful feet welcome surgical intervention if nonoperative methods do not furnish relief. The forefoot is often involved and severe deformities of the metatarsophalangeal joints with painful plantar calluses are frequent. The deformities can be corrected and the calluses prevented or relieved by an operation that does not shorten the metatarsals. Such preserves and restores better function of the foot. After tenotomy of the extensor tendons and resection of the proximal portion of the proximal phalanges the plantar condyles of the metatarsals are excised and the remainder of the head is smoothed but not excised. The distance of the heel to metatarsal head strike during standing and walking is not shortened by this procedure. In some rheumatoid patients who have severe hallus valgus but minimal involvement of the interphalangeal joint the push off function of the great toe that is so important when walking can be preserved by arthrodesis in the correct position of the metatarsophalangeal joint. Arthrodesis of the talonavicular joint before fixed deformities develop in the hindfoot is a procedure that relieves pain and prevents progressive valgus deformity of the hindfoot. Other arthrodesing procedures are indicated occasionally. It must be remembered by the surgeon and thoroughly explained to the patient that activity of the rheumatoid process militates against the results from surgery and that corrected deformities and pain may recur if the disease progresses. | |
| 454495 | Cardiac involvement in rheumatoid arthritis. Followup study. | 1979 Jun | Initial studies from Bowman Gray School of Medicine showed that 18 of 30 patients with classic rheumatoid arthritis (RA) had cardiac involvement from their disease. These abnormalities were detected by echocardiography and consisted of mitral valve and/or pericardial abnormalities. All patients were followed for 4 years from the initial workup. Mitral valve abnormalities were seen on followup in 63% of the patients who initially showed this abnormality, while pericardial effusion remained in 20%. Pericardial thickening persisted in 6 of 7 patients. None of the patients developed constrictive pericarditis or heart failure. There was no definite correlation between persistence of these abnormalities and other clinical data, but it was noticed that patients who had persistent pericardial effusion and mitral valve abnormalities showed a higher number of involved joints and a higher erythrocyte sedimentation rate. The cardiac abnormalities described in this study have remained clinically insignificant in this population of RA patients. | |
| 6742898 | Incidence of metabolic bone disease in rheumatoid arthritis and osteoarthritis. | 1984 Jun | Bone biopsy specimens from the iliac crest were obtained during surgical operations from 45 patients with rheumatoid arthritis (RA) and 41 with osteoarthritis (OA). Control material was obtained from 20 cases of sudden death due to cardiovascular disease. By both conventional histology and image analysis techniques about a quarter of all patients showed some osteoporosis. This was equally common among the OA and RA patients. It was more common among those with transparent skin and those taking corticosteroids. The only case showing mild osteomalacia suffered from OA. No gross differences were apparent between the groups in relation to plasma biochemical studies, diet, or exposure to sunlight. These results are in striking contrast to the high incidence of osteomalacia in RA reported from the west of England; moreover they do not confirm reports of hypercalcaemia among rheumatoid subjects. We conclude that the differences regarding osteomalacia are due to selection of cases. We find no evidence that osteomalacia is specifically associated with RA. | |
| 383624 | Rheumatoid arthritis: review of searches for an infectious cause. Part I. | 1979 | No distinctive pattern has yet emerged from the accumulated mass of results that would provide a generally acceptable hypothesis of the etiology of rheumatoid arthritis. A number of immunologic aberrations have been described, but there has been no identification of a key immunologic defect that might link together the various components of the immune response into an agreed pattern. The possibility of a persistent antigenic stimulus arising from an infection cannot be confirmed or refuted. If a virus is involved, it would seem more likely to be a "slow" virus rather than a commonly recognized form, but there is no strong candidate of this type in view. Despite the fact that mycoplasmas are undoubtedly arthritogenic in other species, their role as an etiologic agent in rheumatoid arthritis has not been proven. The idea that bacterial cell wall peptidoglycan may provide a persistent stimulus has much to offer, but it is not possible at this stage to accept peptidoglycan as a recognized etiologic factor. This suggestion will, however, indoubtedly stimulate much further investigation. |