Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 175467 | [Practical significance of HL-A groups in rheumatology]. | 1975 Mar 26 | Since 1972, several relations have been demonstrated between some HL-A antigens and some articular diseases. The W27 antigen frequency is highly increased in ankylosing spondylitis (88%) and in Reiter disease (78%) compared with controls (5%). In peripheral forms of psoriatic rheumatism, the W17 and HL-A13 antigens are more fréquent (24% and 15%) than in healthy subjects (4% and 5%). In central forms of psoriatic rheumatism, there is a relation with W27 (48%) and still, we do not know if this association concerns only spondylitis or also sacro-ileitis. The HL-A typing may be useful for the diagnosis of some rheumatic diseases, when they present atypical appearances. W27 possesses a considerable value for the diagnosis of ankylosing spondylitis. The relation between W27 and ankylosing spondylitis is clearly stronger than that between Waaler-Rose reaction and rheumatoid arthritis. | |
| 796947 | Clinical study of ketoprofen administered rectally in rheumatology. | 1976 | The effects of ketoprofen suppositories were studied in an open trial in 50 patients with various rheumatic disorders. A beneficial effect was obtained in many patients and this lasted for about 8 hours after administration. Mild local irritation was the commonest side-effect but seldom led to withdrawal of treatment. | |
| 3967441 | Essay on total knee arthroplasty. | 1985 Jan | Patient selection in total knee arthroplasty can be a difficult problem for the surgeon. It appears that more young patients are appearing with advanced arthritis of the knee than in the past. Many patients have had previous knee injuries resulting in premature development of degenerative arthritis. The authors believe that in selected cases total knee arthroplasty may be offered to younger patients. Young patients incapacitated by rheumatoid or inflammatory arthritis should not be denied reconstruction by total knee arthroplasty. The problem arises in the more active patient in his forties or fifties who has advanced arthritis of the knee not suitable for treatment by other means. The authors believe that these patients should not be treated by conventional total knee arthroplasty. On an experimental basis, the authors have been performing cementless total knee arthroplasty in younger, more active patients with disabling arthritis. Precision of surgical technique is critical with the newer cementless type of knee replacement. | |
| 7038852 | Demonstration of Ia antigens on certain dendritic cells and on a novel elongate cell found | 1981 Oct | Adherent cells from dissociated human synovial tissue obtained at surgery contain two types of distinctive cells with one or more elongated branching processes that strongly express Ia antigens. One type of cell with Ia antigens is non-phagocytic and resembles the murine dendritic cell. It is primarily found in patients with rheumatoid arthritis and accounts for a considerable proportion of the identifiable cells with a stellate or dendritic morphology. The expression of Ia antigens progressively diminished in culture. The second type of novel cell with Ia antigens was highly elongate and fibroblastoid. It was readily obtained from patients with osteoarthritis. The cell was frequently characterized by a blunt-ended filopodium-like process at one pole of the cell, one or two tapering processes, and zones of microvilli. Evidence was obtained suggesting that this cell, which might otherwise be considered fibroblast-like, is in the mononuclear phagocyte lineage. | |
| 356239 | A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheum | 1978 | The efficacy and tolerance of proquazone, 900 mg, and ibuprofen, 1200 mg, were compared in a randomized, double-blind clinical trial of 6 months' duration, with 44 patients, 21 on proquazone and 23 on ibuprofen. Comparison of proquazone-treated patients with patients treated with iburofen showed a significantly better improvement , as is demonstrated by the significant differences in the Lansbury Index, in nocturnal pain, final assessment of therapeutic effect, and number of interruptions due to lack of efficacy. All differences were in favour of proquazone, proving its therapeutic superiority over ibuprofen. The side effects in the proquazone group were mainly gastrointestinal, and 2 patients broke off treatment prematurely due to diarrhoea (in one patient, lack of efficacy was a contributory cause). A third patient discontinued because of moderate nausea and dizziness. In the ibuprofen group, 4 patients discontinued because of side effects (skin eruptions, dizziness, epigastric discomfort, and one thrombocytopenia) in addition to lack of efficacy. Proquazone seems to be an effective and well tolerated anti-inflammatory analgesic. | |
| 6150851 | Vasculitis: immunological aspects. | 1984 | The laboratory approach to patients with a vasculitic syndrome is of limited help in defining the diagnosis but may provide clues as to the pathogenesis (immune complex-mediated or cell-mediated reaction). Serial determinations of immune complexes or complement levels can also serve as the basis for assessment of disease activity and therapeutic interventions in some patients. In addition to angiographic findings there is only one way of establishing a tentative diagnosis of vasculitis: by histological demonstration. | |
| 7244585 | Lysosomal hydrolases in different compartments of rheumatoid and osteoarthrotic joints. | 1981 | Tissue samples from 226 rheumatoid and osteoarthrotic joints displayed increased activities of three lysosomal enzymes compared with controls. Variations in activity were evident--one tissue cannot be blamed for all joint destruction, no one enzyme can be used as a diagnostic tool. Free enzyme activities in synovial fluid reflected those in tissues, especially in cartilage and bone. Increased values in osteoarthrotic sera, close correlation of ESR to activities in joint compartments, and higher values in synovial fluid, cartilage and bone of seronegative rheumatoid patients were recorded. | |
| 6282291 | [The production of superoxide anion (O2-) by polymorphonuclear cells in patients with rheu | 1982 Apr 15 | Superoxide anion production has been determined in controls and RA patients PMNs stimulated with zymosan, rheumatoid synovial membrane, nodule and synovial fluid, rheumatoid factor, aggregated gamma-globulins, Mycoplasma and Epstein-Barr virus. Patients with RA showed an increased production of O2- after incubation with zymosan and rheumatoid tissue extracts or synovial fluid in comparison to normal controls. The findings indicate that rheumatoid PMNs become activated by different stimuli to produce an excess of O2- which can contribute to chronic inflammatory process. | |
| 6978496 | Rheumatic diseases in the elderly. Finding a way through the maze. | 1982 Mar | The manifestations of rheumatic disease in the elderly present a confusing array of diagnoses to the primary care physician. Helpful guidelines in pursuing a definitive diagnosis are outlined, with special mention of three rheumatic conditions (pseudogout, polymyalgia rheumatica, and temporal arteritis) which are uniquely characteristic of elderly patients. | |
| 7358754 | Stress fractures after total knee arthroplasty. | 1980 Mar | Fifteen patients sustained fractures of the tibia after geometric and polycentric total knee arthroplasty. The mean follow-up after arthroplasty was 45.1 months. The chief causes for the stress fractures were axial malalignment and improper component orientation. All fifteen patients experienced loosening of the prosthesis and required revision arthroplasty for a satisfactory result. Revision at the time of diagnosis of the fracture did not adversely affect fracture healing. | |
| 960709 | [Cytogenetic investigations in patients receiving an intraarticular injection of gold-198 | 1976 Feb 6 | The chromosomes of lymphocyte cultures from the peripheral blood were investigated in 10 patients (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis of the knee) before and at short-term intervals (1 day, 3 to 4 days, 14 to 18 days) after the injection of gold-198 (5 to 20 mC; usually 8 mC; average particle size 300 A) into the knee-joint. The number of structural chromosomal abberrations increased markedly in 4 of the 10 patients. On the first day after the gold injection the mean aberration rate was significantly higher than the control value (Chi2-5.18; df=1; P less than 0.05). Most of the observed aberrations were chromatid aberrations and this finding is discussed. | |
| 3904889 | Direct immunofluorescence of normal skin in rheumatoid arthritis. | 1985 Nov | The clinical significance of previously described immunoglobulin and complement deposition in the superficial dermal vessel walls of patients with rheumatoid arthritis is unknown. In the present study, skin biopsies were obtained from the normal forearm and buttock of 48 unselected patients with rheumatoid arthritis and were examined by direct immunofluorescence (IF) for the presence of immunoglobulin (IgG,A,M) and complement (C3) in the vessel walls. Deposits of C3, IgM or IgG were detected in 10 patients. Five patients had deposits at the forearm sample alone, four patients had deposits at both biopsy sites, while one patient was positive at the buttock alone. Clinical features were similar in patients with and without vessel IF. However, patients with IF were significantly more seropositive with lower levels of complement and raised levels of serum IgA and IgM. There was also an increased level of circulating IgG immune complexes in these patients. Further analysis following exclusion of seronegative patients revealed similar results. This study suggests that the presence of vessel IF identifies a subgroup of patients who have evidence of more severe immunological disturbance. | |
| 7377017 | PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. | 1980 | Prostaglandins (PG) are currently suspected to be involved in human rheumatoid arthritis (RA). We have studied the PG [PGE2, PGF2 alpha, and Thromboxane B2 (TXB2)] biosynthesis capacity of normal (from amputations) and pathologic (osteoarthritis (OA) and RA) synovia. The measurement is done on the whole homogenate and microsomal fraction after 40 min incubation, without exogenous arachidonic acid (AA) or with a saturating concentration (25 micrograms/ml) of this compound, using a radioimmunoassay method. There is a considerable increase in PGE2 and PGF2 alpha production by the rheumatoid synovia and more PGE2 and PGF2 alpha are formed. This production is more marked for homogenates than microsomal fraction. The OA group is not homogeneous and does not differ significantly either from normals or from RA. The addition of AA considerably increases the biosynthesis of PG in both normal and pathologic tissue. For TXB2, the first results (four synovia) show no or a small biosynthesis in RA as well as in normals. Nevertheless, the levels before incubation seem higher in RA than in normal tissue. | |
| 1085149 | Lymphocyte populations in rheumatoid arthritis. | 1976 Jul | For each of 28 patients with RA and 27 normal controls, the in vitro lymphocyte responses to PHA and to Con A were simultaneously determined on aliquots of the same cell preparation. In the case of RA lymphocytes, the response to Con A was abnormally low when compared with the simultaneous response to PHA (P less than 0.01). Cells capable of responding to PHA were specifically killed with BUdR. The cells remaining after this procedure showed a relatively greater response to Con A than did the original population. In the case of RA lymphocytes, this relative increase in the response to Con A was significantly less than normal (0.02 greater than P greater than 0.01). These results suggest that a lymphocyte subpopulation, responding principally to Con A, is relatively reduced in RA. | |
| 6742912 | Felty's syndrome associated with high levels of IgA rheumatoid factor. | 1984 Jun | A 64-year-old woman with rheumatoid arthritis developed Felty's syndrome. Her serum contained large amounts of IgA rheumatoid factor (RF) but insignificant levels of IgM-RF and IgG-RF. It is postulated that the high levels of IgA-RF may have contributed to the neutropenia. | |
| 3915886 | Long-term study with Ro 12-0068 (tenoxicam) in the treatment of rheumatoid arthritis. | 1985 | Thirty patients were allocated in a double-blind study comparing piroxicam 20 mg to tenoxicam 20 mg. Both drugs were administered once daily, before breakfast, for a period of 6 months. Clinical evaluations were performed weekly during the first 6 weeks and then monthly. The following parameters were evaluated: Ritchie articular index, pain on movement, pain at rest, grip strength, functional status, and morning stiffness. Laboratory examinations were performed before, on the 42nd day and on the 6th month of therapy. Efficacy was considered favourable in 10 cases treated with tenoxicam and in 12 with piroxicam and poor in five treated with the former and in three with piroxicam. Three patients of each group presented side effects of slight intensity. Considering the good results seen in the patients receiving tenoxicam, the treatment was maintained in nine cases for a further period of 6 months. Eleven other patients from the piroxicam group also received tenoxicam for a further period of 6 months. The efficacy was maintained in all 20 patients. Regarding adverse reactions, one patient complained of abdominal pain in the twelfth month of therapy and another patient had a brief episode of meteorism in the ninth month. | |
| 6796008 | Antiprostaglandin synthetase activity of nonsteroidal anti-inflammatory drugs and gastroin | 1981 Oct | By using 51Cr-labelled erythrocytes and 141Ce-labelled microspheres to correct for daily variations in faecal output, gastrointestinal microbleeding was measured in hospital patients with rheumatoid arthritis before and after administration of 2 propionic acid derivatives. These were flurbiprofen and benoxaprofen, respectively a potent and a weak prostaglandin synthetase inhibitor. Increased faecal blood loss occurred consistently with flurbiprofen and not with benoxaprofen. Our results provide indirect evidence for the cytoprotective effect of prostaglandins on the gastrointestinal mucosa in man. The quantitative correlation between faecal occult blood loss as measured by the above techniques and the Haemoccult slide test is also discussed. | |
| 188147 | [Clinical and statistical study of 100 patients with vitiligo. II. Associated lesions]. | 1976 Mar 16 | A study of 100 cases of vitiligo showed the frequency of associated skin and visceral lesions. A skin disease was associated in 24 cases: psoriasis 4 cases, alopecia 4 cases, eczema 3 cases, malignant melanoma 2 cases, dermatitis herpetiformis 1 case, lichen planus 9 cases. However, only one case of Sutton's naevus was noted. Among other associations noted in 28 cases, there were 7 cases of thyroid disease, 5 cases of diabetes, 1 case of chronic rheumatoid arthritis and 3 gastric disorders. The frequency of these various associations was discussed in the light of other authors' reports. If one compares the 21 cases associated with auto-immune disease and the other cases of vitiligo, there was no significant difference for the various parameters studied. Thus the significance of the various biological signs of autoimmunisation remains doubtful and even the precise definition of vitiligo remains uncertain. | |
| 822509 | Polyclonal human antibodies to IgG (rheumatoid factors) which cross-react with cell nuclei | 1976 | Antibodies to human IgG (rheumatoid factors (RF) from serum Han resembled the 'intermediate' complexes of sera from some patients with rheumatoid arthritis. These RF were isolated from heat-inactivated serum by affinity chromatography on agarose-coupled human IgG. Indirect immunofluorescence revealed that the isolated RF cross-reacted with cell nuclei from many species. Virtually all the antinuclear factor (ANF) activity of this serum was extracted by IgG-agarose. Alternative explanations of this phenomenon, such as nonspecific binding of a separate population of ANF, binding of ANF to the immunosorbent via an IgG RF-IgG ANF immune complex, or presence of nuclear antigens on the immunosorbent, were ruled out. The cross-reacting antibodies possessed both kappa and lambda light chains and predominantly gamma and some mu heavy chains, indicating that they were of polyclonal origin. The antinuclear activity was present in the F(ab')2 fragments. The interpretation of this strange cross-reaction is briefly discussed. | |
| 1229741 | [Significance of ear lobe biopsy in the diagnosis of angiopathies inflammatory-rheumatic d | 1975 May | Biopsy of the ear lobule in inflammatory rheumatic and collagen diseases is not a suitable method for detecting vascular involvement. A perivascular cell infiltration van often be found but it non-specific. The intensity of cell infiltration did not correlate with duration, severity or activity of the disease process. |