Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 173010 | Virologic studies in rheumatoid arthritis. | 1975 | Comparison of virus antibody titers in JRA and matched controls failed to implicate rubella, measles, parainfluenza type 1 or Epstein-Barr viruses. Neither RNA viruses or mycoplasma were detected in rheumatoid synovial cell cultures by 3H-uridine incorporation. Mycoplasma were not isolated from rheumatoid synovial membranes or cell cultures using the large specimen-broth culture procedure. The balance of available evidence, including our own, suggests that mycoplasma are not involved in RA. Viruses, however, are better candidates, in spite of similar generally negative studies to date, because methods for detecting known latent infection in animals and in vitro are still in their infancy. Those that are known have not yet been comprehensively applied to RA. Thus, supported by indirect evidence from animal models and human diseases like polyarteritis, the hypothesis that viruses are involved in the pathogenesis of RA remains attractive, although direct evidence is still lacking. | |
| 3978872 | Complement activating properties of complexes containing rheumatoid factor in synovial flu | 1985 Feb | The relationship between complexes containing rheumatoid factor and complexes activating complement was examined in synovial fluids and sera from patients with rheumatoid arthritis (RA). In each case this was performed by quantifying the amount of rheumatoid factor bound by solid phase Fab'2 anti-C3 and/or solid phase conglutinin. Both anti-C3 coated and conglutinin coated microtitre plates bound high levels of complexes containing rheumatoid factor from sera of RA patients with vasculitis. Unexpectedly, these complexes were detected in synovial fluids from only a minority of RA patients with synovitis. However, RA synovial fluids did contain other complexes as shown by the presence of complement consuming activity, C1q binding material and immunoglobulin attaching to conglutinin. It is considered that in RA synovial fluids the complexes containing RF and those activating complement are not necessarily the same whilst in vasculitic sera the complexes containing rheumatoid factor also activate complement. | |
| 6187582 | A highly conserved determinant on human rheumatoid factor idiotypes defined by a mouse mon | 1983 Mar | Different human IgM rheumatoid factor (IgM RF) idiotypes have been described defined by polyclonal rabbit anti-idiotypic antibodies. These antisera do not allow clear genetic analysis of the idiotypic determinants, be they cross-reactive or private. Therefore, we tried to obtain a set of monoclonal anti-idiotypic antibodies directed against RF idiotypes. Purified IgM RF serum from a patient with classical rheumatoid arthritis was used to immunize BALB/c mice. The spleen cells were fused with Sp 2/0 Ag 14, a nonsecreting mouse myeloma cell line, and a hybrid producing monoclonal anti-idiotypic antibody was selected. The mouse antibody, an IgG1 kappa, reacts with an identical or similar determinant located on (or close to) the binding site of all tested monoclonal or polyclonal IgM RF from totally unrelated patients with Waldenströms's macroglobulinemias or rheumatoid arthritis. The monoclonal antibody also reacts with 2 rheumatoid arthritis patients' IgG RF and with a low proportion of normal polyclonal IgM without detectable RF activity. An hypothesis is proposed to explain the existence of a such highly conserved determinant on RF idiotypes. | |
| 6824821 | Proteinuria with gold therapy: when should gold be permanently stopped? | 1983 Feb | The treatment records of patients on gold therapy have been studied with particular respect to the development of proteinuria. This was classified as mild (up to 0.3 g/l), moderate (0.4-2 g/l), or heavy (more than 2.0 g/l). Particular attention was paid to the mode of onset and prognosis of the proteinuria and to subsequent gold administration. Twenty-seven patients with moderate or heavy proteinuria were identified. Two were suffering from psoriatic arthropathy, the rest were diagnosed as having rheumatoid arthritis, although three were persistently sero-negative. There was a direct correlation between the degree of proteinuria and its duration. Heavy proteinuria persisted for at least three months, whereas moderate proteinuria cleared within this period. No patient developed permanent renal impairment. Nine of 10 patients with heavy proteinuria had preceding mild or moderate proteinuria during which period gold administration had been continued. Fourteen of 17 patients with moderate proteinuria had their gold injections continued or re-started and none of these subsequently developed heavy proteinuria. It is suggested that moderate proteinuria should lead to cessation of gold therapy until the urine is clear but that subsequently treatment may be safely re-started. | |
| 6318713 | A comparison of Epstein-Barr virus-specific T-cell immunity in rheumatoid arthritis and os | 1983 Oct | The level of Epstein-Barr virus (EBV)-specific T-cell-mediated immunity in 20 rheumatoid arthritis (RA) patients was compared with 16 age- and sex-matched osteoarthritis (OA) patients using the regression of EBV-transformation assay. The results show that the level of EBV-specific T-cell immunity in RA patients is significantly depressed compared with OA patients (P less than .001) or healthy laboratory controls (P less than .001). In contrast, lymphocytes from RA and OA patients showed a similar ability to act as a responder population in the mixed leucocyte reaction. It is unlikely that the difference in EBV-specific immunity is due to a general T-cell defect in RA patients since there was no correlation between EBV-specific T-cell immunity and mixed leucocyte reactivity. There was no correlation between EBV-specific T-cell immunity and any of the indicators of disease activity nor was there any difference in the anti-EBV antibody titre between both groups of patients. These results indicate that RA patients are deficient in the EBV-specific cytotoxic T-cell precursor population and may explain some of the reported observations of the involvement of EBV in this disease. | |
| 3886120 | Pulmonary manifestations of the rheumatic diseases. | 1985 May | The collagen vascular diseases represent a heterogeneous group of multisystem disorders with a wide range of clinicopathologic features. Although these diseases represent distinct clinical entities, a great deal of overlap exists between them. For example, the diffuse interstitial fibrosis of SLE, RA, DM-PM, PSS, and MCTD are indistinguishable clinically, radiographically, and histologically. Conversely, the pulmonary manifestations of the various vasculitides all differ significantly from each other in their clinicopathologic presentation, as well as in their response to therapy. For diagnostic purposes, histologic evidence will usually be required for the pulmonary manifestations of the rheumatic diseases. Therapy must then be individualized for each of these entities, as the protocol and response are variable. | |
| 377447 | Treatment of rheumatoid arthritis with a single daily dose of benoxaprofen. | 1979 May | A single daily dose of 600 mg of henoxaprofen has been shown to be more effective than a previously reported dosage regime in patients with rheumatoid arthritis. Increased total daily dosage was not associated with a greater incidence of side-effects. The drug worked slowly reaching a plateau after eight days of treatment. It was usually well tolerated especially by the gastro-intestinal tract. | |
| 6607502 | [Familial studies of reactive arthritis]. | 1983 Nov | A survey conducted by the French Society of Rheumatology indicates that 10 p. cent of subjects with reactive arthritis have a family history. This family history can be divided into 3 equal groups of diseases : rheumatic pelvispondylitis, reactive and unclassified arthritis and psoriasis (3.5 p. cent for each condition). The B27 antigen is present in 67 p. cent of cases of reactive arthritis, which is significantly lower than the incidence in rheumatic pelvispondylitis. Informative family studies are presented which demonstrate their value as an in diagnosis, the roles of hereditary factors and the arguments for and against a predisposing gene close to but different from B27. | |
| 975664 | UCI knee replacement. | 1976 Oct | Between March 9, 1972 and December 31, 1973, a total of 103 UCI knee replacements were performed. Follow-up data are available on 83 knees with an average follow-up of 33 months. Patient evaluation of the end results indicates that 78.3 per cent were better, 9.6 per cent unchanged, and 12.1 per cent worse. Patient evaluation of their own knee function averaged 55 per cent preoperatively and 79 per cent postoperatively. Patients were also evaluated on a 100 point Modified Larson Analysis Form. The average preoperative score was 46, and the average postoperative score was 70. There were six (5.8%) biological complications in the 103 knee replacement. Biological complications included infections, wound healing problems and unexplained pain. Mechanical complications were seen in 18 (17.4%) knees, and included knee instability, tibial component loosening or deformation, and patellar problems. Additional surgery was required in 18 (17.4%) knees. Failure of the procedure eventually requiring removal of the prosthesis and fusion or amputation occurred in 4 (3.9%) knees. The intermediate-term results of UCI knee replacement have been clinically satisfactory. We currently recommend consideration of this procedure for patients with disabling arthritis of the knee. | |
| 2581732 | Inflammatory bowel disease. | 1985 Apr | The place of inflammatory bowel disorders in the spondarthritis matrix has been discussed and aetiopathological and clinicoradiological features of their individual arthropathies described. Particular emphasis has been placed on the arthropathies of ulcerative colitis and Crohn's disease, but a comment is also included on the much rarer condition, Whipple's disease. The position of reactive arthritis resulting from enteric infection in relation to the spondarthritis concept is examined in the light of Reiter's-like clinical features and the association with HLA-B27. More 'peripheral' ideas of possible relevance to the spondarthritis idea (drug-induced colitis, intestinal-bypass syndrome) are included, together with a final section on experimental models of inflammatory bowel disease and of their arthropathies. It is concluded that certain inflammatory bowel disorders deserve a continuing place within the spondarthritis complex. Although their aetiopathogenesis is still imperfectly understood, it is likely that a blend of genes of small effect (polygenic inheritance) and environmental factors (e.g. microorganisms and/or their products) trigger disease processes which are enabled to manifest themselves by intermediary immunological processes. The precise way in which this is achieved is not yet known, but there is evidence that microorganisms (presumably in the gut of individuals genetically predisposed and suitably exposed environmentally) generate the formation of immune complexes. It is likely that these not only damage or further damage the mucosal lining of the bowel but also result in arthropathy and features of the disease 'distant' from bowel and joint (e.g. ocular inflammation, oral ulceration and skin manifestations). This concept is summarized in Figure 5. | |
| 6975373 | [Radiological signs of "mixed" connective tissue disorders with anti-RNP antibodies. Repor | 1981 Aug | Case reports of 20 patients with connective tissue disorders and anti-RNP antibodies are reviewed. Specific radiological signs could not be detected : patients with minor forms do not show osteoarticular lesions; in those with congenital types of disorder the radiological anomalies are mainly those of connective tissue lesions. Clearly differentiated forms demonstrate anomalies related to the corresponding affection. | |
| 396668 | Hyporesponsiveness to virus antigens in rheumatoid synovial and blood lymphocytes using th | 1979 | Mononuclear cells (MNC) from rheumatoid synovial tissue and peripheral blood were tested plasma pneumonia by the indirect leucocyte migration inhibition test. MNC from the eleven rheumatoid synovial tissues tested had deficient leucocyte inhibitory factor production against all antigens tested for, and this was also the case in the peripheral blood of seven juvenile rheumatoid arthritis patients (JRA). In the peripheral blood of eight rheumatoid arthritis (RA) patients there was also generally low reactivity. However, significant differences in migration indexes were found with rubella viral antigen and with PPD at 5 micrigram/ml when zero-hour and overnight incubations of the culture were compared. In contrast, MNC of peripheral blood of control donors had significant responses to PPD (19/19), mumps virus (7/11), rubella virus (10/19), cytomegalovirus (4/11), and herpes simplex type 1 virus (4/11) antigen after zero-hour culture, and no differences was seen after overnight incubation. | |
| 6252263 | Bilateral attritional rupture of the ulnar nerve at the elbow. | 1980 Jul | In a 56-year-old woman with severely deforming rheumatoid arthritis, surgical exploration demonstrated partial rupture of one ulnar nerve and complete rupture of the other. | |
| 1083608 | [EA rosettes in patients with progressive chronic polyarthritis]. | 1976 Mar | One subpopulation of human lymphocytes contains Fc-receptors that form rosettes with antibody (IgG) coated human erythrocytes (EA-rosettes). On the average 8.9% of the lymphocytes from patients with rheumatoid arthritis (RA) form EA-rosettes compared with 5.3% in controls. When the lymphocytes were washed three times the EA-rosettes increased to 21.2% for RA patients and 9.5% for controls. This procedure thus reveals more Fc-receptors on the lymphocytes from RA patients than on those from healthy controls. The number of T-lymphocytes was normal in RA patients and controls, no matter how many times the lymphocytes were washed. | |
| 1204948 | Anti-HBsAg assay using the Ausria system with standard antigen dilutions. | 1975 | A simple modification of the radioimmunoassay Ausria I and Ausria II was employed for detecting anti-HGsAg using the inhibition of a constant amount of HBsAg. The highest incidence of anti-HGsAg was demonstrated in follow-up patients recovering from viral hepatitis B (82%) and in hemophilia patients (79%). Lower frequencies were observed in patients with chronic aggressive hepatitis or liver cirrhosis (23%), patients with chronic rheumatoid arthritis (16%), family contacts of patients with viral hepatitis B (10%) and blood donors (3.4%). No difference in sensitivity for the presence of anti-HBsAg was found between the Ausria I and the Ausria II test. | |
| 4094986 | Experience with the bipolar prosthesis in hip arthroplasty. A clinical study. | 1985 Apr | Hip arthroplasty using a bipolar prosthesis was performed in 73 patients (75 hips) with femoral neck fracture, osteoarthritis, rheumatoid arthritis, or degenerative arthritis. Bipolar hip arthroplasty is more conservative than conventional total hip arthroplasty, because methyl methacrylate usually is not needed to fix the bipolar prosthesis to bone. Overall results were 67.1% good to excellent, 20.5% fair, and 12.3% poor; among the arthritic patients, the results were 72.9% good to excellent, 19.1% fair, and 8.5% poor. Complications included one deep wound infection and one arterial embolus; no dislocations occurred. | |
| 825053 | Complement and immunoglobulins in synovial fluid from synovectomized patients with rheumat | 1976 Jun | In order to see if the complement (C) consumption and conversion, which are typical of rheumatoid joints, continue after synovectomy, 23 knee joints in which synovectomy had been performed from 4-5 to 6-5 years previously, were studied. The mean ratio of the concentration of C3, C4, and C5 in synovial fluid to that in palsma of the same patient was significantly lower than the corresponding ratio for the total protein content. This was found both in joints with active arthritis and in joints without clinical signs of arthritis, and in both seropositive and seronegative patients. Conversion products of C3 were found in 7 of the synovial fluids. The study thus indicated that the complement alterations in synovectomized joints are very similar to those in nonsynovectomized rheumatoid joints. In one synovial fluid agarose electrophoresis showed multiple sharp bands in the gamma region. By crossed immunoelectrophoresis some bands seemed to contain IgG with one type of light chains only. In plasma of the same patients the bands were much weaker, indicating local production of oligoclonal IgG in the joint. | |
| 6206811 | Low pleural fluid amylase associated with spontaneous rupture of the esophagus. | 1983 May | All previously reported determinations of pleural fluid amylase in Boerhaave's syndrome have demonstrated elevated values. We treated a patient with Sjögen's syndrome who had a low pleural fluid amylase level and the concomitant unusual finding of leakage of esophageal contents into the right pleural space. | |
| 7039267 | Mechanisms of action of gold. | 1981 Nov | Since the successful introduction of injectable gold compounds for the treatment of rheumatoid arthritis over 50 years ago, numerous studies on the possible mechanism of action have been performed. This heavy metal has been show to possess a bewildering array of biological effects. Studies using gold performed both in vitro and in vivo can be grouped into anti-microbial, anti-immunologic, anti-inflammatory, anti-enzymatic and other effects. In this survey, we have analyzed these multiple approaches to the study of the mechanism of action of injectable gold preparations and apply the findings to rheumatoid arthritis. | |
| 7092168 | Fibronectin in rheumatoid and non-rheumatoid arthritic synovial fluids and in synovial flu | 1982 May | Concentrations of fibronectin, immunoglobulins G, M, and A, and C3 and C4 components of complement, and other plasma proteins were determined in synovial fluids from patients with rheumatoid arthritis (RA) and other diseases (non-RA). Fibronectin concentrations were two to three times greater in all synovial fluids than in plasma, and RA synovial fluids had a significantly higher mean concentration than non-RA fluids (883 microgram per ml vs. 588 microgram per ml, respectively, p less than 0.01). The mean concentrations of other synovial fluid constituents were less than their mean plasma concentrations. These results suggest that unlike other plasma constituents, either plasma fibronectin is concentrated in synovial fluids or that a substantial portion of synovial fluid fibronectin may be derived from synovial tissue cells. Both the C3 and C4 complement components were present in lower concentrations in RA than in non-RA synovial fluids. The C3 contents showed a statistically significant negative correlation with the fibronectin contents. Fibronectin was also found in all synovial fluid cryoprotein fractions tested, although its content varied greatly as a percent of the total cryoprotein protein (0.01 to 43 percent). The data show that fibronectin is a consistent constituent of synovial fluid cryoproteins in agreement with our previously reported finding that fibronectin is found in all serum cryoglobulin fraction tested. |