Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1186542 | Surgical treatment of aortic valvular disease in rheumatoid arthritis. | 1975 Sep 6 | Two patients with severe rheumatoid arthritis and aortic regurgitation, developed progressive symptoms of left ventricular failure. Symptoms were inadequately controlled by medical therapy. Surgical treatment was at first considered with great reluctance because of the theoretical risk of operative and postoperative complications in patients with a diffuse disease of connective tissue. The suspected complications did not materialize. Valvular replacement should be considered in patients with severe valvular disease associated with rheumatoid arthritis. | |
| 6696527 | Progressive cavitating pulmonary changes in rheumatoid arthritis: a case report. | 1984 Feb | Progressive cavitating changes in the lung apices were found in a middle-aged man with seropositive rheumatoid arthritis. These findings were attributed at autopsy to a combination of nodule-type formation, necrosis, and mild fibrosis. | |
| 6099158 | A long-term study of the effect of early synovectomy in rheumatoid arthritis. | 1984 Fall | Joint recurrence of rheumatoid arthritis following synovectomy is often due to residual rheumatoid granulations within the spongiosa of the bone. This occurs much earlier than heretofore believed. Early synovectomy can often prevent local progression of the disease process. The regrowing fibrous lining after almost total and very early synovectomy does not have the ability to form rheumatoid granulations. | |
| 7456775 | [Neutrophil granulocytes in rheumatic tissue destruction]. | 1980 Sep | Periarticular rheumatoid nodules from 27 patients with rheumatoid arthritis were investigated with a histochemical method to identify polymorphonuclear granulocytes (PMN's). In all necrotic areas PMN's were present, however, in different densities. Most of the necrotic areas contained a minimal or intermediate infiltration with these inflammatory cells. Six rheumatoid nodules exhibited a severe vasculitis with dense perivascular infiltrations of PMN's. This vasculitis was preferentially seen in nodules with necrosis densely infiltrated with PMN's. From the present results it is assumed that PMN's may be involved in the pathogenesis of fibrinoid necrosis in rheumatoid nodules. | |
| 7323107 | Some rheological properties of blood during anti-rheumatoid therapy. | 1981 | A study was carried out to compare the whole blood and plasma viscosities in 11 patients with rheumatoid arthritis treated with hydroxychloroquine to the corresponding values in 10 patients with rheumatoid arthritis treated with either sodium aurothiomalate or D-penicillamine to determine whether hydroxychloroquine therapy altered the rheological properties of red blood cells. There was no significant difference for natural and corrected (PVC = 45%) whole blood viscosity measured by Contraves low shear viscometer and Harkness capillary viscometer, plasma viscosity, haematocrit, or erythrocyte sedimentation rate between the two group. | |
| 3984532 | [Course of chronic polyarthritis]. | 1985 Jan | The great variety of rheumatoid arthritis is well known. By means of exemplary cases subgroups are described, which show more homogeneity in relation to onset and course than rheumatoid arthritis as defined by the ARA-criteria. As a result of treatment clinical signs of inflammation as joint pain and swelling and laboratory findings as ESR and Hb may improve, but there is no change in radiological progression. There are correlations between clinical and laboratory measurements but not to radiological findings. It is considered that inflammation and joint destruction may result from independent pathomechanisms. The conclusion is that the pathognomonic process of rheumatoid arthritis, i.e. destruction, shown by radiological progression, is not influenced by treatment and is reflecting the natural course of the disease. | |
| 6976658 | Plasma exchange in rheumatoid vasculitis. | 1981 Nov | Vasculitis is an uncommon, extremely debilitating complication of severe, chronic rheumatoid arthritis. High levels of circulating immune complexes along with vascular deposition of immunoglobulins and complement indicate an immune complex mediated disease. No pharmacologic therapy has been completely effective and the incidence of mortality is exceptionally high. This study shows clinical improvement with combination of plasma exchange and cytoxan therapy. We report an association in the conspicuous decline of immune complexes with objective clinical remission in 2 patients who underwent combination therapy. This adjunctive combination therapeutic modality is recommended in the treatment of rheumatoid vasculitis. | |
| 6480072 | Lymphocyte sub-populations and NSAIDs. Methodological aspects. | 1984 Jun | Activated lymphocytes can be enumerated as the less dense lymphocyte population (LDL) on a Ficoll density gradient column. The numbers of LDL are higher in rheumatoid arthritis (RA) but fall with successful second-line therapy; they correlate with active synovitis rather than with extra-articular disease. A cytospin technique has been developed which uses fewer cells than conventional suspension techniques and which allows further characterization of LDL using monoclonal antibodies. This confirms that these cells are relatively T-depleted but enriched in IA bearing cells, which may relate to homing patterns to the RA synovium. Using this technique, RA patients with active synovitis were shown to have more LDL and IA bearing cells, as were the active disease controls, including patients with other autoimmune disease (vasculitis) and with non-immune disease (sepsis). There were no differences between the ratios of T-suppressor to T-helper cells within these patient groups. | |
| 1210792 | [Morphology of yttrium-90 treated experimental arthritis]. | 1975 Nov | A rheumatoid arthritis was produced in rabbits according to the method described by Klinge. It was treated with a single dosage of 2 mCi Yttrium-90. After 3 weeks the animals treated with Yttrium showed less fibrosis of the synovial membrane than the controls. After 6 weeks the synovial membrane of the non-treated controls showed considerable fibrosis but the synovial villi of the treated animals were slender and largely unchanged. | |
| 7063814 | Plasma exchange in two patients with rheumatoid vasculitis. | 1982 | Plasma exchange was performed in 2 patients with classical rheumatoid arthritis, complicated in one case by necrotic vasculitis, and in the other by mononeuritis multiplex. Immediate improvement in the peripheral circulation was observed in both patients with subsequent healing of necroses and nerve function, respectively. The treatment was combined with low doses of corticosteroids and cytostatic agents. After 2 years, both patients were still receiving intermittent plasma exchanges, performed at 3-4 month intervals. A correlation between immediate circulatory improvement and lowered plasma viscosity by the plasma exchange was indicated. | |
| 6872817 | Role of telethermography and arthrography in rheumatoid wrist. | 1983 | After briefly reviewing some of the problems relating to an early identification of synovial pathology, the authors have pointed out the actual role of telethermography and arthrography, resulting from their diagnostic experience. The two techniques were applied to a group of 40 patients affected with rheumatoid arthritis and were found to be particularly helpful: (i) either providing quite early information (telethermography); or (ii) allowing an exact topographic definition of synovial and tendinous sheath involvement (opaque arthrography), or eventually (iii) supplying a manageable means to follow their development with. | |
| 7149618 | Importance of physical training of rheumatic patients. | 1982 | Rheumatoid arthritis is a systematic disease which affects synovial joints. The inflammatory process begins in the synovial membranes. Going progressively it destroys cartilage and bone and leads to destruction of all parts of joints bringing severe deformities. The proper physical exercises for rheumatic patients are intended to limit the reflectory muscle tension, to enlarge the range of motion, to strengthen muscle force and to improve physical fitness. Physical exercises should not damage the rheumatoid joints but they should be performed with the limitation of joint surface loading. | |
| 531468 | [Rheumatoid foot. Practical podiatric problems]. | 1979 Dec | The rheumatoid foot may obtain relief from practical local measures that prevent the excessive use of drug therapy. These include the decrease in inflammatory phenomena thanks to local injections of corticoids (eventually synoviorthesis), the prevention of deformations through the use of various apparatuses, the protection of the skin of the palms and the nails that are fragile and rapidly altered by local hygiene care. The maintaining of sufficient support and normal walking through the use of plantar prostheses or custommade toe prostheses and by wearing shoes of excellent quality, the maintainance and preservation of articular flexibility and muscular trophicity by adapted kinestherapy and ergo therapy. Major deformations that, while they cannot be modified do not require surgery, can be alleviated with "custom-made shoes" which are at the same time light, adapted and good looking. Whatever the treatment used, local measures are the most effective at any given time. | |
| 4063622 | Determinants of compliance in rheumatoid arthritic patients assessed in their home environ | 1985 Nov | Patient compliance with prescriber's medication instructions was investigated in 178 rheumatoid arthritis patients treated in community practice. The compliance rate in the sample subjects was estimated to be 63.5%. Disease activity, measured objectively with erythrocyte sedimentation rate (ESR) and subjectively by duration of morning stiffness, was a major incentive for adherence to the treatment regimen. Among subjects with active disease (ESR greater than 20 mm in 1 h), the rate of compliance was 73.8%, but this fell to 52.7% among those with a normal ESR (i.e. ESR less than or equal to 20 mm in 1 h). The motivations and perceptions of the subjects concerning their drug therapy also affected compliance. Compliance was however less dependent on perceptions when active inflammation was present. | |
| 6198848 | Bullous and pustular rheumatoid vasculitis: treatment by plasma exchange. | 1983 | A case of rheumatoid vasculitis (RV) with bullous and pustular lesions is reported. These skin manifestations represent very unusual symptoms of RV. A dramatic clinical improvement was obtained by plasma exchange and immunosuppressive therapy. | |
| 6642375 | [Classification of hip joint involvement in rheumatoid polyarthritis]. | 1983 Oct 6 | The involvement of hip joint in rheumatoid arthritis is regarded. According to the onset, clinical picture, progress and macroscopic shape of the synovial membrane a classification of rheumatoid attack is tried. | |
| 493801 | The distribution of radiological joint damage in the rheumatoid hand. | 1979 Aug | We report a detailed study of the relative distribution of joint damage, as assessed by erosion and joint space scores, in the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints of the rheumatoid hand. Hand radiographs of 30 patients with erosive rheumatoid arthritis were studied. There was significantly more damage in the dominant hand. The little-finger PIP joints were more damaged and the thumb interphalangeal (IP) joints less damaged than the other PIP joints. The index and middle finger MCP joints were more damaged than the other MCP joints. There was a significant negative correlation between the erosion scores of the PIP and MCP joints of each individual digit, when digits with only minimal damage were excluded. These findings support the concept that joint damage in the rheumatoid hand is greater in those joints that are subjected to greater mechanical stresses, and that in any digital ray the damage is concentrated at either the IPI or MCP joint. | |
| 1190700 | A population study of rheumatoid factor in Iceland. A 5-year follow-up of 50 women with rh | 1975 Jun | The subject of this paper is a 5-year follow-up of 50 women found with Rose-Waaler Titre greater than or equal 1 : 10 or with a Acryl Fixation Titre greater than or equal 1 : 10 in a general health survey conducted in the Reykjavik area in 1968-1969. The average annual incidence of RA was 2.3 percent. Of four women who died during the follow-up period, three were amongst those with the highest titres. Two of the decreased had cancer mammae and one had lung cancer. Changes in RF-titres and New York Criteria are also discussed. It is suggested that RF-positives could be divided in three different riskgroups. | |
| 6957611 | Remission: the goal of rheumatic disease therapy. | 1982 Jul | This international symposium is devoted to a discussion of the potential remission-inducing properties of an exciting new agent: auranofin (AF). The definition of remission, however, remains imprecise--meaning "cure" to some and various degrees of improvement to others. The proposed parameters of the ARA Committee for Criteria of Remission in Rheumatoid Arthritis (RA), are compared to physicians' global estimate of disease activity from the ARAMIS (American Rheumatism Association Medical Information System) national rheumatic disease data bank. We report which parameters have corresponded most closely to the suggested criteria for remission of RA. Through such analysis we may be better able to define remission and to determine which patients experience remission during a particular course of therapy. | |
| 7302465 | Arteritis associated with hyperviscosity-like syndrome in rheumatoid arthritis, treated by | 1981 Nov | A case is reported of a hyperviscosity-like syndrome in a 53-year-old male suffering from rheumatoid arthritis. The clinical presentation was an acute abdomen, peripheral neuritis, otovestibular areflexy, and central retinal vein thrombosis (papilloedema and retinopathy with venous engorgement, haemorrhages and exudates). Plasma viscosity was normal and whole blood viscosity, measured with an Oswald viscometer, was slightly elevated. The patient had markedly elevated rheumatoid factor tire and fibrinogen level. Histologically, there were no signs of arteritis in the mesentery. Intermittent plasma-exchange resulted in general improvement and no new vascular accidents after 2.5 years. |